HDL metabolism in Diabetes Mellitus-The clinical role of HDL receptor SR-BI/CLA-1-

• Project/Area Number: 20591081
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Kagawa University
• Principal Investigator: MURAO Koji Kagawa University, 医学部附属病院, 講師 (20291982)
• Co-Investigator(Kenkyū-buntansha): IMACHI Hitomi 香川大学, 医学部・附属病院, 助教 (80380187) ; ISHIDA Toshihiko 香川大学, 医学部, 教授 (50159737) ; OHMORI Koji 香川大学, 医学部, 准教授 (00263913)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 脂質異常症 / 糖尿病 / HDL受容体 / SR-BI/CLA-1 / インクレチン / GLP-1 / ABCA1 / SR-BI / CLA-1 / チアゾリジン誘導体 / 高血糖 / p38-MAPK pathway / Sp1 / Fox01 / 血管内皮細胞

Research Abstract

Hyperglycemia suppressed the expression of HDL receptor SR-BI/CLA-1 via the activation of p38-MAPK pathway in Diabetes Mellitus. In diabetes mellitus, hyperglycemia stimulated atherosclerosis by inhibition of HDL metabolism. On the other hand, TZD stimulated the expression of SR-BI/CLA-1 in liver via the activation of PPARs.

Research Products

• [Journal Article] Exendin-4 regulates GLUT2 expression via the CaMKK/CaMKIV pathway in a pancreatic β-cell line. (2011)
  • Author(s): Chen K, Yu X, Murao K, Imachi H, Li J, Muraoka T, Masugata H, Zhang GX, Kobayashi R, Ishida T, Tokumitsu H.
  • Journal Title: Metabolism. 60(4) Pages: 579-585
  • Peer Reviewed
• [Journal Article] Prolactin regulatory element-binding protein involved in cAMP-mediated suppression of adiponectin gene. (2010)
  • Author(s): Li J, Murao K, Imachi H, Yu X, Muraoka T, Kim JB, Ishida T.
  • Journal Title: J Cell Mol Med. 14(6A) Pages: 1294-1302
  • Peer Reviewed
• [Journal Article] Menin, a product of the MENI gene, binds to estrogen receptor to enhance its activity in breast cancer cells : possibility of a novel predictive factor for tamoxifen resistance. (2010)
  • Author(s): Imachi H, Murao K, Dobashi H, Bhuyan MM, Cao X, Kontani K, Niki S, Murazawa C, Nakajima H, Kohno N, Yamashita H, Iwase H, Hayashi S, Ishida T, Yamauchi A.
  • Journal Title: Breast Cancer Res Treat. 122(2) Pages: 395-407
  • Peer Reviewed
• [Journal Article] Exendin-4 regulates pancreatic ABCA1 transcription via CaMKK/CaMKIV pathway. (2010)
  • Author(s): Li J, Murao K, Imachi H, Masugata H, Iwama H, Tada S, Zhang GX, Kobayashi R, Ishida T, Tokumitsu H.
  • Journal Title: J Cell Mol Med. 14(5) Pages: 1083-1087
  • Peer Reviewed
• [Journal Article] Hyperglycemia suppresses ABCA1 expression in vascular smooth muscle cells. (2010)
  • Author(s): Yu X, Murao K, Imachi H, Li J, Nishiuchi T, Hosomi N, Masugata H, Zhang GX, Iwama H, Ishida T.
  • Journal Title: Horm Metab Res. 42(4) Pages: 241-246
  • Peer Reviewed
• [Journal Article] Scavenger receptor class BI mediates the anti-apoptotic effect of erythropoietin. (2010)
  • Author(s): Nishiuchi T, Murao K, Imachi H, Yu X, Dobashi H, Haba R, Ishida T.
  • Journal Title: Ann Med. 42(2) Pages: 151-160
  • Peer Reviewed
• [Journal Article] Transcriptional factor prolactin regulatory element-binding protein-mediated gene transcription of ABCA1 via 3',5'-cyclic adenosine-5'-monophosphate. (2010)
  • Author(s): Nishiuchi Y, Murao K, Imachi H, Nishiuchi T, Iwama H, Ishida T.
  • Journal Title: Atherosclerosis. 212(2) Pages: 418-425
  • Peer Reviewed
• [Journal Article] Hyperglycemia suppresses ABCA1 expression in vascular smoothmuscle cells (2010)
  • Author(s): Yu X, 他
  • Journal Title: Horm Metab Res Volume: 42 Pages: 241-246
  • Peer Reviewed
• [Journal Article] Exendin-4 regulates pancreatic ABCA1 transcription via CaMKK/CaMKIV parkway (2010)
  • Author(s): Li J, 他
  • Journal Title: J Cell Mol Med Volume: 14 Pages: 1083-1087
  • Peer Reviewed
• [Journal Article] Scavenger receptor class BI mediates the anti-apoptotic effect of erythropoietin (2010)
  • Author(s): Nishiuchi T, 他
  • Journal Title: Ann Med Volume: 42 Pages: 151-160
  • Peer Reviewed
• [Journal Article] Scavenger receptor class BI mediates the anti-apoptotic effect of erythropoietin (2010)
  • Author(s): Nishiuchi T
  • Journal Title: Ann Med 42 Pages: 151-160
  • Peer Reviewed
• [Journal Article] Human scavenger receptor class B type 1 is regulated by activators of peroxisome proliferators-activated receptor-gamma in hepatocytes. (2009)
  • Author(s): Ahmed RA, Murao K, Imachi H, Yu X, Li J, Wong NC, Ishida T.
  • Journal Title: Endocrine. 35(2) Pages: 233-242
  • Peer Reviewed
• [Journal Article] PREB regulates transcription of pancreatic glucokinase in response to glucose and cAMP. (2009)
