Basic research on new therapy for leukemia by a decoy peptide.

• Project/Area Number: 20591140
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hematology
• Research Institution: Dokkyo Medical University
• Principal Investigator: MAKI Kazuhiro Dokkyo Medical University, 医学部, 講師 (50337391)
• Co-Investigator(Kenkyū-buntansha): MITANI Kinuko 獨協医科大学, 医学部, 教授 (50251244) ; SASAKI Ko 獨協医科大学, 医学部, 講師 (60282638) ; 山形 哲也 獨協医科大学, 医学部, 准教授 (30424047)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 白血病 / RUNX1 / EVI1 / ヒストン脱アセチル化酵素阻害剤 / 白血病関連キメラ遺伝子 / ペプチド / HDACi / DNAメチル化 / メチル化阻害剤

Research Abstract

RUNX1/EVI1 is a chimeric gene that is observed in advanced-stage MDS and blastic crisis of chronic myelogenous leukemia. RUNX1/EVI1 enhances colony-forming and self-renewal abilities of mouse bone marrow progenitors. We have shown that Histone deacetylase inhibitors exhibit specific repression on these phenotypes.

Research Products

• [Presentation] Molecular pathogenesis of MDS and its clinical implications (2010)
  • Author(s): 牧和宏、三谷絹子
  • Organizer: 第72回日本血液学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2010-09-26
• [Presentation] Molecular pathogenesis of MDS and its clinical implications (2010)
  • Author(s): 牧和宏
  • Organizer: 日本血液学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2010-09-26
• [Presentation] ヒストン脱アセチル化酵素阻害薬を用いたRUNX1/EVI1の造腫瘍活性の抑制 (2008)
  • Author(s): 牧和宏、山形哲也、佐々木光、三谷絹子
  • Organizer: 第70回日本血液学会総会
  • Place of Presentation: 京都
  • Year and Date: 2008-10-12