Development of antibody-conjugatedβ-catenin siRNA therapy against multiple myeloma

• Project/Area Number: 20591121
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hematology
• Research Institution: Kyoto University
• Principal Investigator: ASHIHARA Eishi Kyoto University, 医学研究科, 講師 (70275197)
• Co-Investigator(Kenkyū-buntansha): MAEKAWA Taira 京都大学, 大学院・医学研究科, 教授 (80229286) ; KIMURA Shinya 佐賀大学, 医学部, 教授 (80359794)
• Co-Investigator(Renkei-kenkyūsha): SHIMAZAKI Chihiro 京都府立医科大学, 大学院・医学研究科, 講師 (50170931)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 多発性骨髄腫 / siRNA / β-catenin / CD138 / RNA干渉 / 分子標的

Research Abstract

β-catenin silencing is explored as a novel therapeutic target against multiple myeloma (MM). β-catenin protein is overexpressed in human MM cell lines as well as CD138-positive MM cells obtained from patients. The treatment of β-catenin siRNA with atelocollagen significantly inhibited the proliferation of MM cells in a MM-bearing mouse model. Furthermore, we have developed antibody-conjugated oligo-RNAs. It is suggested that these findings will enable to develop siRNA drugs against MM in the near future.

Research Products

• [Journal Article] Single-step, label-free quantification of antibody in human serum for clinical applications based on localized surface plasmon resonance. (2011)
  • Author(s): Yamamichi J
  • Journal Title: Nanomedicine Volume: (In press)
  • Peer Reviewed
• [Journal Article] Combined effects of novel heat shock protein 90 inhibitor NVP-AUY922 and nilotinib in a random mutagenesis screen. (2011)
  • Author(s): Tauchi T
  • Journal Title: Oncogene Volume: (In press)
  • Peer Reviewed
• [Journal Article] Targeting the Wnt/β-catenin signaling pathway in human cancers. (2011)
  • Author(s): Yao H
  • Journal Title: Expert Opinion on Therapeutic Targets Volume: (In press)
  • Peer Reviewed
• [Journal Article] Rakicidin A effectively induces apoptosis in hypoxia adapted Bcr-Abl positive leukemic cells. (2011)
  • Author(s): Takeuchi M
  • Journal Title: Cancer Sci Volume: 102 Pages: 591-596
  • Peer Reviewed
• [Journal Article] RNA Interference against Polo-like kinase-1 in advanced non-small cell lung cancers. (2011)
  • Author(s): Kawata E
  • Journal Title: J Clin Bioinformatics Volume: 1
  • Peer Reviewed
• [Journal Article] Allograft inflammatory factor-1 is overexpreessed and induces fibroblast chemotaxis in the skin of sclerodermatous GVHD in a murine model. (2011)
  • Author(s): Yamamoto A
  • Journal Title: Immunol Lett Volume: 135 Pages: 144-150
  • Peer Reviewed
• [Journal Article] Galection-9 ameliorates acute Graft-versus-host disease through the induction of T-cell apoptosis (2011)
  • Author(s): Sakai K
  • Journal Title: Eur J Imunol Volume: 41 Pages: 67-75
  • Peer Reviewed
• [Journal Article] Future Prospect of RNA interference for cancer therapies. (2010)
  • Author(s): Ashihara E, Kawata E, Maekawa T
  • Journal Title: Curr Drug Targets 11 Pages: 345-360
  • NAID: 10025634713
  • Peer Reviewed
• [Journal Article] RNA干渉を用いたがん治療 (2010)
  • Author(s): 芦原英司
  • Journal Title: 癌と化学療法 37 Pages: 2033-2041
• [Journal Article] A combination of a DNA-chimera siRNA against PLK-1 and zoledronic acid suppresses the growth of malignant mesothelioma cells in vitro. (2010)
  • Author(s): Kawata E, Ashihara E, Nakagawa Y, Kiuchi T, Ogura M, Yao H, Sakai K, Tanaka R, Nagao R, Yokota A, Takeuchi M, Kimura S, Hirai H, Maekawa T.
