Identification of a novel methylated gene as a prognostic factor in hematological malignancies and its clinical application.
| Project/Area Number |
20591133
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Kochi University |
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Principal Investigator |
DAIBATA Masanori Kochi University, 教育研究部・医療学系, 教授 (50263976)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 血液腫瘍学 / 造血器腫瘍 / メチル化遺伝子 / 癌抑制遺伝子 / 造血・器腫瘍 / 白血病 / 癌遺伝子 / ウイルス |
|---|
| Research Abstract |
Bone morphogenetic proteins (BMP) are multifunctional regulators of cell proliferation and apoptosis in various types of malignant cells. In this study, we investigated BMP-6 promoter methylation in patients with various types of leukemias. The BMP-6 methylation was found preferentially in adult T-cell leukemia (ATL) compared with other types of leukemias. Among subtypes of ATL, the BMP-6 gene was more frequently methylated in aggressive ATL forms of acute and lymphoma types than less malignant chronic ATL and smoldering ATL. Serial analysis demonstrated an increasing methylation of CpG sites in the BMP-6 promoter and the resultant suppression of BMP-6 expression as ATL progressed. These findings suggested that BMP-6 promoter methylation is likely to be a common epigenetic event at later stages of ATL and that the methylation profiles may be useful for the staging of ATL as well as for evaluation of the individual risk of developing the disease.
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Report
(4 results)
Research Products
(41 results)
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[Journal Article] Presence of Merkel cell polyomavirus in Japanese cutaneous squamous cell carcinoma.2011
Author(s)
Murakami M, Imajoh M, Ikawa T, Nakajima H, Kamioka M, Nemoto Y, Ujihara T, Uchiyama J, Matsuzaki S, Sano, S, Daibata M.
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Journal Title
Journal of Clinical Virology. 50
Pages: 37-41
Related Report
Peer Reviewed
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[Journal Article] Gene deregulation and spatial genome reorganization near breakpoints prior to formation of translocations in anaplastic large cell lymphoma.2009
Author(s)
Mathas S, Kreher S, Meaburn K.J, Johrens K, Lamprecht B, Assaf C, Sterry W, Kadin M,E, Daibata M, Joos S, Hummel M, Stein H, Janz M, Anagnostopoulos I, Schrock E, Misteli T, Dorken B.
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Journal Title
Proceeding of the National Academy of Science of the USA. 106
Pages: 5831-5836
Related Report
Peer Reviewed
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