| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Research Abstract |
The transcriptional Mediator complex, subcomplex of the RNA polymerase II holoenzyme complex, ultimately integrates many intracellular signals and conveys these signals to the RNA polymerase II core enzyme complex. In this study, we have shown that the Mediator subunit MED1 plays an important role in malignant, as well as normal, hematopoietic cell differentiation as a specific coactivator for nuclear receptors and GATA1, key activators for hematopoiesis. MED1 appears to promote proliferation of these cells as well. We also propose the molecular mechanisms underlying these processes.
|
