Calcium-sensing receptor agonist inhibits parathyroid proliferation
Project/Area Number |
20591101
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Endocrinology
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Research Institution | Osaka City University |
Principal Investigator |
IMANISHI Yasuo Osaka City University, 大学院・医学研究科, 講師 (50326253)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 副甲状腺アデノーマ / 2次性副甲状腺機能亢進症 / 副甲状腺ホルモン / 副甲状腺機能亢進症 / 副甲状腺腫瘍 |
Research Abstract |
Cinacalcet HCl (Cinacalcet), a type II calcimimetic compound, suppresses PTH secretion from parathyroid cells in both primary and secondary hyperparathyroidism. Effect of cinacalcet on parathyroid cell proliferation was analyzed in a transgenic mouse model of primary hyperparathyroidism (PC2), in which parathyroid-targeted overexpression of the cyclin D1 oncogene causes chronic biochemical hyperparathyroidism and parathyroid cell hyperplasia. Cinacalcet was mixed into the rodent diet (1 mg/g) and orally administrated to 80 weeks-old PC2 mice for 10 days before sacrifice. Compared to untreated PC2 mice, cinacalcet significantly suppressed both serum calcium and PTH. The ratio of BrdU positive cells was significantly increased in untreated PC2 mice compared to wild type mice, and was significantly suppressed by cinacalcet. These data suggest that cinacalcet suppressed both serum PTH level and parathyroid cell proliferation in vivo in this model of primary hyperparathyroidism, and may in part suppress primary hyperparathyroidism by suppressing parathyroid cell proliferation.
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Report
(4 results)
Research Products
(47 results)
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[Journal Article] The levels of somatostatin receptors in causative tumors of oncogenic osteomalacia are insufficient for their agonist to normalize serum phosphate levels2010
Author(s)
Ishii A, Imanishi Y, Kobayashi K, Hashimoto J, Ueda T, Miyauchi A, Koyano HM, Kaji H, Saito T, Oba K, Komatsu Y, Kurajoh M, Nagata Y, Goto H, Wakasa K, Sugimoto T, Miki T, Inaba M, Nishizawa Y
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Journal Title
Calcif Tissue Int 86
Pages: 455-462
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[Journal Article] Osteosarcoma in a pregnant patient with McCune-Albright syndrome2009
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Kanazawa I, Yamauchi M, Yano S, Imanishi Y, Kitazawa R, Nariai Y, Araki A, Kobayashi K, Inaba M, Maruyama R, Yamaguchi T, Sugimoto T
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Journal Title
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[Journal Article] Severe hypophosphatemic osteomalacia with fanconi syndrome, renal tubular acidosis, vitamin D deficiency and primary biliary cirrhosis2009
Author(s)
Bando H, Hashimoto N, Hirota Y, Sakaguchi K, Hisa I, Inoue Y, Imanishi Y, Seino S, Kaji H
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Journal Title
Intern Med 48
Pages: 353-358
NAID
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Peer Reviewed
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[Journal Article]2009
Author(s)
今西康雄
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Journal Title
【病気と薬パーフェクトBOOK 2009】16骨・関節疾患 くる病・骨軟化症(南山堂)
Pages: 1558-1561
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[Journal Article] Serum Levels of TRAP5b, a New Bone Resorption Marker Unaffected by Renal Dysfunction, as a Useful Marker of Cortical Bone Loss in Hemodialysis Patients2008
Author(s)
Shidara K, Inaba M, Okuno S, Yamada S, Kumeda Y, Imanishi Y, Yamakawa T, Ishimura E, Nishizawa Y
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Journal Title
Calcif Tissue Int 82
Pages: 278-287
Related Report
Peer Reviewed
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