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Effect of lipoprotein mediated by sphingosine-1 phosphate receptors and scavenger receptor class B type I

Research Project

Project/Area Number 20591077
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Metabolomics
Research InstitutionGunma University

Principal Investigator

KIMURA Takao  Gunma University, 医学部, 助教 (90396656)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords動脈硬化 / 血管内皮 / HDL / SR-BI / スフィンゴシン1-リン酸 / 血管内皮細胞 / スカベンジャー受容体 / apoA
Research Abstract

HDL exerts a variety of anti-inflammatory and anti-atherogenic actions independently of the cholesterol metabolism. Here, we showed the cross-talk mechanism between statins and HDL in anti-inflammatory and anti-atherogenic actions, with a focus on scavenger receptor class B type I. Simvastatin treatment of HUVECs induces expression of SR-BI, which plays a critical role as a key molecule to enhance HDL-induced anti-inflammatory actions, including NOS activation and inhibition of adhesion molecule expression.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (25 results)

All 2010 2009 2008

All Journal Article (13 results) (of which Peer Reviewed: 13 results) Presentation (12 results)

  • [Journal Article] Mechanism and role of high-density lipoprotein-induced activation of AMP-activated protein kinase in endothelial cells.2010

    • Author(s)
      Kimura T, Tomura H, Sato K, Ito M, Matsuoka I, Im DS, Kuwabara A, Mogi C, Itoh H, Kurose H, Murakami M, Okajima F
    • Journal Title

      J Biol Chem. 285(7)

      Pages: 4387-4397

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cross-talk Between Exogenous Statins and Endogenous High-density Lipoprotein in Anti-inflammatory and Anti-atherogenic Actions.2010

    • Author(s)
      Kimura T, Sato K, Tomura H, Okajima F
    • Journal Title

      Endocr Metab Immune Disord Drug Targets. 10(1)

      Pages: 8-15

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cross-talk Between Exogenous Statins and Endogenous High-density Lipoprotein in Anti-inflammatory and Anti-atherogenic Actions.2010

    • Author(s)
      Kimura T, Sato K, Tomura H, Okaiima F.
    • Journal Title

      Endocr Metab Immune Disord Drug Targets.

      Volume: 10 Pages: 8-15

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanism and role of high-density lipoprotein-induced activation of AMP-activated protein kinase in endothelial cells.2010

    • Author(s)
      Kimura T, Tomura H, Sato K, Ito M, Matsuoka I, Im DS, Kuwabara A, Mogi C, Itoh H, Kurose H, Murakami M, Okajima F.
    • Journal Title

      J Biol Chem. 285

      Pages: 4387-4397

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of Rap1B and Tumor Suppressor PTEN in the Negative Regulation of Lysophosphatidic Acid-induced Migration by Isoproterenol in Glioma Cells.2009

    • Author(s)
      Malchinkhuu E, Sato K, Maehama T, Ishiuchi S, Yoshimoto Y, Mogi C, Kimura T, Kurose H, Tomura H, Okajima F
    • Journal Title

      Mol Biol Cell. 20(24)

      Pages: 5156-5165

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anti-atherogenic Actions of High-density Lipoprotein through Sphingosine 1-Phosphate Receptors and Scavenger Receptor Class B Type I.2009

    • Author(s)
      Okajima F, Sato K, Kimura T.
    • Journal Title

      Endocr J. 56

      Pages: 317-334

    • NAID

      10026913244

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] リポタンパク質作用のメディエーターとしてのS1P2009

    • Author(s)
      岡島史和、木村孝穂、佐藤幸市
    • Journal Title

      生化学 81巻5号

      Pages: 393-397

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of proton-sensing TDAG8 in extracellular acidification-induced inhibition of proinflammatory cytokine production in peritoneal macrophages.2009

    • Author(s)
      Mogi C, Tobo M, Tomura H, Murata N, He XD, Sato K, Kimura T, Ishizuka T, Sasaki T, Sato T, Kihara Y, Ishii S, Harada A, Okajima F
    • Journal Title

      J Immunol. 182(5)

      Pages: 3243-3251

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] LPA1 receptors mediate stimulation, whereas LPA2 receptors mediate inhibition, of migration of pancreatic cancer cells in response to lysophosphatidic acid and malignant ascites.2009

    • Author(s)
      Komachi M, Tomura H, Malchinkhuu E, Tobo M, Mogi C, Yamada T, Kimura T, Kuwabara A, Ohta H, Im DS, Kurose H, Takeyoshi I, Sato K, Okajima F
    • Journal Title

      Carcinogenesis. 30(3)

      Pages: 457-465

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anti-atherogenic Actions of High-density Lipoprotein through Sphingo sine 1-Phosphate Receptors and Scavenger Receptor Class B Type I.2009

    • Author(s)
      Okajima F, Sato K, Kimura T.
    • Journal Title

      Endocr J. 56

      Pages: 317-334

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] リポタンパク質作用のメディエーターとしてのS1P2009

    • Author(s)
      岡島史和、木村孝穂、佐藤幸市
    • Journal Title

      生化学 81

      Pages: 393-397

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of scavenger receptor class B type I is critical for simvastatin enhancement of high-density lipoprotein-induced anti-inflammatory actions in endothelial cells.2008

    • Author(s)
      Kimura T, Mogi C, Tomura H, Kuwabara A, Im DS, Sato K, Kurose H, Murakami M, Okajima F
    • Journal Title

