Growth and differentiation of hematopoietic tumor cells through transcriptional Mediator complex
Project/Area Number |
20591125
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Hematology
|
Research Institution | Kobe University |
Principal Investigator |
ITO Mitsuhiro Kobe University, 大学院・保健学研究科, 教授 (50362794)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 血液内科学 / 転写メディエーター / MED1 / TRAP220 / MED1/TRAP220 / 赤芽球分化 / GATA-1 / K562 / 核内受容体 / コアクチベーター / RNAポリメラーゼIIホロ酵素 |
Research Abstract |
The transcriptional Mediator complex, subcomplex of the RNA polymerase II holoenzyme complex, ultimately integrates many intracellular signals and conveys these signals to the RNA polymerase II core enzyme complex. In this study, we have shown that the Mediator subunit MED1 plays an important role in malignant, as well as normal, hematopoietic cell differentiation as a specific coactivator for nuclear receptors and GATA1, key activators for hematopoiesis. MED1 appears to promote proliferation of these cells as well. We also propose the molecular mechanisms underlying these processes.
|
Report
(4 results)
Research Products
(84 results)
-
-
[Journal Article] Transcriptional Mediator subunit MED1/TRAP220 in stromal cells is involved in hematopoietic stem/progenitor cell support through osteopontin expression.2010
Author(s)
A.Sumitomo, R.Ishino, N.Urahama, K.Inoue, K.Yonezawa, N.Hasegawa, O.Horie, H.Matsuoka, T.Kondo, R.G.Roeder, M.Ito
-
Journal Title
Mol.Cell.Biol. 30
Pages: 4818-4827
Related Report
Peer Reviewed
-
[Journal Article] Association between the neutrophil myeloperoxidase index (MPXI) and subsets of bacterial infections.2010
Author(s)
K.Yonezawa, O.Horie, A.Yoshioka, S.Matsuki, T.Tenjin, Y.Tsukamura, M.Yoneda, K.Shibata, Y.Koike, T.Nomura, M.Yokoyama, N.Urahama, M.Ito
-
Journal Title
Int.J.Lab.Hematol. 32
Pages: 598-605
Related Report
Peer Reviewed
-
[Journal Article] Transcriptional Mediator subunit MED1/TRAP220 in stromal cells is involved in hematopoietic stem/progenitor cell support through osteopontin expression.2010
Author(s)
A.Sumitomo, R.Ishino, N.Urahama, K.Inoue, K.Yonezawa, N.Hasegawa, O.Horie, H.Matsuoka, T.Kondo, R.G.Roeder, M.Ito
-
Journal Title
Mol.Cell.Biol.
Volume: 30
Pages: 4818-4827
Related Report
Peer Reviewed
-
-
[Journal Article] Association between the neutrophil myeloperoxidase index (MPXI) and subsets of bacterial infections.2010
Author(s)
K.Yonezawa, O.Horie, A.Yoshioka, S.Matsuki, T.Tenjin, Y.Tsukamura, M.Yoneda, K.Shibata, Y.Koike, T.Nomura, M.Yokoyama, N.Urahama, M.Ito
-
Journal Title
Int.J.Lab.Hematol.
Volume: 32
Pages: 598-605
Related Report
Peer Reviewed
-
-
-
-
-
-
-
[Journal Article] Association between the neutrophil myeloperoxidase index(MPXI)and subsets of bacterial infections
Author(s)
K.Yonezawa, O.Horie, A.Yoshioka, S.Matsuki, T.Tenjin, Y.Tsukamura, M.Yoneda, K.Shibata, Y.Koike, T.Nomura, M.Yokoyama, N.Urahama, M.Ito
-
Journal Title
Related Report
Peer Reviewed
-
-
-
[Presentation] Association between the neutrophil myeloperoxidase index (MPXI) and subsets of bacterial infections.2010
Author(s)
K.Yonezawa, O.Horie, A.Yoshioka, S.Matsuki, T.Tenjin, Y.Tsukamura, M.Yoneda, K.Shibata, Y.Koike, T.Nomura, M.Yokoyama, N.Urahama, M.Ito
Organizer
23rd International Symposium on Technological Innovations in Laboratory Hematology
Place of Presentation
Brighton, U.K.
