• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Study on the molecular mechanisms of rituximab action and the enhancement of its actions

Research Project

Project/Area Number 20591119
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hematology
Research InstitutionNagoya University

Principal Investigator

KINOSHITA Tomohiro  Nagoya University, 医学系研究科, 准教授 (60283446)

Co-Investigator(Kenkyū-buntansha) 中村 栄男  名古屋大学, 大学院・医学系研究科, 教授 (80180363)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords悪性リンパ腫 / 分子標的治療 / モノクローナル抗体 / rituximab / エピジェネティクス / 分子不要時治療
Research Abstract

To investigate the molecular mechanisms of heterogeneity in rituximab efficacies, rituximab-sensitivities of cell lines established from patients with diffuse large B-cell lymphoma (DLBCL) were analyzed by ADCC and CDC assays. Tumor samples from patients with DLBCL were evaluated for their mutations on CD79B, CARD11 and EZH2, and their correlations with the prognoses of the patients were analyzed. In vitro sensitivity of DLBCL cell lines to rituximab showed no clear patterns with respect to their DLBCL subtypes. CD79B, CARD11 and EZH2 showed somatic mutations in several patients, and patients with mutated CARD11 genes showed significant poor prognoses.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (116 results)

All 2011 2010 2009 2008

All Journal Article (70 results) (of which Peer Reviewed: 35 results) Presentation (32 results) Book (14 results)

  • [Journal Article] Cladribine combined with rituximab (R-2-CdA) therapy is an effective salvage therapy in relapsed or refractory indolent B-cell non-Hodgkin lymphoma.2011

    • Author(s)
      Nagai H, Ogura M, Kusumoto S, Takahashi N, Yamaguchi M, Takayama N, Kinoshita T, Motoji T, Ohyashiki K, Kosugi H, Matsuda S, Ohnishi K, Omachi K, Hotta T.
    • Journal Title

      Eur J Hematol 86

      Pages: 117-123

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 悪性リンパ腫-最近の診断と治療の進展2011

    • Author(s)
      木下朝博
    • Journal Title

      総合臨床

      Volume: 60巻3号 Pages: 459-460

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Cladribine combined with rituximab (R-2-CdA) therapy is an effective salvage therapy in relapsed or refractory indolent B-cell non-Hodgkin lymphoma.2011

    • Author(s)
      Nagai H, Kinoshita T, et al.
    • Journal Title

      Eur J Haematol.

      Volume: 86 Pages: 117-123

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pretreatment total serum protein is a significant prognostic factor for the outcome of patients with peripheral T/natural killer-cell lymphomas.2010

    • Author(s)
      Watanabe T, Kinoshita T, Itoh K, Yoshimura K, Ogura M, Kagami Y, Yamaguchi M, Kurosawa M, Tsukasaki K, Kasai M, Tobinai K, Kaba H, Mukai K, Nakamura S, Ohshima K, Hotta T, Shimoyama M.
    • Journal Title

      Leuk Lymphoma 51

      Pages: 813-821

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Randomized phase II study of concurrent and sequential combinations of rituximab plus CHOP (cyclophosphamide, doxorubicin, vincristine and prednisolone) chemotherapy in untreated indolent B-cell non-Hodgkin lymphoma : 7-year follow-up results2010

    • Author(s)
      Tobinai K, Ogura M, Itoh K, Kinoshita T, Hotta T, Watanabe T, Morishima Y, Igarashi T, Terauchi T, Ohashi Y.
    • Journal Title

      Cancer Sci. 101

      Pages: 2579-2585

    • NAID

      10027834549

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic factors for mature natural killer (NK) cell neoplasms : aggressive NK cell leukemia and extranodal NK cell lymphoma, nasal type.2010

    • Author(s)
      Suzuki R, Suzumiya J, Yamaguchi M, Nakamura S, Kameoka J, Kojima H, Abe M, Kinoshita T,, Yoshino T, Iwatsuki K, Kagami Y, Tsuzuki T, Kurokawa M, Ito K, Kawa K, Oshimi K
    • Journal Title

      Ann Oncol 21

      Pages: 1032-1040

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Central nervous system involvement in intravascular large B-cell lymphoma: a retrospective analysis of 109 patients.2010

