Therapeutic target for aging osteoporosis～New anti-osteoporosis drug with stimulating bone formation～
| Project/Area Number |
20591105
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
OKADA Youske University of Occupational and Environmental Health, Japan, 医学部, 講師 (80333243)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Yoshiya 産業医科大学, 医学部, 教授 (30248562)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 内分泌学 / 骨折 / 2型糖尿病 / ホモシステイン / ピオグリタゾン / メトホルミン / 骨吸収マーカー / 糖尿病 / 閉経後骨粗鬆症 / 骨質 / 選択的エストロゲン受容体モジュレーター / ガレクチン9 / 骨芽細胞 / lipid raft / CD44 / 骨粗鬆症 |
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| Research Abstract |
Galectin-9 is a ・-galactoside-binding lectin expressed in various tissues, including bone. The role of galectin-9 in human osteoblasts, however, remains unclear. We showed that galectin-9 interacts with lipid rafts and induces osteoblast proliferation through the c-Src/ERK signaling pathway.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Human mesenchymal stem cells inhibit osteoclastogenesis through osteoprotegerin production.
Author(s)
Oshita K, Yamaoka K, Udagawa N, Fukuyo S, Sonomoto K, Maeshima K, Kurihara R, Nakano K, Saito K, Okada Y, Chiba K, Tanaka Y
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Journal Title
Arthritis Rheum (in press)
Related Report
Peer Reviewed
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