Development of phosphor sugar derivatives for hematological malignancy therapy
| Project/Area Number |
20591115
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
NAKAMURA Satoki Hamamatsu University School of Medicine, 医学部附属病院, 助教 (20377740)
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| Co-Investigator(Kenkyū-buntansha) |
ONO Takaaki 浜松医科大学, がん教育センター, 助教 (40402276)
FUJIE Michio 浜松医科大学, 実験実習機器センター, 技術専門職員 (90397373)
OHNISHI Kazunori 浜松医科大学, 医学部付属病院, 教授 (80252170)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 癌 / シグナル伝達 / 糖化合物 / 薬理学 / 蛋白質 |
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| Research Abstract |
We investigated the synthesis, identification of target molecules, and characterization of molecular targeted drugs as a new class of potential panti-proliterative materials for leukemia cells and other cancer cells. We will perform the development of cancer-specific drugs for cancer therapy.
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Report
(4 results)
Research Products
(47 results)
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[Journal Article] Synthesis of some 1-aryl-2, 3-dibromophospholanes as novel anti-cancer agents.2010
Author(s)
Yamada M, Asai K, Yamashita J, Suyama T, Niimi T, Maddali K, Fujie M, Nakamura S, Kimura M, Tanaka Y, Toda M, Yamashita M.
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Journal Title
Heterocyclic communications. 2
Pages: 165-171
Related Report
Peer Reviewed
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[Journal Article] A novel phospha sugar analogue : synthesis and evaluation of 2, 3-dibromo-3-methyl-1-phenylphospholane 1-oxide as a new class of potential panti-proliterative materials for leukemia cells.2010
Author(s)
Fujie M, Nakamura S, Asai K, Niimi T, Yamashita J, Kiyofuji K, Shibata K, Suzuki M, Aoshima R, Urano T, Yamashita M.
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Journal Title
Heterocyclic Communications. 30
Pages: 945-950
Related Report
Peer Reviewed
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[Journal Article] Preparation and characterization of novel 4-bromo-3, 4-dimethyl-1-phenyl-2-phospholene 1-oxide and the analogous phosphorus heterocycles or phospha sugars.2010
Author(s)
Yamada M, Yamashita M, Suyama T, Yamashita J, Asai K, Niimi T, Ozaki N, Fujie M, Maddali K, Nakamura S, Ohnishi K.
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Journal Title
Bioorganic & Medicinal Chemistry Letters. 20(19)
Pages: 5943-5946
Related Report
Peer Reviewed
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[Journal Article] Development and pharmacologic characterization of deoxybromophospha sugar derivatives with antileukemic activity.2010
Author(s)
Nakamura S, Yamashita M, Yokota D, Hirano I, Ono T, Fujie M, Shibata K, Niimi T, Suyama T, Maddali K, Asai K, Yamashita J, Iguchi Y, Ohnishi K.
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Journal Title
Investigational New Drugs 28(4)
Pages: 381-391
Related Report
Peer Reviewed
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[Journal Article] Preparation and Characterization of Phospholenes and Phospha Sugars as Novel Anti-cancer Agents.2009
Author(s)
Ito S, Yamashita M, Niimi T, Fujie M, Valluru KR, Totsuka H, Buchammagari H, Maddali KR, Nakamura S, Asai K, Suyama T, Yamashita J, Iguchi Y, Gang Y, Oshikawa T.
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Journal Title
Heterocyclic Communications. 15
Pages: 23-30
Related Report
Peer Reviewed
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