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Analyses of the mechanisms of resistance to monoclonal antibody therapy and exploration of overcoming strategies.

Research Project

Project/Area Number 20591116
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hematology
Research InstitutionNagoya University

Principal Investigator

TOMITA Akihiro  Nagoya University, 医学部附属病院, 講師 (80378215)

Co-Investigator(Renkei-kenkyūsha) KIYOI Hitoshi  名古屋大学, 医学部附属病院, 講師 (90314004)
AOKI Ichio  独立行政法人放射線医学研究所, 分子イメージング研究センター, チームリーダー (10319519)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsCD20 / リツキシマブ / 抗体療法 / 分子標的治療 / エピジェネティクス / 薬剤耐性 / 分子イメージング
Research Abstract

We focused on the phenomenon CD20-negative phenotypic change after performing chemotherapies with rituximab in CD20-positive B-cell lymphoma cells, and the molecular mechanisms of CD20-negative change were analyzed. It appears that aberrant down-regulation of MS4A1 gene expression is closely related to CD20-negative phenotype, and the repression may be introduced by recruitment of Sin3-HDAC1 protein complex to MS4A1 promoter region. CD20-negative phenotype is related to resistance to rituximab therapy. Down-regulated CD20 expression can be partially stimulated by epigenetic drugs resulting in partial restoration of rituximab sensitivity.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (79 results)

All 2010 2009 2008

All Journal Article (24 results) (of which Peer Reviewed: 8 results) Presentation (52 results) Book (2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] B細胞リンパ腫におけるリツキシマブ体制化機序:これまでの研究成果と今後の課題2010

    • Author(s)
      富田章裕、平賀潤二、島田和之、杉本匠、徳永隆之、直江知樹、木下朝博.
    • Journal Title

      血液・腫瘍科 61(1)

      Pages: 35-44

    • Related Report
      2010 Final Research Report
  • [Journal Article] ヒストン脱アセチル化酵素(HDAC)阻害剤(SAHA)によるリンパ腫治療と開発状況.2010

    • Author(s)
      富田章裕.
    • Journal Title

      血液フロンティア別冊. 20(S-1)

      Pages: 157-165

    • Related Report
      2010 Final Research Report
  • [Journal Article] 悪性リンパ腫における抗CD20抗体の薬剤耐性機序2010

    • Author(s)
      富田章裕、島田和之、平賀潤二、杉本匠、直江知樹、木下朝博.
    • Journal Title

      血液フロンティア. 20(1)

      Pages: 61-69

    • Related Report
      2010 Final Research Report
  • [Journal Article] リツキシマブの耐性化機序: epigenetic mechanismによるCD20陰性化.2010

    • Author(s)
      富田章裕、平賀潤二、杉本匠、島田和之、木下朝博、直江知樹
    • Journal Title

      血液・腫瘍科 60(1)

      Pages: 23-29

    • Related Report
      2010 Final Research Report
  • [Journal Article] B細胞リンパ腫におけるリツキシマブ体制化機序:これまでの研究成果と今後の課題2010

    • Author(s)
      富田章裕、平賀潤二、島田和之、杉本匠、徳永隆之、直江知樹、木下朝博
    • Journal Title

      血液・腫瘍科

      Volume: 61(1) Pages: 35-44

    • Related Report
      2010 Annual Research Report
  • [Journal Article] ヒストン脱アセチル化酵素(HDAC)阻害剤(SAHA)によるリンパ腫治療と開発状況2010

    • Author(s)
      富田章裕
    • Journal Title

      血液フロンティア

      Volume: 20(S-1) Pages: 157-165

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 悪性リンパ腫における抗CD20抗体の薬剤耐性機序.2010

    • Author(s)
      富田章裕、島田和之、平賀潤二、杉本匠、直江知樹、木下朝博.
    • Journal Title

      血液フロンティア 20

      Pages: 61-69

    • Related Report
      2009 Annual Research Report
  • [Journal Article] リツキシマブの耐性化機序 : epigenetic mechanismによるCD20陰性化2010

