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Functional analysis of CCN3, a novel growth inhibitor for vascular smooth muscle cells, and its application in the treatment of vascular diseases.

Research Project

Project/Area Number 20591078
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Metabolomics
Research InstitutionChiba University

Principal Investigator

YOKOTE Koutaro  Chiba University, 大学院・医学研究院, 教授 (20312944)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
KeywordsCCN / 動脈硬化 / 平滑筋細胞 / 増殖 / 遊走 / 糖尿病 / CCN3 / 内膜肥厚 / Notch経路
Research Abstract

CCN3 belongs to CCN family, which constitutes multifunctional secreted proteins that act as matricellular regulators. CCN3 suppressed the rat smooth muscle cells (VSMC) migration as well as proliferation induced by fetal bovine serum. CCN3 knockout mice were created and the neointimal hyperplasia induced by photochemically-induced thrombosis, were investigated. Histopathological evaluation of the arteries 21 days after the endothelial injury revealed a 6-fold enhancement of neointimal thickening in the null mice compared with the wild-type. Our findings indicate the involvement of CCN3 in vascular homeostasis, especially upon injury, and the potential usefulness of this molecule in the modulation of atherosclerotic vascular disease.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (52 results)

All 2011 2010 2009 2008 Other

All Journal Article (18 results) (of which Peer Reviewed: 18 results) Presentation (24 results) Book (10 results)

  • [Journal Article] Primary lung cancer associated with Werner syndrome.2011

    • Author(s)
      Ohnishi, S, et al.
    • Journal Title

      Geriatr Gerontol Int

      Volume: 10 Pages: 319-323

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Primary lung cancer associated with Werner syndrome.2010

    • Author(s)
      Ohnishi, S., Fujimoto, M., Oide, T., Nakatani, Y., Tsurutani, Y., Koshizaka, M., Mezawa, M., Ishikawa, T., Takemoto, M., Yokote, K.
    • Journal Title

      Geriatr Gerontol Int. 10(4)

      Pages: 319-323

    • NAID

      10027755431

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species.2010

    • Author(s)
      Suzuki S, Tanaka T, Poyurovsky MV, Nagano H, Mayama T, Ohkubo S, Lokshin M, Hosokawa H, Nakayama T, Suzuki Y, Sugano S, Sato E, Nagao T, Yokote K, Tatsuno I, Prives C.
    • Journal Title

      Proc Natl Acad Sci USA 107

      Pages: 7461-7466

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mexiletine suppresses nodal persistent sodium currents in sensory axons of patients with neuropathic pain.2010

    • Author(s)
      Isose S, Misawa S, Sakurai K, Kanai K, Shibuya K, Sekiguchi Y, Nasu S, Noto Y, Fujimaki Y, Yokote K, Kuwabara S.
    • Journal Title

      Clin Neurophysiol. 121

      Pages: 719-724

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hypoglycemia due to ectopic secretion of insulin-like growth factor-I in a patient with an isolated sarcoidosis of the spleen.2010

    • Author(s)
      Ogiwara Y, Mori S, Iwama M, Sawabe M, Takemoto M, Kanazawa N, Furuta K, Fukuda I, Kondo Y, Kimbara Y, Tamura Y, Chiba Y, Araki A, Yokote K, Maruyama N, Ito H.
    • Journal Title

      Endocr J. 57

      Pages: 325-330

    • NAID

      10029584375

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of Pitavastatin (LIVALO Tablet) on the Estimated Glomerular Filtration Rate (eGFR) in Hypercholesterolemic Patients with Chronic Kidney Disease.2010

    • Author(s)
      Kimura K, Shimano H, Yokote K, Urashima M, Teramoto T.
    • Journal Title

      J Atheroscler Thromb. 17

      Pages: 601-606

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] CCN3 Inhibits Neointimal Hyperplasia Through Modulation of Smooth Muscle Cell Growth and Migration.2010

