Molecular analyses of the metabolic phenotype of PDIP1 knockout mice

• Project/Area Number: 20591076
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Gunma University
• Principal Investigator: SATO Tetsuro Gunma University, 医学部, 助教 (40302484)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 核内受容体 / 転写共役因子 / ノックアウトマウス / 脂質代謝異常 / 肥満 / 脂肪肝 / メタボリック症候群 / 肥満抵抗性 / 脂肪肝抵抗性 / PDIP1 / PPAR / 脂質異常

Research Abstract

We recently isolated PDIP1 as a transcriptional cofactor of PPARγ. To elucidate its physiological function, we generated PDIP1 knockout (KO) mice and analyzed their metabolic phenotypes. KO mice revealed resistance to high-fat diet induced obesity and hepatosteatosis due to reduced lipogenesis and enhanced fatty acid oxidation in the liver. PDIP1 might be a therapeutic target of metabolic syndrome.

Research Products

• [Journal Article] Liver X receptor-α/β expression ratio is increased in ACTH-secreting pituitary adenomas. (2011)
  • Author(s): Hashimoto K, Matsumoto S, Ishida E, Miura A, Horiguchi K, Ozawa A, Shibusawa N, Satoh T, Yamada M, Yamada S, Mori M
  • Journal Title: Neurosci Lett. Vol.494 Pages: 34-37
  • Peer Reviewed
• [Journal Article] Liver X receptor-α/β expression ratio is increased in ACTH-secreting adenomas (2011)
  • Author(s): Hashimoto K
  • Journal Title: Neuroscience Lett Volume: 印刷中
  • Peer Reviewed
• [Journal Article] 転写共役因子とアディポサイエンス (2010)
  • Author(s): 佐藤哲郎、吉野聡、森昌朋
  • Journal Title: Adiposcience Vol.26 Pages: 134-141
• [Journal Article] 新たな転写共役因子PDIP1と疾患 (2010)
  • Author(s): 佐藤哲郎、登丸琢也、吉野聡、片野明子、森昌朋
  • Journal Title: ホルモンと臨床 Vol.58 Pages: 149-156
• [Journal Article] Resistance to thyroid hormone due to a novel thyroid hormone receptor mutant in a patient with hypothyroidism secondary to lingual thyroid and functional characterization of the mutant receptor. (2010)
  • Author(s): Nakajima Y, Yamada M, Horiguchi K, Satoh T, Hashimoto K, Tokuhiro E, Onigata K, Mori M
  • Journal Title: Thyroid Vol.20 Pages: 917-26
  • Peer Reviewed
• [Journal Article] Fasting concentrations of nesfatin-1 are negatively correlated with body mass index in non-obese males. (2010)
  • Author(s): Tsuchiya T, Shimizu H, Yamada M, Osaki A, Oh-I S, Ariyama Y, Takahashi H, Okada S, Hashimoto K, Satoh T, Kojima M, Mori M
  • Journal Title: Clin Endocrinol Vol.73 Pages: 484-490
  • Peer Reviewed
• [Journal Article] Troglitazone, a ligand of peroxisome proliferator-activated receptorγ, stabilizes NUCB2 (Nesfatin) mRNA by activating the ERK1/2 pathway : isolation and characterization of the human NUCB2 gene. (2010)
  • Author(s): Yamada M, Horiguchi K, Umezawa R, Hashimoto K, Satoh T, Ozawa A, Shibusawa N, Monden T, Okada S, Shimizu H, Mori M
  • Journal Title: Endocrinology Vol.151 Pages: 2494-2503
  • Peer Reviewed
• [Journal Article] A liver X receptor (LXR)-beta alternative splicing variant (LXRBSV) is preferentially expressed in the pituitary. (2010)
  • Author(s): Hashimoto K, Ishida E, Miura A, Ozawa A, Shibusawa N, Satoh T, Okada S, Yamada M, Mori M
  • Journal Title: Biochem Biophys Res Commun Vol.394 Pages: 548-552
  • Peer Reviewed
• [Journal Article] 【核内受容体とアディポサイエンス】転写共役因子とアディポサイエンス (2010)
  • Author(s): 佐藤哲郎
  • Journal Title: Adiposcience Volume: 7 Pages: 134-143
