Analyses on the mechanisms for cholesterol excretion from liver.
| Project/Area Number |
20591079
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
TSUKAMOTO Kazuhisa The University of Tokyo, 医学部附属病院, 講師 (20251233)
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| Co-Investigator(Kenkyū-buntansha) |
ISOーO Naoyuki 東京大学, 医科学研究所, 助教 (80420214)
MORIYA Kyouji 東京大学, 医学部附属病院, 教授 (00272550)
FUJIE Hajime 東京大学, 医学部附属病院, 助教 (90332577)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | ABCG5 / ABCG8 / NPC1L1 / 肝臓 / 胆汁 / ステロリン / APoE rich Lipoprotein / spheroid HepG2細胞 |
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| Research Abstract |
The liver is the only organ which excretes cholesterol from the body. The present study suggested 1) the existence of liver-specific sterolin which is important for excretion of cholesterol into the bile, and 2) that the cholesterol in the bile was re-absorbed with NPC1L1, which resulted in the production of apoE rich lipoproteins. Furthermore, it has been indicated that cholesterol in the liver, depending on its source, exerted distinct metabolic properties.
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Report
(4 results)
Research Products
(14 results)
