| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Research Abstract |
Methylation profile was analyzed in patients with childhood acute lymphoblastic leukemia (ALL). Methylation of both MGMT and p16 genes were associated with higher age. Methylation of both p15 and SHP1 genes occurred more frequently in T-ALL than in precursor B-ALL. In contrast, methylation of the DAPK gene was more frequent in precursor B-ALL. Patients with methylation of multiple genes more likely had T cell phenotype, and are classified as medium/high risk. These results suggest that methylation status is associated with clinicopathological features in childhood ALL.
|