• [Journal Article] 【核内受容体と内分泌疾患UPDATE】新たな転写因子PDIP1と疾患 (2010)
  • Author(s): 佐藤哲郎
  • Journal Title: ホルモンと臨床 Volume: 58 Pages: 149-156
• [Journal Article] Resistance to thyroid hormone due to a novel thyroid hormone receptor mutation in a patient with hypothyroidism secondary to lingual thyroid and functional characterization of the mutant receptor (2010)
  • Author(s): Nakajima Y
  • Journal Title: Thyroid Volume: 20 Pages: 917-26
  • Peer Reviewed
• [Journal Article] Fasting concentrations of nesfatin-1 are negatively correlated with body mass index in non-obese males (2010)
  • Author(s): Thchiya T
  • Journal Title: Clin Endocrinol Volume: 73 Pages: 484-490
  • Peer Reviewed
• [Journal Article] Troglitazone, a ligand of peroxisome proliferator-activated receptor-γ, stabilizes NUCB2 (nesfatin) mRNA by activating the ERK1/2 pathway : isolation and characterization of the human NUCB2 gene (2010)
  • Author(s): Yamada M
  • Journal Title: Endocrinology Volume: 151 Pages: 2494-2503
  • Peer Reviewed
• [Journal Article] A liver X receptor (LXR)-beta alternative splicing variant (LXRBSV) is preferentially expressed in thepituitary (2010)
  • Author(s): Hashimoto K
  • Journal Title: Biochem Biophys Res Commun Volume: 394 Pages: 548-52
  • Peer Reviewed
• [Journal Article] A liver X receptor (LXR)-beta alternative splicing variant (LXRBSV) acts as an RNA co-activator of LXR-beta. (2009)
  • Author(s): Hashimoto K, Ishida E, Matsumoto S, Shibusawa N, Okada S, Monden T, Satoh T, Yamada M, Mori M
  • Journal Title: Biochem Biophys Res Commun Vol.390 Pages: 1260-1265
  • Peer Reviewed
• [Journal Article] Isolation of a novel leptin receptor gene promoter preferentially functioning in neuronal cells. (2009)
  • Author(s): Satoh T, Yoshino S, Katano A, Ishizuka T, Tomaru T, Shibusawa N, Hashimoto K, Yamada M, Mori M
  • Journal Title: Biochem Biophys Res Commun Vol.389 Pages: 673-677
  • Peer Reviewed
• [Journal Article] Roles of proteasomal 19S regulatory particles in promoter loading of thyroid hormone receptor. (2009)
  • Author(s): Satoh T, Ishizuka T, Yoshino S, Tomaru T, Nakajima Y, Shibusawa N, Hashimoto K, Yamada M, Mori M
  • Journal Title: Biochem Biophys Res Commun Vol.386 Pages: 697-702
  • Peer Reviewed
• [Journal Article] Tat-binding protein-1 (TBP-1), an ATPase of 19S regulatory particles of the 26S proteasome, enhances androgen receptor function in cooperation with TBP-1- interacting protein/Hop2. (2009)
  • Author(s): Satoh T, Ishizuka T, Tomaru T, Yoshino S, Nakajima Y, Hashimoto K, Shibusawa N, Monden T, Yamada M, Mori M
  • Journal Title: Endocrinology Vol.150 Pages: 3283-3290
  • Peer Reviewed
• [Journal Article] Carbohydrate response element binding protein gene expression is positively regulated by thyroid hormone. (2009)
  • Author(s): Hashimoto K, Ishida E, Matsumoto S, Okada S, Yamada M, Satoh T, Monden T, Mori M
  • Journal Title: Endocrinology Vol.150 Pages: 3417-3424
  • Peer Reviewed
• [Journal Article] Transcriptional activation of the mixed lineage leukemia-p27Kip1 pathway by a somatostatin analogue. (2009)
  • Author(s): Horiguchi K, Yamada M, Satoh T, Hashimoto K, Hirato J, Tosaka M, Yamada S, Mori M
  • Journal Title: Clin Cancer Res Vol.15 Pages: 2620-2629
