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The basic study of protective effects by carnosic acid against anthrocyclin-induced cardiotoxicity

Research Project

Project/Area Number 20591138
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hematology
Research InstitutionIwate Medical University

Principal Investigator

ISHIDA Yoji  Iwate Medical University, 医学部, 教授 (70151389)

Co-Investigator(Kenkyū-buntansha) 佐藤 拓己  岩手大学, 工学部, 准教授 (10300831)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordsアントラサイクリン / 心筋障害 / カルノシン酸 / 抗酸化作用 / 心筋細胞 / 酸化ストレス
Research Abstract

We evaluated the oxidant effects of doxorubicine (DOX) on murine cardio-myocytic cell line. DOX did not have cytotoxic effects on HL-1 cells (~100 ng/ml). Therefore, we have evaluated the cytotoxic effect of acetaminophen (AA), which has much more oxidant effects, instead of DXR. The cytotoxic effect of AA was reduced by the addition of carnosic acid (CA). The RNA was extracted from HL-1 cells, cultured with CA, which concentration showed the maximum anti-oxidant effect. The quantitative RT-PCR was performed, resulting in that phase II enzymes were not highly expressed significantly. These results suggest that anti-oxidant effect of CA might be independent on the expression of Phase II enzymes.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (42 results)

All 2011 2010 2009 2008

All Journal Article (20 results) (of which Peer Reviewed: 10 results) Presentation (20 results) Book (2 results)

  • [Journal Article] Clinical efficacy and safety of biapenem for febrile neutropenia in patients with underlying hematopoietic diseases : a multi-institutional study2011

    • Author(s)
      Nakagawa Y, Suzuki K, Ishida Y, Urabe A, et al.
    • Journal Title

      Journal of Infection and Chemotherapy

      Volume: 17(1) Pages: 58-67

    • NAID

      10027816744

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A palmitoyl conjugate of insect pentapeptide Yamamarin arrests cell proliferation and respiration2011

    • Author(s)
      Sato Y, Ito S, Ishida Y, Suzuki K, et al.
    • Journal Title

      Peptides

      Volume: 31 Pages: 827-833

    • NAID

      120002439247

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deguelin suppresses cell proliferation via the inhibition of surviving expression and STAT3 phosphorylation in HTLV-1- transformed T cells.2010

    • Author(s)
      Ito S, Oyake T, Murai K, Ishida Y
    • Journal Title

      Leuk Res. 34(3)

      Pages: 352-357

    • Related Report
      2010 Final Research Report
  • [Journal Article] Factor XII Ofunato : Lys346Asn mutation associated with blood coagulation factor XII deficiency causes impaired secretion through aproteasome- mediated degradation.2010

    • Author(s)
      Suzuki K, Murai K, Suwabe A, Ishida Y
    • Journal Title

      Thromb Res 125(5)

      Pages: 438-443

    • Related Report
      2010 Final Research Report
  • [Journal Article] Clinical efficacy and safety of biapenem for febrile neutropenia in patients with underlying hematopoietic diseases : a multi-institutional study2010

    • Author(s)
      Nakagawa Y, Suzuki K, Ishida Y, Urabe A, et al.
    • Journal Title

      J Infect Chemother in press

    • NAID

      10027816744

    • Related Report
      2010 Final Research Report
  • [Journal Article] A palmitoyl conjugate of insect pentapeptide Yamamarin arrests cell proliferation and respiration2010

    • Author(s)
      Sato Y, Yang P, An Y, Matsukawa K, Ito K, Imanishi S, Matsuda H, Uchiyama Y, Imai K, Ito S, Ishida Y, Suzuki K
    • Journal Title

      Peptides 31

      Pages: 827-833

    • NAID

      120002439247

    • Related Report
      2010 Final Research Report
  • [Journal Article] Drug susceptibility and clonality of methicillin-resistant Staphylococcus epidermidis in hospitalized patients with hematological malignancies2010

    • Author(s)
      Nomura K. Mizumachi E. Yamashita M. Ohshiro M. Komori T. Sugai M. Taniwaki M. Ishida Y.
    • Journal Title

      Ir J Med Sci 179(3)

      Pages: 351-356

    • Related Report
      2010 Final Research Report
  • [Journal Article] Deguelin suppresses cell proliferation via the inhibition of survivin expression and STAT3 phosphorylation in HTLV-1-transformed T cells.2010

    • Author(s)
      Ito S, Oyake T, Murai K, Ishida Y
    • Journal Title

      Leukemia Research

      Volume: 340(3) Pages: 352-357

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Factor XII Ofunato : Lys346Asn mutation associated with blood coagulation factor XII deficiency causes impaired secretion through aproteasome-mediated degradation.2010