    • Author(s)
      富田章裕、平賀潤二、杉本匠、島田和之、木下朝博、直江知樹
    • Journal Title

      血液・腫瘍科 60

      Pages: 23-29

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Escape mechanisms from antibody therapy to lymphoma cells : Downregulation of CD20 mRNA by recruitment of the HDAC complex and not by DNA methylation.2009

    • Author(s)
      Sugimoto T, Tomita A, Hiraga J, Shimada K, Kiyoi H, Kinoshita T, Naoe T
    • Journal Title

      Biochem Biophys Res Commun. 390(1)

      Pages: 48-53

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Down-regulation of CD20 expression in B-cell lymphoma cells after treatment with rituximab-containing combination chemotherapies: its prevalence and clinical significance.2009

    • Author(s)
      Hiraga J, Tomita A, Sugimoto T, Shimada K, Ito M, Nakamura S, Kiyoi H, Kinoshita T, Naoe T
    • Journal Title

      Blood 113(20)

      Pages: 4885-4893

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Down-regulation of CD20 expression in B-cell lymphoma cells after treatment with rituximab-containing combination chemotherapies : its prevalence and clinical significance.2009

    • Author(s)
      Hiraga J, Tomita A, Sugimoto T, Shimada K, Ito M, Nakamura S, Kiyoi H, Kinoshita T, Naoe T.
    • Journal Title

      Blood 113

      Pages: 4885-93

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Escape mechanisms from antibody therapy to lymphoma cells : Downregulation of CD20 mRNA by recruitment of the HDAC complex and not by DNA methylation.2009

    • Author(s)
      Sugimoto T, Tomita A, Hiraga J, Shimada K, Kiyoi H, Kinoshita T, Naoe T.
    • Journal Title

      Biochem Biophys Res Commun. 390

      Pages: 48-53

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Down-regulation of CD20 expression in B-cell lymphoma cells after treatment with rituximab-containing combination chemotherapies : its prevalence and clinical significance.2009

    • Author(s)
      Hiraga J, Tomita A, Sugimoto T, Shimada K, Ito M, Nakamura S, Kiyoi H, Kinoshita T, Naoe T
    • Journal Title

      Blood (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Abnormal cytoplasmic dyslocalisation and/or reduction of nucleophosmin protein level rarely occurs in myelodysplastic syndromes2008

    • Author(s)
      Ishikawa Y, Xu J, Sakashita G, Urano T, Suzuki T, Tomita A, Kiyoi H, Nakamura S, Naoe T
    • Journal Title

      Leuk Lymphoma. 49(12)

      Pages: 2359-2364

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical significance of nuclear non-phosphorylated beta-catenin in acute myeloid leukaemia and myelodysplastic syndrome.2008

    • Author(s)
      Xu J, Suzuki M, Niwa Y, Hiraga J, Nagasaka T, Ito M, Nakamura S, Tomita A, Abe A, Kiyoi H, Kinoshita T, Naoe T
    • Journal Title

      Br J Haematol. 140(4)

      Pages: 394-401

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 抗体治療の薬剤耐性に関わるエピジェネティック機構.2008

    • Author(s)
      富田章裕、平賀潤二、木下朝博、直江知樹
    • Journal Title

      血液フロンティア. 18(11)

      Pages: 1741-1748

    • Related Report
      2010 Final Research Report
  • [Journal Article] 血液疾患の遺伝学(総説)2008

    • Author(s)
      富田章裕、直江知樹.
    • Journal Title

      最新医学 63(9)

      Pages: 1802-1813

    • Related Report
      2010 Final Research Report
  • [Journal Article] B細胞リンパ腫におけるrituximab耐性化の機序とその克服2008

    • Author(s)
      富田章裕、平賀潤二、木下朝博、直江知樹.
    • Journal Title

      内科 102(2)

      Pages: 345-350

    • Related Report
      2010 Final Research Report
  • [Journal Article] リツキシマブ使用後のCD20陰性化.2008