  • Peer Reviewed
• [Journal Article] Aberrant histone modifications at the thyrotropin-releasing hormone gene in resistance to thyroid hormone : analysis of F455S mutant thyroid hormone receptor. (2009)
  • Author(s): Umezawa R, Yamada M, Horiguchi K, Ishii S, Hashimoto K, Okada S, Satoh T, Mori M
  • Journal Title: Endocrinology Vol.150 Pages: 3425-3432
  • Peer Reviewed
• [Journal Article] Peripheral administration of nesfatin-1 reduces food intake in mice : the leptin-independent mechanism. (2009)
  • Author(s): Shimizu H, Oh-I S, Hashimoto K, Nakata M, Yamamoto S, Yoshida N, Eguchi H, Kato I, Inoue K, Satoh T, Okada S, Yamada M, Yada T, Mori M
  • Journal Title: Endocrinology Vol.150 Pages: 662-671
  • Peer Reviewed
• [Journal Article] Liver X receptor-alpha regulates proopiomelanocortin (POMC) gene transcription in the pituitary. (2009)
  • Author(s): Matsumoto S, Hashimoto K, Yamada M, Satoh T, Hirato J, Mori M
  • Journal Title: Mol Endocrinol Vol.23 Pages: 47-60
  • Peer Reviewed
• [Journal Article] Tat-binding protein-1(TBP-1), an ATPase of 19S regulatory particles of the 26Sproteasome, enhances androgen receptor function in cooperation with TBP-1-interacting protein/Hop2. (2009)
  • Author(s): Satoh T
  • Journal Title: Endocrinology 150 Pages: 3283-3290
  • Peer Reviewed
• [Journal Article] Roles of proteasomal 19S regulatory particles in promoter loading of thyroid hormone receptor. (2009)
  • Author(s): Satoh T
  • Journal Title: Biochem Biophys Res Commun 386 Pages: 697-702
  • Peer Reviewed
• [Journal Article] Isolation of a novel leptin receptor gene promoter preferentially functioning in neuronal cells. (2009)
  • Author(s): Satoh T
  • Journal Title: Biochem Biophys Res Commun 389 Pages: 673-677
  • Peer Reviewed
• [Journal Article] Transcriptional activation of the mixed lineage leukemia-p27 kip1 pathway by a somatostatin analogue. (2009)
  • Author(s): Horiguchi K
  • Journal Title: Clin Cancer Res 15 Pages: 2620-2629
  • Peer Reviewed
• [Journal Article] Aberrant histone modifications at the thyrotropin-releasing hormone gene in resistance to thyroid hormone : analysis of F455S mutant thyroid hormone receptor. (2009)
  • Author(s): Umezawa R
  • Journal Title: Endocrinology 150 Pages: 3425-3432
  • Peer Reviewed
• [Journal Article] Carbohydrate response element binding protein gene xepression is negatively regulated by thyroid hormone. (2009)
  • Author(s): Hashimoto K
  • Journal Title: Endocrinology 150 Pages: 3417-3424
  • Peer Reviewed
• [Journal Article] A liver X receptor(LXR)-beta alternative splicing variant(LXRVBS)is acts as an RNA co-activator of LXR-beta. (2009)
  • Author(s): Hashimoto K
  • Journal Title: Biochem Biophys Res Commun 390 Pages: 1260-1265
  • Peer Reviewed
• [Journal Article] Tat-binding protein-1, an ATPase of 19S regulatory particles of proteasome enhances androgen receptor function cooperativ ely with Tat-binding protein-l-interacting protein/Hon2 (2009)
  • Author(s): Satoh T, et al.
  • Journal Title: Endocrinology (in press)
  • Peer Reviewed
• [Journal Article] Carbohydrate response element binding protein (ChREBP) gene exnression is positively regulated by thyroid hormone. (2009)
  • Author(s): Hashimoto K, et al.
