The effect and function of co-stimulatory molecules (B7 family molecules) on myeloma
| Project/Area Number |
20591157
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Nippon Medical School |
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Principal Investigator |
TAMURA Hideto Nippon Medical School, 医学部, 助教 (70256949)
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| Co-Investigator(Kenkyū-buntansha) |
OGATA Kiyoyuki 日本医科大学, 医学部, 教授 (20169171)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 血液免疫学 / 骨髄腫 / 補助刺激分子 / B7-H1 / 細胞周期 / B7系分子 |
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| Research Abstract |
The results of our study suggest that the expression of some molecules belonging to the B7 family on myeloma cells is induced or enhanced in the bone marrow microenvironment and that these molecules inhibit the proliferation of myeloma-specific cytotoxic T cells directly or indirectly. Furthermore, these B7 molecules are associated with tumor proliferation and the inhibition of tumor cell apoptosis.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Interferon-γ and tumor necrosis factor-α induce an immunoinhibitory molecule, B7-H1, via nuclear factor κB activation in blasts in myelodysplastic syndromes.2010
Author(s)
Kondo A, Yamashita T, Tamura H, Zhao W, Tsuji T, Shimizu M, Shinya E, Takahashi H, Tamada K, Chen L, Dan K, Ogata K.
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Journal Title
Blood 116(7)
Pages: 1124-1131
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[Presentation] Expression and function of B7.2 and B7-H2 molecules on myeloma cells.2008
Author(s)
Taishi Yamashita, Hideto Tamura, Chikako Sato, Asaka Kondo, Eiji Shinya, Hidemi Takahashi, Lieping Chen, Takashi Tsuji, Kazuo Dan, Kiyoyuki Ogata
Organizer
50th Annual Meeting, American Society of Hematology
Place of Presentation
San Francisco
Related Report
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