    • Author(s)
      富田章裕、平賀潤二、木下朝博、直江知樹.
    • Journal Title

      血液・腫瘍科 56(40

      Pages: 466-471

    • Related Report
      2010 Final Research Report
  • [Journal Article] Abnormal cytoplasmic dyslocalisation and/or reduction of nucleophosm in protein level rarely occurs in myelodysplastic syndromes.2008

    • Author(s)
      Ishikawa Y, Xu J, Sakashita G, Urano T, Suzuki T, Tomita A, Kiyoi H, Nakamura S, Naoe T
    • Journal Title

      Leuk Lymphoma. 49

      Pages: 2359-64

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 抗体治療の薬剤耐性に関わるエピジェネティック機構2008

    • Author(s)
      富田章裕, 平賀潤二, 木下朝博, 直江知樹
    • Journal Title

      血液フロンティア 18

      Pages: 1741-1748

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 血液疾患の遺伝学(総説)2008

    • Author(s)
      富田章裕, 直江知樹
    • Journal Title

      最新医学 63

      Pages: 1802-1813

    • Related Report
      2008 Annual Research Report
  • [Journal Article] B細胞リンパ腫におけるrituximab耐性化の機序とその克服2008

    • Author(s)
      富田章裕, 平賀潤二, 木下朝博, 直江知樹
    • Journal Title

      内科 102

      Pages: 345-350

    • Related Report
      2008 Annual Research Report
  • [Journal Article] リツキシマブ使用後のCD20陰性化2008

    • Author(s)
      富田章裕, 平賀潤二, 木下朝博, 直江知樹
    • Journal Title

      血液・腫瘍科 56

      Pages: 466-471

    • Related Report
      2008 Annual Research Report
  • [Presentation] CD20-Negative Phenotypic Change In B-Cell Lymphoma Cells After Using Rituximab: Possibility of a Particular Clinicopathologic Phenomenon Post- Rituximab Extranodal CD20-Negative Lymphoma2010

    • Author(s)
      冨田章裕, 徳永隆之, 入山智沙子, 島田和之, 平賀潤二, 杉本匠, 清井仁, 中村栄男, 木下朝博士, 直江知樹
    • Organizer
      The American Society of Hematology, 52th Annual Meeting
    • Place of Presentation
      Orlando, FL, USA
    • Year and Date
      2010-12-05
    • Related Report
      2010 Final Research Report
  • [Presentation] CD20-Negative Phenotypic Change In B-Cell Lymphoma Cells After Using Rituximab : Possibility of a Particular Clinicopathologic Phenomenon Post- Rituximab Extranodal CD20-Negative Lymphoma. (Poster)2010

    • Author(s)
      Akihiro Tomita, Takashi Tokunaga, Chisako Iriyama Kazuyuki Shimada, Junji Hiraga, Takumi Sugimoto, Hitoshi Kiyoi, Shigeo Nakamura, Tomohiro Kinoshita, Tomoki Naoe.
    • Organizer
      The American Society of Hematology, 52th Annual Meeting
    • Place of Presentation
      Orlando, FL, USA
    • Year and Date
      2010-12-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] A Clinical pharmacology and Exploratory study of azacitidine administered by subcutaneously or intravenously in Japanese patients with myelodysplastic syndromes.2010

    • Author(s)
      Yukio Kobayashi, Alcihiro Tomita, 他14名、12番目
    • Organizer
      The American Society of Hematology, 52th Annual Meeting
    • Place of Presentation
      Orlando, FL, USA
    • Year and Date
      2010-12-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] 亜ヒ酸耐性耐性に重要なPML-RARAのミスセンス変異2010

    • Author(s)
      後藤絵美、冨田章裕、早川文彦、渥美晃秀、清井仁、直江知樹
    • Organizer
      第70回日本血液学会総会、(口演)
    • Place of Presentation
      横浜
    • Year and Date
      2010-09-26
    • Related Report
      2010 Final Research Report
  • [Presentation] パイロシークエンス法を用いた骨髄、末梢血、血清血漿遊離DNAにおけるTET2遺伝子変異の解析2010