  • Journal Title: Endocrinology (in press)
  • Peer Reviewed
• [Journal Article] Transcriptional activation of the mixed leukemia-p27kip 1 path way by a somatostatin analogue. (2009)
  • Author(s): Horiguchi K; et al.
  • Journal Title: Clin Cancer Res (in press)
  • Peer Reviewed
• [Journal Article] Abberant histone modifications at the thyrotropin-releasing hormone gene in resistance to thyroid hormone:analysis of F455S mutant thyroid hormone receptor. (2009)
  • Author(s): Umezawa R, et al.
  • Journal Title: Endocrinology (in press)
  • Peer Reviewed
• [Journal Article] Peripheral administration of nesfatin-1 reduces food intake in mice:the leptin-independent mechanism. (2009)
  • Author(s): Shimizu H, et al.
  • Journal Title: Endocrinology 150 Pages: 622-671
  • Peer Reviewed
• [Journal Article] Liver X receptor-alpha regulates proopiomelanocortin (POMC) gene transcrintion in the pituitary. (2009)
  • Author(s): Matsumoto S, et al.
  • Journal Title: Mol Endocrinol 23 Pages: 47-60
  • Peer Reviewed
• [Journal Article] Pueraria mirifica phytoestrogens improve dyslipidemia in postmenopausal women probably by activating estrogen receptor subtypes. (2008)
  • Author(s): Okamura S, Sawada Y, Satoh T, Sakamoto H, Saito Y, Sumino H, Takizawa T, Kogure T, Chaichantipyuth C, Higuchi Y, Ishikawa T, Sakamaki T.
  • Journal Title: Tohoku J Exp Med Vol.216 Pages: 341-351
  • Peer Reviewed
• [Journal Article] A novel splice variant of the nuclear coactivator p120 functions strongly for androgen receptor : characteristic expression in prostate disease. (2008)
  • Author(s): Hosoya T, Monden T, Fukabori Y, Hashimoto K, Satoh T, Kasai K, Yamada M, Mori M
  • Journal Title: Endocr J Vol.55 Pages: 657-665
  • Peer Reviewed
• [Journal Article] Pueraria mirifica phytoestrogen improve dyslipidemia in post-menopausal womwn probably by activating estrogen receptor subtvpes. (2008)
  • Author(s): Okamura S, et al.
  • Journal Title: Tohoku J. Exp Med 216 Pages: 341-351
  • Peer Reviewed
• [Journal Article] A novel splicing variant of the nuclear coactivator p120 functions strongly for androgen receptor: characteristic expres sion in prostate disease. (2008)
  • Author(s): Hosoya T, et al.
  • Journal Title: Endocr J 55 Pages: 657-665
  • Peer Reviewed
• [Presentation] 甲状腺癌組織におけるp18INK遺伝子、p28Kip1遺伝子、MEN1遺伝子およびRET遺伝子の発現解析 (2010)
  • Author(s): 小澤厚志
  • Organizer: 第53回 日本甲状腺学会
  • Place of Presentation: 長崎ブリックホール(長崎)
  • Year and Date: 2010-11-13
• [Presentation] 潜在性甲状腺機能低下症は甲状腺機能低下症であり、女性の高LDL血症の危険因子である (2010)
  • Author(s): 中島康代
  • Organizer: 第53回 日本甲状腺学会
  • Place of Presentation: 長崎プリックホール(長崎)
  • Year and Date: 2010-11-13
• [Presentation] TRHによる膵ランゲルハンス島遺伝子発現調節機構 (2010)
  • Author(s): 渋沢信行
  • Organizer: 第53回日本甲状腺学会
  • Place of Presentation: 長崎ブリックホール(長崎)
  • Year and Date: 2010-11-12
