Roles of Wnt signaling pathway in progression of vascular calcification

• Project/Area Number: 20591082
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Osaka City University
• Principal Investigator: SHIOI Atsushi Osaka City University, 大学院・医学研究科, 講師 (90260801)
• Co-Investigator(Kenkyū-buntansha): FUKUMOTO Shinya 大阪市立大学, 大学院・医学研究科, 講師 (90381996)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 骨 / カルシウム代謝異常 / 血管石灰化 / 動脈硬化 / Wntシグナル / アポEノックアウトマウス / TOPGALマウス / アルカリホスファターゼ / 血管平滑筋細胞 / 動脈効果 / 血管老化

Research Abstract

We investigated the roles of Wnt signaling pathway in the development of atherosclerosis and vascular calcification. This study clarified that Wnt signaling pathway is activated in atherosclerotic plaques including calcified lesions and that this pathway plays an important role in acquisition of osteoblastic phenotype of vascular smooth muscle cells. Activation of Wnt signaling pathway in vascular lesions may be induced by inflammatory stimuli. Moreover, cellular senescence may also contribute to the development of atherosclerosis and vascular calcification.

Research Products

• [Journal Article] Fetuin-A is associated with calcified coronary artery disease. (2010)
  • Author(s): Mori K, Ikari Y, Jono S, Emoto M, Shioi A, Koyama H, Shoji T, Ishimura E, Inaba M, Hara K, Nishizawa Y
  • Journal Title: Coron Artery Dis 21 Pages: 281-285
  • Peer Reviewed
• [Journal Article] Receptor for advanced glycation end-product (RAGE) regulation of adiposity and adiponectin is associated with atherosclerosis in apoE-deficient mouse. (2010)
  • Author(s): Ueno H, Koyama H, Shoji T, Monden M, Fukumoto S, Tanaka S, Otsuka Y, Mima Y, Morioka T, Mori K, Shioi A, Yamamoto H, Inaba M, Nishizawa Y
  • Journal Title: Atherosclerosis 211 Pages: 431-436
  • Peer Reviewed
• [Journal Article] Serum osteoprotegerin levels and long-term prognosis in subjects with stable coronary artery disease. (2010)
  • Author(s): Jono S, Otsuki S, Higashikuni Y, Shioi A, Mori K, Hara K, Hashimoto H, Ikari Y
  • Journal Title: J Thromb Haemost 8 Pages: 1170-1175
  • Peer Reviewed
• [Journal Article] Association of serum TRAIL level with coronary artery diseases. (2010)
  • Author(s): Mori K, Ikari Y, Jono S, Shioi A, Ishimura E, Emoto M, Inaba M, Hara K, Nishizawa Y
  • Journal Title: Thromb Res 125 Pages: 322-325
  • Peer Reviewed
• [Journal Article] Effects of pravastatin on serum osteoprotegerin levels in patients with hypercholesterolemia and type 2 diabetes. (2010)
  • Author(s): Mori K, Jono S, Emoto M, Kawagishi T, Yasumoto H, Konishi T, Furumitsu Y, Shioi A, Shoji T, Inaba M, Nishizawa Y
  • Journal Title: Angiology 61 Pages: 86-91
  • Peer Reviewed
• [Journal Article] 血管石灰化の分子機構 (2010)
  • Author(s): 塩井淳
  • Journal Title: CLINICAL CALCIUM 20 Pages: 1611-1619
• [Journal Article] 血管石灰化・リモデリングと糖尿病 (2010)
  • Author(s): 塩井淳
  • Journal Title: 脈管学 50 Pages: 561-567
  • NAID: 10027743091
• [Journal Article] 血管石灰化の分子機構 (2010)
  • Author(s): 塩井淳
  • Journal Title: 血管医学 11 Pages: 141-148
• [Journal Article] Fetuin-A is associated with calcified coronary artery disease. (2010)
  • Author(s): Mori K, et al.
  • Journal Title: Coron Artery Dis Volume: 21 Pages: 281-285
  • Peer Reviewed
• [Journal Article] Receptor for advanced glycation end-products (RAGE) regulation of adiposity and adiponectin is associated with atherogenesis in apoE-deficient mice. (2010)
  • Author(s): Ueno H, et al.
  • Journal Title: atherosclerosis Volume: 211 Pages: 431-436
  • Peer Reviewed
• [Journal Article] Serum osteoprotegerin levels and long-term prognosis in subjects with stable coronary artery disease. (2010)