    • Author(s)
      Suzuki K, Murai K, SuwabeA, Ishida Y
    • Journal Title

      Thrombosis Research

      Volume: 125(5) Pages: 438-443

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Drug susceptibility and clonality of methicillin-resistant Staphylococcus epidermidis in hospitalized patients with hematological malignancies2010

    • Author(s)
      Nomura K, Taniwaki M, Ishida Y, et al.
    • Journal Title

      Ir J Med Sci

      Volume: 179(3) Pages: 351-356

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deguelin suppresses cell proliferation via the inhibition via the inhibition of survivn expression and STAT3 phosphorylation in HTLV-1 transformed T cells2010

    • Author(s)
      Ito S
    • Journal Title

      Leuk Res 34(3)

      Pages: 352-357

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Japan Haematology/Oncology Study (J-HOST) Group. Risk factors for infection in haematology patients treated with rituximab.2009

    • Author(s)
      Kanbayashi Y, Nomura K, Fujimoto Y, Yamashita M, Ohshiro M, Okamoto K, Matsumoto Y, Horiike S, Takagi T, Ishida Y, Taniwaki M
    • Journal Title

      Eur J Haematol 82(1)

      Pages: 26-30

    • Related Report
      2010 Final Research Report
  • [Journal Article] Japan Hematology/Oncology Study (J-HOST) Group Kyoto. Absence of pseudomembranes in Clostridium difficile-associated diarrhea in patients using immunosuppression agents.2009

    • Author(s)
      Nomura K, Fujimoto Y, Yamashita M, Morimoto Y, Ohshiro M, Sato K, Oyake T, Kowata S, Konishi H, Yoshikawa T, Ishida Y, Taniwaki M
    • Journal Title

      Scand J Gastroenterol 44(1)

      Pages: 74-78

    • Related Report
      2010 Final Research Report
  • [Journal Article] Risk factors for infection in haematology patients treated with rituximab2009

    • Author(s)
      Kanbayashi Y
    • Journal Title

      Eur J Haematol 82(1)

      Pages: 26-30

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Absence of pseudomembranes in Clostridium difficile-associated diarrhea in patients using immunosuppression agents.2009

    • Author(s)
      Nomura K
    • Journal Title

      Scand J Gastroenterol 44(1)

      Pages: 74-78

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2009

    • Author(s)
      石田陽治
    • Journal Title

      EBM血液疾患の治療(中外医学社)

      Pages: 39-44

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Risk factors for infection in haematology patients treated with rituximab.2009

    • Author(s)
      Kanbayashi Y, et al.
    • Journal Title

      Eur J Haematol 82(1)

      Pages: 26-30

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Absence of pseudomembranes in Clostridium difficile-associated diarrhea in patient s using immunosuppression agent.2009

    • Author(s)
      Nomura K., et al.
    • Journal Title

      Scand J Gastroenterol. 44(1)

      Pages: 74-78

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 遺伝性溶血性貧血2009

    • Author(s)
      石田陽治
    • Journal Title

      今日の治療指針2009 51

      Pages: 485-486

    • Related Report
      2008 Annual Research Report
  • [Journal Article] proplatelet2008

    • Author(s)
      古和田周吾, 他
    • Journal Title

      血液フロンティア 18(2)

      Pages: 1912-1917

    • Related Report
      2008 Annual Research Report
  • [Presentation] Bortezomib induced thrombocytopenia might be due to the inhibition of proplatelet formation of megakaryocyte2010

    • Author(s)
      Murai K, Kowata S, Abo A, Oyake T, Ishida Y, et al.
    • Organizer
      52^<nd> American Society of Hematology Annual Meeting and Exposition
    • Place of Presentation
      Orland, USA
    • Year and Date
      2010-12-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] Resveratrol Induces cell growth arrest and cell death of adult T-cell leukemia cells via deacetylation of STAT3 by SIRT12010

    • Author(s)
      Ito S, Oyake T, Murai K, Ishida Y.
    • Organizer
      52^<nd> American Society of Hematology Annual Meeting and Exposition
    • Place of Presentation
      Orland, USA
    • Year and Date
      2010-12-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] Micafungin versus voriconazole for empirical antifungal therapy in febrile neutropenic patients with acute myeloid leukemia : A Randomized controlled study2010

