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Development of phosphor sugar derivatives for hematological malignancy therapy

Research Project

Project/Area Number 20591115
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hematology
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

NAKAMURA Satoki  Hamamatsu University School of Medicine, 医学部附属病院, 助教 (20377740)

Co-Investigator(Kenkyū-buntansha) ONO Takaaki  浜松医科大学, がん教育センター, 助教 (40402276)
FUJIE Michio  浜松医科大学, 実験実習機器センター, 技術専門職員 (90397373)
OHNISHI Kazunori  浜松医科大学, 医学部付属病院, 教授 (80252170)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords癌 / シグナル伝達 / 糖化合物 / 薬理学 / 蛋白質
Research Abstract

We investigated the synthesis, identification of target molecules, and characterization of molecular targeted drugs as a new class of potential panti-proliterative materials for leukemia cells and other cancer cells. We will perform the development of cancer-specific drugs for cancer therapy.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (47 results)

All 2010 2009 2008 2007 Other

All Journal Article (25 results) (of which Peer Reviewed: 25 results) Presentation (19 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] The FOXM1 transcriptional factor promotes the proliferation of leukemia cells through modulation of cell cycle progression in acute myeloid leukemia.2010

    • Author(s)
      Nakamura S, Hirano I, Okinaka K, Takemura T, Yokota D, Ono T, Shigeno K, Shibata K, Fujisawa S, Ohnishi K.
    • Journal Title

      Carcinogenesis. 31

      Pages: 2012-2021

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Research and development of phospha sugar anti-cancer agents with anti-leukemic activity.2010

    • Author(s)
      Yamashita J, Suyama T, Asai K, Yamada M, Niimi T, Fujie M, Nakamura S, Ohnishi K, Yamashita M.
    • Journal Title

      Heterocyclic communications. 2

      Pages: 89-98

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of some 1-aryl-2, 3-dibromophospholanes as novel anti-cancer agents.2010

    • Author(s)
      Yamada M, Asai K, Yamashita J, Suyama T, Niimi T, Maddali K, Fujie M, Nakamura S, Kimura M, Tanaka Y, Toda M, Yamashita M.
    • Journal Title

      Heterocyclic communications. 2

      Pages: 165-171

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel phospha sugar analogue : synthesis and evaluation of 2, 3-dibromo-3-methyl-1-phenylphospholane 1-oxide as a new class of potential panti-proliterative materials for leukemia cells.2010

    • Author(s)
      Fujie M, Nakamura S, Asai K, Niimi T, Yamashita J, Kiyofuji K, Shibata K, Suzuki M, Aoshima R, Urano T, Yamashita M.
    • Journal Title

      Heterocyclic Communications. 30

      Pages: 945-950

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preparation and characterization of novel 4-bromo-3, 4-dimethyl-1-phenyl-2-phospholene 1-oxide and the analogous phosphorus heterocycles or phospha sugars.2010

    • Author(s)
      Yamada M, Yamashita M, Suyama T, Yamashita J, Asai K, Niimi T, Ozaki N, Fujie M, Maddali K, Nakamura S, Ohnishi K.
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters. 20(19)

      Pages: 5943-5946

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development and pharmacologic characterization of deoxybromophospha sugar derivatives with antileukemic activity.2010

    • Author(s)
      Nakamura S, Yamashita M, Yokota D, Hirano I, Ono T, Fujie M, Shibata K, Niimi T, Suyama T, Maddali K, Asai K, Yamashita J, Iguchi Y, Ohnishi K.
    • Journal Title

      Investigational New Drugs 28(4)

      Pages: 381-391

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development and pharmacologic characterization of deoxybromophospha sugar derivatives with antileukemic actity.2010

    • Author(s)
      Nakamura Satoki
    • Journal Title

      Investigational New Drugs

      Volume: 28 Pages: 381-391

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preparation and Characterization of novel 4-bromo-3, 4-dimethyl-1-phenyl-2-phospholene 1-oxide and the analogous phosphorus heter ocycles or phospha sugars.2010

