Cell therapy using adipose tissue-derived mesenchymal stem cells for primary myelofibrosis
| Project/Area Number |
20591118
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Nagoya University |
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Principal Investigator |
NAKAYAMA Takayuki Nagoya University, 医学部附属病院, 医員 (00456659)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAMOTO Kouji 名古屋大学, 医学部附属病院, 講師 (90362251)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 脂肪由来間葉系幹細胞 / 造血微小環境 / ケモカイン / 再生医学 / 細胞療法 |
|---|
| Research Abstract |
Mesenchymal stem cells (MSCs) have emerged as a new therapeutic modality for reconstituting the hematopoietic microenvironment. However, the availability of conventional bone marrow (BM)-derived MSCs (BMSCs) is limited. Recent studies showed that a large number of MSCs could be easily isolated from fat tissue (adipose tissue-derived MSCs [ADSCs]). We extensively evaluated the hematopoiesis-supporting properties of mouse ADSCs. Mouse ADSCs injected into the BM cavity of fatally irradiated mice reconstituted hematopoiesis more promptly than mouse BMSCs and subsequently rescued mice that had received a low number of HSCs. Human ADSCs possessed the higher hematopoiesis-supporting properties than human BMSCs as well.
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Report
(4 results)
Research Products
(6 results)
