Drug-resistant genes downstream of Polycomb group genes in leukemia stem cells
| Project/Area Number |
20591128
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Hiroshima University |
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Principal Investigator |
MIHARA Keichiro Hiroshima University, 原爆放射線医科学研究所, 助教 (90363077)
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| Co-Investigator(Kenkyū-buntansha) |
TAKIHARA Yoshihiro 広島大学, 原爆放射線医科学研究所, 教授 (60226967)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2008: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | BMI-1 / Survivin / MDR / survivin |
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| Research Abstract |
Lymphoma (ML) cells transduced with BMI-1 obtained resistance to anti-cancer drugs. Survivin was enhanced in cell lines overexpressing BMI-1. Intriguingly, survivin mRNA was not induced in transduced cell lines, leading to the post-translational regulation involved. The expression of BMI-1 and survivin was much higher in chemotherapy-resistant samples than that in chemotherapy-sensitive.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Synergistic and persistent effect of T-cell immunotherapy with anti-CD19 or anti-CD38 chimeric receptor in conjunction with rituximab on B-cell non-Hodgkin lymphoma.2010
Author(s)
Mihara K, Yanagihara K, Takigahira M, Kitanaka A, Imai C, Bhattacharyya J, Kubo T, Takei Y, Yasunaga S, Takihara Y, Kimura A.
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Journal Title
Br J Haematol. 151(1)
Pages: 37-46
Related Report
Peer Reviewed
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[Journal Article] Antitumor effect of SN-38-releasing polymeric micelles, NK012, on spontaneous peritoneal metastases from orthotopic gastric cancer in mice compared with irinotecan.2008
Author(s)
Nakajima TE, Yanagihara K, Takigahira M, Yasunaga M, Kato K, Hamaguchi T, Yamada Y, Shimada Y, Mihara K, Ochiya T, Matsumura Y.
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Journal Title
Cancer Res. 15;68(22)
Pages: 9318-9322
Related Report
Peer Reviewed
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