  • Journal Title: Cancer Lett 294 Pages: 245-253
  • NAID: 120002462958
  • Peer Reviewed
• [Journal Article] Anti-myeloma activity of modified galectin-9 through JNK and p38 MAPK pathways. (2010)
  • Author(s): Kobayashi T, Kuroda J, Ashihara E, Terui Y, Oomizu S, Yamamoto M, Taniyama A, Matsumoto Y, Horiike S, Hatake K, Yamauchi A, Hirashima M, Taniwaki F.
  • Journal Title: Leukemia 24 Pages: 843-850
  • Peer Reviewed
• [Journal Article] Loxoprofen Sodium, a Non-Selective NSAID, Reduces Atherosclerosis in Mice by Reducing Inflammation. (2010)
  • Author(s): Hamaguchi M
  • Journal Title: J Clin Biochem Nutr Volume: 47 Pages: 138-147
  • Peer Reviewed
• [Journal Article] Combined effects of bisphosphonate and radiation on osteosarcoma cells. (2010)
  • Author(s): Ryu K
  • Journal Title: Anticancer Res Volume: 30 Pages: 2713-2720
  • Peer Reviewed
• [Journal Article] Activity of the multi-targeted kinase inhibitor, AT9283, in imatinib-resis tant BCR-ABL positive leukemic cells. (2010)
  • Author(s): Tanaka R
  • Journal Title: Blood Volume: 116 Pages: 2089-2095
  • Peer Reviewed
• [Journal Article] Zoledronic acid inhibits proliferation of human fibrosarcoma cells with induction of apoptosis, and shows combined effects with other anticancer agents. (2010)
  • Author(s): Koto K
  • Journal Title: Oncol Rep Volume: 24 Pages: 233-239
  • Peer Reviewed
• [Journal Article] Noninvasive tracking of donor cell homing by near-infrared fluorescence imaging shortly after bone marrow transplantation. (2010)
  • Author(s): Ushiki T
  • Journal Title: PLoS One Volume: 5
  • Peer Reviewed
• [Journal Article] A combination of a DNA-chimera siRNA against PLK-1 and zoledronicacid suppresses the growth of malignant mesothelioma cells in vitro. (2010)
  • Author(s): Kawata E
  • Journal Title: Cancer Lett Volume: 294 Pages: 245-253
  • Peer Reviewed
• [Journal Article] RNA干渉による造血器悪性腫瘍治療 (2010)
  • Author(s): 芦原英司
  • Journal Title: 京都府立医科大学雑誌 Volume: 119 Pages: 729-746
• [Journal Article] RNA干渉を用いたがん治療 (2010)
  • Author(s): 芦原英司
  • Journal Title: 癌と化学療法 Volume: 37 Pages: 2033-2041
• [Journal Article] Future Prospect of RNA interference for cancer therapies. (2010)
  • Author(s): Ashihara E
  • Journal Title: Curr Drug Targets 11 Pages: 345-360
  • NAID: 10025634713
  • Peer Reviewed
• [Journal Article] Anti-myeloma activity of modified galectin-9 through JNK and p38 MAPK pathways (2010)
  • Author(s): Kobayashi T
  • Journal Title: Leukemia (In press)
  • Peer Reviewed
• [Journal Article] Use of bicistronic vectors in combination with flow cytometry to screen for effective small interfering RNA target sequences. (2010)
  • Author(s): Kamio N
  • Journal Title: Biochem Biophys Res Commun 393 Pages: 498-503
  • Peer Reviewed
• [Journal Article] A combination of a DNA-chimera siRNA against PLK-1 and zoledronicacid suppresses the growth of malignant mesothelioma cells in vitro. (2010)
