Identification and functional analysis of common genetic basis between type 1 diabetes and type 2 diabetes.
| Project/Area Number |
20591074
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Kinki University |
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Principal Investigator |
NOSO Shinsuke Kinki University, 医学部, 講師 (90460849)
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| Co-Investigator(Kenkyū-buntansha) |
IKEGAMI Hiroshi 近畿大学, 医学部, 教授 (20221062)
BABAYA Naru 近畿大学, 医学部, 講師 (10449837)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | エネルギー / 糖質代謝異常 / 1型糖尿病 / 2型糖尿病 / NODマウス / NSYマウス / 遺伝解析 / コンジェニックマウス |
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| Research Abstract |
The etiology of type 1 and type 2 diabetes is thought to be different. However, type 2 diabetes is often observed in the family of patients with type 1 diabetes, suggesting the common genetic basis among them. We identified the susceptibility genes to type 1 diabetes, as well as type 2 diabetes, in the Japanese individuals, and susceptibility loci to glucose tolerance, body weight, and insulin resistance in the mouse model of type 2 diabetes, in order to establish the screening panel of association study of common susceptibility genes to type 1 and type 2 diabetes. We reported a newly identified susceptibility gene to type 1 diabetes in both mice and human, and the association study with type 2 diabetes was performed.
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Report
(4 results)
Research Products
(103 results)
