Molecular pathogenesis of abnormal kpm (Lats2) expression in leukemia
| Project/Area Number |
20591122
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Ritsumeikan University |
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Principal Investigator |
HORI Toshiyuki Ritsumeikan University, 生命科学部, 教授 (70243102)
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| Co-Investigator(Renkei-kenkyūsha) |
KAWAMATA Shin 先端医療振興財団, 先端医療センター研究所, 専門役 (00360842)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 癌 / 白血病 / シグナル伝達 / Hippo経路 / kpm(Lats2) / 薬剤耐性 / RASSF / 薬剤反応性 |
|---|
| Research Abstract |
Kpm (Lats2) is a serine-threonine kinase that is one of the core components of the Hippo signaling pathway. We measured expression levels of kpm (Lats2) in various leukemias and found that expression of kpm was downregulated in refractory leukemias. Knockdown of kpm (Lats2) rendered leukemic cells resistant to anti-cancer drugs. We demonstrated that stabilization of nuclear p73 after DNA damage and subsequent induction of PUMA and p21 require phosphorylation of YAP2 at serine-127 by Kpm (Lats2). Thus, downregulation of kpm (Lats2) seems to be one of the mechanisms for chemoresistance.
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] TSLP fosters human breast cancer tumor development by promoting type 2 inflammation.2011
Author(s)
Alexander Pedroza-Gonzalez1, Kangling Xu, Te-Chia Wu, Caroline Aspord, Sasha Tindle, Florentina Marches, Michael Gallegos, Elizabeth C. Burton, Daniel Savino, Toshiyuki Hori, Yuetsu Tanaka, Sandra Zurawski, Gerard Zurawski, Laura Bover, Yong-Jun Liu, Jacques, Banchereau, A.Karolina Palucka
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Journal Title
J.Exp.Med. 208
Pages: 479-490
Related Report
Peer Reviewed
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[Journal Article] Mycophenolate mofetil combined with tacrolimus and minidose methotrexate after unrelated donor bone marrow transplantation with reduced-intensity conditioning.2009
Author(s)
Chisaki Mizumoto, Junya Kanda, Tatsuo Ichinohe, Takayuki Ishikawa, Masashi Matsui, Norimitsu Kadowaki, Tadakazu Kondo, Kazunori, Imada, Masakatsu Hishizawa, Hiroshi Kawabata, Momoko Nishikori, Kouhei Yamashita, Akifumi Takaori-Kondo, Toshiyuki Hori, Takashi Uchiyama
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Journal Title
Int.J.Hematol. 89
Pages: 538-545
NAID
Related Report
Peer Reviewed
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[Presentation] Poor tolerability to imatinib in elderly CML patients may lead to inadequate responses.2010
Author(s)
Masatoshi Nishikawa, Tadakazu Kondo, Masakatsu Hishizawa, Momoko Nishikori, Kohei Yamashita, Toshiyuki Kitano, Tatsuo Ichinohe, Hiroshi Kawabata, Akifumi Takaori, Norimitsu Kadowaki, Toshiyuki Hori, Hiroshi Takayama, Takayuki Ishikawa, Takashi Uchiyama
Organizer
第72回日本血液学会総会
Place of Presentation
パシフィコ横浜(神奈川県)
Year and Date
2010-09-26
Related Report
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