  • Author(s): Kawata E
  • Journal Title: Cancer Lett (In press)
  • Peer Reviewed
• [Journal Article] β-catenin siRNA successfully suppressed progression of multiple myeloma in a mouse model. (2009)
  • Author(s): Ashihara E, Kawata E, Nakagawa Y, Shimazaki C, Kuroda J, Taniguchi T, Uchiyama H, Tanaka R, Yokota A, Takeuchi M, Kamitsuji Y, Inaba T, Taniwaki M, Kimura S, Maekawa T
  • Journal Title: Clin Cancer Res 15 Pages: 2731-2738
  • Peer Reviewed
• [Journal Article] β-catenin siRNA successfully suppressed progression of multiple myeloma in a mouse model. (2009)
  • Author(s): Ashihara E
  • Journal Title: Clin Cancer Res 15 Pages: 2731-2738
  • Peer Reviewed
• [Journal Article] RNA干渉を用いたがん治療の可能性 (2009)
  • Author(s): 芦原英司
  • Journal Title: 臨床血液(教育講演特集号) 50 Pages: 1577-1588
  • NAID: 10025634713
• [Journal Article] Modified ELISPOT assay may predict T-cell hyporesponsiveness to non-inherited maternal antigens. (2009)
  • Author(s): Taniguchi K
  • Journal Title: Int J Lab Hematol (in press)
  • Peer Reviewed
• [Journal Article] Risk Factors for Recurrence of Primary Sderosing Cholangitis After Living Donor Liver Transplantation : A Single Center Experience. (2009)
  • Author(s): Egawa H
  • Journal Title: Dig Dis Sci 32(in press)
  • Peer Reviewed
• [Journal Article] A novel method to isolate mesenchymal stem cells from bone marrow in a closed system using a device made by non-woven fabric。 (2009)
  • Author(s): Ito K
  • Journal Title: Tissue Eng Part C Methods (in press)
  • Peer Reviewed
• [Journal Article] Dual BCR/ABL tyrosine kinase inhibitor, INNO-406. (2009)
  • Author(s): Takeuchi M
  • Journal Title: Drug of the Future (in press)
  • Peer Reviewed
• [Journal Article] JAK2V617F-positive essential thrombocythemia and multiple myeloma with IGH/CCND1 gene translocation co-exits, but originate from separate clones. (2008)
  • Author(s): Kuroda J, Matsumoto Y, Tanaka R, Kurita K, Kobayashi T, Shimizu D, Kimura S, Shimazaki C, Horiike S, Shimazaki C, Taniwaki M.
  • Journal Title: Acta Haematol 120 Pages: 177-181
  • Peer Reviewed
• [Journal Article] Anti-myeloma effect of homoharringtonine with concomitant targeting of the myeloma-promoting molecules, Mcl-1, XIAP, and beta-catenin. (2008)
  • Author(s): Kuroda J, Kamitsuji Y, Kimura S, Ashihara E, Kawata E, Nakagawa Y, Takeuichi M, Murotani Y, Yokota A, Tanaka R, Andreeff M, Taniwaki M, Maekawa T.
  • Journal Title: Int J Hematol 87 Pages: 507-515
  • Peer Reviewed
• [Journal Article] Administration of PLK-1 small interfering RNA with atelocollagen prevents the growth of liver metastases of lung cancer. (2008)
  • Author(s): Kawata E, Ashihara E, Kimura S, Takenaka K, Sato K, Tanaka R, Yokota A, Kamitsuji Y, Takeuchi M, Kuroda J, Tanaka F, Yoshikawa T, Maekawa T.