    • Author(s)
      Shimada K, Murase T, Matsue K, Okamoto M, Ichikawa N, Tsukamoto N, Niitsu N, Miwa H, Asaoku H, 小杉浩史, Kikuchi A, Matsumoto M, Saburi Y, Masaki Y, Yamamoto K, Yamaguchi M, Nakamura S, Naoe T, Kinoshita T
    • Journal Title

      Cancer Sci. 101

      Pages: 1480-1486

    • NAID

      10026593809

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phase II study of ABVd therapy for newly diagnosed clinical stage II-IV Hodgkin lymphoma : Japan Clinical Oncology Group study (JCOG 9305)2010

    • Author(s)
      Ogura M, Itoh K, Kinoshita T, Fukuda H, Takenaka T, Ohtsu T, Kagami Y, Tobinai K, Okamoto M, Asaoku H, Sasaki T, Mikuni C, Hirano M, Chou T, Ohnishi K, Ohno H, Nasu K, Okabe K, Ikeda S, Nakamura S, Hotta T, Shimoyama M.
    • Journal Title

      Int J Hematol. 92

      Pages: 713-724

    • NAID

      10027674421

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic analysis and a new risk model for Hodgkin lymphoma in Japan.2010

    • Author(s)
      Itoh K, Kinoshita T, Watanabe T, yoshimura K, Okamoto R, Chou T, Ogura M, Hirano M, Asaoku H, Kurosawa M, Maeda Y, Omachi K, Moriuchi Y, Kasai M, Ohnishi K, Takayama N, Morishima Y, Tobinai K, Kaba H, Yamamoto S, Fukuda H, Kikuchi M, Yoshino T, Matsuno Y, Hotta T, Shimoyama M.
    • Journal Title

      Int J Hematol 91

      Pages: 446-455

    • NAID

      10026401252

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant DNA methylation of the p57KIP2 gene is a sensitive biomarker for detecting minimal residual disease in diffuse large B cell lymphoma.2010

    • Author(s)
      Hagiwara K, Li Y, Kinoshita T, Kunishma S, Ohashi H, Hotta T, Nagai H.
    • Journal Title

      Leuk Res. 34

      Pages: 50-54

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hepatic toxicity and prognosis in HCV-infected patients with diffuse large B-cell lymphoma treated with rituximab-containing chemotherapy regimens : a Japanese multicenter analysis.2010

    • Author(s)
      Ennishi D, Kinoshita T, et al.
    • Journal Title

      Blood 116

      Pages: 5119-5125

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 悪性リンパ腫-最近の診断と治療の進展2010

    • Author(s)
      木下朝博
    • Journal Title

      総合臨床 60巻3号

      Pages: 459-460

    • Related Report
      2010 Final Research Report
  • [Journal Article] 単クローン性γグロブリン血症における血清遊離軽鎖測定の臨床的有用性2010

    • Author(s)
      島崎千尋、村上博和、澤村守夫、松田正之、木下朝博、畑裕之、杉浦勇、津下圭太郎、名倉英一、小杉浩史、伊藤淳治、清水一之
    • Journal Title

      臨床血液 51

      Pages: 245-252

    • NAID

      10026332474

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 【難治性悪性リンパ腫の治療戦略】血管内リンパ腫2010

    • Author(s)
      島田和之、木下朝博
    • Journal Title

      血液フロンティア 20巻2号

      Pages: 71-76

    • Related Report
      2010 Final Research Report
  • [Journal Article] 【リンパ系腫瘍研究におけるわが国からの情報発信と今後の課題】Intravascular large B-cell lymphoma2010

    • Author(s)
      島田和之、木下朝博
    • Journal Title

      これまでの研究成果と今後の課題、血液・腫瘍科 61

      Pages: 24-28

    • Related Report
      2010 Final Research Report
  • [Journal Article] 【ドラッグラグ解消に向けて】プロテアソーム阻害薬(ボルテゾミブ)によるマントル細胞リンパ腫の治療2010

    • Author(s)
      木下朝博
    • Journal Title

      血液フロンティア別冊-血液疾患における分子標的治療-

      Pages: 150-156

    • Related Report
      2010 Final Research Report
  • [Journal Article] 非Hodgkinリンパ腫2010

    • Author(s)
      木下朝博
    • Journal Title

      medicina 47巻13号

      Pages: 2156-2158

    • Related Report
      2010 Final Research Report
  • [Journal Article] 初発限局期DLBCLに対する標準的治療と最新の治療動向2010