      J Immunol. 181(10)

      Pages: 7332-7340

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Induction of scavenger receptor class B type I is critical for simvastatin enha ncement of high-density lipoprotein-induced anti-inflammatory actions in endot helial cells.2008

    • Author(s)
      K imura T, Mogi C, Tomura H, Kuwabara A, Im DS, Sato K, Kurose H, Murakami M, Okajima F.
    • Journal Title

      J Immunol 181

      Pages: 7332-7340

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Rapid non-genomic action of thyroid hormone and the expression of deiodinase in endothelial cells.2010

    • Author(s)
      T.Kimura, T.Aoki, K.Sato, A.Kuwabara, M.Nara, K.Tsunekawa, T.Morimura, O.Araki, H.Sumino, H.Tomura, I.Kobayashi, Y.Kondo, F.Okajima, M.Murakami
    • Organizer
      第14回国際甲状腺学会
    • Place of Presentation
      パリ国際会議場(パリ、フランス共和国)
    • Year and Date
      2010-09-12
    • Related Report
      2010 Final Research Report
  • [Presentation] Rapid non-genomic action of thyroid hormone and the expression of deiodinase in endothelial cells2010

    • Author(s)
      T.Kimura, T.Aoki, K.Sato, A.Kuwabara, M.Nara, K.Tsunekawa, T.Morimura, O.Araki, H.Sumino, H.Tomura, I.Kobayashi, Y.Kondo, F.Okajima, M.Murakami
    • Organizer
      14^<th>International Thyroid Congress
    • Place of Presentation
      パリ(フランス)
    • Year and Date
      2010-09-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] Enhancement of high-density lipoprotein induced anti-inflammatory and anti-atherogenic actions through modulating the expression of scavenger receptor class B type I2010

    • Author(s)
      T.Kimura, M.Murakami, F.Okajima
    • Organizer
      第42回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      長良川国際会議場(岐阜県)
    • Year and Date
      2010-07-16
    • Related Report
      2010 Final Research Report
  • [Presentation] Mechanism and role of high-density lipoprotein-induced AMP-activated protein kinase activation in endothelial cells.2010

    • Author(s)
      T.Kimura, H.Tomura, K.Sato, M.Murakami, F. Okajima
    • Organizer
      国際心血管内分泌シンポジウム
    • Place of Presentation
      奈良県新公会堂(奈良県)
    • Year and Date
      2010-04-01
    • Related Report
      2010 Final Research Report
  • [Presentation] Simvastain、fenofibrateは血管内皮細胞のSR-BI発現誘導を介しHDLの抗動脈硬化作用を増強する2009

    • Author(s)
      木村孝穂、岡島史和、村上正巳
    • Organizer
      第13回日本心血管内分泌代謝学会学術総会
    • Place of Presentation
      大宮ソニックシティ(埼玉県)
    • Year and Date
      2009-10-24
    • Related Report
      2010 Final Research Report
  • [Presentation] Simvastatin promoted HDL-induced anti-atherogenic action through enhancement of SR-BI expression in endothelial cells.2009

    • Author(s)
      Takao Kimura, Masami Murakami, Fumikazu Okajima
    • Organizer
      第41回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      海峡メッセ下関(山口県)
    • Year and Date
      2009-07-18
    • Related Report
      2010 Final Research Report
  • [Presentation] HDLによる血管内皮機能調節機構2009

    • Author(s)
      木村孝穂、岡島史和、村上正巳
    • Organizer
      第82回日本内分泌学会学術総会 シンポジウム血管新生と心血管内分泌の新展開
    • Place of Presentation
      群馬県民会館(群馬県)
    • Year and Date
      2009-04-23
    • Related Report
      2010 Final Research Report
  • [Presentation] HDLによる血管内皮機能調節機構2009

    • Author(s)
      木村孝穂、岡島史和、村上正巳
    • Organizer
      第82回日本内分泌学会学術総会
    • Place of Presentation
      群馬県民会館
    • Year and Date
      2009-04-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] シンバススタチンは血管内皮細胞のSR-BI発現増強を介してHDLのNO合成を促進する2008

    • Author(s)
      木村孝穂、岡島史和、村上正巳
    • Organizer
      第40回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      つくば国際会議場(茨城県)
    • Year and Date
      2008-07-10
    • Related Report
      2010 Final Research Report
  • [Presentation] フェノフィブレートは血管内皮細胞のSR-BI発現増強を介してHDLのNO合成を促進する2008

    • Author(s)
      木村孝穂、岡島史和、村上正巳
    • Organizer
      第40回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      つくば国際会議場(茨城県)
    • Year and Date
      2008-07-10
    • Related Report
      2010 Final Research Report
  • [Presentation] シンバススチンは血管皮細胞のSR-BI発現増強を介してHDLのNO合成を促進する2008

    • Author(s)
      木村孝穂、村上正巳、岡島史和
    • Organizer
      第40回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      つくば国際会議場
    • Year and Date
      2008-07-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] Enhancement of High-Density Lipoprotein-induced Anti-Inflammatory Actions in Endeothelial Cells by Simvastatin-induced expression of Scavenger Receptor Class B Type I2008

    • Author(s)
      木村孝穂、村上正巳、岡島史和
    • Organizer
      第72回日本循環器学会総会・学術集会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2008-03-21
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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