| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
The MYH9 disorders are autosomal dominant congenital platelet disorders, characterized by giant platelets, thrombocytopenia, and granulocyte inclusion bodies. COS7 cells transfected with wild-type full length MYH9 cDNA and that with the single base deletion mutation of Exon 40 identified in patients showed the normal fiber localization of NMMHC-IIA protein without forming inclusion bodies. Inhibition of lamellipodial extension and increase in the number of focal adhesion complex in transfected COS7 cells, with or without MYH9 mutation, suggested functional expression of mutant NMMHC-IIA.
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