    • Author(s)
      木下朝博
    • Journal Title

      臨床血液 51巻10号

      Pages: 75-81

    • NAID

      10026727774

    • Related Report
      2010 Final Research Report
  • [Journal Article] 単クローン性γグロブリン血症における血清遊離軽鎖測定の臨床的有用性2010

    • Author(s)
      木下朝博, 他
    • Journal Title

      臨床血液

      Volume: 51巻4号 Pages: 245-252

    • NAID

      10026332474

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 血管内リンパ腫2010

    • Author(s)
      島田和之、木下朝博
    • Journal Title

      血液フロンティア

      Volume: 20巻2号 Pages: 71-76

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Intravascular large B-cell lymphoma:これまでの研究成果と今後の課題2010

    • Author(s)
      島田和之、木下朝博
    • Journal Title

      血液・腫瘍科

      Volume: 61巻1号 Pages: 24-28

    • Related Report
      2010 Annual Research Report
  • [Journal Article] プロテアソーム阻害薬(ボルテゾミブ)によるマントル細胞リンパ腫の治療2010

    • Author(s)
      木下朝博
    • Journal Title

      血液フロンティア

      Volume: 20巻別冊 Pages: 150-156

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 非Hodgkinリンパ腫2010

    • Author(s)
      木下朝博
    • Journal Title

      Medicina

      Volume: 47巻13号 Pages: 2156-2158

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 初発限局期DLBCLに対する標準的治療と最新の治療動向2010

    • Author(s)
      木下朝博
    • Journal Title

      臨床血液

      Volume: 51巻10号 Pages: 75-81

    • NAID

      10026727774

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Pretreatment total serum protein is a significant prognostic factor for the outcome of patients with peripheral T/natural killer-cell lymphomas.2010

    • Author(s)
      Watanabe T, Kinoshita T, et al.
    • Journal Title

      Leuk Lymphoma

      Volume: 51 Pages: 813-821

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] all collaborators of the I-CBSGiJ. Randomized phase II study of concurrent and sequential combinations of rituximab plus CHOP (cyclophosphamide, doxorubicin, vincristine and prednisolone) chemotherapy in untreated indolent B-cell non-Hodgkin Iymphoma : 7-year follow-up results.2010

    • Author(s)
      Tobinai K, Kinoshita T, et al.
    • Journal Title

      Cancer Sci.

      Volume: 101 Pages: 2579-2585

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic factors for mature natural killer(NK) cell neoplasms : aggressive NK cell leukemia and extranodal NK cell lymphoma, nasal type.2010

    • Author(s)
      Suzuki R, Kinoshita T, et al.
    • Journal Title

      Ann Oncol.

      Volume: 21 Pages: 1032-1040

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Central nervous system involvement in intravascular large B-cell lymphoma : a retrospective analysis of 109 patients.2010

    • Author(s)
      Shimada K, Kinoshita T, et al.
    • Journal Title

      Cancer Sci.

      Volume: 101 Pages: 1480-1486

    • NAID

      10026593809

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phase II study of ABVd therapy for newly diagnosed clinical stage II-IV Hodgkin lymphoma : Japan Clinical Oncology Group study(JCOG 9305).2010

    • Author(s)
      Ogura M, Kinoshita T, et al.
    • Journal Title

      Int J Hematol.

      Volume: 92 Pages: 713-724

    • NAID

      10027674421

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic analysis and a new risk model for Hodgkin lymphoma in Japan.2010

    • Author(s)
      Itoh K, Kinoshita T, et al
    • Journal Title

      Int J Hematol.

      Volume: 91 Pages: 446-455

    • NAID

      10026401252

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant DNA methylation of the p57KIP2 gene is a sensitive biomarker for detecting minimal residual disease in diffuse large B cell lymphoma.2010

    • Author(s)
      Hagiwara K, Kinoshita T, et al.
    • Journal Title

      Leuk Res.

