Basic research on new therapy for leukemia by a decoy peptide.
| Project/Area Number |
20591140
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
MAKI Kazuhiro Dokkyo Medical University, 医学部, 講師 (50337391)
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| Co-Investigator(Kenkyū-buntansha) |
MITANI Kinuko 獨協医科大学, 医学部, 教授 (50251244)
SASAKI Ko 獨協医科大学, 医学部, 講師 (60282638)
山形 哲也 獨協医科大学, 医学部, 准教授 (30424047)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 白血病 / RUNX1 / EVI1 / ヒストン脱アセチル化酵素阻害剤 / 白血病関連キメラ遺伝子 / ペプチド / HDACi / DNAメチル化 / メチル化阻害剤 |
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| Research Abstract |
RUNX1/EVI1 is a chimeric gene that is observed in advanced-stage MDS and blastic crisis of chronic myelogenous leukemia. RUNX1/EVI1 enhances colony-forming and self-renewal abilities of mouse bone marrow progenitors. We have shown that Histone deacetylase inhibitors exhibit specific repression on these phenotypes.
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Report
(4 results)
Research Products
(3 results)