  • Author(s): Muraoka T, Murao K, Imachi H, Yu X, Li J, Wong NC, Ishida T.
  • Journal Title: J Cell Mol Med. 13(8B) Pages: 2386-2395
  • Peer Reviewed
• [Journal Article] The transcriptional factor PREB mediates MCP-1 transcription induced by cytokines in human vascular endothelial cells. (2009)
  • Author(s): Murao K, Imachi H, Yu X, Muraoka T, Hosami N, Dobashi H, Ishida T.
  • Journal Title: Atherosclerosis. 207(1) Pages: 45-50
  • Peer Reviewed
• [Journal Article] Exendin-4 regulates glucokinase expression by CaMKK/CaMKIV pathway in pancreatic beta-cell line. (2009)
  • Author(s): Murao K, Li J, Imachi H, Muraoka T, Masugata H, Zhang GX, Kobayashi R, Ishida T, Tokumitsu H.
  • Journal Title: Diabetes Obes Metab. 11(10) Pages: 939-946
  • Peer Reviewed
• [Journal Article] Human scavenger receptor class B type 1 is regulated by activators of peroxisome proliferators-activated receptor-gamma in hepatocytes (2009)
  • Author(s): Ahmed RA
  • Journal Title: Endocrine 35 Pages: 233-242
  • Peer Reviewed
• [Journal Article] Exendin-4 regulates pancreatic ABCA1 transcription via CaMKK/CaMKIV pathway (2009)
  • Author(s): Li J
  • Journal Title: J Cell Mol Med (印刷中)
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): 井町仁美
  • Journal Title: 内科(脂質異常症)(南江堂) Pages: 112-115
• [Journal Article] Hyperglycemia suppresses hepatic scavenger receptor class B type I expression. (2008)
  • Author(s): Murao K, Yu X, Imachi H, Cao WM, Chen K, Matsumoto K, Nishiuchi T, Wong NC, Ishida T.
  • Journal Title: Am J Physiol Endocrinol Metab. 294(1)
  • Peer Reviewed
• [Journal Article] Interferon alpha decreases expression of human scavenger receptor class BI, a possible HCV receptor in hepatocytes. (2008)
  • Author(s): Murao K, Imachi H, Yu X, Cao WM, Nishiuchi T, Chen K, Li J, Ahmed RA, Wong NC, Ishida T.
  • Journal Title: Gut. 57(5) Pages: 664-671
  • Peer Reviewed
• [Journal Article] The transcriptional factor prolactin regulatory element-binding protein mediates the gene transcription of adrenal scavenger receptor class B type I via 3',5'-cyclic adenosine 5'-monophosphate. (2008)
  • Author(s): Murao K, Imachi H, Yu X, Cao WM, Muraoka T, Dobashi H, Hosomi N, Haba R, Iwama H, Ishida T.
  • Journal Title: Endocrinology. 149(12) Pages: 6103-6112
  • Peer Reviewed
• [Journal Article] The prolactin regulatory element-binding regulates of the 11beta-hydroxylase gene. (2008)
  • Author(s): Imachi H, Murao K, Cao WM, Muraoka T, Nishiuchi T, Dobashi H, Hosomi N, Iwama H, Ishida T.
  • Journal Title: Biochem Biophys Res Commun. 21;376(3) Pages: 531-535
  • Peer Reviewed
• [Journal Article] Hyperglycemia suppresses hepatic scavenger receptor class B type I expression (2008)
  • Author(s): Murao K, Yu X, Imachi H, 他
  • Journal Title: Am J Physiol Endocrinol Metab 294
  • Peer Reviewed
• [Journal Article] Interferon-α decreases expression of human scavenger receptor class BI, possible HCV receptor in hepatocytes. (2008)
  • Author(s): Murao K, Imachi H, Yu X, 他
  • Journal Title: GUT 57 Pages: 664-671
  • Peer Reviewed
• [Journal Article] The transcriptional factor prolactin regulatory element-binding protein mediates the gene transcription of adrenal scavenger receptor class BIvia cAMP (2008)
  • Author(s): Murao K, Imachi H, Yu X, 他
  • Journal Title: Endocrinology 149 Pages: 6103-6112
  • Peer Reviewed
• [Presentation] 膵β細胞におけるHDL代謝異常 (2010)
  • Author(s): 村尾孝児
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: 岡山、岡山コンベンションセンター(招待講演)
  • Year and Date: 2010-05-27
• [Presentation] 糖尿病におけるHDL代謝異常 (2009)
  • Author(s): 村尾孝児
  • Organizer: 第52回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪、大阪国際会議場
  • Year and Date: 2009-05-23
• [Presentation] 糖尿病におけるHDL代謝(コレステロール逆転送系)異常 (2009)
  • Author(s): 村尾孝児、井町仁美、村岡都美江、石田俊彦
  • Organizer: 第52回日本糖尿病学会学術総会,シンポジウム
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2009-04-27
• [Presentation] 研究奨励賞受賞講演『High-density lipoprotein (HDL)受容体(scavenger receptor class BI/CLA-1)の同定および臨床的機能解析』 (2008)
  • Author(s): 村尾孝児
  • Organizer: 第81回日本内分泌学会学術総会
  • Place of Presentation: 青森
  • Year and Date: 2008-05-17
• [Book] 内分泌代謝テキストブック (2011)
  • Author(s): 村尾孝児, 他
  • Publisher: Springer(印刷中)
• [Book] 内分泌代謝テキストブック (2010)
  • Author(s): 村尾孝児, 他
  • Publisher: Springer印刷中
• [Book] 糖尿病学の進歩2008 (2008)
  • Author(s): 村尾孝児, 井町仁美, 村岡都美江, 石田俊彦
  • Publisher: 診断と治療社