Role of MLL/menin-cell cycle pathway in neuroendocrine tumorigenesis
Project/Area Number |
20591087
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Endocrinology
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Research Institution | Gunma University |
Principal Investigator |
YAMADA Masanobu Gunma University, 医学部, 講師 (90261833)
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Project Period (FY) |
2008 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | MLL / p27 / 下垂体腫瘍 / オクトレオチド / menin / プロモーター |
Research Abstract |
Menin, the product of the MEN1 gene, form a nuclear complex with mixed lineage leukemia (MLL) protein, a human histone methyltransferase and activated transcription of the p27^<Kip1> and p18^<Ink4C> genes. In multiple endocrine neoplasia type 1 (MEN1), a mutation of menin caused decreased expression of the p27^<Kip1> and p18^<Ink4C> genes and deregulated cell growth. We found that the MLL-p27^<Kip1> pathway was downregulated in the pituitary adenomas, and octreotide increased the p27^<Kip1> level, at least in part, by sequential transcriptional stimulation of the MLL and p27^<Kip1> genes through PI3K/Akt and MAPK pathways.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Attenuated expression of menin and p27 (Kip1) in an aggressive case of multiple endocrine neoplasia type 1 (MEN1) associated with an atypical prolactinoma and a malignant pancreatic endocrine tumor.2011
Author(s)
Ishida E, Yamada M, Horiguchi K, Taguchi R, Ozawa A, Shibusawa N, Hashimoto K, Satoh T, Yoshida S, Tanaka Y, Yokota M, Tosaka M, Hirato J, Yamada S, Yoshimoto Y, Mori M
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Journal Title
NAID
Related Report
Peer Reviewed
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[Journal Article] Troglitazone, a ligand of peroxisome proliferator-activated receptor-{gamma}, stabilizes NUCB2 (Nesfatin) mRNA by activating the ERK1/2 pathway : isolation and characterization of the human NUCB2 gene.2010
Author(s)
Yamada M, Horiguchi K, Umezawa R, Hashimoto K, Satoh T, Ozawa A, Shibusawa N, Monden T, Okada S, Shimizu H, Mori M
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Journal Title
Endocrinology. 151
Pages: 2494-2503
Related Report
Peer Reviewed
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[Journal Article] Tat-binding Protein-1, an ATPase of 19S Regulatory Particles of the 26S Proteasome, Enhances Androgen Receptor Function in Cooperation with Tat-binding Protein-1-interacting Protein/Hop2.2009
Author(s)
Satoh T, Ishizuka T, Tomaru T, Yoshino S, Nakajima Y, Hashimoto K, Shibusawa N, Monden T, Yamada M, Mori M
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Journal Title
Endocrinology 386
Pages: 697-702
Related Report
Peer Reviewed
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[Journal Article] Peripheral administration of nesfatin-1 reduces food intake in mice : the leptin-independent mechanism.2009
Author(s)
Shimizu H, Oh-I S, Hashimoto K, Nakata M, Yamamoto S, Yoshida N, Eguchi H, Kato I, Inoue K, Satoh T, Okada S, Yamada M, Yada T, Mori M
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Journal Title
Endocrinology. 150
Pages: 662-671
Related Report
Peer Reviewed
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[Presentation] Expression level of p18, but not p27, is reduced in thyroid tumors2009
Author(s)
Ozawa A, Yamada M, Koibuchi Y, Horiguchi J, Horiguchi K, Shibusawa N, Hashimoto K, Satoh T, Mori M
Organizer
9^<th> Asia and Oceania Thyroid Association Congress
Place of Presentation
Nagoya Japan
Year and Date
2009-11-02
Related Report
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