      Volume: 34 Pages: 50-54

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hepatic toxicity and prognosis in HCV-infected patients with diffuse large B-cell lymphoma treated with rituximab-containing chemotherapy regimens : a Japanese multicenter analysis.2010

    • Author(s)
      Ennishi D, Kinoshita T, et al.
    • Journal Title

      Blood

      Volume: 116 Pages: 5119-5125

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2010

    • Author(s)
      島田和之、木下朝博
    • Journal Title

      Annual Review血液2010(中外医学社)

      Pages: 119-123

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Phase I/II study of concurrent chemoradiotherapy for localized nasal natural killer/T-cell lymphoma : Japan Clinical Oncology Group Study JCOG 0211.2009

    • Author(s)
      Yamaguchi M, Kinoshita T, et al.,
    • Journal Title

      J Clin Oncol 27

      Pages: 5594-5600

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic factors for mature natural killer(NK)cell neoplasms : aggres sive NK cell leukemia and extranodal NK cell lymphoma, nasal type2009

    • Author(s)
      Suzuki R, Kinoshita T, et al.,
    • Journal Title

      Ann Oncol

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Escape mechanisms from antibody therapy to lymphoma cells : downregulation of CD20 mRNA by recruitment of the HDAC complex and not by DNA methylation2009

    • Author(s)
      Sugimoto T, Kinoshita T, et al.,
    • Journal Title

      Biochem Biophys Res Commun 390

      Pages: 48-53

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Presentation and management of intravascular large B-cell lymphoma2009

    • Author(s)
      Shimada K, Kinoshita T, et. al.,
    • Journal Title

      Lancet Oncol 10

      Pages: 895-902

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Down-regulation of CD20 expression in B-cell lymphoma cells after treatment with rituximab-containing combination chemotherapies : its prevalence and clinical significance.2009

    • Author(s)
      Hiraga J, Kinoshita T, et al.,
    • Journal Title

      Blood 113

      Pages: 4885-4893

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant DNA methylation of the p57KIP2 gene is a sensitive biomarker for detecting minimal residual disease in diffuse large B cell lymphoma.2009

    • Author(s)
      Hagiwara K, Kinoshita T, et al.,
    • Journal Title

      Leuk Res 34

      Pages: 50-54

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Age-related Epstein-Barr virus(EBV)-associated B-cell lymphoproliferative disorders : comparison with EBV-positive classic Hodgkin lymphoma in elderly patients.2009

    • Author(s)
      Asano N, Kinoshita T, et al.,
    • Journal Title

      Blood 113

      Pages: 2629-2636

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Combinations of cytogenetics and international scoring system can predict poor prognosis in multiple myeloma after high-dose chemotherapy and autologous stem cell transplantation2009

    • Author(s)
      Inamoto Y, Kinoshita T, et al.,
    • Journal Title

      Am J Hematol 84

      Pages: 283-286

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 【造血器腫瘍における薬剤耐性の機序とその対策】悪性リンパ腫における抗CD20抗体の薬剤耐性機序2009

    • Author(s)
      富田章裕、木下朝博
    • Journal Title

      血液フロンティア 20巻1号

      Pages: 61-69

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 「がんプロフェッショナル養成プラン」の実態調査と満足度の解析2009

    • Author(s)
      安藤雄一、木下朝博
    • Journal Title

      腫瘍内科 4巻2号

      Pages: 175-182

    • NAID

      40016830835

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 限局期症例にどう対処するのか限局期の定義、リスク因子、放射線治療の意義、再発例への対処2009

    • Author(s)
      堀田知光、木下朝博
    • Journal Title

      カレントテラピー 27巻8号

      Pages: 728-737

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 【知っておきたい分子標的治療】悪性リンパ腫2009

    • Author(s)
      木下朝博、直江知樹
    • Journal Title

      コンセンサス癌治療 8巻2号

      Pages: 102-105

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 【がんの分子標的治療の現状】びまん性大細胞型B細胞リンパ腫(DLBCL)2009

    • Author(s)
      木下朝博
    • Journal Title

      MEDICO 40巻6号

      Pages: 224-227

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 悪性リンパ腫における脊椎病変の発生頻度と治療2009

    • Author(s)
      片山良仁、木下朝博
    • Journal Title

      整形外科 60巻5号

      Pages: 401-405

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 低悪性度リンパ腫2009

    • Author(s)
      木下朝博
    • Journal Title

      血液疾患診療ハンドブック-診療の手引きと臨床データ集改訂版

      Pages: 363-386

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 中悪性度非ホジキンリンパ腫2009

    • Author(s)
      満間綾子、木下朝博
    • Journal Title

      現場で役立つ血液腫瘍治療プロトコール集

      Pages: 114-122

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2009

    • Author(s)
      木下朝博
    • Journal Title

      血液疾患診療ハンドブック-診療の手引きと臨床データ集 改訂版(南江堂)