    • Author(s)
      Yamada Manabu, Nakamura Satoki
    • Journal Title

      Bioorg Med Chem Lett

      Volume: 20 Pages: 5943-5946

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The FOXM1 transcriptional factor promotes the proliferation of leukemia cells through mmodulation of cell cycle progressi on in acute myeloid leukemia.2010

    • Author(s)
      Nakamura Satoki
    • Journal Title

      Carcinogenesis

      Volume: 31 Pages: 2012-2021

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Research and development of phospha sugar anti-cancer agents with anti-leukemic activity.2010

    • Author(s)
      Yamashita Junko Nakamura Satoki
    • Journal Title

      Heterocyclic communications

      Volume: 2 Pages: 89-98

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of some 1-aryl-2, 3-dibromophospholanes as novel anti-cancer agents.2010

    • Author(s)
      Yamada Manabu Nakamura Satoki
    • Journal Title

      Heterocyclic communications

      Volume: 2 Pages: 165-171

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel phospha sugar analogue : synthesis and evaluation of 2, 3-dibromo- 3-methyl-1-phenylphospholane 1-oxide as a new class of potential panti-proliterative materials for leukemia cells.2010

    • Author(s)
      Fujie Micio Nakamura Satoki
    • Journal Title

      Heterocyclic communications

      Volume: 30 Pages: 945-950

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduction of raf kinase inhibitor protein expression by BCR-ABL contributes to chronic myelogenous leukemia proliferation2010

    • Author(s)
      Takemura Tomonari Nakamura Satoki
    • Journal Title

      Journal of Biological Chemistory (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel phospha sugar analogue : synthesis and evaluation of 2, 3-dibromo-3-methyl-1-phenylphospholane 1-oxide having potential anti-proliferative effects for human tumors.2009

    • Author(s)
      Fujie M, Nakamura S, Asai H, Yamashita J, Kiyofuji K, Yamashita M.
    • Journal Title

      Journal of Environmental Biology 30(6)

      Pages: 945-950

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preparation and Characterization of Phospholenes and Phospha Sugars as Novel Anti-cancer Agents.2009

    • Author(s)
      Ito S, Yamashita M, Niimi T, Fujie M, Valluru KR, Totsuka H, Buchammagari H, Maddali KR, Nakamura S, Asai K, Suyama T, Yamashita J, Iguchi Y, Gang Y, Oshikawa T.
    • Journal Title

      Heterocyclic Communications. 15

      Pages: 23-30

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fbw7 promotes ubiquitin-dependent degradation of c-Myb-involvement of GSK3-mediated phosphorylation of Thr-572 in mouse c-Myb2009

    • Author(s)
      Kitagawa Kyoko, Nakamura satoki
    • Journal Title

      Oncogene 28巻25号

      Pages: 2393-2405

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Depletion of pleckstrin homology domain leucine-rich repeat protein phosphatase 1 and 2 by Bcr-Abl promotes chronic myelogenous leukemia cell proliferation through continuous phosphorylation of Akt isoforms2009

    • Author(s)
      Hirano Isao, Nakamura Satoki
    • Journal Title

      Journal of Biological Chemistory 284巻33号

      Pages: 22155-22165

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preparation and Characterization of Phospholenes and Phospha Sugars as Novel Anti-cancer Agents2009

    • Author(s)
      Ito Satoru, Nakamura Satoki
    • Journal Title

      Heterocyclic Communications 15巻

      Pages: 23-30

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel phospha sugar analogue : synthesis and evaluation of 2,3-dibromo- 3-methyl-1-phenylphospholane 1-oxide having potential anti-proliferative effects for human tumors2009

    • Author(s)
      Fujie Michio, Nakamura Satoki
    • Journal Title

      Journal of Environmental Biology 30巻6号

      Pages: 945-950

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Electrospray ionization tandem mass spectrometric determination of monomethylarsonic acid and dimethylarsinic acid after adduct formation with citric acid2009

