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Development of novel tumor-associated antigens peptide vaccine inducing a graft-versus-leukemia effect after umbilical cord blood transplantation

Research Project

Project/Area Number 20591146
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hematology
Research InstitutionKanazawa University

Principal Investigator

KONDO Yukio  Kanazawa University, 附属病院, 助教 (10322116)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords腫瘍関連抗原 / ワクチン療法 / 臍帯血移植 / 樹状細胞 / 白血病 / 癌 / GITRL / GVL効果
Research Abstract

The expression of GITRL was observed both on leukemic cells and leukemic dendritic cells. The binding of GITRL to GITR on T cells inhibited induction of CDK2, One of the leukemia-associated antigens, -specific cytotoxic T cells (CTL) and restrained CTL activity. The GITR/GITRL interaction also increased indoleamine 2, 3-dioxygenase (IDO) activity even in leukemic cells and inducing kynurenine secretion from leukemic cells. The administration of anti-IDO agents or anti-GITRL blocking Abs combined with CDK2 vaccination may therefore effectively induce CDK2-specific CTLs in unrelated cord blood transplantation recipients.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (19 results)

All 2010 2009 2008

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (14 results)

  • [Journal Article] Loss of HLA CIass-I Expression In Leukemic Cells That Relapsed After HLA-Matched and -Mismatched SCT2010

    • Author(s)
      Kondo Y, Espinosa L, Katagiri T, Qi Z, Nakao S
    • Journal Title

      BLOOD

      Volume: 116 Pages: 1379-1379

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] GITR Ligation with GITR Ligand On Leukemic Cells Suppresses Induction of Leukemia-Associated Antigen Specific T cells by Increasing Indoleamine 2, 3-Dioxygenase (IDO) Activity Leading to Kynurenine Secretion.2009

    • Author(s)
      Kondo Y, Espinosa L, Katagiri T, Qi Z, Nakao S
    • Journal Title

      BLOOD 114

      Pages: 1379-1379

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] GITR Ligation with GITR Ligand On Leukemic Cells Suppresses Induction of Leukemia-Associated Antigen Specific T cells by Increasing Indoleamine 2, 3-Dioxygenase(IDO)Activity Leading to Kynurenine Secretion.2009

    • Author(s)
      Kondo Y, Espinosa L, Katagiri T, Qi Z, Nakao S
    • Journal Title

      BLOOD 114

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] GITR Ligand on Leukemic Myeloid Dendritic Cells Suppresses Induction of Leukemia-Associated Antigen-Specific CTLs from Naive CD8+ T Cells.2008

    • Author(s)
      Kondo Y, Katagiri T, Ohata K, Nakao S
    • Journal Title

      BLOOD 112

      Pages: 817-818

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] GITR Ligand on Leukemio Myeloid Dendritic Cells Suppresses Induction of Leukemia-Associated Antigen-Specific CTLs from Naive CD8+T Cells2008

    • Author(s)
      Kondo Y, Katagiri T, Ohata K, Nakao S
    • Journal Title

      BLOOD 112

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] GITR-GITRリガンド結合を介した白血病細胞によるCTL の抑制:白血病細胞内インドールアミン酸素添加酵素(IDO)の関与2010

    • Author(s)
      近藤恭夫、ルイス エスピノーザ、片桐孝和、中尾眞二
    • Organizer
      第32回日本造血細胞移植学会総会
    • Place of Presentation
      アクトシティ浜松(静岡県)
    • Year and Date
      2010-02-20
    • Related Report
      2010 Final Research Report
  • [Presentation] Loss of HLA class-I expression in leukemic cells relapsed after HLA-matched and -mismatched SCT.2010

    • Author(s)
      Kondo Y, Katagiri T, Hosokawa K, Ohata K, Ishiyama K.Yamzaki H, Takami A, Nakao S
    • Organizer
      第72回日本血液学会
    • Place of Presentation
      ノぐシフィコ横浜(神奈川県)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Loss of HLA CIass-I Expression In Leukemic Cells That Relapsed After HLA-Matched and -Mismatched SCT2010

    • Author(s)
      Kondo Y, Katagiri T, Hosokawa K, Ohata K, Yamzaki H, Ozawa S, Nakao S
    • Organizer
      第52回アメリカ血液学会総会
    • Place of Presentation
      Orlando.USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] GITR-GITRリガンド結合を介した白血病細胞によるCTLの抑制:白血病細胞内インドールアミン酸素添加酵素(IDO)の関与2010

