Study on the molecular mechanisms of rituximab action and the enhancement of its actions
| Project/Area Number |
20591119
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Nagoya University |
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Principal Investigator |
KINOSHITA Tomohiro Nagoya University, 医学系研究科, 准教授 (60283446)
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| Co-Investigator(Kenkyū-buntansha) |
中村 栄男 名古屋大学, 大学院・医学系研究科, 教授 (80180363)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 悪性リンパ腫 / 分子標的治療 / モノクローナル抗体 / rituximab / エピジェネティクス / 分子不要時治療 |
|---|
| Research Abstract |
To investigate the molecular mechanisms of heterogeneity in rituximab efficacies, rituximab-sensitivities of cell lines established from patients with diffuse large B-cell lymphoma (DLBCL) were analyzed by ADCC and CDC assays. Tumor samples from patients with DLBCL were evaluated for their mutations on CD79B, CARD11 and EZH2, and their correlations with the prognoses of the patients were analyzed. In vitro sensitivity of DLBCL cell lines to rituximab showed no clear patterns with respect to their DLBCL subtypes. CD79B, CARD11 and EZH2 showed somatic mutations in several patients, and patients with mutated CARD11 genes showed significant poor prognoses.
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Report
(4 results)
Research Products
(116 results)
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[Journal Article] Cladribine combined with rituximab (R-2-CdA) therapy is an effective salvage therapy in relapsed or refractory indolent B-cell non-Hodgkin lymphoma.2011
Author(s)
Nagai H, Ogura M, Kusumoto S, Takahashi N, Yamaguchi M, Takayama N, Kinoshita T, Motoji T, Ohyashiki K, Kosugi H, Matsuda S, Ohnishi K, Omachi K, Hotta T.
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Journal Title
Eur J Hematol 86
Pages: 117-123
Related Report
Peer Reviewed
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[Journal Article] Pretreatment total serum protein is a significant prognostic factor for the outcome of patients with peripheral T/natural killer-cell lymphomas.2010
Author(s)
Watanabe T, Kinoshita T, Itoh K, Yoshimura K, Ogura M, Kagami Y, Yamaguchi M, Kurosawa M, Tsukasaki K, Kasai M, Tobinai K, Kaba H, Mukai K, Nakamura S, Ohshima K, Hotta T, Shimoyama M.
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Journal Title
Leuk Lymphoma 51
Pages: 813-821
Related Report
Peer Reviewed
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[Journal Article] Randomized phase II study of concurrent and sequential combinations of rituximab plus CHOP (cyclophosphamide, doxorubicin, vincristine and prednisolone) chemotherapy in untreated indolent B-cell non-Hodgkin lymphoma : 7-year follow-up results2010
Author(s)
Tobinai K, Ogura M, Itoh K, Kinoshita T, Hotta T, Watanabe T, Morishima Y, Igarashi T, Terauchi T, Ohashi Y.
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Journal Title
Cancer Sci. 101
Pages: 2579-2585
NAID
Related Report
Peer Reviewed
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[Journal Article] Prognostic factors for mature natural killer (NK) cell neoplasms : aggressive NK cell leukemia and extranodal NK cell lymphoma, nasal type.2010
Author(s)
Suzuki R, Suzumiya J, Yamaguchi M, Nakamura S, Kameoka J, Kojima H, Abe M, Kinoshita T,, Yoshino T, Iwatsuki K, Kagami Y, Tsuzuki T, Kurokawa M, Ito K, Kawa K, Oshimi K
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Journal Title
Ann Oncol 21
Pages: 1032-1040
Related Report
Peer Reviewed
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[Journal Article] Central nervous system involvement in intravascular large B-cell lymphoma: a retrospective analysis of 109 patients.2010
Author(s)
Shimada K, Murase T, Matsue K, Okamoto M, Ichikawa N, Tsukamoto N, Niitsu N, Miwa H, Asaoku H, 小杉浩史, Kikuchi A, Matsumoto M, Saburi Y, Masaki Y, Yamamoto K, Yamaguchi M, Nakamura S, Naoe T, Kinoshita T
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Journal Title
Cancer Sci. 101
Pages: 1480-1486
NAID
Related Report
Peer Reviewed
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[Journal Article] Phase II study of ABVd therapy for newly diagnosed clinical stage II-IV Hodgkin lymphoma : Japan Clinical Oncology Group study (JCOG 9305)2010
Author(s)
Ogura M, Itoh K, Kinoshita T, Fukuda H, Takenaka T, Ohtsu T, Kagami Y, Tobinai K, Okamoto M, Asaoku H, Sasaki T, Mikuni C, Hirano M, Chou T, Ohnishi K, Ohno H, Nasu K, Okabe K, Ikeda S, Nakamura S, Hotta T, Shimoyama M.
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Journal Title
Int J Hematol. 92
Pages: 713-724
NAID
Related Report
Peer Reviewed
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[Journal Article] Prognostic analysis and a new risk model for Hodgkin lymphoma in Japan.2010
Author(s)
Itoh K, Kinoshita T, Watanabe T, yoshimura K, Okamoto R, Chou T, Ogura M, Hirano M, Asaoku H, Kurosawa M, Maeda Y, Omachi K, Moriuchi Y, Kasai M, Ohnishi K, Takayama N, Morishima Y, Tobinai K, Kaba H, Yamamoto S, Fukuda H, Kikuchi M, Yoshino T, Matsuno Y, Hotta T, Shimoyama M.
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Journal Title
Int J Hematol 91
Pages: 446-455
NAID
Related Report
Peer Reviewed
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[Journal Article]2010
Author(s)
島田和之、木下朝博
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Journal Title
Annual Review血液2010(中外医学社)
Pages: 119-123
Related Report
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[Journal Article]2009
Author(s)
木下朝博
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Journal Title
血液疾患診療ハンドブック-診療の手引きと臨床データ集 改訂版(南江堂)
Pages: 363-386
Related Report
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[Journal Article]2009
Author(s)
満間綾子、木下朝博
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Journal Title
現場で役立つ血液腫瘍治療プロトコール集(医薬ジャーナル社)
Pages: 114-122
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