Identification and functional analysis of novel hypothalamic peptides
Project/Area Number |
20591100
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Endocrinology
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Research Institution | University of Miyazaki |
Principal Investigator |
YAMAGUCHI Hideki University of Miyazaki, 医学部, 講師 (10305097)
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Co-Investigator(Kenkyū-buntansha) |
TOSHINAI Koji 宮崎大学, 医学部, 講師 (80381101)
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Project Period (FY) |
2008 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | 生理活性ペプチド / 摂食調節 / エネルギー代謝調節 / 免疫染色 |
Research Abstract |
We have identified two novel carboxy-terminally amidated peptides, Neuroendocrine regulatory peptide (NERP)-1 and NERP-2. Icv administration of NERP-2 increased food intake in rats. NERP-2 expression localized to the lateral hypothalamus, colocalizing with orexins that activate feeding behavior and arousal. Icv administration of NERP-2 also increased body temperature, oxygen consumption, and locomotor activity in rats. Bioactivities of NERP-2 were abrogated by blunting orexin signaling pathway. NERP-2 plays a role in the control of food intake and energy homeostasis via the orexin pathway.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Distribution of neuroendocrine regulatory peptide-1 and -2, and proteolytic processing of their precursor VGF protein in the rat.2010
Author(s)
Mishiro-Sato E, Sasaki K, Matsuo T, Kageyama H, Yamaguchi H, Date Y, Matsubara M, Ishizu T, Yoshizawa-Kumagaye K, Satomi Y, Takao T, Shioda S, Nakazato M, Minamino N.
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Journal Title
J Neurochem. 114
Pages: 1097-1106
Related Report
Peer Reviewed
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[Journal Article] Neuropeptide W : an anorectic peptide regulated by leptin and metabolic state.2010
Author(s)
Date Y, Mondal MS, Kageyama H, Ghamari-Langroudi M, Takenoya F, Yamaguchi H, Shimomura Y, Mori M, Murakami N, Shioda S, Cone RD, Nakazato M.
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Journal Title
Endocrinology
Volume: 151
Pages: 2200-2210
Related Report
Peer Reviewed
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[Journal Article] Distribution of neuroendocrine regulatory peptide-1 and -2, and proteolytic processing of their precursor VGF protein in the rat.2010
Author(s)
Mishiro-Sato E, Sasaki K, Matsuo T, Kageyama H, Yamaguchi H, Date Y, Matsubara M, Ishizu T, Yoshizawa-Kumagaye K, Satomi Y, Takao T, Shioda S., Nakazato M., Minamino N.
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Journal Title
J Neurochem.
Volume: 114
Pages: 1097-1106
Related Report
Peer Reviewed
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[Journal Article] Ontogeny of a new enteric peptide, neuropeptide W (NPW), in the developing rat stomach.2008
Author(s)
Mondal MS, Yamaguchi H, Date Y, Tsuruta T, Shimbara T, Toshinai K, Shimomura Y, Mori M, Nakazato M.
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Journal Title
Regul Pept, 145 : 141-146 (2008) 145
Pages: 141-146
Related Report
Peer Reviewed
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[Journal Article] A hypothalamic peptide, neuroendocrine regulatory peptide-2, modulates the orexin system.
Author(s)
Toshinai K, Yamaguchi H, Kageyama H, Matsuo T, Koshinaka K, Sasaki K, Shioda S, inamino N, Nakazato M
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Journal Title
Related Report
Peer Reviewed
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[Presentation] 新規生理活性ペプチドNERPの機能解析2008
Author(s)
山口秀樹, 佐々木一樹, 里見佳典, 影山晴秋, 伊達 紫, 十枝内厚次, Muhtashan S. Mondal, 新原琢也. 松尾 崇, 塩田清二, 高尾敏文, 南野直人, 中里雅光
Organizer
第81回日本内分泌学会学術総会
Place of Presentation
青森
Related Report