    • Author(s)
      近藤恭夫、ルイスエスピノーザ、片桐孝和、中尾眞二
    • Organizer
      第32回日本造血細胞移植学会総会
    • Place of Presentation
      アクトシティ浜松(浜松)
    • Related Report
      2009 Annual Research Report
  • [Presentation] GITR Ligation with GITR Ligand On Leukemic Cells Suppresses Induction of Leukemia-Associated Antigen Specific T cells by Increasing Indoleamine 2, 3-Dioxygenase (IDO) Activity Leading to Kynurenine Secretion.2009

    • Author(s)
      Kondo Y, Espinosa L, Katagiri T, Qi Z, Nakao S
    • Organizer
      51st annual meeting of the American Society of Hematology.
    • Place of Presentation
      Ernest N.Memorial Convention Center (USA)
    • Year and Date
      2009-12-06
    • Related Report
      2010 Final Research Report
  • [Presentation] 血病細胞は抑制性補助刺激分子を発現してLAAs特異的CTLの誘導を抑制する2009

    • Author(s)
      近藤恭夫、大畑欣也、祁志栄、中尾眞二
    • Organizer
      第71回日本血液学会総会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2009-10-25
    • Related Report
      2010 Final Research Report
  • [Presentation] 白血病細胞が発現しているGITRLによって抗白血病免疫が抑制される2009

    • Author(s)
      近藤恭夫、ルイスエスピノーザ、片桐孝和、中尾眞二
    • Organizer
      第1回造血器腫瘍免疫療法研究会
    • Place of Presentation
      千里ライフサイエンスセンター(大阪)
    • Year and Date
      2009-08-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] 白血病細胞は抑制性補助刺激分子を発現してLAAs特異的CTLの誘導を抑制する2009

    • Author(s)
      近藤恭夫、大畑欣也、祁志栄、中尾眞二
    • Organizer
      第71回日本血液学会
    • Place of Presentation
      国立京都国際会館(京都)
    • Related Report
      2009 Annual Research Report
  • [Presentation] GITR Ligation with GITR Ligand On Leukemic Cells Suppresses Induction of Leukemia-Associated Antigen Specific T cells by Increasing Indoleamine 2, 3-Dioxygenase(IDO)Activity Leading to Kynurenine Secretion.2009

    • Author(s)
      Kondo Y, Espinosa L, Katagiri T, Qi Z, Nakao S
    • Organizer
      第51回アメリカ血液学会総会
    • Place of Presentation
      Ernest N.Memorial Convention Center(USA)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 白血病細胞由来樹状細胞上のGITR リガンドはCDK2ペプチド特異的CTLの誘導を抑制する2009

    • Author(s)
      近藤恭夫, 大畑欣也, 中尾眞二
    • Organizer
      第31回日本造血細胞移植学会総会
    • Place of Presentation
      札幌
    • Related Report
      2008 Annual Research Report
  • [Presentation] GITR Ligand on Leukemic Myeloid Dendritic Cells Suppresses Induction of Leukemia-Associated Antigen-Specific CTLs from Naive CD8+ T Cells.2008

    • Author(s)
      近藤恭夫, 片桐孝和, 大畑欣也, 中尾眞二
    • Organizer
      50th annual meeting of the American Society of Hematology.
    • Place of Presentation
      Moscone Convention Center (USA)
    • Year and Date
      2008-12-09
    • Related Report
      2010 Final Research Report
  • [Presentation] 白血病細胞由来樹状細胞は健常者のT細胞を刺激してCDK2ペプチド特異的CTLを誘導する2008

    • Author(s)
      近藤恭夫、大畑欣也、石山謙、中尾眞二
    • Organizer
      第3回血液腫瘍免疫フォーラム
    • Place of Presentation
      大和屋(愛媛県)
    • Year and Date
      2008-04-06
    • Related Report
      2010 Final Research Report
  • [Presentation] 白血病細胞由来樹状細胞は健常者のT細胞を刺激してCDK2ペプチド特異的CTLの誘導を誘導する2008

    • Author(s)
      近藤恭夫, 大畑欣也, 石山謙, 中尾眞二
    • Organizer
      第3回血液腫瘍免疫フォーラム会
    • Place of Presentation
      松山
    • Related Report
      2008 Annual Research Report
  • [Presentation] GITR Ligand on Leukemic Myeloid Dendritic Cells Suppresses Induction of Leukemia-Associated Antigen-Specific CTLs from Naive CD8+T Cells2008

    • Author(s)
      Kondo Y, Katagiri T, Ohata K, Nakao S
    • Organizer
      第50回アメリカ血液学会総会
    • Place of Presentation
      サンフランシスコ
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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