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Analyses on the mechanisms for cholesterol excretion from liver.

Research Project

Project/Area Number 20591079
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Metabolomics
Research InstitutionThe University of Tokyo

Principal Investigator

TSUKAMOTO Kazuhisa  The University of Tokyo, 医学部附属病院, 講師 (20251233)

Co-Investigator(Kenkyū-buntansha) ISOーO Naoyuki  東京大学, 医科学研究所, 助教 (80420214)
MORIYA Kyouji  東京大学, 医学部附属病院, 教授 (00272550)
FUJIE Hajime  東京大学, 医学部附属病院, 助教 (90332577)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
KeywordsABCG5 / ABCG8 / NPC1L1 / 肝臓 / 胆汁 / ステロリン / APoE rich Lipoprotein / spheroid HepG2細胞
Research Abstract

The liver is the only organ which excretes cholesterol from the body. The present study suggested 1) the existence of liver-specific sterolin which is important for excretion of cholesterol into the bile, and 2) that the cholesterol in the bile was re-absorbed with NPC1L1, which resulted in the production of apoE rich lipoproteins. Furthermore, it has been indicated that cholesterol in the liver, depending on its source, exerted distinct metabolic properties.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (14 results)

All 2011 2010 2009

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (10 results)

  • [Journal Article] Plant Sterols Increased IL-6 and TNF-α Secretion from Macrophages, but to a Lesser Extent than Cholesterol.2011

    • Author(s)
      Kurano M, Iso-O N, Hara M, Noiri E, Koike K, Kadowaki T, Tsukamoto K.
    • Journal Title

      J Atheroscler Thromb (Epub ahead of print)

    • NAID

      130004845378

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Plant Sterols Increased IL-6 and TNF-α Secretion from Macrophages, but to a Lesser Extent than Cholesterol.2011

    • Author(s)
      Kurano M., Tsukamoto K., et al
    • Journal Title

      J Atheroscler Thromb

      Volume: (掲載確定,掲載確定)

    • NAID

      130004845378

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a novel mutation for phytosterolemia. Genetic analyses of 2 cases.2009

    • Author(s)
      Togo M, Hashimoto Y, Iso-O N, Kurano M, Hara M, Kadowaki T, Koike K, Tsukamoto K.
    • Journal Title

      Clin Chim Acta. 401(1-2)(Epub 2008 Nov 5)

      Pages: 165-9

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of novel mutations for phytosterolemia2009

    • Author(s)
      Togo M., Tsukamoto K., et al
    • Journal Title

      Clinica Chimica Acta 401

      Pages: 165-169

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Modulation of Lipoprotein and Glucose Metabolism with the Over-expression of Niemann-pick C1 Like 1 Protein (NPC1L1) In Mice Liver.2010

    • Author(s)
      Kurano M., Tsukamoto K., et al.
    • Organizer
      American Heart Association 2010 Scientific Sessions.
    • Place of Presentation
      Chicago, IL, USA
    • Year and Date
      2010-11-16
    • Related Report
      2010 Final Research Report
  • [Presentation] Modulation of, Lipoprotein and Glucose Metabolism with the Over-expression of Niemann-pick C1 Like 1 Protein (NPC1L1) In Mice Liver.2010

    • Author(s)
      Kurano M., Tsukamoto K., et al
    • Organizer
      American Heart Association 2010 Scientific Sessions
    • Place of Presentation
      Chicago, IL, USA
    • Year and Date
      2010-11-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] LXR Agonist Increases ApoE Secretion from HepG2 Spheroid Together with Increased Production of VLDL and ApoE-Rich Large HDL.2010

    • Author(s)
      Kurano M., Tsukamoto K., et al
    • Organizer
      日本動脈硬化学会学術集会
    • Place of Presentation
      岐阜
    • Year and Date
      2010-07-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] LXR Agonist Increases ApoE Secretion from HepG2 Spheroid Together with Increased Production of VLDL and ApoE-Rich Large HDL.2010

    • Author(s)
      Kurano M., Tsukamoto K., et al.
    • Organizer
      Arterioscler Thromb Vasc Biol 2010 Scientific Sessions.
    • Place of Presentation
      San Francisco, CA, USA.
    • Year and Date
      2010-04-10
    • Related Report
      2010 Final Research Report
  • [Presentation] LXR Agonist Increases ApoE Secretion from HepG2 Spheroid Together with Increased Production of VLDL and ApoE-Rich Large HDL.2010

    • Author(s)
      Kurano M., Tsukamoto K., et al
    • Organizer
      Arterioscler Thromb Vasc Biol 2010 Scientific Sessions
    • Place of Presentation
      San Francisco, CA, USA
    • Year and Date
      2010-04-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Plant Sterols Increased Il-6 and TNF-α Secretion from Macrophages but to a Lesser Extent than Cholesterol.2010

    • Author(s)
      Kurano M., Tsukamoto K., et al.
    • Organizer
      Arterioscler Thromb Vasc Biol 2010 Scientific Sessions.
    • Place of Presentation
      San Francisco, CA, USA.
    • Year and Date
      2010-04-09
    • Related Report
      2010 Final Research Report
  • [Presentation] Plant Sterols Increased I1-6 and TNF-α Secretion from Macrophages but to a Lesser Extent than Cholesterol.2010

    • Author(s)
      Kurano M., Tsukamoto K., et al
    • Organizer
      Arterioscler Thromb Vasc Biol 2010 Scientific Sessions
    • Place of Presentation
      San Francisco, CA, USA
    • Year and Date
      2010-04-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] HepG2 スフェロイドのin vitro脂質代謝研究における有用性2010

    • Author(s)
      蔵野信、塚本和久, et al.
    • Organizer
      第44回日本成人病(生活習慣病)学会
    • Place of Presentation
      東京
    • Year and Date
      2010-01-09
    • Related Report
      2010 Final Research Report
  • [Presentation] HepG2スフェロイドのin vivtro脂質代謝研究における有用性2010

    • Author(s)
      蔵野信、塚本和久, et al.
    • Organizer
      第44回 日本成人病(生活習慣病)学会
    • Place of Presentation
      東京
    • Year and Date
      2010-01-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] Pytosterols induced secretion of inflammatory cytokines from macrophages, but to alesser extent than cholesterol2009

    • Author(s)
      Kurano M., Tsukamoto K., et al
    • Organizer
      第41回 日本動脈硬化学会総会
    • Place of Presentation
      下関
    • Year and Date
      2009-07-18
    • Related Report
      2009 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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