Activation of platelet toll-like receptors and its clinical significance
| Project/Area Number |
20591153
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Hematology
|
|---|
| Research Institution | Ehime University |
|---|
Principal Investigator |
HATO Takaaki Ehime University, 医学部附属病院, 准教授 (30172943)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
YAMANOUCHI Jun 愛媛大学, 医学部附属病院, 講師 (10423451)
YASUKAWA Masaki 愛媛大学, 医学系研究科, 教授 (60127917)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | 血小板 / TOLL-like receptor / 自然免疫 / 細菌感染症 / Toll-like receptor / インテグリン / GPIIb-IIIa / 敗血症 / 感染症 / 免疫学 |
|---|
| Research Abstract |
We examined the role of toll-like receptors (TLR) on the platelet surface. Stimulation of platelet TLR with bacterial components promoted the platelet adhesive response through another platelet receptor. Serum from patients with sepsis, a severe bacterial infection, promoted the platelet adhesive response through platelet TLR. These results indicate that the linkage between platelets and various pathogens promotes the platelet adhesive activity, suggesting a crucial role of platelets on the host defense mechanism.
|
Report
(4 results)
Research Products
(33 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Identification of an epitope derived from CML66, a novel tumor-associated antigen expressed broadly in human leukemia, recognized by human leukocyte antigen-A*2402- restricted cytotoxic T lymphocytes.2008
Author(s)
Suemori K, Fujiwara H, Ochi T, Azuma T, Yamanouchi J, Narumi H, Yakushijin Y, Hato T, Hasegawa H, Yasukawa M
-
Journal Title
Cancer Sci 99
Pages: 1414-1419
NAID
Related Report
Peer Reviewed
-
-
-
[Journal Article] Identification of an epitope derived from CML66, a novel tumor-associated antigen expressed broadly in human leukemia, recognized by human leukocyte antigen-A*2402-restricted cytotoxic T lymphocytes.2008
Author(s)
Suemori K, Fujiwara H, Ochi T, Azuma T, Yamanouchi J, Narumi H, Yakushijin Y, Hato T, Hasegawa H, Yasukawa M
-
Journal Title
Cancer Science 99
Pages: 1414-1419
NAID
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