    • Author(s)
      入山智沙子、冨田章裕、星野秀明、清井仁、日比陽子、千崎康司、山田清文、真田昌、小川誠司、直江知樹
    • Organizer
      第70回日本血液学会総会、(口演)
    • Place of Presentation
      横浜
    • Year and Date
      2010-09-26
    • Related Report
      2010 Final Research Report
  • [Presentation] 亜ヒ酸耐性耐性に重要なPML-RARAのミスセンス変異(口演)2010

    • Author(s)
      後藤絵美、冨田章裕、早川文彦、渥美晃秀、清井仁、直江知樹
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2010-09-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] パイロシークエンス法を用いた骨髄、末梢血、血清血漿遊離DNAにおけるTET2遺伝子変異の解析(口演)2010

    • Author(s)
      入山智沙子、冨田章裕、星野秀明、清井仁、日比陽子、千崎康司、山田清文、真田昌、小川誠司、直江知樹
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2010-09-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Retrospective analysis of iron overload in patients with transfusion-dependent MDS and AA.(口演)2010

    • Author(s)
      Hisashi Tsurumi, Alcihiro Tomita, 他12名、5番目
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2010-09-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Storage iron metabolism in iron overload as observed by serum ferritinkinetics.(口演)2010

    • Author(s)
      Hiroshi Saito, Akihiro Tomita, Haruhiko Ohashi, Hideaki Maeda, Tomoki Naoe.
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2010-09-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 初発B細胞性リンパ腫におけるCD20蛋白発現の免疫染色とフローサイト解析における乖離2010

    • Author(s)
      徳永隆之、冨田章裕、島田和之、杉本匠、平賀潤二、中村栄男、木下朝博士、直江知樹
    • Organizer
      第70回日本血液学会総会、(口演)
    • Place of Presentation
      横浜
    • Year and Date
      2010-09-25
    • Related Report
      2010 Final Research Report
  • [Presentation] 初発B細胞性リンパ腫におけるCD20蛋白発現の免疫染色とフローサイト解析における乖離(口演)2010

    • Author(s)
      徳永隆之、冨田章裕、島田和之、杉本匠、平賀潤二、中村栄男、木下朝博士、直江知樹
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2010-09-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] Utilization of DNA methyltransferase inhibitors for hematological malignancies2010

    • Author(s)
      冨田章裕, 直江知樹
    • Organizer
      第69回日本癌学会学術総会(International Sessions;シンポジウム英語口演)
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-22
    • Related Report
      2010 Final Research Report
  • [Presentation] Utilization of DNA methyltransferase inhibitors for hematological malignancies.(International Sessions;シンポジウム英語招待口演)2010

    • Author(s)
      Akihiro Tomita, Tomoki Naoe
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] Post-rituximab eraにおける新たな予後不良疾患群の可能性 -リツキシマブ治療後のCD20陰転化-2010

    • Author(s)
      冨田章裕、徳永隆之、入山智沙子、島田和之、杉本匠、平賀潤二、直江知樹、木下朝博
    • Organizer
      第50回日本網内系学会総会、(口演)(秀ポスター賞にて口演発表)
    • Place of Presentation
      新潟
    • Year and Date
      2010-06-18
    • Related Report
      2010 Final Research Report
  • [Presentation] Post-rituximab eraにおける新たな予後不良疾患群の可能性-リツキシマブ治療後のCD20陰転化-(優秀ポスター演題にて口演)2010

    • Author(s)
      冨田章裕、徳永隆之、入山智沙子、島田和之、杉本匠、平賀潤二、直江知樹、木下朝博.
    • Organizer
      50回日本網内系学会総会
    • Place of Presentation
      新潟
    • Year and Date
      2010-06-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] 悪性腫瘍細胞に発現する異常アンチセンスキメラRNAによる特定遺伝子発現のノックダウン.2010

    • Author(s)
      冨田章裕、杉本匠、安部明弘、清井仁、直江知樹
    • Organizer
      第4回日本エピジェネティクス研究会
    • Place of Presentation
      米子
    • Year and Date
      2010-05-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] 悪性腫瘍細胞に発現する異常アンチセンスキメラRNAによる特定遺伝子発現のノックダウン2010

