Role of Senescence Marker Protein-30in Glucose Homeostasis

• Project/Area Number: 20591066
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: HASEGAWA Goji Kyoto Prefectural University of Medicine, 医学研究科, 准教授 (00295643)
• Co-Investigator(Kenkyū-buntansha): ISHIGAMI Akihito 東邦大学, 薬学部, 准教授 (50270658)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: エネルギー・糖質代謝異常 / 糖尿病 / 老化 / 生体分子 / インスリン

Research Abstract

The impairment of early phase of insulin secretion due to dysfunction of the distal portion of insulin secretion pathway underlies glucose intolerance in SMP30 knockout mice. Decreased SMP30 may contribute to the worsening of glucose tolerance that occurs in normal aging.

Research Products

• [Journal Article] Senescence Marker Protein-30/Gluconolactonase deletion worsens glucose tolerance through impairment of acute insulin secretion. (2010)
  • Author(s): Hasegawa G, Yamasaki M, Kadono M, Tanaka M, Asano M, Senmaru T, Kondo Y, Fukui M, Obayashi H, Maruyama N, Nakamura N, Ishigami A.
  • Journal Title: Endocrinologyl 51(2) Pages: 529-536
  • Peer Reviewed
• [Journal Article] Hepatic senescence marker protein-30 is involved in the progression of nonalcoholic fatty diease. (2010)
  • Author(s): Park H, Ishigami A, Shima T, Mizuno M, Maruyama N, Yamaguchi K, Mitsuyoshi H, Minami M, Yasui K, Itoh Y, Yoshikawa T, Fukui M, Hasegawa G, Nkamura N, Ohta M, Obayashi H, Okanoue T.
  • Journal Title: J Gastroenterol 45(4) Pages: 426-434
  • Peer Reviewed
• [Journal Article] Decreased Senescence Marker Protein-30 could be a factor that contributes to the worsening of glucose tolerance in normal aging. (2010)
  • Author(s): Hasegawa G.
  • Journal Title: Islets 2(4) Pages: 258-260
  • Peer Reviewed
• [Journal Article] Decreased Senescence Marker Protein-30 could be a factor that contributes to the worsening of glucose tolerance in normal aging. (2010)
  • Author(s): Hasegawa G
  • Journal Title: Islets Volume: 2 Pages: 258-260
  • Peer Reviewed
• [Journal Article] Senescence Marker Protein-30/Gluconolactonase deletion worsens glucose tolerance through impairment of acute insulin secretion (2010)
  • Author(s): Hasegawa G, et al
  • Journal Title: Endocrinology 151 Pages: 529-536
  • Peer Reviewed
• [Journal Article] Hepatic senescence marker protein-30 is involved in the progression of nonalcoholic fatty diease (2010)
  • Author(s): Park H, et al
  • Journal Title: J Gastroenterol 45 Pages: 426-434
  • Peer Reviewed
• [Presentation] Senescence Marker Protein-30 deletion worsens glucose tolerance through impairment of acute insulin secretion (2010)
  • Author(s): 長谷川剛二
  • Organizer: 14th International Congress of Endocrinology
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2010-03-29
• [Presentation] Senescence Marker Protein-30 deficient mice exhibit impaired acute insulin secretion due to dysfunction of the distal portion of secretion pathway. (2010)
  • Author(s): 千丸貴史, 長谷川剛二, 石神昭人, 近藤嘉高, 田中武兵, 山崎真裕, 福井道明, 中村直登
  • Organizer: 8^<th> international diabetes federation western pacific region congress.
  • Place of Presentation: Busan, Korea
• [Presentation] Senescence Marker Protein-30 deficient mice exhibit impaired insulin secretion due to dysfunction of the distal portion of secretion pathway. (2010)
  • Author(s): 千丸貴史, 長谷川剛二, 石神昭人, 近藤嘉高, 田中武兵, 山崎真裕, 福井道明, 中村直登
  • Organizer: 70^<th> annual meeting and scientific sessions of American Diabetes Association.
  • Place of Presentation: Orland, USA.
• [Presentation] Senescence Marker protein-30 (SMP30)の減少は早期インスリン分泌を障害する (2010)
  • Author(s): 千丸貴史、長谷川剛二、石神昭人、近藤嘉高、田中武兵、山崎真裕、福井道明、中村直登
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: 岡山
• [Presentation] Senescence Marker Protein-30 deletion worsens glucose tolerance through impairment of acute insulin secretion. (2010)
  • Author(s): 長谷川剛二, 石神昭人, 近藤嘉高, 田中武兵, 千丸貴史, 山崎真裕, 福井道明, 中村直登
  • Organizer: 14^<th> international congress of endocrinology
  • Place of Presentation: Kyoto, Japan
• [Presentation] Senescence Marker protein-30(SMP30)の減少は早期インスリン分泌を障害する (2010)
  • Author(s): 千丸貴史
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: 岡山
• [Presentation] Senescence Marker Protein-30 deficient mice exhibit impaired insulin secretion due to dysfunction of the distal portion of secretion pathway (2010)
  • Author(s): 千丸貴史
  • Organizer: 70^<th> annual meeting and scientific sessions of American Diabetes Association
  • Place of Presentation: Orland, USA
• [Presentation] Senescence Marker Protein-30 deficient mice exhibit impaired acute insulin secretion due to dysfunction of the distal portion of secretion pathway (2010)
  • Author(s): 千丸貴史
  • Organizer: 8^<th> international diabetes federation western pacific region congress
  • Place of Presentation: Busan, Korea
• [Presentation] 加齢指標蛋白質SMP30の糖代謝における役割 (2009)
  • Author(s): 千丸貴史
  • Organizer: 第82回日本内分泌学会学術総会
  • Place of Presentation: 前橋
  • Year and Date: 2009-04-25
• [Presentation] 加齢指標蛋白質SMP30の糖代謝における役割 (2009)
  • Author(s): 千丸貴史、長谷川剛二、石神昭人、近藤嘉高、山崎真裕、田中武兵、浅野麻衣、福井道明、中村直登
  • Organizer: 第82回日本内分泌学会学術総会
  • Place of Presentation: 東京
• [Presentation] Role of senescence marker protein-30 in glucose home ostasis (2008)
  • Author(s): 長谷川 剛二
  • Organizer: 68^<th> annual meeting and scientific sessions of American Diabetes Association
  • Place of Presentation: 米国、サンフランシスコ
  • Year and Date: 2008-06-08
• [Presentation] Role of senescence marker protein-30 in glucose homeostasis. (2008)
  • Author(s): Hasegawa G, Ishigami A, Kondo Y, Kadono M, Asano M, Tanaka M, Hosoda H, Yamasaki M, Fukui M, Nakamura N
  • Organizer: 68^<th> annual meeting and scientific sessions of American Diabetes Association
  • Place of Presentation: San Francisco, USA.