The basic study of protective effects by carnosic acid against anthrocyclin-induced cardiotoxicity
Project/Area Number |
20591138
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Hematology
|
Research Institution | Iwate Medical University |
Principal Investigator |
ISHIDA Yoji Iwate Medical University, 医学部, 教授 (70151389)
|
Co-Investigator(Kenkyū-buntansha) |
佐藤 拓己 岩手大学, 工学部, 准教授 (10300831)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | アントラサイクリン / 心筋障害 / カルノシン酸 / 抗酸化作用 / 心筋細胞 / 酸化ストレス |
Research Abstract |
We evaluated the oxidant effects of doxorubicine (DOX) on murine cardio-myocytic cell line. DOX did not have cytotoxic effects on HL-1 cells (~100 ng/ml). Therefore, we have evaluated the cytotoxic effect of acetaminophen (AA), which has much more oxidant effects, instead of DXR. The cytotoxic effect of AA was reduced by the addition of carnosic acid (CA). The RNA was extracted from HL-1 cells, cultured with CA, which concentration showed the maximum anti-oxidant effect. The quantitative RT-PCR was performed, resulting in that phase II enzymes were not highly expressed significantly. These results suggest that anti-oxidant effect of CA might be independent on the expression of Phase II enzymes.
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Report
(4 results)
Research Products
(42 results)
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[Journal Article] A palmitoyl conjugate of insect pentapeptide Yamamarin arrests cell proliferation and respiration2010
Author(s)
Sato Y, Yang P, An Y, Matsukawa K, Ito K, Imanishi S, Matsuda H, Uchiyama Y, Imai K, Ito S, Ishida Y, Suzuki K
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Journal Title
Peptides 31
Pages: 827-833
NAID
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[Journal Article] Japan Haematology/Oncology Study (J-HOST) Group. Risk factors for infection in haematology patients treated with rituximab.2009
Author(s)
Kanbayashi Y, Nomura K, Fujimoto Y, Yamashita M, Ohshiro M, Okamoto K, Matsumoto Y, Horiike S, Takagi T, Ishida Y, Taniwaki M
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Journal Title
Eur J Haematol 82(1)
Pages: 26-30
Related Report
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[Journal Article] Japan Hematology/Oncology Study (J-HOST) Group Kyoto. Absence of pseudomembranes in Clostridium difficile-associated diarrhea in patients using immunosuppression agents.2009
Author(s)
Nomura K, Fujimoto Y, Yamashita M, Morimoto Y, Ohshiro M, Sato K, Oyake T, Kowata S, Konishi H, Yoshikawa T, Ishida Y, Taniwaki M
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Journal Title
Scand J Gastroenterol 44(1)
Pages: 74-78
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