    • Author(s)
      Oyake T, Kowata S, Murai K, Ishida Y, et al.
    • Organizer
      52^<nd> American Society of Hematology Annual Meeting and Exposition
    • Place of Presentation
      Orland, USA
    • Year and Date
      2010-12-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] Bortezomib induced thrombocytopenia might be due to the inhibition of proplatelet formation of megakaryocyte.2010

    • Author(s)
      Murai K, Kowata S, Abo A, Oyake T, Ishida Y, et al.
    • Organizer
      52^<nd> American Society of Hematology Annual Meeting and Exposition December 6^<th>
    • Place of Presentation
      Orland, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] Micafungin versus voriconazole for empirical anti- fungal therapy in febrile neutron- penic patients with acute myeloid leukemia : A Randomized, controlled study.2010

    • Author(s)
      Oyake T, Kowata S, Murai K, Ishida Y, et al.
    • Organizer
      52^<nd> American Society of Hematology Annual Meeting and Exposition December 4^<th>
    • Place of Presentation
      Orland, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] Resveratrol Induces cell growth arrest and cell death of adult T- cell leukemia cells via deacetylation of STAT3 bySIRT1.2010

    • Author(s)
      Ito S, Oyake T, Murai K, Ishida Y.
    • Organizer
      52^<nd> American Society of Hematology Annual Meeting and Exposition December 5^<th>
    • Place of Presentation
      Orland, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] The Role of Actin Nucleating Factors, Arp3 and mDial, During Proplatelet Formation of Megakaryocytes2009

    • Author(s)
      Shugo Kowata
    • Organizer
      The 2009 Annual Meeting of the American Society of Hematology in New Orleans
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2009-12-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] The role of actin nucleating factors, Arp3 and mDia1, during proplatelet formation of megakaryocytes.2009

    • Author(s)
      Kowata S, Oyake T, Murai K, Ishida Y, et al.
    • Organizer
      51^<st> American Society of Hematology Annual Meeting and Exposition December 6^<th>
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] Deguelin induced cell growth arrest and cell death via the suppression of BCR-ABL and Survivin expression in BCR-ABL-T315 mutant cells.2009

    • Author(s)
      Oyake T, Ito S, Kowata S, Ishida Y, et al.
    • Organizer
      51^<st> American Societyof Hematology Annual Meeting and Exposition December 7^<th>
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] Deguelin inducs cell growth arrestand cell death by destabilizing phosphorylated STAT 3 and survivinin adult T-cell leukemia cells.2009

    • Author(s)
      Ito S, Oyake T, Murai K, Ishida Y.
    • Organizer
      51^<st> American Society of HematologyAnnual Meeting and Exposition December 7^<th>
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] T細胞リンパ腫への自家抹血幹細胞移植の有効性に関する検討2008

    • Author(s)
      泉田亘, 他
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] 高齢者における再発、難治性のびまん性大型B 細胞性リンパ腫へのCHASER療法の検討2008

    • Author(s)
      青木有正, 他
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] 同種造血幹細胞移植後における難治性急性移植片対宿主病へ対するペントスタチンの有効性の検討2008

    • Author(s)
      小宅達郎, 他
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] 化学療法が奏効した心臓原発非ホジキンリンパ腫の3例2008

    • Author(s)
      藤島行輝, 他
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] 抗細菌薬不応性の発熱性好中球減少症へ対するVRCZとMCFGの有効性に関する比較検討2008

    • Author(s)
      古和田周吾, 他
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] 再生不良性貧血に対する免疫抑制療法後のシクロスポリン依存性の検討2008

    • Author(s)
      亀岡淳一, 他
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] 血液疾患におけるFebrile neutropenia(FN)に対するビアペネムの有効性・安全性の検討・他施設共同研究2008

    • Author(s)
      廣瀬貴之, 他
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] 成人T細胞性白血病細胞株におけるデグェリンの殺細胞効果に関する検討2008

    • Author(s)
      伊藤薫樹, 他
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] WTI-mRNAによる急性前骨髄単球性白血病化誘導療法の早期有効性を判定の試み2008

    • Author(s)
      村井一範, 他
    • Organizer
      第7O回日本血液学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] 当科における精巣原発の非ホジキンリンパ腫7例の検討2008

    • Author(s)
      峯貴浩, 他
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-10
    • Related Report
      2008 Annual Research Report
  • [Book] 臨床検査ガイド,東京他 14件2010

    • Author(s)
      石田陽治
    • Publisher
      文光堂
    • Related Report
      2010 Final Research Report
  • [Book] 臨床検査ガイド2010

    • Author(s)
      石田陽治
    • Total Pages
      1067
    • Publisher
      文光堂、東京
    • Related Report
      2010 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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