Impact of mitochondrial reactive oxygen species in the pathogenesis of diabetic nephropathy
| Project/Area Number |
20591065
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Kumamoto University |
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Principal Investigator |
NISHIKAWA Takeshi Kumamoto University, 大学院・生命科学研究部, 特任准教授 (70336212)
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| Co-Investigator(Kenkyū-buntansha) |
MIYAMURA Nobuhiro 熊本大学, 大学院・生命科学研究部, 准教授 (40274716)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | エネルギー / 糖代謝異常 / 糖尿病 / 糖尿病合併症 / ミトコンドリア / 活性酸素 / MnSOD / MnSODA / メタボリックシンドローム |
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| Research Abstract |
We previously reported that mitochondrial reactive oxygen species (mtROS) is one of the major factors in the pathogenesis of diabetic vascular complications. In this study, we examined the impact of mtROS in the pathogenesis of diabetic nephropathy using endothelial cells and transgenic mice, which specifically express manganese superoxide dismutase (MnSOD) in vascular endothelial cells.
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Report
(4 results)
Research Products
(50 results)
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[Journal Article] Telmisartan Exerts Antiatherosclerotic Effects by Activating Peroxisome Proliferator-Activated Receptor-γ in Macrophages.2011
Author(s)
Matsumura T, Kinoshita H, Ishii N, Fukuda K, Motoshima H, Senokuchi T, Taketa K, Kawasaki S, Nishimaki-Mogami T, Kawada T, Nishikawa T, Araki E
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Journal Title
Arterioscler Thromb Vasc Biol in press
Related Report
Peer Reviewed
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[Journal Article] Caloric restriction decreases ER stress in liver and adipose tissue in ob/ob mice.2011
Author(s)
Tsutsumi A, Motoshima H, Kondo T, Kawasaki S, Matsumura T, Hanatani S, Igata M, Ishii N, Kinoshita H, Kawashima J, Taketa K, Furukawa N, Tsuruzoe K, Nishikawa T, Araki E
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Journal Title
Biochem Biophys Res Commun 404
Pages: 339-344
Related Report
Peer Reviewed
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[Journal Article] The effect of group-based lifestyle interventions on risk factors and insulin resistance in subjects at risk for metabolic syndrome : The Tabaruzaka Study 1.2010
Author(s)
Yamashiro T, Nishikawa T, Isami S, Wei C, Fukumoto K, Matsuo H, Yoshinaga T, Kukidom D, Motoshima H, Matsumura T, Ueda A, Araki E
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Journal Title
Diabetes Obes.Metab. 12
Pages: 790-797
Related Report
Peer Reviewed
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[Journal Article] Nifedipine induces peroxisome proliferator-activated receptor-gamma activation in macrophages and suppresses the progression of atherosclerosis in apolipoprotein E-deficient mice.2010
Author(s)
Ishii N, Matsumura T, Kinoshita H, Fukuda K, Motoshima H, Senokuchi T, Nakao S, Tsutsumi A, Kim-Mitsuyama S, Kawada T, Takeya M, Miyamura N, Nishikawa T, Araki E
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Journal Title
Arterioscler Thromb Vasc Biol 30
Pages: 1598-1605
Related Report
Peer Reviewed
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[Journal Article] Angptl 4 deficiency improves lipid metabolism, suppresses foam cell formation and protects against atherosclerosis.2009
Author(s)
Adachi H, Fujiwara Y, Kondo T, Nishikawa T, Ogawa R, Matsumura T, Ishii N, Nagai R, Miyata K, Tabata M, Motoshima H, Furukawa N, Tsuruzoe K, Kawashima J, Takeya M, Yamashita S, Koh GY, Nagy A, Suda T, Oike Y, Araki E
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Journal Title
Biochem Biophys Res Coromun 379
Pages: 806-811
Related Report
Peer Reviewed
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[Journal Article] Activation of AMP-activated protein kinase suppresses oxidised low-density lipoprotein-induced macrophage proliferation.2009
Author(s)
Ishii N, Matsumura T, Kinoshita H, Motoshima H, Kojima K, Tsutsumi A, Kawasaki S, Yano M, Senokuchi T, Asano T, Nishikawa T, Araki E
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Journal Title
J Biol Cbem 284
Pages: 34561-34569
Related Report
Peer Reviewed
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[Journal Article] Rottlerin activates AMPK possibly through LKBl in vascular cells and tissues.2008
Author(s)
Kojima K, Motoshima H, Tsutsumi A, Igata M, Matsumura T, Kondo T, Kawashima J, Ichinose K, Furukawa N, Inukai K, Katayama S, Goldstein BJ, Nishikawa T, Tsuruzoe K, Araki E
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Journal Title
Biochem Biophys Res Commun 376
Pages: 434-438
Related Report
Peer Reviewed
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[Presentation] 熊本県における高齢者の腎機能障害の現状2010
Author(s)
西川武志, 山城武司, 久木留大介, 吉永智昭, 本島寛之, 松村剛, 宮村信博, 荒木栄一
Organizer
日本老年医学会 第20回九州地方会
Place of Presentation
熊本大学医学部医学教育図書棟
Year and Date
2010-03-13
Related Report
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