    • Author(s)
      Minakata Kiyoko, Nakamura Satoki
    • Journal Title

      J Chromatogr B Analyt Technol Biomed Life Sci 877巻25号

      Pages: 2624-2629

    • NAID

      10028022512

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CMC-544 (inotuzumab ozogamicin) shows less effect on multidrug resistant cells : analyses in cell lines and cells from patients with B-cell chronic lymphocytic leukaemia and lymphoma2009

    • Author(s)
      Takeshita Akihiro, Nakamura Satoki
    • Journal Title

      Br J Haematol 146巻1号

      Pages: 34-43

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development and pharmacologic characterization of deoxybromophospha sugar derivatives with antileukemic actity2009

    • Author(s)
      Nakamura Satoki
    • Journal Title

      Investigational New Drugs (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development and pharmacologic characterization of deoxybromophospha sugar derivatives with antileukemic activity.2009

    • Author(s)
      Nakamura Satoki
    • Journal Title

      Investigational New Drugs (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Depletion of pleckstrin homology domain leucine-rich repeat protein phos phatase 1 and 2 by Bcr-Abl promotes chronic myelogenous leukemia cell proliferation through continuous phosphorylation of Akt isoforms.2009

    • Author(s)
      Hirano Isao
    • Journal Title

      Journal of Biological Chemistory (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] KIS induces proliferation and the cell cycle progression through the phosphorylation of p27Kip1 in leukemia cells.2008

    • Author(s)
      Nakamura Satoki
    • Journal Title

      Leukemia Research 32

      Pages: 1358-1365

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Identification of target molecules and anti-leukemic effects of novel phospha sugar derivative, TMPP.2010

    • Author(s)
      中村悟己
    • Organizer
      101^<th> annual meeting of American Association for Cancer Research.
    • Place of Presentation
      Washington DC, USA.
    • Year and Date
      2010-04-19
    • Related Report
      2010 Final Research Report
  • [Presentation] Identification of target molecules and anti-leukemic effects of novel phospha sugar derivative, TMPP.2010

    • Author(s)
      Nakamura Satoki
    • Organizer
      101^<th> annual meeting of American Association for Cancer Research
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2010-04-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Bcr-Ablを介した脱リン酸化酵素PHLPP1, 2の発現抑制は Akt isoforms の持続的な活性化によるCML細胞増殖を促進させる2009

    • Author(s)
      平野功, 中村悟己
    • Organizer
      第32回 日本分子生物学会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Year and Date
      2009-12-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] CML細胞におけるBcr-AblによるTHAP11発現抑制を介した細胞増殖促進効果の検討2009

    • Author(s)
      横田大輔, 中村悟己
    • Organizer
      第32回 日本分子生物学会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Year and Date
      2009-12-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] CML細胞増殖におけるBcr-AblのRKIP発現抑制を介したRaf-1経路の活性化2009

    • Author(s)
      竹村兼成, 中村悟己
    • Organizer
      第32回 日本分子生物学会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Year and Date
      2009-12-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] Downregulation of THAP11 by Bcr-Abl promotes c-Myc-mediated CML cell Droliferation2009

    • Author(s)
      横田大輔, 中村悟己
    • Organizer
      American Society of Hematology 51^<th> annual meeting
    • Place of Presentation
      New Orleans, LA, USA
    • Year and Date
      2009-12-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] Depletion of PHLPP1 and 2 by Bcr-Abl promotes CML cell proliferation through the continuous phosphorylation of Akt2009

    • Author(s)
      平野功, 中村悟己
    • Organizer
      American Society of Hematology 51^<th> annual meeting
    • Place of Presentation
      New Orleans, LA, USA
    • Year and Date
      2009-12-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] Bcr-Ablを介した脱リン酸化酵素PHLPP1, 2の発現抑制は Akt isoforms の持続的な活性化によるCML細胞増殖を促進させる2009

    • Author(s)
      平野功, 中村悟己
    • Organizer
      第71回 日本血液学会総会
    • Place of Presentation
      国立京都国際会館、京都
    • Year and Date
      2009-10-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] CML細胞におけるBcr-AblによるTHAP11発現抑制を介した細胞増殖促進効果の検討2009