    • Author(s)
      富田章裕、杉本匠、安部明弘、清井仁、直江知樹
    • Organizer
      第4回日本エピジェネティクス研究会、(ポスター)
    • Place of Presentation
      米子
    • Year and Date
      2010-05-28
    • Related Report
      2010 Final Research Report
  • [Presentation] R-CHOPクリニカルパス作成後の正当性評価および電子パス作成への応用2010

    • Author(s)
      仲井麻記、冨田章裕、杉村歩美、金森今日子、久保田亜希、吉見陽、徳永隆之、松本佐恵子、木下朝博、直江知樹
    • Organizer
      第8回日本臨床腫瘍学会、(ポスター)
    • Place of Presentation
      東京
    • Year and Date
      2010-03-19
    • Related Report
      2010 Final Research Report
  • [Presentation] CD20 Down-Regulation in B-Cell lymphoma after Rituximab Treatment.2010

    • Author(s)
      富田章裕
    • Organizer
      Malignant Lymphoma Academy、(英語招待口演)
    • Place of Presentation
      東京
    • Year and Date
      2010-03-14
    • Related Report
      2010 Final Research Report
  • [Presentation] Role of Antisense-chimeric RNA Raised from Aberrant Chromosomal Translocation.2009

    • Author(s)
      富田章裕
    • Organizer
      National Institute of Health (NIH) Seminar(Invited speaker, Oral presentation)
    • Place of Presentation
      Bethesda, MD, USA.
    • Year and Date
      2009-12-09
    • Related Report
      2010 Final Research Report
  • [Presentation] Role of Antisense-chimeric RNA Raised from Aberrant Chromosomal Translocation.2009

    • Author(s)
      Akihiro Tomita,
    • Organizer
      National Institute of Health(NIH)Seminar
    • Place of Presentation
      Bethesda, MD, USA.
    • Year and Date
      2009-12-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] MS4A1 (CD20) Gene Expression Is Down-Regulated by Recruiting the Histone Deacetylase Protein Complex to the Promoter in the CD20-Negative B-Lymphoma Cells After Treatment with Rituximab.2009

    • Author(s)
      杉本匠, 冨田章裕, 平賀潤二, 島田和之, 清井仁, 木下朝博, 直江知樹
    • Organizer
      The American Society of Hematology, 51th Annual Meeting
    • Place of Presentation
      New Orleans, LA, USA
    • Year and Date
      2009-12-05
    • Related Report
      2010 Final Research Report
  • [Presentation] Double Genetic Mutations in PML-Rara Fusion Gene Confirmed in a Patient Showing Resistance to All-Trans Retinoic Acid and Arsenic-Trioxide Therapy.2009

    • Author(s)
      高橋恵美子, 冨田章裕, 渥美晃秀, 清井仁, 直江知樹
    • Organizer
      The American Society of Hematology, 51th Annual Meeting
    • Place of Presentation
      New Orleans, LA, USA.
    • Year and Date
      2009-12-05
    • Related Report
      2010 Final Research Report
  • [Presentation] MS4Al(CD20)Gene Expression Is Down-Regulated by Recruiting the Histone Deacetylase Protein Complex to the Promoter in the CD20-Negative B-Lymphoma Cells After Treatment with Rituximab.2009

    • Author(s)
      Takumi Sugimoto, Akihiro Tomita, Junji Hiraga, Kazuyuki Shimada, Hitoshi Kiyoi, Tomohiro Kinoshita, Tomoki Naoe,
    • Organizer
      The American Society of Hematology, 51th Annual Meeting
    • Place of Presentation
      New Orleans, LA, USA
    • Year and Date
      2009-12-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] Double Genetic Mutations in PML-Rara Fusion Gene Confirmed in a Patient Showing Resistance to All-Trans Retinoic Acid and Arsenic-Trioxide Therapy.2009

    • Author(s)
      Emi Goto, Akihiro Tomita, Akihide Atsumi, Hitoshi Kiyoi, Tomoki Naoe.
    • Organizer
      The American Society of Hematology, 51th Annual Meeting
    • Place of Presentation
      New Orleans, LA, USA
    • Year and Date
      2009-12-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] Epigenetic mechanisms of MS4Al(CD20)gene down-regulation in the CD20-negative B-lymphoma cells after treatment with rituximab.2009

