| Project/Area Number |
20591147
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
INOUE Katsue University of Yamanashi, 大学院・医学工学総合研究部, 准教授 (10324211)
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|---|
| Co-Investigator(Kenkyū-buntansha) |
INOUE Osamu 山梨大学, 大学院・医学工学総合研究部, 助教 (00432154)
OZAKI Yukio 山梨大学, 大学院・医学工学総合研究部, 教授 (30134539)
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| Co-Investigator(Renkei-kenkyūsha) |
SATOH Kaneo 山梨大学, 医学部, 助手 (20242662)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 血小板 / CLEC-2 / ポドプラニン / 癌転移 / podoplanin |
|---|
| Research Abstract |
Novel platelet activation receptor CLEC-2 binds to podoplanin expressed on the surface of several kinds of cancer cells, which results in platelet activation and facilitates cancer metastasis. In the present study, we sought to identify an internal ligand of CLEC-2 other than podoplanin. We found two cancer cell lines, which express a CLEC-2 ligand other than podoplanin, although we were not able to identify the protein. We also found that CLEC-2 forms homophilic association in a manner depending on platelet activation, which stabilizes thrombus formation.
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