Significance of CD8-positive T lymphocytes in graft and recipient peripheral blood in the immunoresponse after allogeneic cord blood transplantation
| Project/Area Number |
20591149
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Hematology
|
|---|
| Research Institution | Nagoya University |
|---|
Principal Investigator |
MURATA Makoto Nagoya University, 医学部附属病院, 講師 (40378063)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
SUZUKI Haruhiko 名古屋大学, 大学院・医学系研究科, 准教授 (90283431)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | 臍帯血移植 / 骨髄移植 / 生着 / 拒絶 / 移植片対宿主病 / 移植片対白血病効果 / T細胞 / HLA / CD8 / CD4 |
|---|
| Research Abstract |
We analyzed a significance of CD8-positive T lymphocytes in graft and recipient peripheral blood in the immunoresponse after allogeneic hematopoietic stem cell transplantation. We observed the followings : (1) recovery of nalve CD8-positive T lymphocytes after cord blood transplantation is comparable to that after bone marrow transplantation, (2) CD8-positive T lymphocytes that survive beyond pre-transplant conditioning can cause graft rejection, and (3) under immunological pressure by CD8-positive T lymphocytes that recognize mismatched HLA molecule between donor and recipient, residual leukemia blast clones whose HLA expression is low can expand and result in relapse.
|
Report
(4 results)
Research Products
(47 results)
-
[Journal Article] Cytotoxic T-lymphocyte antigen 4 haplotype correlates with relapse and survival after allogeneic hematopoietic SCT.2011
Author(s)
Murase M, Nishida T, Onizuka M, Inamoto Y, Sugimoto K, Imahashi N, Murata M, Miyamura K, Kodera Y, Inoko H, Naoe T.
-
Journal Title
Bone Marrow Transplantation 印刷中
Related Report
Peer Reviewed
-
[Journal Article] A prospective dose-finding trial using a modified continual reassessment method for optimization of fludarabine plus melphalan conditioning for marrow transplantation from unrelated donors in patients with hematopoietic malignancies.2011
Author(s)
Terakura S, Atsuta Y, Sawa M, Ohashi H, Kato T, Nishiwaki S, Imahashi N, Yasuda T, Murata M, Miyamura K, Suzuki R, Naoe T, Ito T, Morishita Y.
-
Journal Title
Related Report
Peer Reviewed
-
-
-
[Journal Article] Donor single nucleotide polymorphism in the CCR9 gene affects the incidence of skin GVHD.2010
Author(s)
Inamoto Y, Murata M, Katsumi A, Kuwatsuka Y, Tsujimura A, Ishikawa Y, Sugimoto K, Onizuka M, Terakura S, Nishida T, Kanie T, Taji H, Iida H, Suzuki R, Abe A, Kiyoi H, Matsushita T, Miyamura K, Kodera Y, Naoe T.
-
Journal Title
Bone Marrow Transplantation 45
Pages: 363-369
Related Report
Peer Reviewed
-
-
-
[Journal Article] Irrespective of CD34 expression, lineage- committed cell fraction reconstitutes and reestablishes transformed Philadelphia chromosome-positive leukemia in NOG mice.2009
Author(s)
Tanizaki R, Nomura Y, Miyata Y, Minami Y, Abe A, Hanamura A, Sawa M, Murata M, Kiyoi H, Matsushita T, Naoe T.
-
Journal Title
Cancer Science 101(3)
Pages: 631-638
Related Report
Peer Reviewed
-
[Journal Article] Clinicopathological manifestations and treatment of intestinal transplant-associated microangiopathy (i-TAM).2009
Author(s)
Inamoto Y, Ito M, Suzuki R, Nishida T, Iida H, Kohno A, Sawa M, Murata M, Nishiwaki S, Oba T, Yanada M, Naoe T, Ichihashi R, Fujino M, Yamaguchi T, Morishita Y, Hirabayashi N, Kodera Y, Miyamura K.
-
Journal Title
Bone Marrow Transplantation 44
Pages: 43-49
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Optimization of fludarabine + melphalan conditioning for marrow transplantation from unrelated donors for patients with hematopoietic malignancies : a prospective dose-finding trial using modified continual reassessment method.2009
Author(s)
Terakura S, Sawa M, Ohashi H, Kato T, Nishiwaki S, Imahashi N, Murata M, Miyamura K, Atsuta Y, Suzuki R, Naoe T, Ito T, Morishita Y.
Organizer
The 51st Annual Meeting of the American Society of Hematology
Place of Presentation
New Orleans Convention Center(ルイジアナ州ニューオーリンズ)
Year and Date
2009-12-06
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