  • Journal Title: Mol Cancer Ther 7 Pages: 2904-2912
  • Peer Reviewed
• [Journal Article] Administration of PLK-1 small interfering RNA with atelocollagen prevents the growth of liver metastases of lung cancer. (2008)
  • Author(s): Kawata E
  • Journal Title: Mol Cancer Ther 7 Pages: 2904-2912
  • Peer Reviewed
• [Journal Article] Fully automated and super-rapid system for the detection of JAK2V617F mutation. (2008)
  • Author(s): Tanaka R
  • Journal Title: Leuk Res 32 Pages: 1462-1467
  • Peer Reviewed
• [Journal Article] ABT-737 is a useful component of combinatory chemotherapies for chronic myelogenous leukaemias with diverse drug resistance mechanisms. (2008)
  • Author(s): Kuroda J
  • Journal Title: Br J Haematol 140 Pages: 181-190
  • Peer Reviewed
• [Journal Article] Skeletal muscle-derived progenitors capable of differentiating into cardiomyocytes proliferate through myostatin-independent TGF-beta family signaling. (2008)
  • Author(s): Nomura T
  • Journal Title: Biochem Biophys Res Commun 365 Pages: 863-869
  • Peer Reviewed
• [Journal Article] Comparison of imatinib, dasatinib, nilotinib and INNO-406 in imatinib-resistant cell lines. (2008)
  • Author(s): Deguchi Y
  • Journal Title: Luek Res 32 Pages: 980-983
  • Peer Reviewed
• [Journal Article] Kinetics of circulating endothelial progenitors in patients with sclerodermatous chronic graft-versus-host disease. (2008)
  • Author(s): Shimura K
  • Journal Title: Biol Blood Marrow Transplant 14 Pages: 426-437
  • Peer Reviewed
• [Journal Article] Consulting clinic for related family donors in hematopoietic stem cell transplantation. (2008)
  • Author(s): Muramatsu H
  • Journal Title: Bone marrow Transplant 41 Pages: 1073-1075
  • Peer Reviewed
• [Journal Article] Anti-myeloma effect of homoharringtonine with concomitant targeting of the myeloma-promoting molecules, Mcl-1, XIAP, and beta-catenin. (2008)
  • Author(s): Kuroda J
  • Journal Title: Int J Hematol 87 Pages: 507-515
  • Peer Reviewed
• [Journal Article] The Bcr-Abl kinase inhibitor INNO-406 induces autophagy and different modes of cell death execution in Bcr-Abl-positive leukemias. (2008)
  • Author(s): Kamitsuji Y
  • Journal Title: Cell Death Differ 15 Pages: 1712-1722
  • Peer Reviewed
• [Journal Article] Predictive parameters for granulocyte colony-stimulating factor-induced peripheral blood stem cell mobilization. (2008)
  • Author(s): Okano A
  • Journal Title: J Clin Apher 23 Pages: 171-177
  • Peer Reviewed
• [Journal Article] JAK2V617F-positive essential thrombocythemia and multiple myeloma with IGH/CCNDl gene translocation co-exits, but originate from separate clones. (2008)
  • Author(s): Kuroda J
  • Journal Title: Acta Haematol 120 Pages: 177-181
  • Peer Reviewed
• [Journal Article] Intravesical administration of gammadelta T cells successfully prevents the growth of bladder cancer in the murine model. (2008)
  • Author(s): Yuasa T
  • Journal Title: Cancer Immunol Immunother 58 Pages: 493-502
  • Peer Reviewed
• [Journal Article] Targeting the Wnt/β-catenin signaling pathway in human cancers.
