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The mechanism of polycythemia vera and essential thrombocythemia

Research Project

Project/Area Number 20591137
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hematology
Research InstitutionUniversity of Miyazaki

Principal Investigator

SHIMODA Kazuya  University of Miyazaki, 医学部, 教授 (90311844)

Co-Investigator(Kenkyū-buntansha) SHIDE Kotaro  宮崎大学, 医学部, 研究員 (20468028)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords血液内科学 / 血液腫瘍学 / 原発性骨髄線維症 / 真性多血症 / 本態性血小板血症 / JAK2
Research Abstract

The expression level of mutant JAK2 would determine the cell lineage to grow, as higher expression of mutant JAK2 would favor erythrocytosis, and low JAK2 expression would favor thrombocytosis in mutant JAK2 transgenic mice.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (43 results)

All 2011 2010 2009 2008 Other

All Journal Article (20 results) (of which Peer Reviewed: 20 results) Presentation (7 results) Book (15 results) Remarks (1 results)

  • [Journal Article] Tyrosine kinase 2 interacts with the proapoptotic protein Siva-1 and augments its apoptotic functions.2010

    • Author(s)
      Shimoda HK, Shide K, Kameda T, Matsunaga T, Shimoda K
    • Journal Title

      Biochem Biophys Res Commun. 400

      Pages: 252-257

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Absence of gain-of-function JAK1 and JAK3 mutations in adult T cell leukemia/lymphoma.2010

    • Author(s)
      Kameda T, Shide K, Shimoda HK, Hidaka T, Kubuki Y, Katayose K, Taniguchi Y, Sekine M, Kamiunntenn A, Maeda K, Nagata K, Matsunaga T, Shimoda K
    • Journal Title

      Int J Hematol 92

      Pages: 320-325

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] JAK2 V617F uses distinct signalling pathways to induce cell proliferation and neutrophil activation.2010

    • Author(s)
      Oku S, Takenaka K, Kuriyama T, Shide K, Kumano T, Kikushige Y, Urata S, Yamauchi T, Iwamoto C, Shimoda HK, Miyamoto T, Nagafuji K, Kishimoto J, Shimoda K, Akashi K.
    • Journal Title

      Br J Haematol. 150

      Pages: 334-344

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] p27 deregulation by Skp2 overexpression induced by the JAK2V617 mutation.2010

    • Author(s)
      Furuhata A, Kimura A, Shide K, Shimoda K, Murakami M, Ito H, Gao S, Yoshida K, Tagawa Y, Hagiwara K, Takagi A, Kojima T, Suzuki M, Abe A Naoe T, Murate T
    • Journal Title

      Biochem Biophys Res Commun. 383

      Pages: 411-416

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic impact of immunohistochemical biomarkers in diffuse large B-cell lymphoma in the rituximab era.2010

    • Author(s)
      Seki R, Ohshima K, Fujisaki T, Uike N, Kawano F, Gondo H, Makino S, Eto T, Moriuchi Y, Taguchi F, Kamimura T, Tsuda H, Ogawa R, Shimoda K, Yamashita K, Suzuki K, Suzushima H, Tsukazaki K, Higuchi M, Utsunomiya A, Iwahashi M, Imamura Y, Tamura K, Suzumiya J, Yoshida M, Abe Y, Matsumoto T, Okamura T
    • Journal Title

      Cancer Science 100

      Pages: 1842-1847

    • NAID

      10027195531

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tyrosine kinase 2 interacts with the proapoptotic protein Siva-1 and augments its apoptotic functions.2010

    • Author(s)
      Shimoda HK, Shide K, Kameda T, Matsunaga T, Shimoda K
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 400 Pages: 252-257

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Absence of gain-of-function JAK1 and JAK3 mutations in adult T cell leukemia/lymphoma.2010

    • Author(s)
      Kameda T, Shide K, Shimoda HK, Hidaka T, Kubuki Y, Katayose K, Taniguchi Y, Sekine M, Kamiunntenn A, Maeda K, Nagata K, Matsunaga T, Shimoda K.
    • Journal Title

      Int J Hematol.