• [Presentation] Stearoyl-CoA desaturase-1遺伝子発現は甲状腺ホルモンによって負に調節されている (2010)
  • Author(s): 橋本貢士
  • Organizer: 第53回 日本甲状腺学会
  • Place of Presentation: 長崎ブリックホール(長崎)
  • Year and Date: 2010-11-12
• [Presentation] 甲状腺ホルモンによるSeladin-1/DHCR24遺伝子転写調節制御機構の解析 (2010)
  • Author(s): 石田恵美
  • Organizer: 第53回 日本甲状腺学会
  • Place of Presentation: 長崎ブリックホール(長崎)
  • Year and Date: 2010-11-12
• [Presentation] 膵臓Langerhans島における遺伝子発現に対するTRHの影響 (2010)
  • Author(s): ガライ・ジェニファー
  • Organizer: 第31回 日本肥満学会
  • Place of Presentation: 前橋元気プラザ21(群馬)
  • Year and Date: 2010-10-02
• [Presentation] メタボローム解析を用いたPDIPIKOマウスにおける高脂肪食誘導性脂肪肝抵抗性の分子病態解析 (2010)
  • Author(s): 佐藤哲郎
  • Organizer: 第31回 日本肥満学会
  • Place of Presentation: 前橋テルサ(群馬)
  • Year and Date: 2010-10-02
• [Presentation] 核内受容体PPARγの転写共役活性化因子PDIP1結合蛋白の同定 (2010)
  • Author(s): 片野明子
  • Organizer: 第31回 日本肥満学会
  • Place of Presentation: 煥乎堂前橋本店(群馬)
  • Year and Date: 2010-10-02
• [Presentation] Energy eloquenceの分子基盤と肥満PDIP1とエネルギーエロクエンス (2010)
  • Author(s): 佐藤哲郎
  • Organizer: 第31回日本肥満学会
  • Place of Presentation: 前橋テルサ(群馬県)(シンポジスト)
  • Year and Date: 2010-10-01
• [Presentation] メタボローム解析を用いたPDIP1KOマウスにおける高脂肪食誘導性脂肪肝抵抗性の分子病態解析 (2010)
  • Author(s): 佐藤哲郎
  • Organizer: 第31回日本肥満学会
  • Place of Presentation: 前橋テルサ(群馬県)
  • Year and Date: 2010-10-01
• [Presentation] PDIP1ノックアウトマウスは低TG血症と高脂肪食誘導性肥満抵抗性と脂肪肝抵抗性を示す (2010)
  • Author(s): 吉野聡
  • Organizer: 第31回日本肥満学会
  • Place of Presentation: 前橋テルサ(群馬県)
  • Year and Date: 2010-10-01
• [Presentation] 核内受容体PPARγの転写活性型共役因子PDIP1結合蛋白の同定 (2010)
  • Author(s): 片野明子
  • Organizer: 第31回日本肥満学会
  • Place of Presentation: 前橋テルサ(群馬県)
  • Year and Date: 2010-10-01
• [Presentation] チアゾリジン誘導体のNUCB2 mRNA安定性制御機構 (2010)
  • Author(s): 山田正信
  • Organizer: 第31回 日本肥満学会
  • Place of Presentation: 前橋テルサ(群馬)
  • Year and Date: 2010-10-01
• [Presentation] 摂食調節ペプチドnesfatin-1に対する細胞内シグナル伝達とmelanocortin receptorの関連 (2010)
  • Author(s): 石田恵美
  • Organizer: 第31回 日本肥満学会
  • Place of Presentation: 煥乎堂前橋本店(群馬)
  • Year and Date: 2010-10-01
• [Presentation] 甲状腺ホルモンはSteroyl-CoA desaturase-1遺伝子発現を負に調節する (2010)
  • Author(s): 橋本貢士
  • Organizer: 第31回 日本肥満学会
  • Place of Presentation: 前橋テルサ(群馬)
  • Year and Date: 2010-10-01
• [Presentation] PDIP1ノックアウトマウスは低TG血症と高脂肪食誘導性肥満抵抗性と脂肪肝抵抗性を示す (2010)
  • Author(s): 吉野聡
  • Organizer: 第31回 日本肥満学会
  • Place of Presentation: 前橋テルサ(群馬)
  • Year and Date: 2010-10-01
• [Presentation] Energy eloquenceの分子基盤と肥満 PDIP1とエネルギーエロクアンス (2010)
  • Author(s): 佐藤哲郎
  • Organizer: 第31回 日本肥満学会
  • Place of Presentation: 前橋テルサ(群馬)
  • Year and Date: 2010-10-01
• [Presentation] MEN1遺伝子ヘテロ欠損マウスにおいて発症する膵内分泌腫瘍の定量的解析 (2010)
  • Author(s): 小澤厚志
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: 岡山市デジタルミュージァム(岡山)
  • Year and Date: 2010-05-29
• [Presentation] TRHの膵臓β細胞に対する作用解析 (2010)
  • Author(s): 渋沢信行
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: 岡山市デジタルミュージアム(岡山)
  • Year and Date: 2010-05-29
