The role of megakaryocytic lineage cells in leukemia/lymphoma cell proliferation
Project/Area Number |
20591113
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Hematology
|
Research Institution | The University of Tokyo |
Principal Investigator |
HATTORI Koichi The University of Tokyo, 医科学研究所, 特任准教授 (10360116)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 癌 / 酵素 / 細胞・組織 / 生体分子 / 凝固・線溶 / 血液線維素溶解系 / マトリックスメタロプロテイナーゼ / プロテアーゼ阻害剤 / プラスミノーゲン / Kit-ligand / 血管新生因子 / 骨髄由来細胞 / 血小板 / プラスミン / 血管新生 / tPA / 虚血性壊死 / 血液線経素溶解系 / ケモカイン / 血管内皮増殖因子 |
Research Abstract |
The main fibrinolytic enzyme, plasmin, can activate matrix metalloproteinases (MMPs) which has been linked to various malignancies. Here we provide the evidence that blockade of Plg reduces leukemia-lymphoma growth by inhibiting MMP activity. The data presented in this study demonstrate a previously undescribed role of plasmin in lymphoproliferative disorders and provide strong evidence that specific blockade of Plg represents a promising approach for the regulation of leukemia-lymphoma growth.
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Report
(4 results)
Research Products
(89 results)
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[Journal Article] Tissue type plasminogen activator regulates myeloid-cell2010
Author(s)
Ohki M, Ohki Y, Ishihara M, Rosenkvist J, Gritli I, Tashiro Y, Akiyama H, Komiyama H, Lund LR, Nitta A, Yamada K, Zhu Z, Ogawa H, Yagita H, Okumura K, Nakauchi H, Werb Z, Heissig B, Hattori K
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Journal Title
dependent neoangiogenesis during tissue regeneration Blood 115
Pages: 4302-4312
Related Report
Peer Reviewed
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