| Project/Area Number |
20591168
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Kyoto University |
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Principal Investigator |
USUI Takashi Kyoto University, 大学院・医学研究科, 特定准教授 (90362483)
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| Co-Investigator(Renkei-kenkyūsha) |
MIMORI Tsunryo 京都大学, 医学研究科, 教授 (10157589)
WAKATSUKI Yoshio 京都大学, 医学研究科, 講師 (40220826)
NISHIKOMORI Ryuta 京都大学, 医学研究科, 准教授 (70359800)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 関節リウマチ / 関節炎モデルマウス / IL-17 / gamma / delta T細胞 / 自己免疫疾患 / サイトカイン / IFN-gamma / ケモカイン / SKGマウス / コラーゲン誘導関節炎 |
|---|
| Research Abstract |
Although interleukin-17 (IL-17)-producing T cells were reported to play pathogenic roles in murine autoimmune disease models, there are few information about it in human autoimmune diseases. One of the aims of this study was to analyze which are the predominant cells, IL-17 producing T cells or IFN-gamma producing T cells in murine arthritis models as well as rheumatoid arthritis.
IL-17 producing T cells were predominant population in both collagen-induced arthritis (CIA) in mice and SKG mice in affected joints. In CIA mice, the majority of IL-17 producing T cells were not alpha/beta T cells but gamma/delta T cells, in contrast, IL-17 producing T cells were not gamma/delta T cells but alpha/beta T cells in affected joints of SKG mice. Furthermore, IFN-gamma producing T cells were predominant in the joints of RA. These results demonstrate that there were significant differences in the cytokine profile of T cells in the arthritic joints of two murine models and human RA.
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