  • Author(s): Jono S, et al.
  • Journal Title: J Thromb Haemost Volume: 8 Pages: 1170-1175
  • Peer Reviewed
• [Journal Article] Vascular calcification : osteogenic transformation of vascular smooth muscle cells (2010)
  • Author(s): Shioi A, Nishizawa Y
  • Journal Title: J Oral Biosci 52 Pages: 26-32
  • NAID: 10027105239
• [Journal Article] Phosphatidylinositol 3-kinase/Akt pathway regulates inflammatorymediators-induced calcification of human vascular smooth muscle cells. (2009)
  • Author(s): Okazaki H, Shioi A, Hirowatari K, Koyama H, Fukumoto S, Ishimura E, Nishizawa Y
  • Journal Title: Osaka City Med J 55 Pages: 71-80
  • Peer Reviewed
• [Journal Article] Vascular calcification in chronic kidney disease : pathogenesis and clinical implications. (2009)
  • Author(s): 塩井淳, 西沢良記
  • Journal Title: J Ren Nutr 19 Pages: 78-81
• [Journal Article] Atheroprotective and plaque-stabilizing effects of enzymatically modified isoquercitrin in atherogenic apoE-deficient mice. (2009)
  • Author(s): Motoyama K, Koyama H, Moriwaki M, Emura K, Okuyama S, Sato E, Inoue M, Shioi A, Nishizawa Y
  • Journal Title: Nutrition 25 Pages: 421-427
  • Peer Reviewed
• [Journal Article] 血管石灰化におけ るリンの役割 (2009)
  • Author(s): 塩井淳、西沢良記
  • Journal Title: CLINICAL CALCIUM 19 Pages: 180-185
• [Journal Article] Atheroprotective and plaque-stabilizing effects of enzymatically modified isoquercitrin in atherogenic apoE-deficient mice (2009)
  • Author(s): Motoyama K, et al.
  • Journal Title: Nutrition 25 Pages: 421-427
  • Peer Reviewed
• [Journal Article] Phosphatidylinositol 3-kinase/Akt pathway regulates inflammatory media tors-induced calcification of human vascular smooth muscle cells (2009)
  • Author(s): Okazaki H, et al.
  • Journal Title: Osaka City Med J 55 Pages: 71-80
  • Peer Reviewed
• [Journal Article] Vascular calcification in chronic kidney disease : pathogenesis and clinical implications (2009)
  • Author(s): Shioi A, Nishizawa Y
  • Journal Title: J Ren Nutr 19 Pages: 78-81
  • Peer Reviewed
• [Journal Article] Differential risk factors for vascular calcification in end-stage renal disease between diabetics and nondiabetics : the respective importance of glycemic and phosphate control. (2008)
  • Author(s): Ishimura E, et al.
  • Journal Title: Kidney Blood Press Res 31 Pages: 10-15
  • Peer Reviewed
• [Presentation] 血管石 灰化の調節機構 (2010)
  • Author(s): 塩井淳、森克仁、西沢良記
  • Organizer: 第28回日本骨代謝学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2010-07-21
• [Presentation] 血管石灰化の調節機構 (2010)
  • Author(s): 塩井淳、森克仁、西澤良記
  • Organizer: 日本骨代謝学会
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2010-07-21
• [Presentation] Chronic proteinuric nephropathy induced by immune-mediated glomerular injury accelerates atherosclerosis in apoE-deficient mice. (2010)
  • Author(s): Shioi A, Okazaki H, Koyama H, Ishimura E, Nishizawa Y
  • Organizer: European Renal Association-European Dialysis Transplantation Association
  • Place of Presentation: Munich
  • Year and Date: 2010-06-26
• [Presentation] 血管石灰化の分子機構 (2010)
  • Author(s): 塩井淳、森克仁、岡崎博一、西沢良記
  • Organizer: 第74回日本循環器学会総会
  • Place of Presentation: 京都
  • Year and Date: 2010-03-05
• [Presentation] Molecular mechanism of vascular calcification (2010)
  • Author(s): Shioi A, Mori K, Okazaki H, Nishizawa Y
  • Organizer: Japanese Circulation Society
  • Place of Presentation: Kyoto
  • Year and Date: 2010-03-05
• [Book] 血管石灰化とその調節機構,CKD-MBD ハンドブック (2009)
  • Author(s): 塩井淳、西沢良記
  • Total Pages: 253
  • Publisher: 日本メディカルセンター