• [Presentation] PPARγ-DNA-binding domain-interacting proteinl (PDIPI)ノックアウトマウスはメタボリック症候群抵抗性を示す (2010)
  • Author(s): 吉野聡
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: 岡山コンベンションセンター(岡山)
  • Year and Date: 2010-05-29
• [Presentation] マウスPPARγ-DNA-binding domain-interacting protein1 (PDIP1)のクローニングとその発現およびin vitro機能解析 (2010)
  • Author(s): 片野明子
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: ホテルグランヴィア岡山(岡山県)
  • Year and Date: 2010-05-28
• [Presentation] 摂食抑制ペプチドnesfatin-1の細胞内シグナル伝達機構の解析 (2010)
  • Author(s): 石田恵美
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: 岡山国際交流センター(岡山)
  • Year and Date: 2010-05-28
• [Presentation] マウスPPARγ-DNA-binding proteinl (PDIP1)のクローニングとその発現およびin vitro機能解析 (2010)
  • Author(s): 片野明子
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: ホテルグランヴィア岡山(岡山)
  • Year and Date: 2010-05-28
• [Presentation] Stearoyl-CoA desaturase-1遺伝子発現は甲状腺ホルモンにより負に調節されている (2010)
  • Author(s): 橋本貢士
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: 岡山市デジタルミュージアム(岡山)
  • Year and Date: 2010-05-27
• [Presentation] チアゾリジン誘導体の新たなnon-genomic効果 ERK1/2経路を介したNUVB2 mRNA安定性制御機構 (2010)
  • Author(s): 山田正信
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: ラヴィール岡山(岡山)
  • Year and Date: 2010-05-27
• [Presentation] Deficiency of the transcriptional coregulator PDIP1 prevents high-fat diet-induced obesity. (2010)
  • Author(s): Satoh T, Masatomo Mori
  • Organizer: Obesity and Metabolic Syndrome, 14^<th> International Congress of Endocrinology Official Satellite Symposium
  • Place of Presentation: Shiran Kaikan (Kyoto)(シンポジスト)
  • Year and Date: 2010-03-31
• [Presentation] Deficiency of the transcriptional coregulator PDIP1 prevents high-fat diet-induced obesity. (2010)
  • Author(s): Tetsurou Satoh
  • Organizer: Official Satellite Symposium of ICE2010 Obesity and Metabolic Syndrome
  • Place of Presentation: 京都
  • Year and Date: 2010-03-31
• [Presentation] Melanocortin 3/4 receptor is essential to the intracellular signaling pathway of nesfatin-1. (2010)
  • Author(s): Emi Ishida
  • Organizer: 14^<th> International Congress of Endocrinology
  • Place of Presentation: 京都
  • Year and Date: 2010-03-30
• [Presentation] Molecular mechanism of hypotriglyceridemia and resistance to high-fat diet-induced obesity in PDIP1 knockout mice. (2010)
  • Author(s): Satoshi Yoshino
  • Organizer: 14^<th> International Congress of Endocrinology
  • Place of Presentation: 京都
  • Year and Date: 2010-03-30
• [Presentation] Effect of thyrotropin-releasing hormone on gene expression in the islet of langerhans of the pancreas : microarray hybridization analysis of TRH-deficient mouse. (2010)
  • Author(s): Nobuyuki Shibusawa
  • Organizer: 14^<th> International Congress of Endocrinology
  • Place of Presentation: 京都
  • Year and Date: 2010-03-30
