| Project/Area Number |
20591107
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Endocrinology
|
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
HINO Jun National Cardiovascular Center Research Institute, 生化学部, 室長 (40260351)
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| Co-Investigator(Kenkyū-buntansha) |
MIYAZATO Mikiya 独立行政法人立循環器病研究センター, 生化学部, 部長 (50291183)
ARAI Yuji 独立行政法人立循環器病研究センター, 分子生物学部, 室長 (30202724)
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| Co-Investigator(Renkei-kenkyūsha) |
KANGAWA Kenji 独立行政法人国立循環器病研究センター, 研究所長 (00112417)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | BMP-3b / アディポサイトカイン / 肥満 / 脂肪細胞 / TGF-β / 分化因子 / 分子型 / 複合体 / TGF-b / 分化 / 内分泌 / 前駆体 |
|---|
| Research Abstract |
We originally isolated BMP-3b,which inhibited osteogenesis, from bone tissue. BMP-3b is strongly expressed not only in the bone but also in adipose tissue. However, the function of BMP-3b in adipose tissue is still unknown. Recent studies show that adipocytokine, which exists in adipose tissue, is involved in metabolic syndrome or its related diseases. We performed functional analysis of BMP-3b in adipose tissue, which demonstrated that BMP-3b acts as a novel adipocytokine that inhibits adipogenesis and its secreted molecular form is a unique complex.
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