    • Author(s)
      横田大輔, 中村悟己
    • Organizer
      第71回 日本血液学会総会
    • Place of Presentation
      国立京都国際会館、京都
    • Year and Date
      2009-10-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] CML細胞増殖におけるBcr-AblのRKIP発現抑制を介したRaf-1経路の活性化2009

    • Author(s)
      竹村兼成, 中村悟己
    • Organizer
      第71回 日本血液学会総会
    • Place of Presentation
      国立京都国際会館、京都
    • Year and Date
      2009-10-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新規合成リン糖誘導体TMPPの標的分子同定と抗白血病効果の機序の解明2009

    • Author(s)
      中村悟己
    • Organizer
      第71回日本血液学会総会
    • Place of Presentation
      国立京都国際会館、京都
    • Year and Date
      2009-10-23
    • Related Report
      2010 Final Research Report
  • [Presentation] 新規合成リン糖誘導体TMPPの標的分子同定と抗白血病効果の機序の解明2009

    • Author(s)
      中村悟己
    • Organizer
      第71回 日本血液学会総会
    • Place of Presentation
      国立京都国際会館、京都
    • Year and Date
      2009-10-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] Bcr-Ablを介した脱リン酸化酵素PHLPP 1, 2の発現抑制は Akt isoforms の持続的な活性化によるCML細胞増殖を促進させる2009

    • Author(s)
      中村悟己
    • Organizer
      第68回 日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Year and Date
      2009-10-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] Development and pharmacologic characterization of deoxybromophospha sugar derivatives with anti-leukemic effects : Inhibition of cell cycle progression through FoxM1 regulation.2009

    • Author(s)
      中村悟己
    • Organizer
      100^<th> annual meeting of American Association for Cancer Research
    • Place of Presentation
      Denver, Colorado, USA.
    • Year and Date
      2009-04-20
    • Related Report
      2010 Final Research Report
  • [Presentation] Development and pharmacologic characterization of deoxybromophospha sugar derivatives with anti-leukemic effects : Inhibition of cell cycle progression through FoxM1 regulation2009

    • Author(s)
      中村悟己
    • Organizer
      American Association for Cancer Research 100^<th> annual meeting
    • Place of Presentation
      Denver, Colorado, USA
    • Year and Date
      2009-04-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] 癌(がん)の早期発見・早期治療のための医用材料のイノベーション2009

    • Author(s)
      山下光司
    • Organizer
      イノベーションジャパン2009
    • Place of Presentation
      東京国際会議場、東京
    • Related Report
      2010 Final Research Report
  • [Presentation] 癌 (がん) の早期発見・早期治療のための医用材料のイノベーション2009

    • Author(s)
      山下光司, 中村悟己
    • Organizer
      イノベーションジャパン2009
    • Place of Presentation
      東京国際会議場、東京
    • Related Report
      2009 Annual Research Report
  • [Presentation] Development and characterization of phospha sugar derivatives, TMPP and DMPP, with anti-leukemic effects.2008

    • Author(s)
      Nakamura Satoki
    • Organizer
      American Society of Hematology 50^<th> annual meeting
    • Place of Presentation
      San Francisco USA
    • Year and Date
      2008-12-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] 白血病細胞増殖抑制効果をもつリン糖誘導体の開発とその作用機序について2008

    • Author(s)
      中村悟己
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場名古屋
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 含リン化合物及び抗腫瘍剤2008

    • Inventor(s)
      中村悟己
    • Industrial Property Rights Holder
      浜松医科人学
    • Industrial Property Number
      2007-035083
    • Filing Date
      2008-09-16
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 含リン化合物及び抗腫瘍剤2007

    • Inventor(s)
      山下光司、中村悟己、藤江三千男
    • Industrial Property Rights Holder
      国立大学法人静岡大学
    • Industrial Property Number
      2007-035083
    • Filing Date
      2007-02-15
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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