  • Author(s): Yao H, Ashihara E, Maekawa T
  • Journal Title: Expert Opinion on Therapeutic Targets in press
  • Peer Reviewed
• [Presentation] 多発性骨髄腫に対する新規Wnt/β-cateninシグナル阻害剤の抗腫瘍効果 (2010)
  • Author(s): 八尾尚幸、芦原英司、平位秀世、前川平
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-22
• [Presentation] 多発性骨髄腫に対する新規Wnt/β-cateninシグナル阻害剤の抗腫瘍効果 (2010)
  • Author(s): 八尾尚幸
  • Organizer: 第11回がん若手研究ワークショップ
  • Place of Presentation: 茅野市
  • Year and Date: 2010-09-02
• [Presentation] A combination of a DNA-chimera siRNA against PLK-1 and zoledronic acid suppresses the growth of malignant mesothlioma cells in vitro. (2010)
  • Author(s): Kawata T, Ashihara E, Hirai H, Maekawa T
  • Organizer: 第16回日本遺伝子治療学会年次学術集会
  • Place of Presentation: 栃木
  • Year and Date: 2010-07-02
• [Presentation] A flow cytometry-based method for screening of effective small interfering RNA target sequences. (2010)
  • Author(s): Kamio N
  • Organizer: 第16回日本遺伝子治療学会年次学術集会
  • Place of Presentation: 栃木
  • Year and Date: 2010-07-02
• [Presentation] A combination of a DNA-chimera siRNA against PLK-1 and zoledronicacid suppresses the growth of malignant mesothlioma cells in vitro. (2010)
  • Author(s): Kawata E
  • Organizer: 第16回日本遺伝子治療学会年次学術集会
  • Place of Presentation: 栃木
  • Year and Date: 2010-07-02
• [Presentation] Combined effects of the Hedgehog pathway inhibitor LDE225 and nilotinib in a random mutagenesis screen. (2010)
  • Author(s): Tauchi T
  • Organizer: The 52^<nd> American Society of Hematology Annual Meeting and Exposition.
  • Place of Presentation: 米国、オーランド
• [Presentation] Isopentenyl Pyrophosphate (IPP), a Metabolite produced in Myeloma Cells Induces the Chemotaxis of yδT Cells. (2010)
  • Author(s): Ashihara E
  • Organizer: The 52^<nd> American Society of Hematology Annual Meeting and Exposition.
  • Place of Presentation: 米国、オーランド
• [Presentation] Candidemia-Induced Emergency Granulopoiesis Consists of Successive Dual Waves Triggered by the Shift From C/EBPalpha to C/EBPbeta Dependency. (2010)
  • Author(s): Satake S
  • Organizer: The 52^<nd> American Society of Hematology Annual Meeting and Exposition.
  • Place of Presentation: 米国、オーランド
• [Presentation] A Novel Automated Assay for the Detection of BCR-ABL Kinase Domain Mutations (2010)
  • Author(s): Tanaka R
  • Organizer: The 52^<nd> American Society of Hematology Annual Meeting and Exposition.
  • Place of Presentation: 米国、オーランド
• [Presentation] Anti-myeloma activity of modified galectin-9 through JNK and p38 MAPK pathways. (2009)
  • Author(s): Kobayashi T
  • Organizer: e 51^<st> American Society of Hematology Annual Meeting and Exposition
  • Place of Presentation: ニューオーリンズ、米国
  • Year and Date: 2009-12-08