    • Author(s)
      Akihiro Tomita, Takumi Sugimoto, Junji Hiraga, Kazuyuki Shimada, Hitoshi Kiyoi, Tomohiro Kinoshita, Tomoki Naoe.
    • Organizer
      International Conference on Differentiation Therapy.
    • Place of Presentation
      Chicago, IL, USA
    • Year and Date
      2009-11-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] Epigenetic mechanisms of MS4A1 (CD20) gene down-regulation in the CD20-negative B-lymphoma cells after treatment with rituximab.2009

    • Author(s)
      Akihiro Tomita, Takumi Sugimoto, Junji Hiraga, Kazuyuki Shimada, Hitoshi Kiyoi, Tomohiro Kinoshita, Tomoki Naoe
    • Organizer
      International Conference on Differentiation Therapy
    • Place of Presentation
      Chicago, IL, USA
    • Year and Date
      2009-11-12
    • Related Report
      2010 Final Research Report
  • [Presentation] B細胞性悪性リンパ腫細胞におけるCD20発現量の免疫染色とフローサイト解析における乖離.2009

    • Author(s)
      徳永隆之、富田章裕、島田和之、杉本匠、平賀潤二、渡会雅也、高橋恵美子、中村栄男、木下朝博、直江知樹
    • Organizer
      第71回日本血液学会総会、(ポスター)
    • Place of Presentation
      京都
    • Year and Date
      2009-10-25
    • Related Report
      2010 Final Research Report
  • [Presentation] 慢性骨髄性白血病由来樹立細胞株におけるTEL/EVI1融合遺伝子の機能解析.2009

    • Author(s)
      島田和之、冨田章裕、南陽介、谷崎亮平、安部明弘、清井仁、木下朝博1直江知樹.
    • Organizer
      第71回日本血液学会総会、(ポスター)
    • Place of Presentation
      京都
    • Year and Date
      2009-10-25
    • Related Report
      2010 Final Research Report
  • [Presentation] B細胞性悪性リンパ腫細胞におけるCD20発現量の免疫染色とフローサイト解析における乖離.2009

    • Author(s)
      徳永隆之、富田章裕、島田和之、杉本匠、平賀潤二、渡会雅也、高橋恵美子、中村栄男、木下朝博、直江知樹
    • Organizer
      第71回 日本血液学会総会
    • Place of Presentation
      京都
    • Year and Date
      2009-10-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] 慢性骨髄性白血病由来樹立細胞株におけるTEL/EVI1融合遺伝子の機能解析.2009

    • Author(s)
      島田和之、冨田章裕、南陽介、谷崎亮平、安部明弘、清井仁、木下朝博、直江知樹
    • Organizer
      第71回 日本血液学会総会
    • Place of Presentation
      京都
    • Year and Date
      2009-10-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] 染色体相互転座から転写されるアンチセンスキメラRNAによる特定遺伝子発現のノックダウン2009

    • Author(s)
      杉本匠、富田章裕、安部明弘、清井仁、直江知樹.
    • Organizer
      第71回日本血液学会総会、(口演)
    • Place of Presentation
      京都
    • Year and Date
      2009-10-24
    • Related Report
      2010 Final Research Report
  • [Presentation] ATRAおよびATO治療に抵抗性を示したAPL患者に確認されたPML-RARα付加的遺伝子変異の解析2009

    • Author(s)
      後藤絵美、富田章裕、渥美晃秀、清井仁、直江知樹
    • Organizer
      第71回日本血液学会総会、(ポスター)
    • Place of Presentation
      京都
    • Year and Date
      2009-10-24
    • Related Report
      2010 Final Research Report
  • [Presentation] ATRAおよびATO治療に抵抗性を示したAPL患者に確認されたPML-RARα付加的遺伝子変異の解析.2009