• [Presentation] An HDAC inhibitor, valproate improves the abnormalities in resistance to thyroid hormone. (2010)
  • Author(s): Koshi Hashimoto
  • Organizer: 14^<th> International Congress of Endocrinology
  • Place of Presentation: 京都
  • Year and Date: 2010-03-30
• [Presentation] Differential roles of 19S regulatory particles of 26S proteasome in the positive and negative gene regulation by thyroid hormone receptor. (2010)
  • Author(s): Tetsurou Satoh
  • Organizer: 14^<th> International Congress of Endocrinology
  • Place of Presentation: 京都
  • Year and Date: 2010-03-30
• [Presentation] gsp mutations and the MLL-p27^<kip1> pathway in pituitary adenoma. (2010)
  • Author(s): Kazuhiko Horiguchi
  • Organizer: 14^<th> International Congress of Endocrinology
  • Place of Presentation: 京都
  • Year and Date: 2010-03-30
• [Presentation] Pueraria mirifica phytoestrogen improves dyslipidemia in post-menopausal women probably by activating estrogen receptor subtypes. (2010)
  • Author(s): Akiko Katano
  • Organizer: 14^<th> International Congress of Endocrinology
  • Place of Presentation: 京都
  • Year and Date: 2010-03-30
• [Presentation] Analysis of messenger RNA level of p18INK4, P27Kip1, MEN1 and RET in thyroid tumors. (2010)
  • Author(s): Atsushi Ozawa
  • Organizer: 14^<th> International Congress of Endocrinology
  • Place of Presentation: 京都
  • Year and Date: 2010-03-30
• [Presentation] Profile of genes in cells expressing wild-type and A242V menin. (2010)
  • Author(s): Ryo Taguchi
  • Organizer: 14^<th> International Congress of Endocrinology
  • Place of Presentation: 京都
  • Year and Date: 2010-03-30
• [Presentation] Abberant histone modification involved in resistance to thyroid hormone. (2010)
  • Author(s): Masanobu Yamada
  • Organizer: 14^<th> International Congress of Endocrinology
  • Place of Presentation: 京都
  • Year and Date: 2010-03-28
• [Presentation] Thyrotropin-releasing hormone affects gene expression in the islet of Langerhans of the pancreas. (2010)
  • Author(s): Jennifer Garay
  • Organizer: 14^<th> International Congress of Endocrinology
  • Place of Presentation: 京都
  • Year and Date: 2010-03-27
• [Presentation] 甲状腺ホルモン不応症(RTH)における耐糖能と糖代謝関連遺伝子発現の解析 (2009)
  • Author(s): 橋本貢士
  • Organizer: 第52回日本甲状腺学会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-11-04
• [Presentation] Effect of thyrotropin-releasing hormone(TRH)on gene expression in the islet of Langerhans of the pancreas : microarray hybridization analysis of TRH-deficient mouse. (2009)
  • Author(s): Nobuyuki Shibusawa
  • Organizer: 9^<th> Asia and Oseania Thyroid Association Congress
  • Place of Presentation: 名古屋
  • Year and Date: 2009-11-02
• [Presentation] Roles of 19S regulatory particles of 26S proteasome in ligand-induced promoter loading of thyroid hormone receptor. (2009)
  • Author(s): Tetsurou Satoh
  • Organizer: 9^<th> Asia and Oseania Thyroid Association Congress