• [Presentation] Inhibition of Wnt/β-Catenin Signaling by AV65 Treatment Caused Cell Cycle Arrest and Induced Caspase-Independent or -Dependent Apoptosis in CML Cells. (2009)
  • Author(s): Nagao R
  • Organizer: The 51^<st> American Society of Hematology Annual Meeting and Exposition
  • Place of Presentation: ニューオーリンズ、米国
  • Year and Date: 2009-12-06
• [Presentation] AV-65, a Novel Inhibitor of the Wnt/β-catenin Signaling Pathway, Inhibits the Proliferation of Myeloma Cells. (2009)
  • Author(s): Yao H
  • Organizer: The 51^<st> American Society of Hematology Annual Meeting and Exposition
  • Place of Presentation: ニューオーリンズ、米国
  • Year and Date: 2009-12-05
• [Presentation] RNA干渉を用いたがん治療の可能性. (2009)
  • Author(s): 芦原英司
  • Organizer: 第71回日本血液学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2009-10-25
• [Presentation] 多発性骨髄腫に対する新規Wnt/b-cateninシグナル阻害剤 の抗腫瘍効果. (2009)
  • Author(s): 八尾尚幸
  • Organizer: 第71回日本血液学会学術総会
  • Place of Presentation: 京都
  • Year and Date: 2009-10-24
• [Presentation] 多発性骨髄腫に対する新規Wnt/β-cateninシグナル阻害剤の抗腫瘍効果 (2009)
  • Author(s): 八尾尚幸、芦原英司、長尾里奈、武内美紀、田中瑠璃子、横田明日美、平位秀世、前川平
  • Organizer: 第71回日本血液学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2009-10-23
• [Presentation] 新規β-catenin阻害剤AV65の、イマチニブ耐性CML細胞株に対する増殖阻害効果. (2009)
  • Author(s): 長尾里奈
  • Organizer: 第71回日本血液学会学術総会
  • Place of Presentation: 京都
  • Year and Date: 2009-10-23
• [Presentation] RNA干渉によるがん治療の開発 (2009)
  • Author(s): 芦原英司
  • Organizer: 第18回日本アポトーシス研究会・学術集会 シンポジウム
  • Place of Presentation: 長崎
  • Year and Date: 2009-08-01
• [Presentation] RNA干渉によるがん治療の開発 (2009)
  • Author(s): 芦原英司
  • Organizer: 第18回日本アポトーシス研究会・学術集会
  • Place of Presentation: 長崎
  • Year and Date: 2009-08-01
• [Presentation] 多発性骨髄腫に対する新規Wnt/β-cateninシグナル阻害剤の抗腫瘍効果. (2009)
  • Author(s): 八尾尚幸
  • Organizer: 第13回日本がん分子標的治療学会学術集会
  • Place of Presentation: 徳島
  • Year and Date: 2009-06-26
• [Presentation] 各種イマチニブ耐性CML細胞株に対する新規β-catenin阻害剤AV65の増殖阻害効果. (2009)
  • Author(s): 長尾里奈
  • Organizer: 第13回日本がん分子標的治療学会学術集会
  • Place of Presentation: 徳島
  • Year and Date: 2009-06-26
• [Presentation] AV-65, a Novel inhibitor of the Wnt/β-catenin signaling pathway, inhibits the proliferation of myeloma cells. (2009)
  • Author(s): Yao H, Ashihara E, Nagao R, Kimura S, Hirai H, Strovel JW, Padia J, Cholody WM, Maekawa T
  • Organizer: The 51st American Society of Hematology Annual Meeting and Exposition
  • Place of Presentation: New Orleans, USA.
• [Presentation] Roles of Osteoclasts in Leukemic Cells. (2008)
  • Author(s): Yokota A
  • Organizer: The American Society of Hematology 50th Annual Meeting and Exposition
  • Place of Presentation: アメリカ・サンフランシスコ
  • Year and Date: 2008-12-08
• [Presentation] Glyoxalase-I inhibition eliminates hypoxia-adapted CML cells resistant to imatinib, dasatinib, and INNO-406. (2008)
  • Author(s): Takeuchi M