    • Author(s)
      後藤絵美、富田章裕、渥美晃秀、清井仁、直江知樹
    • Organizer
      第71回 日本血液学会総会
    • Place of Presentation
      京都
    • Year and Date
      2009-10-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] 染色体相互転座から転写されるアンチセンスキメラRNAによる特定遺伝子発現のノックダウン.2009

    • Author(s)
      杉本匠、富田章裕、安部明弘、清井仁、直江知樹.
    • Organizer
      第71回 日本血液学会総会
    • Place of Presentation
      京都
    • Year and Date
      2009-10-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] 染色体相互転座から転写されるアンチセンスキメラRNAによる特定遺伝子発現のノックダウン.2009

    • Author(s)
      富田章裕、杉本匠、安部明弘、清井仁、直江知樹.
    • Organizer
      第6回 日本癌学会学術総会
    • Place of Presentation
      神奈川
    • Year and Date
      2009-10-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] CD20抗原の発現量と抗CD20モノクローナル抗体感受性との関連.2009

    • Author(s)
      島田和之、富田章裕、杉本匠、木下朝博、直江知樹.
    • Organizer
      第49回日本網内系学会総会、(ポスター)
    • Place of Presentation
      兵庫
    • Year and Date
      2009-07-10
    • Related Report
      2010 Final Research Report
  • [Presentation] CD20抗原の発現量と抗CD20モノクローナル抗体感受性との関連.2009

    • Author(s)
      島田和之、富田章裕、杉本匠、木下朝博、直江知樹.
    • Organizer
      第49回 日本網内系学会総会
    • Place of Presentation
      兵庫
    • Year and Date
      2009-07-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] Epigenetic Regulation of CD20 B-cell Specific Antigen Expression and the Resistance to Rituximab Monoclonal Antibody Therapy.2008

    • Author(s)
      富田章裕
    • Organizer
      National Institute of Health (NIH) Seminar(Invited speaker, Oral presentation)
    • Place of Presentation
      Bethesda, MD, USA.
    • Year and Date
      2008-12-12
    • Related Report
      2010 Final Research Report
  • [Presentation] Epigenetic Regulation of CD20 B-cell Specific Antigen Expression and the Resistance to Rituximab Monoclonal Antibody Therapy.2008

    • Author(s)
      富田章裕
    • Organizer
      University of Cincinnati Seminar(Invited speaker, Oral presentation)
    • Place of Presentation
      Cincinnati, OH, USA
    • Year and Date
      2008-12-10
    • Related Report
      2010 Final Research Report
  • [Presentation] Relationship between post-translational modification of CD20 protein and the responsiveness to rituximab treatment.2008

    • Author(s)
      Takumi Sugimoto, Akihiro Tomita, Kazuyuki Shimada, Junji Hiraga, Hitoshi Kiyoi, Tomohiro Kinoshita, Tomoki Naoe.
    • Organizer
      The American Society of Hematology 50th Annual Meeting
    • Place of Presentation
      San Francisco
    • Year and Date
      2008-12-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] Relationship between post-translational modification of CD20 protein and the responsiveness to rituximab treatment.2008

    • Author(s)
      杉本匠, 富田章裕, 島田和之, 平賀潤二, 清井仁, 木下朝博, 直江知樹
    • Organizer
      The American Society of Hematology, 50th Annual Meeting
    • Place of Presentation
      San Francisco, CA, USA.
    • Year and Date
      2008-12-06
    • Related Report
      2010 Final Research Report
  • [Presentation] Significance of CD20 protein expression pattern in rituximab-resistant B-cell lymphoma cells.2008

    • Author(s)
      Akihiro Tomita, Junji Hiraga, Hitoshi Kiyoi, Masafumi Ito, Tomohiro Kinoshita, Tomoki Naoe
    • Organizer
      第67回日本癌学会学術総会、(English Workshop ; 英語口演)
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
    • Related Report
      2010 Final Research Report
  • [Presentation] Significance of CD20 protein expression pattern in rituximab-resistant B-cell lymphoma cells. (English Workshop ; 口演)2008

