Effect of lipoprotein mediated by sphingosine-1 phosphate receptors and scavenger receptor class B type I

• Project/Area Number: 20591077
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Gunma University
• Principal Investigator: KIMURA Takao Gunma University, 医学部, 助教 (90396656)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 動脈硬化 / 血管内皮 / HDL / SR-BI / スフィンゴシン1-リン酸 / 血管内皮細胞 / スカベンジャー受容体 / apoA

Research Abstract

HDL exerts a variety of anti-inflammatory and anti-atherogenic actions independently of the cholesterol metabolism. Here, we showed the cross-talk mechanism between statins and HDL in anti-inflammatory and anti-atherogenic actions, with a focus on scavenger receptor class B type I. Simvastatin treatment of HUVECs induces expression of SR-BI, which plays a critical role as a key molecule to enhance HDL-induced anti-inflammatory actions, including NOS activation and inhibition of adhesion molecule expression.

Research Products

• [Journal Article] Mechanism and role of high-density lipoprotein-induced activation of AMP-activated protein kinase in endothelial cells. (2010)
  • Author(s): Kimura T, Tomura H, Sato K, Ito M, Matsuoka I, Im DS, Kuwabara A, Mogi C, Itoh H, Kurose H, Murakami M, Okajima F
  • Journal Title: J Biol Chem. 285(7) Pages: 4387-4397
  • Peer Reviewed
• [Journal Article] Cross-talk Between Exogenous Statins and Endogenous High-density Lipoprotein in Anti-inflammatory and Anti-atherogenic Actions. (2010)
  • Author(s): Kimura T, Sato K, Tomura H, Okajima F
  • Journal Title: Endocr Metab Immune Disord Drug Targets. 10(1) Pages: 8-15
  • Peer Reviewed
• [Journal Article] Cross-talk Between Exogenous Statins and Endogenous High-density Lipoprotein in Anti-inflammatory and Anti-atherogenic Actions. (2010)
  • Author(s): Kimura T, Sato K, Tomura H, Okaiima F.
  • Journal Title: Endocr Metab Immune Disord Drug Targets. Volume: 10 Pages: 8-15
  • Peer Reviewed
• [Journal Article] Mechanism and role of high-density lipoprotein-induced activation of AMP-activated protein kinase in endothelial cells. (2010)
  • Author(s): Kimura T, Tomura H, Sato K, Ito M, Matsuoka I, Im DS, Kuwabara A, Mogi C, Itoh H, Kurose H, Murakami M, Okajima F.
  • Journal Title: J Biol Chem. 285 Pages: 4387-4397
  • Peer Reviewed
• [Journal Article] Role of Rap1B and Tumor Suppressor PTEN in the Negative Regulation of Lysophosphatidic Acid-induced Migration by Isoproterenol in Glioma Cells. (2009)
  • Author(s): Malchinkhuu E, Sato K, Maehama T, Ishiuchi S, Yoshimoto Y, Mogi C, Kimura T, Kurose H, Tomura H, Okajima F
  • Journal Title: Mol Biol Cell. 20(24) Pages: 5156-5165
  • Peer Reviewed
• [Journal Article] Anti-atherogenic Actions of High-density Lipoprotein through Sphingosine 1-Phosphate Receptors and Scavenger Receptor Class B Type I. (2009)
  • Author(s): Okajima F, Sato K, Kimura T.
  • Journal Title: Endocr J. 56 Pages: 317-334
  • NAID: 10026913244
  • Peer Reviewed
• [Journal Article] リポタンパク質作用のメディエーターとしてのS1P (2009)
  • Author(s): 岡島史和、木村孝穂、佐藤幸市
  • Journal Title: 生化学 81巻5号 Pages: 393-397
  • Peer Reviewed
• [Journal Article] Involvement of proton-sensing TDAG8 in extracellular acidification-induced inhibition of proinflammatory cytokine production in peritoneal macrophages. (2009)
  • Author(s): Mogi C, Tobo M, Tomura H, Murata N, He XD, Sato K, Kimura T, Ishizuka T, Sasaki T, Sato T, Kihara Y, Ishii S, Harada A, Okajima F
  • Journal Title: J Immunol. 182(5) Pages: 3243-3251
  • Peer Reviewed
• [Journal Article] LPA1 receptors mediate stimulation, whereas LPA2 receptors mediate inhibition, of migration of pancreatic cancer cells in response to lysophosphatidic acid and malignant ascites. (2009)
  • Author(s): Komachi M, Tomura H, Malchinkhuu E, Tobo M, Mogi C, Yamada T, Kimura T, Kuwabara A, Ohta H, Im DS, Kurose H, Takeyoshi I, Sato K, Okajima F
  • Journal Title: Carcinogenesis. 30(3) Pages: 457-465
  • Peer Reviewed
• [Journal Article] Anti-atherogenic Actions of High-density Lipoprotein through Sphingo sine 1-Phosphate Receptors and Scavenger Receptor Class B Type I. (2009)
  • Author(s): Okajima F, Sato K, Kimura T.
  • Journal Title: Endocr J. 56 Pages: 317-334