  • Organizer: The American Society of Heraatology 50th Annual Meeting and Exposition
  • Place of Presentation: アメリカ・サンフランシスコ
  • Year and Date: 2008-12-08
• [Presentation] A novel beta-catenin inhibitor, AV65 suppresses the growth of CML cell lines which acquire imatinib-resistance because of Abl kinase domain mutations including T315I and hypoxia-adaptation. (2008)
  • Author(s): Nagao R
  • Organizer: The American Society of Hematology 50th Annual Meeting and Exposition
  • Place of Presentation: アメリカ・サンフランシスコ
  • Year and Date: 2008-12-06
• [Presentation] Activity of the Multi-Targeted Kinase Inhibitor, AT9283 on Imatinib-Resistant CML Models. (2008)
  • Author(s): Tanaka R
  • Organizer: The American Society of Hematology 50th Annual Meeting and Exposition
  • Place of Presentation: アメリカ・サンフランシスコ
  • Year and Date: 2008-12-06
• [Presentation] 京大病院における過去5年間の新鮮凍結血漿使用量の推移 (2008)
  • Author(s): 万木紀美子
  • Organizer: 第52回日本輸血・細胞治療学会近畿支部総会
  • Place of Presentation: 奈良
  • Year and Date: 2008-11-29
• [Presentation] Homoharringtonineのアポトーシス抵抗性分子多重阻害による抗骨髄腫細胞効果 (2008)
  • Author(s): 黒田純也
  • Organizer: 第38回日本骨髄腫研究会総会
  • Place of Presentation: 広島
  • Year and Date: 2008-11-15
• [Presentation] 多発性骨髄腫に対する新規Wnt/β-cateninシグナル阻害剤AV-65の抗腫瘍効果 (2008)
  • Author(s): 八尾尚幸
  • Organizer: 第38回日本骨髄腫研究会総会
  • Place of Presentation: 広島
  • Year and Date: 2008-11-15
• [Presentation] JAK2V617F陽性本態性血小板増加症に合併したTGH/CCND1陽性JAK2V617F陰性多発性骨髄腫 : 造血器腫瘍重複における異クローン性の証明 (2008)
  • Author(s): 古林勉
  • Organizer: 第38回日本骨髄腫研究会絵会
  • Place of Presentation: 広島
  • Year and Date: 2008-11-15
• [Presentation] γδT細胞による細胞免疫療法の基礎 (2008)
  • Author(s): 芦原英司
  • Organizer: 第4回東京骨髄腫講演会
  • Place of Presentation: 東京
  • Year and Date: 2008-10-17
• [Presentation] 同種造血幹細胞移植後の閉塞性細気管支炎症例における末梢血血管内皮前駆細胞の動態 (2008)
  • Author(s): 芦原英司
  • Organizer: 第70回日本血液学会
  • Place of Presentation: 京都
  • Year and Date: 2008-10-12
• [Presentation] 破骨細胞かin vitroとin vivoでBa/F3 wt bcr-ablの細胞増殖に与える影響- (2008)
  • Author(s): 横田明日美
  • Organizer: 第70回日本血液学会
  • Place of Presentation: 京都
  • Year and Date: 2008-10-12
• [Presentation] 新規Bcr-Abl阻害剤INNO-406によるbcr-abl陽性白血病細胞株に対する細胞死誘導 (2008)
  • Author(s): 上辻由里
  • Organizer: 第70回日本血液学会
  • Place of Presentation: 京都
  • Year and Date: 2008-10-10
• [Presentation] 低酸素環境適応性CML細胞に対するGlyoxalase-1阻害時の効果 (2008)
  • Author(s): 武内美紀
  • Organizer: 第70回日本血液学会
  • Place of Presentation: 京都
  • Year and Date: 2008-10-10
• [Presentation] 新規Auroraキナーゼ阻害剤AT9283のBCR-ABL/T315Iに対する効果 (2008)
  • Author(s): 田中瑠璃子
  • Organizer: 第70回日本血液学会
  • Place of Presentation: 京都
  • Year and Date: 2008-10-10
• [Presentation] ガレクチン-9による急性GVHD抑制効果 (2008)
  • Author(s): 河田英里
  • Organizer: 第32回京都造血幹細胞移植研究会
  • Place of Presentation: 京都
  • Year and Date: 2008-10-03