      Volume: 92 Pages: 320-325

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] JAK2 V617F uses distinct signalling pathways to induce cell proliferation and neutrophil activation.2010

    • Author(s)
      Oku S, Takenaka K, Kuriyama T, Shide K, Kumano T, Kikushige Y, Urata S, Yamauchi T, Iwamoto C, Shimoda HK, Miyamoto T, Nagafuji K, Kishimoto J, Shimoda K, Akashi K.
    • Journal Title

      Br J Haematol.

      Volume: 150 Pages: 334-344

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] VLA-5-mediated adhesion to fibronectin accelerates hemin-stimulated erythroid differentiation of K562 cells through induction of VLA-4 expression.2009

    • Author(s)
      Tanaka R, Owaki T, Kamiya S, Matsunaga T, Shimoda K, Kodama H, Hayashi R, Abe T, Harada YP, Shimonaka M, Yamaji H, Terada H, Fukai F
    • Journal Title

      J.Biol.Chem. 284

      Pages: 19817-19825

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The impact of cytogenetic abnormalities on the prognosis of primary myelofibrosis : a prospective survey of 202 cases in Japan.2009

    • Author(s)
      Hidaka T, Shide K, Shimoda H, Kameda T, Toyama K, Katayose K, Kubuki Y, Nagata K, Takenaka K, Akashi K, Okamura T, Niho Y, Mizoguchi H, Omine M, Ozawa K, Harada M, Shimoda K
    • Journal Title

      Eur J Haematol. 83

      Pages: 328-333

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] p27 deregulation by Skp2 overexpression induced by the JAK2V617 mutation2009

    • Author(s)
      Furuhata A, Shimoda K, et al.
    • Journal Title

      Biochem Biophys Res Commun 383

      Pages: 411-416

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] VLA-5-mediated adhesion to fibronectin accelerates hemin-stimulated erythroid differentiation of K562 cells, through induction of VLA-4 expression2009

    • Author(s)
      Tanaka R, Shimoda K, et al.
    • Journal Title

      J Biol Chem 284

      Pages: 19817-19825

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic impact of immunohistochemical biomarkers in diffuse large B-cell lymphoma in the rituximab era2009

    • Author(s)
      Seki R, Shimoda K, et al.
    • Journal Title

      Cancer Science 100

      Pages: 1842-1847

    • NAID

      10027195531

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The impact of cytogenetic abnormalities on the prognosis of primary myelofibrosis : a prospective survey of 202 cases in Japan2009

    • Author(s)
      Hidaka T, Shimoda K, et al.
    • Journal Title

      Eur J Haematol 83

      Pages: 328-333

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of ET, primary myelofibrosis, and PV in mice expressing JAK2 V617F.2008

    • Author(s)
      Shide K,ShimodaHK, Kumano T, Karube K, KamedaT, Takenaka K, Abe H, Oku S, Katayose K K, Kusumoto K, Hasuike S, Tahara Y, Nagata K, Matsuda T, Ohshima K, Hrada M, Shimoda K
    • Journal Title

      Leukemia 22

      Pages: 87-89

    • NAID

      120007123093

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Endoscopic characterization of the small bowel in patients with portal hypertension evaluated by double balloon endoscopy.2008

    • Author(s)
      Kodama M,UtoH,Numata M, Hori T, Murayama T, Sasaki F, Tsubouchi N, IdoA, Shimoda K, Tsubouchi H.
    • Journal Title

      J.Gastroenterol. 43

      Pages: 589-596

    • NAID

      10021937551

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tyk2-signaling plays an important role in host defense against Escherichia coli through IL-23-induced IL-17 production by gammadelta T cells.2008

    • Author(s)
      Nakamura R, Shibata K, Yamada H, Shimoda K, Nakayama K, Yoshikai Y.
    • Journal Title

      J.Immunol. 181

      Pages: 2071-2075

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of ET, primary myelofibrosis, and PV in miceexpressing JAK2 V617F.2008