      Pages: 363-386

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2009

    • Author(s)
      満間綾子、木下朝博
    • Journal Title

      現場で役立つ血液腫瘍治療プロトコール集(医薬ジャーナル社)

      Pages: 114-122

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2009

    • Author(s)
      木下朝博
    • Journal Title

      今日の治療方針 私はこう治療している(医学書院)

      Pages: 555-557

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2009

    • Author(s)
      木下朝博
    • Journal Title

      悪性リンパ腫 治療マニュアル(南江堂)

      Pages: 69-72

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2009

    • Author(s)
      木下朝博
    • Journal Title

      悪性リンパ腫 治療マニュアル(南江堂)

      Pages: 103-107

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2009

    • Author(s)
      木下朝博
    • Journal Title

      悪性リンパ腫 治療マニュアル(南江堂)

      Pages: 157-160

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Down-regulation of CD20 expression in B-cell lymphoma cells after treatment with rituximab-containing comlbination chemotherapies : its prevalence and clinical significance.2009

    • Author(s)
      Junji Hiraga.
    • Journal Title

      Blood (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Age-related EBV-associated B-cell lymphoproliferative disorders : comparison with EBV-positive classical Hodgkin lymphoma in elderly patients.2009

    • Author(s)
      Asano, N.
    • Journal Title

      Blood (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 癌薬物療法学-基礎・臨床のアップデート-XI. 各臓器がんに対する薬物療法リンパ増殖性疾患非ホジキンリンパ腫2009

    • Author(s)
      直江知樹
    • Journal Title

      日本臨床 67巻増刊号1

      Pages: 771-777

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Age-related Epstein-Barr virus-associated B-cell lymphoprolife rative disorders : special references to lymphomas surrounding this newly recognized clinicopathologic disease.2008

    • Author(s)
      Shimoyama, Y.
    • Journal Title

      Cancer Sci 99

      Pages: 1085-91

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Retrospective analysis of intravascular large B-cell lymphoma treated with rituximab-containing chemotherapy as reported by the IVL study group in Japan.2008

    • Author(s)
      Shimada, K.
    • Journal Title

      J Clin Oncol 26

      Pages: 3189-95

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of organ involvement in intravascular large B-cell lymphoma by 18F-fluorodeoxyglucose positron emission tomography.2008

    • Author(s)
      Shimada, K.
    • Journal Title

      Int J Hematol 88

      Pages: 149-53

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sustained remission after rituXimab-containing chemotherapy for intravascular large B-cell lymphoma.2008

    • Author(s)
      Shimada, K.
    • Journal Title

      J Clin Exp Hematop 48

      Pages: 25-8

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intravascular large B-cell lyraphoma治療におけるリツキシマブの役割2008

    • Author(s)
      島田和之
    • Journal Title

      血液・腫瘍科 57 ; 5

      Pages: 556-561

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 【造血器腫瘍とエピジェネティクス】抗体療法の薬剤耐性に関わるエピジェネティック機構2008

    • Author(s)
      富川章裕
    • Journal Title

      液フロンティア 18 ; 11

      Pages: 1741-1748

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 【造血器腫瘍とエピジェネティクス】エピジェネティクス 造血器腫瘍の病態、診断から治療へ2008

    • Author(s)
      木下朝博
    • Journal Title

      血液フロンティア 18 ; 11

      Pages: 1689-1691

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 限局期びまん性大細胞型B細胞リンパ腫の治療現在の標準治療と今後の課題2008

    • Author(s)
      木下朝博
    • Journal Title

      血液・腫瘍科 57 ; 4

      Pages: 441-447

    • NAID

      40019063919

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 序-エピジェネティクス-造血器腫瘍の病態、診断から治療へ2008

    • Author(s)
      木下朝博
    • Journal Title

      血液フロンティア 18

      Pages: 17-19

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 抗体療法の薬剤耐性に関わるエピジェネティック機構2008

    • Author(s)
      冨田章裕
    • Journal Title

      血液フロンティア 18

      Pages: 69-76

    • Related Report
      2008 Annual Research Report
  • [Journal Article] リツキシマブ使用後のCD20陰性転化2008