    • Author(s)
      Akihiro Tomita, Junji Hiraga, Hioshi Kiyoi, Masafumi Ito, Tomohiro Kinoshita, Tomoki Naoe.
    • Organizer
      第67回曰本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] Relationship between CD20 protein expression pattern and responsiveness to rituximab treatment in CD20-negative and -positive B-cell lymphoma cells.2008

    • Author(s)
      富田章裕, 杉本匠, 島田和之, 平賀潤二, 木下朝博, 直江知樹
    • Organizer
      The XXXIInd World Congress of the International Society of hematology(Oral presentation)
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      2008-10-22
    • Related Report
      2010 Final Research Report
  • [Presentation] Relationship between CD20 protein expression pattern and responsiveness to rituximab treatment in CD20-negative and-positive B-cell lymp homa cells. (Oral presentation)2008

    • Author(s)
      Akihiro Tomita. Takumi Sugimoto, Kazuyuki Shimada, Junji Hiraga, Tomohiro Kinoshita, Tomoki Naoe.
    • Organizer
      The XXXIInd World Congress of the International Society of hematology
    • Place of Presentation
      Bangkok
    • Year and Date
      2008-10-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] リツキシマブ治療抵抗症例におけるCD20抗原発現と耐性機序の解析2008

    • Author(s)
      冨田章裕、杉本匠、平賀潤二、島田和之、木下朝博、直江知樹
    • Organizer
      第70回日本血液学会総会、(ポスター)
    • Place of Presentation
      京都
    • Year and Date
      2008-10-10
    • Related Report
      2010 Final Research Report
  • [Presentation] MDS患者に認められたt(12;17)により生じる新規TEL/ETV6融合遺伝子の解析2008

    • Author(s)
      杉本匠、冨田章裕、安部明弘、清井仁、直江知樹
    • Organizer
      第70回日本血液学会総会、(ポスター)
    • Place of Presentation
      京都
    • Year and Date
      2008-10-10
    • Related Report
      2010 Final Research Report
  • [Presentation] リツキシマブ治療抵抗症例におけるCD20抗原発現と耐性機序の解析2008

    • Author(s)
      冨田章裕, 杉本匠, 平賀潤二, 島田和之, 木下朝博, 直江知樹
    • Organizer
      第70回曰本血液学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] MDS患者に認められたt(12 ; 17)により生じる新規TEL/ETV6融合遺伝子の解析2008

    • Author(s)
      杉本匠, 冨田章裕, 安部明弘, 清井仁, 直江知樹
    • Organizer
      第70回曰本血液学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] リツキシマブ治療抵抗症例におけるCD20抗原発現と耐性機序の解析2008

    • Author(s)
      杉本匠、冨田章裕、島田和之、平賀潤二、木下朝博、直江知樹
    • Organizer
      第48回日本網内系学会総会、(口演)(優秀ポスターにて口演発表)
    • Place of Presentation
      札幌
    • Year and Date
      2008-06-13
    • Related Report
      2010 Final Research Report
  • [Presentation] リツキシマブ治療抵抗症例におけるCD20抗原発現と耐性機序の解析(口演)2008

    • Author(s)
      杉本匠, 冨田章裕, 島田和之, 平賀潤二, 木下朝博, 直江知樹
    • Organizer
      第48回曰本網内系学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2008-06-13
    • Related Report
      2008 Annual Research Report
  • [Book] 新臨床腫瘍学-がん薬物療法専門医のために(エピジェネティック標的薬)2009

    • Author(s)
      富田章裕
    • Publisher
      改訂第2版
    • Related Report
      2010 Final Research Report
  • [Book] 新臨床腫瘍学-がん薬物療法専門医のために、改訂第2版2009

    • Author(s)
      日本臨床腫瘍学会、富田章裕, ほか
    • Total Pages
      809
    • Publisher
      南江堂
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] CD20陰転化B細胞性悪性リンパ腫細胞株及びその利用2009

    • Inventor(s)
      直江知樹、冨田章裕、平賀潤二
    • Industrial Property Rights Holder
      国立大学法人名古屋大学
    • Industrial Property Number
      2008-536354
    • Filing Date
      2009-03-12
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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