| Project/Area Number |
20591068
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Osaka City University |
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Principal Investigator |
EMOTO Masanori Osaka City University, 大学院・医学研究科, 准教授 (90275248)
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| Co-Investigator(Kenkyū-buntansha) |
MORI Katsuhito 大阪市立大学, 大学院・医学研究科, 講師 (60382040)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | メタボリックシンドローム / 糖尿病 / 動脈硬化 / 超音波法 / サロゲートマーカー / インスリン抵抗性 / 人工膵臓 / 血管内皮機能 / 頸動脈IMT |
|---|
| Research Abstract |
In metabolic syndrome including diabetes mellitus, dyslipidemia, and obesity, the morphological and functional changes of atherosclerosis of carotid artery, intima-media thickness (IMT) and stiffness parameter, were found to be differently associated with classical risk factors, novel biomarkers (fetuin-A and TRAIL), endothelial and smooth muscle dysfunction, and cardiovascular diseases. These findings indicate that simultaneous quantitative measurements of these dual properties of early atherosclerotic changes are of great importance in view of diagnosis, monitoring and treatment for atherosclerotic diseases.
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