  • Peer Reviewed
• [Journal Article] リポタンパク質作用のメディエーターとしてのS1P (2009)
  • Author(s): 岡島史和、木村孝穂、佐藤幸市
  • Journal Title: 生化学 81 Pages: 393-397
  • Peer Reviewed
• [Journal Article] Induction of scavenger receptor class B type I is critical for simvastatin enhancement of high-density lipoprotein-induced anti-inflammatory actions in endothelial cells. (2008)
  • Author(s): Kimura T, Mogi C, Tomura H, Kuwabara A, Im DS, Sato K, Kurose H, Murakami M, Okajima F
  • Journal Title: J Immunol. 181(10) Pages: 7332-7340
  • Peer Reviewed
• [Journal Article] Induction of scavenger receptor class B type I is critical for simvastatin enha ncement of high-density lipoprotein-induced anti-inflammatory actions in endot helial cells. (2008)
  • Author(s): K imura T, Mogi C, Tomura H, Kuwabara A, Im DS, Sato K, Kurose H, Murakami M, Okajima F.
  • Journal Title: J Immunol 181 Pages: 7332-7340
  • Peer Reviewed
• [Presentation] Rapid non-genomic action of thyroid hormone and the expression of deiodinase in endothelial cells. (2010)
  • Author(s): T.Kimura, T.Aoki, K.Sato, A.Kuwabara, M.Nara, K.Tsunekawa, T.Morimura, O.Araki, H.Sumino, H.Tomura, I.Kobayashi, Y.Kondo, F.Okajima, M.Murakami
  • Organizer: 第14回国際甲状腺学会
  • Place of Presentation: パリ国際会議場(パリ、フランス共和国)
  • Year and Date: 2010-09-12
• [Presentation] Rapid non-genomic action of thyroid hormone and the expression of deiodinase in endothelial cells (2010)
  • Author(s): T.Kimura, T.Aoki, K.Sato, A.Kuwabara, M.Nara, K.Tsunekawa, T.Morimura, O.Araki, H.Sumino, H.Tomura, I.Kobayashi, Y.Kondo, F.Okajima, M.Murakami
  • Organizer: 14^<th>International Thyroid Congress
  • Place of Presentation: パリ(フランス)
  • Year and Date: 2010-09-12
• [Presentation] Enhancement of high-density lipoprotein induced anti-inflammatory and anti-atherogenic actions through modulating the expression of scavenger receptor class B type I (2010)
  • Author(s): T.Kimura, M.Murakami, F.Okajima
  • Organizer: 第42回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 長良川国際会議場(岐阜県)
  • Year and Date: 2010-07-16
• [Presentation] Mechanism and role of high-density lipoprotein-induced AMP-activated protein kinase activation in endothelial cells. (2010)
  • Author(s): T.Kimura, H.Tomura, K.Sato, M.Murakami, F. Okajima
  • Organizer: 国際心血管内分泌シンポジウム
  • Place of Presentation: 奈良県新公会堂(奈良県)
  • Year and Date: 2010-04-01
• [Presentation] Simvastain、fenofibrateは血管内皮細胞のSR-BI発現誘導を介しHDLの抗動脈硬化作用を増強する (2009)
  • Author(s): 木村孝穂、岡島史和、村上正巳
  • Organizer: 第13回日本心血管内分泌代謝学会学術総会
  • Place of Presentation: 大宮ソニックシティ(埼玉県)
  • Year and Date: 2009-10-24
• [Presentation] Simvastatin promoted HDL-induced anti-atherogenic action through enhancement of SR-BI expression in endothelial cells. (2009)
  • Author(s): Takao Kimura, Masami Murakami, Fumikazu Okajima
  • Organizer: 第41回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 海峡メッセ下関(山口県)
  • Year and Date: 2009-07-18
• [Presentation] HDLによる血管内皮機能調節機構 (2009)
  • Author(s): 木村孝穂、岡島史和、村上正巳
  • Organizer: 第82回日本内分泌学会学術総会 シンポジウム血管新生と心血管内分泌の新展開
  • Place of Presentation: 群馬県民会館(群馬県)
  • Year and Date: 2009-04-23
• [Presentation] HDLによる血管内皮機能調節機構 (2009)
  • Author(s): 木村孝穂、岡島史和、村上正巳
  • Organizer: 第82回日本内分泌学会学術総会
  • Place of Presentation: 群馬県民会館
  • Year and Date: 2009-04-23
• [Presentation] シンバススタチンは血管内皮細胞のSR-BI発現増強を介してHDLのNO合成を促進する (2008)
  • Author(s): 木村孝穂、岡島史和、村上正巳
  • Organizer: 第40回日本動脈硬化学会総会・学術集会
  • Place of Presentation: つくば国際会議場(茨城県)
  • Year and Date: 2008-07-10
• [Presentation] フェノフィブレートは血管内皮細胞のSR-BI発現増強を介してHDLのNO合成を促進する (2008)
  • Author(s): 木村孝穂、岡島史和、村上正巳
  • Organizer: 第40回日本動脈硬化学会総会・学術集会
  • Place of Presentation: つくば国際会議場(茨城県)
  • Year and Date: 2008-07-10
• [Presentation] シンバススチンは血管皮細胞のSR-BI発現増強を介してHDLのNO合成を促進する (2008)
  • Author(s): 木村孝穂、村上正巳、岡島史和
  • Organizer: 第40回日本動脈硬化学会総会・学術集会
  • Place of Presentation: つくば国際会議場
  • Year and Date: 2008-07-10
• [Presentation] Enhancement of High-Density Lipoprotein-induced Anti-Inflammatory Actions in Endeothelial Cells by Simvastatin-induced expression of Scavenger Receptor Class B Type I (2008)
  • Author(s): 木村孝穂、村上正巳、岡島史和
  • Organizer: 第72回日本循環器学会総会・学術集会
  • Place of Presentation: 大阪国際会議場(大阪府)
  • Year and Date: 2008-03-21