| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
We previously reported that mitochondrial reactive oxygen species (mtROS) is one of the major factors in the pathogenesis of diabetic vascular complications. In this study, we examined the impact of mtROS in the pathogenesis of diabetic nephropathy using endothelial cells and transgenic mice, which specifically express manganese superoxide dismutase (MnSOD) in vascular endothelial cells.
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