    • Author(s)
      Shimoyama,T., Hiraoka, S., Takemoto, M., Koshizaka, M., Tokuyama, H., Tokuyama, T., Watanabe, A., Fujimoto, M., Kawamura, H., Sato, S., Tsurutani, Y., Saito, Y., Perbal, B., Koseki, H., Yokote, K.
    • Journal Title

      Arterioscler Thromb Vasc Biol.30

      Pages: 675-682

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of Pitavastatin (LIVALO Tablet) on the Estimated Glomerular Filtration Rate (eGFR) in Hypercholesterolemic Patients with Chronic Kidney Disease.2010

    • Author(s)
      Kimura, K, et al.
    • Journal Title

      J Atheroscler Thromb

      Volume: 17 Pages: 601-609

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CCN3 Inhibits Neointimal Hyperplasia Through Modulation of Smooth Muscle Cell Growth and Mieration.2010

    • Author(s)
      Shimoyama, T, et al.
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 30 Pages: 675-682

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CCN3 inhibits neointimal hyperplasia through modulation of smooth muscle cell growth and migration.2009

    • Author(s)
      Shimoyama T
    • Journal Title

      Arterioscler Thromb Vasc Biol. 30

      Pages: 675-682

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Perturbation of Hepatic TGF-β Signaling by HepatitisB Virus X Protein in Chronic Hepatitis.2009

    • Author(s)
      Murata, M
    • Journal Title

      Hepatology 49

      Pages: 1203-1217

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Low HDL cholesterol is associated with the risk of stroke in elderly diabetic individuals : changes in the risk for atherosclerotic diseases at various ages.2009

    • Author(s)
      Hayashi T
    • Journal Title

      Diabetes Care 32

      Pages: 1221-1223

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of Pitavastatin(LIVALO Tablet)on High Density Lipoprotein Cholesterol(HDL-C)in Hypercholesterolemia : Sub-analysis of LIVALO Effectiveness and Safety(LIVES)Study2009

    • Author(s)
      Teramoto T
    • Journal Title

      J Atheroscler Thromb. 49

      Pages: 1203-1217

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical outcome and mechanism of soft tissue calcification in Werner syndrome.2008

    • Author(s)
      Honjo s. et al
    • Journal Title

      Rejuvenation Res. 11

      Pages: 809-819

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multicenter collaborative randomized parallel group comparative study of pitavastatin and atorvastatin in Japanese hypercholesterolemic patients-Collaborative study on Hypercholesterolemia drug Intervention and their Benefits for Atherosclerosis prevention2008

    • Author(s)
      Yokote K et al.
    • Journal Title

      Atherosclerosis 201

      Pages: 345-352

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Halofuginone prevents extracellular matrix deposition in diabetic nephropathy.2008

    • Author(s)
      Sato S et al.
    • Journal Title

      Biochem Biophys Res Commun 379

      Pages: 411-416

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypoglycemia due to Ectopic Secretion of Insulin-Like Growth Factor-I in a Patient with an Isolated Sarcoidosis of the Spleen.

    • Author(s)
      Ogawa Y
    • Journal Title

      Endocrine Journal (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influence of statins on glucose tolerance in patients with type 2 diabetes mellitus : a subanalysis of Collaborative study on Hypercholesterolemia drug Intervention and their Benefits for Atherosclerosis prevention.

    • Author(s)
      Yokote, K
    • Journal Title

      J Atheroscler Thromb. (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Inhibitory effect of CCN3 on arterial neointimal hyperplasia though modulation of smooth muscle cell growth migration.2010

    • Author(s)
      Yokote., K
    • Organizer
      6th INTERNATIONAL CCN WORKSHOP
    • Place of Presentation
      Northern Ireland
    • Year and Date
      2010-10-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新たな抗肥満薬とその展望2010

    • Author(s)
      横手幸太郎
    • Organizer
      第31回日本肥満学会
    • Place of Presentation
      群馬
    • Year and Date
      2010-10-02
    • Related Report
      2010 Final Research Report
  • [Presentation] 動脈硬化予防の現状と展望2010

