Development of novel tumor-associated antigens peptide vaccine inducing a graft-versus-leukemia effect after umbilical cord blood transplantation
| Project/Area Number |
20591146
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Hematology
|
|---|
| Research Institution | Kanazawa University |
|---|
Principal Investigator |
KONDO Yukio Kanazawa University, 附属病院, 助教 (10322116)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 腫瘍関連抗原 / ワクチン療法 / 臍帯血移植 / 樹状細胞 / 白血病 / 癌 / GITRL / GVL効果 |
|---|
| Research Abstract |
The expression of GITRL was observed both on leukemic cells and leukemic dendritic cells. The binding of GITRL to GITR on T cells inhibited induction of CDK2, One of the leukemia-associated antigens, -specific cytotoxic T cells (CTL) and restrained CTL activity. The GITR/GITRL interaction also increased indoleamine 2, 3-dioxygenase (IDO) activity even in leukemic cells and inducing kynurenine secretion from leukemic cells. The administration of anti-IDO agents or anti-GITRL blocking Abs combined with CDK2 vaccination may therefore effectively induce CDK2-specific CTLs in unrelated cord blood transplantation recipients.
|
Report
(4 results)
Research Products
(19 results)