    • Author(s)
      Shide K, ShimodaH K, Kumano T, Karube K, KamedaT, Takenaka K, Abe H, Oku S, Katayose K K, Kusumoto K, Hasuike S, Tahara Y, Nagata K, Matsuda T, Ohshima K, Hrada M, Shimoda K
    • Journal Title

      Leukemia 22

      Pages: 87-89

    • NAID

      120007123093

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endoscopic characterization of the small bowel in patients with portal hypertension evaluated by double balloon endoscopy.2008

    • Author(s)
      Kodama M, UtoH, Numata M, Hori T, Murayama T, Sasaki F, Tsubouchi N, Ido A, Shimoda K, Tsubouchi H.
    • Journal Title

      J. Gastroenterol. 43

      Pages: 589-596

    • NAID

      10021937551

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tyk2-signaling plays an important role in host defence against Escherichia coli through IL-23-induced IL-17 production by gammadelta T cells.2008

    • Author(s)
      Nakamura R, Shibata K, Yamada H, Shimoda K, Nakayama K, Yoshikai Y
    • Journal Title

      J. Immunol. 181

      Pages: 2071-2075

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Prognostic impact of cytogenetic abnormalities in primary myelofibrosis : prospective survey in Japan.2010

    • Author(s)
      Shide K, Matsunaga T, Takenaka K, Hidaka T, Shimoda H, Kameda T, Katayose K, Kubuki Y, Akashi K, Okamura T, Niho Y, Mizoguchi H, Omine M, Ozawa K, Harada M, Shimoda K.
    • Organizer
      第72回日本血液学会学術集会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2010-09-26
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Elevated neutrophil alkaline phosphatase scores induced by Jak2 V617F mutation via Stat32009

    • Author(s)
      Oku S, Shimoda K, Katsuto T, Kumano T, Kuriyama T, Urata S, Yamauchi T, Shide K, Shimoda H, Miyamoto T, Shimoda K, Akashi K.
    • Organizer
      第71回日本血液学会学術集会
    • Place of Presentation
      京都府京都市
    • Year and Date
      2009-10-24
    • Related Report
      2010 Final Research Report
  • [Presentation] 新規JAK2阻害剤R723は、骨髄増殖疾患モデルマウスの病態を改善する2009

    • Author(s)
      幣光太郎、亀田拓郎、Markobtsov Vadim、下田晴子、下田和哉, 他
    • Organizer
      第71回日本血液学会学術集会
    • Place of Presentation
      京都府京都市
    • Year and Date
      2009-10-24
    • Related Report
      2010 Final Research Report
  • [Presentation] 成人T細胞性白血病/リンパ腫におけるJAK1遺伝子変異の検討2009

    • Author(s)
      亀田拓郎、幣光太郎、下田晴子、日高智徳、下田和哉, 他
    • Organizer
      第71回日本血液学会学術集会
    • Place of Presentation
      京都府京都市
    • Year and Date
      2009-10-24
    • Related Report
      2010 Final Research Report
  • [Presentation] Elevated neutrophil alkaline phosphatase scores induced by Jak2 V617F mutation via Stat32009

    • Author(s)
      Oku S, Shimoda K, et al
    • Organizer
      第71回日本血液学会学術集会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2009-10-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] The animal model for myelofibrosis2008

    • Author(s)
      下田晴子
    • Organizer
      The 32nd World Congress of the International Society of Hematology
    • Place of Presentation
      Thailand
    • Year and Date
      2008-10-23
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] JAK2 V617F発現マウスは真性多血症、本態性血小板増多症、原発性骨髄線維症を発症する2008

    • Author(s)
      幣光太郎、下田晴子、加留部謙之輔、熊野孝、亀田拓郎、下田和哉, 他
    • Organizer
      第70日本血液学会総会
    • Place of Presentation
      京都府京都市
    • Year and Date
      2008-10-11
    • Related Report
      2010 Final Research Report
  • [Book] 今日の治療指針 2011年版 (慢性リンパ性白血病chronic lymphocytic leukemia(CLL))2011

