Elucidation of molecular pathogenesis and control of thrombosis in metabolic syndrome
| Project/Area Number |
20591148
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Nagoya University |
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Principal Investigator |
YAMAMOTO Koji Nagoya University, 医学部附属病院, 講師 (90362251)
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| Co-Investigator(Kenkyū-buntansha) |
KOJIMA Tetsuhito 名古屋大学, 医学部, 教授 (40161913)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 血栓症 / 高血圧 / 肥満 / 糖尿病 / ストレス / 脂肪細胞 / サイトカイン / 線溶 |
|---|
| Research Abstract |
Dramatic induction both of PAI-1, a principal regulator of fibrinolytic system, and TF, an initiator of coagulation, was observed in obese mouse, especially in their adipose tissues, which consist of large adipocytes. When obese mice encounter mental stress, they produce more amounts of PAI-1 and TF. These observations suggest that prothrombotic state progresses in metabolic syndrome, especially in stressful conditions.
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] A novel splice site mutation in intron C of PROS1 leads to markedly reduced mutant mRNA level, absence of thrombin-sensitive region, and impaired secretion and cofactor activity of mutant protein S.2010
Author(s)
Okada H, Kunishima S, Hamaguchi M, Takagi A, Yamamoto K, Takamatsu J, Matsushita T, Saito H, Kojima T, Yamazaki T.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Severe hemophilia A in a Japanese female caused by an F8-intron 22 inversion associated with skewed X chromosome inactivation.2010
Author(s)
Miyawaki Y, Suzuki A, Fujimori Y, Takagi A, Murate T, Suzuki N, Katsumi A, Naoe T, Yamamoto K, Matsushita T, Takamatsu J, Kojima T.
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Journal Title
International Journal of Hematology 92
Pages: 405-408
NAID
Related Report
Peer Reviewed
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[Journal Article] A novel splice site mutation in intron C of PROS1 leads to markedly reduced mutant mRNA level, absence of thrombin-sensitive region, and impaired secretion and cofactor activity of mutant protein S.2010
Author(s)
Okada H, Kunishima S, Hamaguchi M, Takagi A, Yamamoto K, Takamatsu J, Matsushita T, Saito H, Kojima T, Yamazaki T.
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Journal Title
Thrombosis Research
Volume: 125
Related Report
Peer Reviewed
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[Journal Article] Severe hemophilia A in a Japanese female caused by an F8-intron 22 inversion associated with skewed X chromosome inactivation.2010
Author(s)
Miyawaki Y, Suzuki A, Fujimori Y, Takagi A, Murate T, Suzuki N, Katsumi A, Naoe T, Yamamoto K, Matsushita T, Takamatsu J, Kojima T.
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Journal Title
International Journal of Hematology
Volume: 92
Pages: 405-408
NAID
Related Report
Peer Reviewed
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