Molecular analyses of the metabolic phenotype of PDIP1 knockout mice
| Project/Area Number |
20591076
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Gunma University |
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Principal Investigator |
SATO Tetsuro Gunma University, 医学部, 助教 (40302484)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 核内受容体 / 転写共役因子 / ノックアウトマウス / 脂質代謝異常 / 肥満 / 脂肪肝 / メタボリック症候群 / 肥満抵抗性 / 脂肪肝抵抗性 / PDIP1 / PPAR / 脂質異常 |
|---|
| Research Abstract |
We recently isolated PDIP1 as a transcriptional cofactor of PPARγ. To elucidate its physiological function, we generated PDIP1 knockout (KO) mice and analyzed their metabolic phenotypes. KO mice revealed resistance to high-fat diet induced obesity and hepatosteatosis due to reduced lipogenesis and enhanced fatty acid oxidation in the liver. PDIP1 might be a therapeutic target of metabolic syndrome.
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Report
(4 results)
Research Products
(97 results)
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[Journal Article] Liver X receptor-α/β expression ratio is increased in ACTH-secreting pituitary adenomas.2011
Author(s)
Hashimoto K, Matsumoto S, Ishida E, Miura A, Horiguchi K, Ozawa A, Shibusawa N, Satoh T, Yamada M, Yamada S, Mori M
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Journal Title
Neurosci Lett. Vol.494
Pages: 34-37
Related Report
Peer Reviewed
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[Journal Article] Fasting concentrations of nesfatin-1 are negatively correlated with body mass index in non-obese males.2010
Author(s)
Tsuchiya T, Shimizu H, Yamada M, Osaki A, Oh-I S, Ariyama Y, Takahashi H, Okada S, Hashimoto K, Satoh T, Kojima M, Mori M
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Journal Title
Clin Endocrinol Vol.73
Pages: 484-490
Related Report
Peer Reviewed
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[Journal Article] Troglitazone, a ligand of peroxisome proliferator-activated receptorγ, stabilizes NUCB2 (Nesfatin) mRNA by activating the ERK1/2 pathway : isolation and characterization of the human NUCB2 gene.2010
Author(s)
Yamada M, Horiguchi K, Umezawa R, Hashimoto K, Satoh T, Ozawa A, Shibusawa N, Monden T, Okada S, Shimizu H, Mori M
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Journal Title
Endocrinology Vol.151
Pages: 2494-2503
Related Report
Peer Reviewed
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[Journal Article] Tat-binding protein-1 (TBP-1), an ATPase of 19S regulatory particles of the 26S proteasome, enhances androgen receptor function in cooperation with TBP-1- interacting protein/Hop2.2009
Author(s)
Satoh T, Ishizuka T, Tomaru T, Yoshino S, Nakajima Y, Hashimoto K, Shibusawa N, Monden T, Yamada M, Mori M
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Journal Title
Endocrinology Vol.150
Pages: 3283-3290
Related Report
Peer Reviewed
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[Journal Article] Peripheral administration of nesfatin-1 reduces food intake in mice : the leptin-independent mechanism.2009
Author(s)
Shimizu H, Oh-I S, Hashimoto K, Nakata M, Yamamoto S, Yoshida N, Eguchi H, Kato I, Inoue K, Satoh T, Okada S, Yamada M, Yada T, Mori M
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Journal Title
Endocrinology Vol.150
Pages: 662-671
Related Report
Peer Reviewed
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[Journal Article] Pueraria mirifica phytoestrogens improve dyslipidemia in postmenopausal women probably by activating estrogen receptor subtypes.2008
Author(s)
Okamura S, Sawada Y, Satoh T, Sakamoto H, Saito Y, Sumino H, Takizawa T, Kogure T, Chaichantipyuth C, Higuchi Y, Ishikawa T, Sakamaki T.
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Journal Title
Tohoku J Exp Med Vol.216
Pages: 341-351
Related Report
Peer Reviewed
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