Pathogenesis and treatment of small dense LDL metabolism in patients with coronary heart disease
| Project/Area Number |
20591085
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
HASHIMOTO Koichi Jikei University School of Medicine, 医学部, 助教 (30317987)
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| Research Collaborator |
IKEWAKI Katsunori 防衛医科大学校, 医学教育部医学科専門課程, 教授 (40287199)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | リポ蛋白 / 安定同位体 / LDL / small dense LDL / stable isotoPe / apoprotein / stable isotope |
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| Research Abstract |
Dyslipidemia has been considered as a major risk factor for cardiovascular disease (CVD). LDL-centric treatment has failed to reduce CVD, thus highlighting other atherogenic lipoproteins. Among those, small dense LDL (sdLDL) is associated with postprandial lipemia. However, exact metabolism and treatment strategy of sdLDL is yet to be established. In the present study, we performed in vivo metabolic study using stable isotopically-labeled amino acid and found that rate of catabolism was 34% lower in sdLDL and this delayed catabolism was normalized by statin treatment.
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Report
(4 results)
Research Products
(17 results)