• [Presentation] β-catenin siRNAによる骨髄腫増殖抑制効果 (2008)
  • Author(s): 木村晋也
  • Organizer: 第16回京都がん研究会
  • Place of Presentation: 京都
  • Year and Date: 2008-09-12
• [Presentation] β-catenin siRNAによる骨髄腫増殖抑制効果 (2008)
  • Author(s): 芦原英司、河田英里、黒田純也、木村晋也、前川平
  • Organizer: 第12回がん分子標的治療研究会
  • Place of Presentation: 東京
  • Year and Date: 2008-06-26
• [Presentation] 新規ABL阻害剤INNO-406の開発状況 (2008)
  • Author(s): 本村晋也
  • Organizer: 第12回がん分子標的治療研究会
  • Place of Presentation: 東京
  • Year and Date: 2008-06-26
• [Presentation] がんの診断および治療に関与する点突然変異の超迅速・全自動検出法開発 (2008)
  • Author(s): 田中瑠璃子
  • Organizer: 第12回がん分子標的治療研究会
  • Place of Presentation: 東京
  • Year and Date: 2008-06-26
• [Presentation] 慢性骨髄性白血病細胞の低酸素環境適応におけるGlyoxalase-1の重要性 (2008)
  • Author(s): 武内美紀
  • Organizer: 第12回がん分子標的治療研究会
  • Place of Presentation: 東京
  • Year and Date: 2008-06-26
• [Presentation] マウス正所性膀胱がんモデルに対するγδT細胞局所注入療法 (2008)
  • Author(s): 木村晋也
  • Organizer: 第12回京都分子血液フォーラム
  • Place of Presentation: 京都
  • Year and Date: 2008-06-21
• [Presentation] ABO式血液型不適合同種造血幹細胞移植後の輸血量と抗A、抗B抗体残存期間の検討 (2008)
  • Author(s): 万木紀美子
  • Organizer: 第56回日本輸血・細胞治療学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2008-04-27
• [Presentation] A FACS-based method for screening of effective small interfering RNA target sequences.
  • Author(s): Kamio N
  • Organizer: Joint Symposium of the 5^<th> Annual Meeting of the Oligonucleotide Therapeutics Society and the 19th Antisense Symposium.
  • Place of Presentation: 福岡
• [Book] 遺伝子MOOK15最新RNAと疾患研究 (2009)
  • Author(s): 芦原英司、前川平
  • Publisher: メディカルドゥ
• [Book] 最新RNAと疾患研究2009. (2009)
  • Author(s): 芦原英司
  • Total Pages: 206
  • Publisher: メディカルドウ
• [Book] ナーシング・グラフィカ (2008)
  • Author(s): 芦原英司
  • Total Pages: 5
  • Publisher: イーエックス
• [Book] がんの分子標的治療 (2008)
  • Author(s): 前川平
  • Total Pages: 8
  • Publisher: 南山堂
• [Book] BLOOD MASTER-血液疾患症例に学ぶ- (2008)
  • Author(s): 芦原英司
  • Total Pages: 12
  • Publisher: インターメディカ
• [Remarks] ホームページ等
  • URL: http://www.kuhp.kyoto-u.ac.jp/~dtm/index.html
• [Remarks]
  • URL: http://www.kuhp.kyoto-u.ac.jp/~dtm/index.html
• [Remarks]
  • URL: http://kpum-molecular-cell-physiology.info/
• [Remarks]
  • URL: http://www.kuhp.kyoto-u.ac.jp/~dtm/index.html
• [Remarks]
  • URL: http://www.kuhp.kyoto-u,ac.jp/~dtm/index.html
• [Patent(Industrial Property Rights)] 細胞培養容器及びその容器を用いた細胞培養方法 (2010)
  • Inventor(s): 務中達也、阿部浩久、叶井正樹、明地将一、前川平、木村晋也、芦原英司、庄子習一、川合健太郎
  • Industrial Property Rights Holder: 島津製作所、京都大学、早稲田大学
  • Industrial Property Number: 2010-200679
  • Filing Date: 2010-09-08
• [Patent(Industrial Property Rights)] 細胞運動評価用マイクロ反応装置 (2009)
  • Inventor(s): 務中達也、阿部浩久、叶井正樹、前川平、木村晋也、芦原英司、庄子習一
  • Industrial Property Rights Holder: 島津製作所、京都大学、早稲田大学
  • Industrial Property Number: 2009-148339
  • Filing Date: 2009-06-23