    • Author(s)
      冨田章裕
    • Journal Title

      血液・腫瘍科 56 ; 4

      Pages: 466-471

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 【悪性リンパ腫診療update in 2008最新のエビデンスに基づく診断と治療】B細胞リンパ腫におけるrituximab耐性化の機序とその克服2008

    • Author(s)
      冨田章裕
    • Journal Title

      内科 102 ; 2

      Pages: 345-350

    • Related Report
      2008 Annual Research Report
  • [Presentation] CD20-Negative Phenotypic Change In B-Cell Lymphoma Cells After Using Rituximab : Possibility of a Particular Clinicopathologic Phenomenon Post-Rituximab Extranodal CD20-Negative Lymphoma.2010

    • Author(s)
      冨田章裕, 木下朝博, et al.
    • Organizer
      The 52nd American Society of Hematology Annual Meeting
    • Place of Presentation
      Florida
    • Related Report
      2010 Final Research Report
  • [Presentation] Discrepancy of CD20 protein expression in IHC nad FCM analyses in primary B-cell lymphoma cells2010

    • Author(s)
      冨田章裕, 木下朝博, et al.
    • Organizer
      第72回日本血液学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] 教育講演S-4びまん性大細胞型B細胞リンパ腫(Diffuse large B-cell lymphoma : DLBCL)に対する標準的治療と最新の治療動向、初発限局期DLBCLに対する標準的治療と最新の治療動向2010

    • Author(s)
      木下朝博
    • Organizer
      第72回日本血液学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] Post-rituximab eraにおける新たな予後不良疾患群の可能性 リツキシマブ治療後のCD20陰転化2010

    • Author(s)
      冨田章裕、木下朝博, 他
    • Organizer
      第50回リンパ網内系学会総会
    • Place of Presentation
      新潟
    • Related Report
      2010 Final Research Report
  • [Presentation] CD20-Negative Phenotypic Change In B-Cen Lymphoma Cells After Using Rituximab : Possibiity of a Particular Clinicopathologic Phenomenon Post-Rituximab Extranodal CD20-Negative Lymphoma.2010

    • Author(s)
      Akihiro Tomita, Tomohiro Kinoshita, et al.
    • Organizer
      The 52^<nd> American Society of Hematology Annual Meeting
    • Place of Presentation
      Orlando, Florida
    • Related Report
      2010 Annual Research Report
  • [Presentation] Discrepancy of CD20 protein expression in IHC and FCM analyses in primary B-cell lymphoma cells.2010

    • Author(s)
      Takashi Tokunaga, Tomohiro Kinoshita, et al.
    • Organizer
      第72回日本血液学会学術集会
    • Place of Presentation
      横浜、パシフィコ横浜
    • Related Report
      2010 Annual Research Report
  • [Presentation] 教育講演S-4びまん性大細胞型B細胞リンパ腫(Diffuse large B-cell lymphoma : DLBCL)に対する標準的治療と最新の治療動向、初発限局期DLBCLに対する標準的治療と最新の治療動向2010

    • Author(s)
      木下朝博
    • Organizer
      第72回日本血液学会学術集会
    • Place of Presentation
      横浜、パシフィコ横浜
    • Related Report
      2010 Annual Research Report
  • [Presentation] Post-rituximab eraにおける新たな予後不良疾患群の可能性 リツキシマブ治療後のCD20陰転化2010

    • Author(s)
      冨田章裕、木下朝博, 他
    • Organizer
      第50回日本リンパ網内系学会総会
    • Place of Presentation
      新潟、朱鷺メッセ新潟コンベンションセンター
    • Related Report
      2010 Annual Research Report
  • [Presentation] The Impact of Outcome and Hepatic Toxicity in HCV-Infected Patients with Diffuse Large B-Cell Lymphoma Treated with Rituximab Plus CHOP Therapy ; A Retrospective Multicenter Japanese Analysis2009

    • Author(s)
      Yoshinobu Maeda, Tomohiro Kinoshita, et al.,
    • Organizer
      American Society of Hematology
    • Place of Presentation
      New Orleans
    • Related Report
      2009 Annual Research Report
  • [Presentation] Gene Expression Is Down-Regulated by Recruiting the Histone Deacetylase Protein Complex to the Promoter in the CD20-Negative B-Lymphoma Cells After Treatment with Rituximab.2009

