Pathogenesis and treatment of small dense LDL metabolism in patients with coronary heart disease

• Project/Area Number: 20591085
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Jikei University School of Medicine
• Principal Investigator: HASHIMOTO Koichi Jikei University School of Medicine, 医学部, 助教 (30317987)
• Research Collaborator: IKEWAKI Katsunori 防衛医科大学校, 医学教育部医学科専門課程, 教授 (40287199)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: リポ蛋白 / 安定同位体 / LDL / small dense LDL / stable isotoPe / apoprotein / stable isotope

Research Abstract

Dyslipidemia has been considered as a major risk factor for cardiovascular disease (CVD). LDL-centric treatment has failed to reduce CVD, thus highlighting other atherogenic lipoproteins. Among those, small dense LDL (sdLDL) is associated with postprandial lipemia. However, exact metabolism and treatment strategy of sdLDL is yet to be established. In the present study, we performed in vivo metabolic study using stable isotopically-labeled amino acid and found that rate of catabolism was 34% lower in sdLDL and this delayed catabolism was normalized by statin treatment.

Research Products

• [Journal Article] Cilostazol enhances macrophage reverse cholesterol transport in vitro and in vivo. (2010)
  • Author(s): Nakaya K, Ayaori M
  • Journal Title: Atherosclerosis 213 Pages: 135-41
  • Peer Reviewed
• [Journal Article] Coffee consumption enhances high-density lipoprotein-mediated cholesterol efflux in macrophages. (2010)
  • Author(s): Uto-Kondo H, Ayaori M
  • Journal Title: Circ Res. 106 Pages: 779-87
  • Peer Reviewed
• [Journal Article] Ventricular Tachyarrhythmia diagnosed during electrophysiological study for non-sustained tachycardia. (2010)
  • Author(s): Hisada T, Miyagawa T
  • Journal Title: Aviat.Space Environ.Med 81 Pages: 593-596
  • Peer Reviewed
• [Journal Article] Jikei Heart Study group. Sex differences in effects of valsartan administration on cardiovascular outcomes in hypertensive patients : findings from the Jikei Heart Study. (2010)
  • Author(s): Yoshida H, Shimizu M
  • Journal Title: J Hypertens. 28 Pages: 1150-7
  • Peer Reviewed
• [Journal Article] Difference in risk factors between acute coronary syndrome and stable angina pectoris in the Japanese : smoking as a crucial risk factor of acute coronary syndrome. (2010)
  • Author(s): Yagi H., Komukai K., Hashimoto K., et al
  • Journal Title: Journal of Cardiology Volume: 55 Pages: 345-53
  • NAID: 10027052623
  • Peer Reviewed
• [Journal Article] Cilostazol enhances macrophage reverse cholesterol transport in vitro and in vivo. (2010)
  • Author(s): Nakaya K., Ayaori M., Uto-Kondo H., et al
  • Journal Title: Atherosclerosis Volume: 213 Pages: 135-41
  • Peer Reviewed
• [Journal Article] Coffee consumption enhances high-density lipoprotein-mediated cholesterol efflux in macrophages. (2010)
  • Author(s): Uto-Kondo H., Ayaori M., Ogura M., et al
  • Journal Title: Circulation Research Volume: 106 Pages: 779-87
  • Peer Reviewed
• [Journal Article] Effects of atorvastatin on nuclear magnetic resonance-defined lipoprotein sub-classes and inflammatory markers in patients with hypercholesterolemia. (2009)
  • Author(s): Ikewaki K, Terao Y
  • Journal Title: J Atheroscler Thromb. 16 Pages: 51-6
  • NAID: 10025764858
  • Peer Reviewed
• [Journal Article] Dietary mono-unsaturated fat activates metabolic pathways for triglyceride-rich lipoproteins that involve apolipoproteins E and C-III. (2008)
  • Author(s): Zheng C, Khoo C
  • Journal Title: Am J Clin Nutr 88 Pages: 272-281
  • Peer Reviewed
• [Presentation] Pioglitazone enhances cholesterol efflux from macrophages by increasing ABCA1/ABCG1 expressions via LXRα/PPARγ pathway : findings from in vitro and ex vivo studies. (2010)
  • Author(s): Ozasa H
  • Organizer: American Heart Association, Scientific Sessions
  • Place of Presentation: シカゴ
  • Year and Date: 2010-11-16
• [Presentation] 治療高血圧症におけるメタボリックシンドローム合併の循環器系臨床像への影響 (2010)
  • Author(s): 橋本浩一
  • Organizer: 日本心臓病学会
  • Place of Presentation: 東京
  • Year and Date: 2010-09-18
• [Presentation] 未治療高血圧症におけるメタボリックシンドローム合併の循環器系臨床像への影響 (2010)
  • Author(s): 橋本浩一
  • Organizer: 日本心臓病学会
  • Place of Presentation: 東京
  • Year and Date: 2010-09-18
• [Presentation] Significant Regression of Left Ventricular Hypertrophy by ARB Valsartan assessd by Echocardiography (2010)
  • Author(s): Ikewaki K
  • Organizer: A Finding from JIKEI Heart Study The European Society of Cardiology at ESC Congress
  • Place of Presentation: ストックホルム
  • Year and Date: 2010-08-30
• [Presentation] Increased TG Accelerates Cardio-metabolic dsyfunction in low HDL cholesterol Subject (2009)
  • Author(s): Ogura M
  • Organizer: 第41回日本動脈硬化学会総会
  • Place of Presentation: 下関
  • Year and Date: 2009-07-18
• [Presentation] Kinetics of ApoB-containing Lipoproteins (2009)
  • Author(s): Ikewaki K
  • Organizer: An Update XV International Symposium on Atherosclerosis
  • Place of Presentation: ボストン
  • Year and Date: 2009-06-19
• [Presentation] Impact of new insights of lipoprotein metabolism in autosomal recessive hypercholesterolemia : a stable isotope kinetic study in vivo. (2009)
  • Author(s): Tada H
  • Organizer: The 73rd Annual scientific meeting of the Japanese Circulation Society
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-21
• [Presentation] RAR Agonists Enhance HDL-mediated Cholesterol Efflux from Macrophages by Inducing ABCG1 Expression though RARα/RXR Acting on LXR Responsive Elements. (2008)
  • Author(s): Ayaori M
  • Organizer: American Heart Association, Scientific Sessions
  • Place of Presentation: ニューオリンズ
  • Year and Date: 2008-11-10