Related Report
-
-
-
-
-
-
-
[Presentation] Mediator subunit MED1/TRAP220 in stromal cells is involved in hematopoietic stem/progenitor cell support through osteopontin expression.2010
Author(s)
A.Sumitomo, R.Ishino, N.Urahama, K.Inoue, K.Yonezawa, N.Hasegawa, O.Horie, H.Matsuoka, T.Kondo, R.G.Roeder, M.Ito
Organizer
第33回日本分子生物学会年会第83回日本生化学会大会合同大会
Place of Presentation
神戸
Related Report
-
-
-
-
-
-
[Presentation] Association between the neutrophil myeloperoxidase index (MPXI) and subsets of bacterial infections.2010
Author(s)
K.Yonezawa, O.Horie, A.Yoshioka, S.Matsuki, T.Tenjin, Y.Tsukamura, M.Yoneda, K.Shibata. Y.Koike, T.Nomura, M.Yokoyama, N.Urahama. M.Ito
Organizer
23rd International Symposium on Technological Innovations in Laboratory Hematology
Place of Presentation
Brighton, (U.K.)
Related Report
-
-
-
-
-
-
-
[Presentation] Mediator subunit MED1/TRAP220 in stromal cells is involved in hematopoietic stem/progenitor cell support through osteopontin expression.2010
Author(s)
A.Sumitomo, R.Ishino, N.Urahama, K.Inoue, K.Yonezawa, N.Hasegawa, O.Horie, H.Matsuoka, T.Kondo, R.G.Roeder, M,Ito
Organizer
第33回日本分子生物学会年会第83回日本生化学会大会合同大会
Place of Presentation
神戸国際展示場(兵庫県)
Related Report
-
-
-
-
-
-
[Presentation] Association of neutrophil myeloperoxidase index (MPXI) with subsets of bacterial infection.2009
Author(s)
K.Yonezawa, O.Horie, A.Yoshioka, S.Matsuki, T.Tenjin, Y.Tsukamura, M.Yoneda, K.Shibata, Y.Koike, T.Nomura, Y.Yokoyama, M.Ito
Organizer
European Hematology Association 14th Annual Congress.
Year and Date
2009-06-07
Related Report
-
[Presentation] Association of neutrophil myeloperoxidase index(MPXI)with subsets of bacterial infection2009
Author(s)
米澤賢二, 堀江修, 吉岡亜矢, 松木慎一郎, 天神貴子, 束村義志, 米田雅子, 柴田邦彦, 小池祐三, 野村哲彦, 横山光宏, 伊藤光宏
Organizer
European Hematology Association 14th Annual Congress
Place of Presentation
Berlin, Germany
Year and Date
2009-06-07
Related Report
-
-
-
-
-
[Presentation] Transcriptional Mediator subunit MED1/TRAP220 acts in stromal cells to support hematopoietic stem/progenitor cells through coactivation of osteopontin transcription.2009
Author(s)
A.Sumitomo, N.Urahama, K.Inoue, R.Ishino, K.Yonezawa, N.Hasegawa, C.Iwasaki, O.Horie, N.Seki, M.Ito
Organizer
51st Annual Meeting of the American Society of Hematology
Place of Presentation
New Orleans, L.A., USA.(口演)
Related Report
-
[Presentation] Transcriptional Mediator subunit MED1/TRAP220 acts in stromal cells to support hematopoietic stem/progenitor cells through coactivation of osteopontin transcription2009
Author(s)
A.Sumitomo, N.Urahama, K.Inoue, R.Ishino, K.Yonezawa, N.Hasegawa, C.Iwasaki, O.Horie, N.Seki, M.Ito
Organizer
51st Annual Meeting of the American Society of Hematology
Place of Presentation
New Orleans, USA
Related Report
-
-
-
-
[Presentation] 細菌感染症における平均好中球ミエロペ ルオキシダーゼ活性指数(MPXI)2009
Author(s)
米澤賢二, 堀江修, 松木慎一郎, 吉岡亜矢, 竹内文絵, 天神貴子, 束村義志, 米田雅子, 柴田邦彦, 小池祐三, 野村哲彦, 横山光宏, 伊藤光宏
Organizer
第71回日本血液学会総会
Place of Presentation
(京都府)国立京都国際会館
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] 原発性硬化胆肝炎(PSC)経過中に発症し、生体肝移植後に貧血の改善を示した赤芽球癆(PRCA)の一例2008
Author(s)
川野裕子, 小野香奈子, 船越洋平, 川野宏樹, 川森有里子, 西川真一郎皆川健太郎, 薬師神公和, 岡村篤夫, 下山学, 定明子, 山本克也, 片山義雄, 松井利充, 伊藤光宏, 尾形哲, 具英成
Organizer
第50回日本血液学会総会
Place of Presentation
京都
Related Report
-
-
-
-
-
-
-
-