    • Author(s)
      横手幸太郎
    • Organizer
      第31回日本肥満学会
    • Place of Presentation
      群馬
    • Year and Date
      2010-10-01
    • Related Report
      2010 Final Research Report
  • [Presentation] 新しい診断基準における合併症の考え方2010

    • Author(s)
      横手幸太郎
    • Organizer
      第31回日本肥満学会
    • Place of Presentation
      群馬
    • Year and Date
      2010-10-01
    • Related Report
      2010 Final Research Report
  • [Presentation] 新しい診断基準における合併症の考え方2010

    • Author(s)
      横手幸太郎
    • Organizer
      第31回日本肥満学会
    • Place of Presentation
      前橋市
    • Year and Date
      2010-10-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] 日本におけるスタチン治療のエビデンス2010

    • Author(s)
      横手幸太郎
    • Organizer
      第42回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      岐阜
    • Year and Date
      2010-07-16
    • Related Report
      2010 Final Research Report
  • [Presentation] 臼本におけるスタチン治療のエビデンス2010

    • Author(s)
      横手幸太郎
    • Organizer
      第42回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      岐阜市
    • Year and Date
      2010-07-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Trends in guidelines overseas. Special symposium : Update for JAS guideline on management of Atherosclerosis.2010

    • Author(s)
      横手幸太郎
    • Organizer
      The 42nd Annual scientific Meeting of the Japan Atherosclerosis Society.
    • Place of Presentation
      Gifu
    • Year and Date
      2010-07-15
    • Related Report
      2010 Final Research Report
  • [Presentation] ウエルナー症候群の病態把握、診療指針作成と新規治療法の開発を目的とした全国研究2010

    • Author(s)
      石川崇弘、竹本稔、藤本昌紀、葛谷雅文、森聖二郎、横手幸太郎
    • Organizer
      第52回日本老年病医学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2010-06-25
    • Related Report
      2010 Final Research Report
  • [Presentation] 高脂血症2010

    • Author(s)
      横手幸太郎
    • Organizer
      第52回日本老年医学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2010-06-24
    • Related Report
      2010 Final Research Report
  • [Presentation] 質異常から見たCKDへのアプローチ2010

    • Author(s)
      横手幸太郎
    • Organizer
      第53回日本腎臓学会学術総会ランチョンセミナー6
    • Place of Presentation
      神戸
    • Year and Date
      2010-06-16
    • Related Report
      2010 Final Research Report
  • [Presentation] 早老症から学ぶ血管のアンチエイジング2010

    • Author(s)
      横手幸太郎
    • Organizer
      第10回日本抗加齢医学会総会
    • Place of Presentation
      京都
    • Year and Date
      2010-06-13
    • Related Report
      2010 Final Research Report
  • [Presentation] WRN遺伝子に複合型ヘテロ接合体変異を同定したウェルナー症候群の一例2010

    • Author(s)
      田守義和、高橋哲也、中島進介、西本祐希、大野恭太、竹本稔、横手幸太郎、喜多哲也
    • Organizer
      第191回日本内科学会近畿地方会
    • Place of Presentation
      京都
    • Year and Date
      2010-06-12
    • Related Report
      2010 Final Research Report
  • [Presentation] 我が国における脂質関連大規模臨床試験2010

    • Author(s)
      横手幸太郎
    • Organizer
      第53回日本糖尿病学会年次学術集会
    • Place of Presentation
      岡山
    • Year and Date
      2010-05-28
    • Related Report
      2010 Final Research Report
  • [Presentation] 糖尿病・IGTにおけるスタチンの役割:臨床的立場から2010

    • Author(s)
      横手幸太郎
    • Organizer
      第53回日本糖尿病学会年次学術集会、ランチョンセミナー25
    • Place of Presentation
      岡山
    • Year and Date
      2010-05-28
    • Related Report
      2010 Final Research Report
  • [Presentation] Twist-1 : A new negative-feedback regulator of peroxisome proliferator-activated receptor-gamma co-activator-1.2010