    • Author(s)
      Takumi Sugimoto, Tomohiro Kinoshita, et al.,
    • Organizer
      American Society of Hematology
    • Place of Presentation
      New Orleans
    • Related Report
      2009 Annual Research Report
  • [Presentation] a Clinicopathologic Study in Comparison with Nodal Peripheral T-Cell Lymphoma of Not Otherwise Specified Type Possessing CM Expression2009

    • Author(s)
      Jun-Ichi Tamaru, Tomohiro Kinoshita, et al.,
    • Organizer
      American Society of Hematology
    • Place of Presentation
      New Orleans
    • Related Report
      2009 Annual Research Report
  • [Presentation] Retrospective analysis of CD5-positive diffuse large B-cell lymphoma(CD5+DLBCL)treated with chemotherapy with or without rituximab2009

    • Author(s)
      K.Miyazaki, T.Kinoshita, et al.
    • Organizer
      American Society of Clinical Oncology
    • Place of Presentation
      Orlando
    • Related Report
      2009 Annual Research Report
  • [Presentation] C-VAD療法を寛解導入とする多発性骨髄腫に対する自己末梢血幹細胞移植の有効性と安全性の検討(臨床第II相試験)C-SHOT04012009

    • Author(s)
      杉浦勇、木下朝博
    • Organizer
      第7回日本臨床腫瘍学会学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2009 Annual Research Report
  • [Presentation] R-CHOPパス入院における病棟担当薬剤師の役割2009

    • Author(s)
      久保田亜希、木下朝博
    • Organizer
      第7回日本臨床腫瘍学会学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2009 Annual Research Report
  • [Presentation] 急性骨髄性白血病におけるRhoH遺伝子発現と予後の関連2009

    • Author(s)
      勝見章、木下朝博
    • Organizer
      第7回日本臨床腫瘍学会学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2009 Annual Research Report
  • [Presentation] B細胞性悪性リンパ腫細胞におけるCD20発現量の免疫染色とフローサイト解析における乖離2009

    • Author(s)
      富田章裕、木下朝博
    • Organizer
      第71回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] 慢性骨髄性白血病由来樹立細胞株におけるTEL/EVI1融合遺伝子の機能解析2009

    • Author(s)
      島田和之、木下朝博
    • Organizer
      第71回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] 加齢性EBV関連リンパ増殖性疾患の発症に関与する免疫学的な病態の解明2009

    • Author(s)
      森島聡子、木下朝博
    • Organizer
      第71回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] Rituximab eraにおけるびまん性大細胞型B細胞リンパ腫(DLBCL)診療の実際2009

    • Author(s)
      木下朝博
    • Organizer
      第71回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] 悪性リンパ腫 WHO病理分類の改訂(2008年)と臨床におよぼす影響B細胞リンパ腫の臨床2009

    • Author(s)
      木下朝博
    • Organizer
      第47回日本癌治療学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] CD20抗原の発現量と抗CD20モノクローナル抗体感受性との関連2009

    • Author(s)
      島田和之、木下朝博
    • Organizer
      第49回日本リンパ網内系学会
    • Place of Presentation
      淡路
    • Related Report
      2009 Annual Research Report
  • [Presentation] Relationship Between Post-Translational Modification of CD20 Protein and the Responsiveness to Ri tuximab Treatment.2008

    • Author(s)
      Sugimoto, S.
    • Organizer
      American Society of Hematology
    • Place of Presentation
      San Franciso
    • Year and Date
      2008-12-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] 血管内大細胞型B細胞リンパ腫に対するリツキシマプ治療(Treatment of intravascular large B-cell lymphoma in rituximab era)2008

    • Author(s)
      木下朝博
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] リツキシマプ治療抵抗症例におけるCD20蛋白発現様式の意義(Significance of CD20 protein expression pattern in ritucimab-resistant B-cell lymphoma cells)2008

    • Author(s)
      富田章裕
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] 血管内大細胞型B細胞リンパ腫に対するrituximab併用化学療法の有用性に関する検討2008

    • Author(s)
      島田和之
    • Organizer
      第70回日本血液学会総
    • Place of Presentation
      京都
    • Year and Date
      2008-10-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] リツキシマブ治療抵抗症例におけるCD20抗原発現と耐性機序の解析2008

    • Author(s)
      富田章裕
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] 未治療進行期低悪性度B-NHLに対するR-CHOP療法のランダム化第II相試験7年追跡結果2008

    • Author(s)
      森島泰雄
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] FDG-PETによる血管内大細胞型B細胞性リンパ腫における臓器浸潤の評価2008

