| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
Menin, the product of the MEN1 gene, form a nuclear complex with mixed lineage leukemia (MLL) protein, a human histone methyltransferase and activated transcription of the p27^<Kip1> and p18^<Ink4C> genes. In multiple endocrine neoplasia type 1 (MEN1), a mutation of menin caused decreased expression of the p27^<Kip1> and p18^<Ink4C> genes and deregulated cell growth. We found that the MLL-p27^<Kip1> pathway was downregulated in the pituitary adenomas, and octreotide increased the p27^<Kip1> level, at least in part, by sequential transcriptional stimulation of the MLL and p27^<Kip1> genes through PI3K/Akt and MAPK pathways.
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