    • Author(s)
      Fujimoto, M., Yokote, K.
    • Organizer
      The 14th International Congress of Endocrinology (ICE2010).
    • Place of Presentation
      Kyoto.
    • Year and Date
      2010-03-29
    • Related Report
      2010 Final Research Report
  • [Presentation] 透析中に早朝低血糖を繰り返し、インスリノーマと診断された1例。2010

    • Author(s)
      樋口誠一郎, 他
    • Organizer
      第47回日本糖尿病学会 関東甲信越地方会
    • Place of Presentation
      大宮
    • Year and Date
      2010-01-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] 日常診療の中でTG・HDLをどう考えどう治療するか?2010

    • Author(s)
      横手幸太郎
    • Organizer
      第44回日本成人病(生活習慣病)学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-01-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] 早老症から学ぶ血管のアンチエイジング2010

    • Author(s)
      横手幸太郎
    • Organizer
      第10回日本抗加齢医学会総会
    • Place of Presentation
      京都市
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脂質異常から見たCKDへのアプローチ2010

    • Author(s)
      横手幸太郎
    • Organizer
      第53回日本腎臓学会学術総会ランチョンセミナー6
    • Place of Presentation
      神戸市
    • Related Report
      2010 Annual Research Report
  • [Presentation] 高脂血症2010

    • Author(s)
      横手幸太郎
    • Organizer
      第52回日本老年医学会学術集会
    • Place of Presentation
      神戸市
    • Related Report
      2010 Annual Research Report
  • [Presentation] 動脈硬化予防の現状と展望2010

    • Author(s)
      横手幸太郎
    • Organizer
      第31回日本肥満学会
    • Place of Presentation
      前橋市
    • Related Report
      2010 Annual Research Report
  • [Presentation] 体質と高脂血症。2009

    • Author(s)
      横手幸太郎
    • Organizer
      日本体質医学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-07-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] 動脈硬化形成におけるCCNファミリー分子NOVの役割に関する検討2008

    • Author(s)
      下山立志、他
    • Organizer
      第40回日本動脈硬化学会
    • Place of Presentation
      エポカルつくば(つくば市)
    • Year and Date
      2008-07-11
    • Related Report
      2008 Annual Research Report
  • [Book] 今日の診断指針、6(Werner症候群)2010

    • Author(s)
      横手幸太郎
    • Publisher
      医学書院
    • Related Report
      2010 Final Research Report
  • [Book] NHKきょうの健康大百科2010

    • Author(s)
      横手幸太郎
    • Publisher
      NHK出版
    • Related Report
      2010 Annual Research Report
  • [Book] 日経メディカル2010

    • Author(s)
      横手幸太郎
    • Publisher
      日経BP
    • Related Report
      2010 Annual Research Report
  • [Book] The Lipid2010

    • Author(s)
      横手幸太郎
    • Publisher
      メディカルレビュー社
    • Related Report
      2010 Annual Research Report
  • [Book] ザィ・ピア51, 動脈硬化をめぐって予防と治療の新し喉開2010

    • Author(s)
      横手幸太郎
    • Publisher
      FUJIREBIO INC
    • Related Report
      2010 Annual Research Report
  • [Book] Geriatric Medicine2010

    • Author(s)
      横手幸太郎
    • Publisher
      老年医学
    • Related Report
      2010 Annual Research Report
  • [Book] 心血管リメクを防ぐ!高血圧診療ガイド.2010

    • Author(s)
      王子剛, 他
    • Publisher
      南山堂
    • Related Report
      2010 Annual Research Report
  • [Book] 糖尿病・高血圧合併例の脂質異常コントロール2010

    • Author(s)
      滝口朋子, 他
    • Publisher
      日本医事新報
    • Related Report
      2010 Annual Research Report
  • [Book] 細胞The CELL2010

    • Author(s)
      横手幸太郎
    • Publisher
      ニューサイエンス社
    • Related Report
      2010 Annual Research Report
  • [Book] 動脈硬化性疾患予防のための脂質異常症治療ガイド2008年版2008

    • Author(s)
      日本動脈硬化学会編
    • Total Pages
      105
    • Publisher
      協和企画(東京)
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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