| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
The main fibrinolytic enzyme, plasmin, can activate matrix metalloproteinases (MMPs) which has been linked to various malignancies. Here we provide the evidence that blockade of Plg reduces leukemia-lymphoma growth by inhibiting MMP activity. The data presented in this study demonstrate a previously undescribed role of plasmin in lymphoproliferative disorders and provide strong evidence that specific blockade of Plg represents a promising approach for the regulation of leukemia-lymphoma growth.
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