    • Author(s)
      島田和之
    • Organizer
      第48回日本リンパ網内系学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2008-06-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] リツキシマブ治療抵抗症例におけるCD20抗原発現の解析2008

    • Author(s)
      杉本匠
    • Organizer
      第48回日本リンパ網内系学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2008-06-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] 新しいWHO悪性リンパ腫分類と今後の展開WHO悪性リンパ腫分類第4版のB細胞リンパ腫2008

    • Author(s)
      木下朝博
    • Organizer
      第48回日本リンパ網内系学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2008-06-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] Intravascular large B-CELL lymphoma (IVLBCL) : International consensus on diagnostic and therapeutic issues.2008

    • Author(s)
      Ponzoni, M.
    • Organizer
      International Conference on Malignant Lymphoma
    • Place of Presentation
      Lugano, Switzerland
    • Year and Date
      2008-06-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] A retrospective analysis of rituximab-containing chemotheraples for intravascular B-CELL lyraphoma.2008

    • Author(s)
      Matsue, K.
    • Organizer
      International Conference on Malignant Lymphoma
    • Place of Presentation
      Lugano, Switzerland
    • Year and Date
      2008-06-06
    • Related Report
      2008 Annual Research Report
  • [Book] 末梢性T細胞リンパ腫,非特定型、みんなに役立つ悪性リンパ腫の基礎と臨床2011

    • Author(s)
      木下朝博
    • Publisher
      医薬ジャーナル社
    • Related Report
      2010 Final Research Report
  • [Book] びまん性大細胞型B細胞リンパ腫、血液疾患最新の治療2011

    • Author(s)
      木下朝博
    • Publisher
      南江堂
    • Related Report
      2010 Final Research Report
  • [Book] 悪性リンパ腫の基礎と臨床2011

    • Author(s)
      木下朝博, 他
    • Publisher
      医薬ジャーナル社
    • Related Report
      2010 Annual Research Report
  • [Book] 悪性リンパ腫 疾病と治療II 消化器系/代謝・内分泌系/血液・造血器系/アレルギー/膠原病2010

    • Author(s)
      木下朝博
    • Publisher
      南江堂
    • Related Report
      2010 Final Research Report
  • [Book] 奏効例のエビデンスと抵抗例の治療は?(EBM がん科学療法・分子標的治療法)(MALT(mucosa-assosiated lymphoid tissue)リンパ腫に対するHelicobacter pylori除菌のエビデンス)2010

    • Author(s)
      木下朝博
    • Publisher
      中外医学社
    • Related Report
      2010 Final Research Report
  • [Book] Burkittリンパ腫(BL)、悪性リンパ腫‐診療ハンドブック‐2010

    • Author(s)
      木下朝博
    • Publisher
      南江堂
    • Related Report
      2010 Final Research Report
  • [Book] 濾胞性リンパ腫の治療、悪性リンパ腫2010

    • Author(s)
      木下朝博
    • Publisher
      中外医学社
    • Related Report
      2010 Final Research Report
  • [Book] 悪性リンパ腫2010

    • Author(s)
      木下朝博, 他
    • Publisher
      中外医学社
    • Related Report
      2010 Annual Research Report
  • [Book] 悪性リンパ腫-診療ハンドブック2010

    • Author(s)
      木下朝博, 他
    • Publisher
      南江堂
    • Related Report
      2010 Annual Research Report
  • [Book] 血液疾患最新の治療2011-20132010

    • Author(s)
      木下朝博、満間綾子, 他
    • Publisher
      南江堂
    • Related Report
      2010 Annual Research Report
  • [Book] EBM-がん化学療法・分子標的治療法2011-20122010

    • Author(s)
      木下朝博, 他
    • Publisher
      中外医学社
    • Related Report
      2010 Annual Research Report
  • [Book] 疾病と治療II2010

    • Author(s)
      木下朝博, 他
    • Publisher
      南江堂
    • Related Report
      2010 Annual Research Report
  • [Book] Cancer Treatment Navigator2008

    • Author(s)
      木下朝博
    • Publisher
      メディカルレビュ-社東京
    • Related Report
      2008 Annual Research Report
  • [Book] 講義録血液・造血器疾患学2008

    • Author(s)
      木下朝博
    • Publisher
      メジカルビュー社
    • Related Report
      2008 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi