| Project/Area Number |
20591067
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Osaka City University |
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Principal Investigator |
KOYAMA Hidenori Osaka City University, 医学部, 准教授 (80301852)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUMOTO Shinya 大阪市立大学, 大学院・医学研究科, 講師 (90381996)
TANAKA Shinji 大阪市立大学, 大学院・医学研究科, 講師 (20448749)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAMOTO Hiroshi 金沢大学, 大学院・医学系研究科, 教授 (00115198)
ELAINE W.Raines University of Washington, Department of Pathology, Professor
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 終末糖化産物 / 肥満 / メタボリックシンドローム / インスリン抵抗性 / 動脈硬化 / RAGE / PPAR / 終末糖化産物(AGE) / 炎症 / 血管内皮前駆細胞 / 心血管疾患 / 腎不全 / 糖尿病 / 脂肪細胞分化 / インスリン / 遺伝子発現 |
|---|
| Research Abstract |
Advanced glycation end-products, AGEs and their receptor, RAGE, has been implicated in vascular complications in diabetes. In this study, we show that RAGE is involved in adiposity and atherosclerosis induced by high fat diet in non-diabetic condition, where RAGE regulated plasma adiponectin take an important role. Moreover, gene chip analyses of mRNA specifically regulated by RAGE-deficient adipose tissues reveal that insulin signaling and adipocyte differentiation pathway are potential targets of RAGE, which could contribute to adiposity and altered adipocytokine regulation.
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