| Project/Area Number |
20591094
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Kyoto University |
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Principal Investigator |
HOSODA Kiminori Kyoto University, 医学研究科, 教授 (40271598)
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| Co-Investigator(Renkei-kenkyūsha) |
MASUZAKI Hiroaki 京都大学, 大学院・医学研究科, 講師 (00291899)
EBIHARA Ken 京都大学, 大学院・医学研究科, 准教授 (70362514)
FUJIKURA Junji 京都大学, 大学院・医学研究科, 助教 (70378743)
IWAKURA Hiroshi 京都大学, 大学院・医学研究科, 助教 (20378615)
TOMITA Tsutomu 京都大学, 大学院・医学研究科, 非常勤講師 (50402897)
NOGUCHI Michio 京都大学, 大学院・医学研究科, 特定研究員 (00432394)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | インスリン分泌 / GPR40 / 肥満 / コレツキーラット / 中性脂肪 / 糖尿病 / β細胞 / 膵臓 / Pdx1 |
|---|
| Research Abstract |
GPR40 is a Gq-coupled receptor, the ligand of which is middle-chain and long-chain free fatty acids. GPR40 has been reported to be expressed in pancreatic beta cells and implicated in augmentation of insulin secretion. We investigated GPR40 gene expression in pancreatic islets in genetically obese Koletsky rats. In 14-week-old Koletsky rats which shows severe obesity and sufficiency of insulin secretion, GPR40 levels were approximately 25% of those in nonobese lettermates.
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