| Project/Area Number |
20591105
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Endocrinology
|
|---|
| Research Institution | University of Occupational and Environmental Health, Japan |
|---|
Principal Investigator |
OKADA Youske University of Occupational and Environmental Health, Japan, 医学部, 講師 (80333243)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TANAKA Yoshiya 産業医科大学, 医学部, 教授 (30248562)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | 内分泌学 / 骨折 / 2型糖尿病 / ホモシステイン / ピオグリタゾン / メトホルミン / 骨吸収マーカー / 糖尿病 / 閉経後骨粗鬆症 / 骨質 / 選択的エストロゲン受容体モジュレーター / ガレクチン9 / 骨芽細胞 / lipid raft / CD44 / 骨粗鬆症 |
|---|
| Research Abstract |
Galectin-9 is a ・-galactoside-binding lectin expressed in various tissues, including bone. The role of galectin-9 in human osteoblasts, however, remains unclear. We showed that galectin-9 interacts with lipid rafts and induces osteoblast proliferation through the c-Src/ERK signaling pathway.
|