    • Author(s)
      下田和哉
    • Publisher
      医学書院
    • Related Report
      2010 Final Research Report
  • [Book] WHO血液腫瘍分類~WHO分類2008をうまく活用するために~(骨髄増殖性腫瘍7.肥満細胞症)2010

    • Author(s)
      下田晴子、下田和哉
    • Publisher
      医薬ジャーナル社
    • Related Report
      2010 Final Research Report
  • [Book] WHO血液腫瘍分類~WHO分類2008をうまく活用するために~(骨髄増殖性腫瘍4.原発性骨髄線維症 Primary myelofibrosis)2010

    • Author(s)
      幣光太郎、下田和哉
    • Publisher
      医薬ジャーナル社
    • Related Report
      2010 Final Research Report
  • [Book] WHO血液腫瘍分類~WHO分類2008をうまく活用するために~(骨髄増殖性腫瘍4.骨髄増殖性腫瘍、分類不能型Myeloproliferative neoplasma, unclassifiable)2010

    • Author(s)
      久冨木庸子、下田和哉
    • Publisher
      医薬ジャーナル社
    • Related Report
      2010 Final Research Report
  • [Book] 今日の診断指針原発性骨髄線維症2010

    • Author(s)
      下田和哉
    • Publisher
      医学書院
    • Related Report
      2010 Final Research Report
  • [Book] 血液疾患最新の治療2011-2013(骨髄増殖性腫瘍)2010

    • Author(s)
      松永卓也、下田和哉
    • Publisher
      南江堂
    • Related Report
      2010 Final Research Report
  • [Book] 造血器腫瘍治療 これは困ったぞ、どうしよう!(52歳の骨髄線維証.移植,摘脾,治療方針は?)2010

    • Author(s)
      松永卓也、下田和哉
    • Publisher
      中外医学社
    • Related Report
      2010 Final Research Report
  • [Book] ガイドラインパースペクティブ(造血幹細胞移植骨髄増殖性疾患)2009

    • Author(s)
      幣光太郎、下田和哉
    • Publisher
      (株)医薬ジャーナル社
    • Related Report
      2010 Final Research Report
  • [Book] 臨床に直結する血液疾患診療のエビデンス骨髄増殖性疾患におけるJAK2遺伝子変異解析の臨床的意義は?2009

    • Author(s)
      亀田拓郎、下田和哉
    • Publisher
      文光堂
    • Related Report
      2010 Final Research Report
  • [Book] 内科学書(骨髄線維症)2009

    • Author(s)
      下田和哉
    • Publisher
      中山書店
    • Related Report
      2010 Final Research Report
  • [Book] 血液疾患診療ハンドブック(-診療の手引きと臨床データ集改訂版原発性骨髄線維症)2009

    • Author(s)
      下田和哉、原田実根
    • Publisher
      医薬ジャーナル社
    • Related Report
      2010 Final Research Report
  • [Book] 新臨床腫瘍学(改訂第2版)(がん薬物療法専門医のために慢性骨髄性白血病・骨髄増殖性腫瘍)2009

    • Author(s)
      下田和哉
    • Publisher
      (株)南江堂
    • Related Report
      2010 Final Research Report
  • [Book] 血液診療エキスパート 白血病慢性骨髄増殖性疾患((真性多血症、本態性血小板血症、原発性骨髄線維症)の病態と治療)2009

    • Author(s)
      日高智徳、下田和哉
    • Publisher
      中外医学社
    • Related Report
      2010 Final Research Report
  • [Book] 今日の治療指針2008年版(真性多血症、本態性血小板血症、慢性特発性骨髄線維症)2008

    • Author(s)
      下田和哉
    • Publisher
      医学書院
    • Related Report
      2010 Final Research Report
  • [Book] Annual Review血液(2008真性多血症における新たなJAK2の遺伝子変異)2008

    • Author(s)
      幣光太郎、下田和哉
    • Publisher
      中外医学社
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2018-02-22  

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