  • Place of Presentation: 名古屋
  • Year and Date: 2009-11-02
• [Presentation] DP1ノックアウトマウスの作製と解析 (2009)
  • Author(s): 田口亮
  • Organizer: 第36回日本神経内分泌学会
  • Place of Presentation: 福岡
  • Year and Date: 2009-09-04
• [Presentation] Gsp変異とオクトレオチドのMLL/p27Kip1経路刺激作用 (2009)
  • Author(s): 堀口和彦
  • Organizer: 第36回日本神経内分泌学会
  • Place of Presentation: 福岡
  • Year and Date: 2009-09-04
• [Presentation] 甲状腺ホルモン不応症(RTH)における糖代謝異常の解析 (2009)
  • Author(s): 橋本貢士
  • Organizer: 第52回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-05-22
• [Presentation] バルプロ酸ナトリウムは甲状腺ホルモン不応症の遺伝子発現異常を改善する (2009)
  • Author(s): 橋本貢士
  • Organizer: 第82回日本内分泌学会学術集会
  • Place of Presentation: 前橋
  • Year and Date: 2009-04-25
• [Presentation] PPARγの転写活性型共役因子PDIP1ノックアウトマウスにおける低TG血症および肥満抵抗性の分子病態解析 (2009)
  • Author(s): 吉野聡
  • Organizer: 第82回日本内分泌学会学術集会
  • Place of Presentation: ベイシア文化ホール(群馬県)
  • Year and Date: 2009-04-24
• [Presentation] 摂食抑制蛋白nesfatin-1の細胞内シグナル伝達とmelanocortin receptorの関与 (2009)
  • Author(s): 石田恵美
  • Organizer: 第82回日本内分泌学会学術集会
  • Place of Presentation: 前橋
  • Year and Date: 2009-04-24
• [Presentation] PPAR_Yの転写活性型共役因子PDIP1ノックアウトマウスにおける低TG血症および肥満抵抗性の分子病態解析 (2009)
  • Author(s): 吉野聡
  • Organizer: 第82回日本内分泌学会学術集会
  • Place of Presentation: 前橋
  • Year and Date: 2009-04-24
• [Presentation] 下垂体全容においてproopiomelanocortin(PMOC)遺伝子はliver X receptor(LXR)αにより制御される (2009)
  • Author(s): 松本俊一
  • Organizer: 第82回日本内分泌学会学術集会
  • Place of Presentation: 前橋
  • Year and Date: 2009-04-24
• [Presentation] マウスレプチン受容体遺伝子プロモーター領域の解析 (2009)
  • Author(s): 佐藤哲郎
  • Organizer: 第82回日本内分泌学会学術集会
  • Place of Presentation: 前橋商工会議所(群馬県)
  • Year and Date: 2009-04-23
• [Presentation] 視床下部TRHの新たなTSH発現抑制機構の発見 (2009)
  • Author(s): 中島康代
  • Organizer: 第82回日本内分泌学会学術総会
  • Place of Presentation: 前橋
  • Year and Date: 2009-04-23
• [Presentation] オクトレオチドによるMLL転写抑制機構 (2009)
  • Author(s): 堀口和彦
  • Organizer: 第82回日本内分泌学会学術集会
  • Place of Presentation: 前橋
  • Year and Date: 2009-04-23
• [Presentation] マウスレプチン受容体遺伝子プロモーター領域の解析 (2009)
  • Author(s): 佐藤哲郎
  • Organizer: 第82回日本内分泌学会学術集会
  • Place of Presentation: 前橋
  • Year and Date: 2009-04-23
• [Presentation] レプチン受容体遺伝子の甲状腺ホルモンによる制御機能の解析 (2008)
  • Author(s): 佐藤哲郎、他
  • Organizer: 第52回日本甲状腺学会学術総会
  • Place of Presentation: 宇都宮市
  • Year and Date: 2008-11-23
• [Presentation] PPARγの新規転写活性型共役因子PDIP1ノックアウトマウスにおける低TG血症の分子病態解析 (2008)
  • Author(s): 吉野聡、他
  • Organizer: 第81回日本内分泌学会学術総会
  • Place of Presentation: 弘前市
  • Year and Date: 2008-05-18
• [Presentation] Tat-binding prtein-1によるアンド口ゲン(AR)受容体転写活性化増強機能の解析 (2008)
  • Author(s): 吉野聡、他
  • Organizer: 第81回日本内分泌学会学術総会
  • Place of Presentation: 弘前市
  • Year and Date: 2008-05-16
• [Presentation] PPARγの新規転写活性型共役因子PDIP1ノックアウトマウスにおける低TG血症の分子病態解析 (2008)
  • Author(s): 吉野聡
  • Organizer: 第81回日本内分泌学会学術総会
  • Place of Presentation: 弘前グランドホテル(青森県)
  • Year and Date: 2008-05-06