Development of new anti-inflammatory compounds and/or biologics to achieve disease specific immune-regulation
| Project/Area Number |
20591168
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Kyoto University |
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Principal Investigator |
USUI Takashi Kyoto University, 大学院・医学研究科, 特定准教授 (90362483)
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| Co-Investigator(Renkei-kenkyūsha) |
MIMORI Tsunryo 京都大学, 医学研究科, 教授 (10157589)
WAKATSUKI Yoshio 京都大学, 医学研究科, 講師 (40220826)
NISHIKOMORI Ryuta 京都大学, 医学研究科, 准教授 (70359800)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 関節リウマチ / 関節炎モデルマウス / IL-17 / gamma / delta T細胞 / 自己免疫疾患 / サイトカイン / IFN-gamma / ケモカイン / SKGマウス / コラーゲン誘導関節炎 |
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| Research Abstract |
Although interleukin-17 (IL-17)-producing T cells were reported to play pathogenic roles in murine autoimmune disease models, there are few information about it in human autoimmune diseases. One of the aims of this study was to analyze which are the predominant cells, IL-17 producing T cells or IFN-gamma producing T cells in murine arthritis models as well as rheumatoid arthritis.
IL-17 producing T cells were predominant population in both collagen-induced arthritis (CIA) in mice and SKG mice in affected joints. In CIA mice, the majority of IL-17 producing T cells were not alpha/beta T cells but gamma/delta T cells, in contrast, IL-17 producing T cells were not gamma/delta T cells but alpha/beta T cells in affected joints of SKG mice. Furthermore, IFN-gamma producing T cells were predominant in the joints of RA. These results demonstrate that there were significant differences in the cytokine profile of T cells in the arthritic joints of two murine models and human RA.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] DIP2 disco-interacting protein 2 homolog A (Drosophila) is a candidate receptor for follistatin-related protein/follistatin-like 1 -analysis of their binding with TGF-β superfamily proteins.2010
Author(s)
Tanaka M, Murakami K, Ozaki S, Imura Y, Tong XP, Watanabe T, Sawaki T, Kawanami T, Kawabata D, Fujii T, Usui T, Masaki Y, Fukushima T, Jin ZX, Umehara H, Mimori T
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Journal Title
FEBS J. 277(20)
Pages: 4278-89
Related Report
Peer Reviewed
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[Journal Article] Anti-U1 RNP antibodies in cerebrospinal fluid are associated with central neuropsychiatric manifestations in systemic lupus erythematosus and mixed connective tissue disease.2010
Author(s)
Sato T, Fujii T, Yokoyama T, Fujita Y, Imura Y, Yukawa N, Kawabata D, Nojima T, Ohmura K, Usui T, Mimori T
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Journal Title
Arthritis Rheum. 62(12)
Pages: 3730-40
NAID
Related Report
Peer Reviewed
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[Journal Article] The RIG-I-like receptor IFIH1/MDA5 is a dermatomyositis-specific autoantigen identified by the anti-CADM-140 antibody.2010
Author(s)
Nakashima R, Imura Y, Kobayashi S, Yukawa N, Yoshifuji H, Nojima T, Kawabata D, Ohmura K, Usui T, Fujii T, Okawa K, Mimori T.
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Journal Title
Rheumatology (Oxford). 49(3)
Pages: 433-40
Related Report
Peer Reviewed
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[Journal Article] DIP2 disco-interacting protein 2 homolog A (Drosophila) is a candidate receptor for follistatin-related protein/follistatin-like 1-analysis of their binding with TGF-β superfamily proteins.2010
Author(s)
Tanaka M, Murakami K, Ozaki S, Imura Y, Tong XP, Watanabe T, Sawaki T, Kawanami T, Kawabata D, Fujii T, Usui T, Masaki Y, Fukushima T, Jin ZX, Umehara H, Mimori T.
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Journal Title
FEBS J
Volume: 277
Pages: 4278-89
Related Report
Peer Reviewed
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[Journal Article] Anti-U1 RNP antibodies in cerebrospinal fluid are associated with central neuropsychiatric manifestations in systemic lupus erythematosus and mixed connective tissue disease.2010
Author(s)
Sato T, Fujii T, Yokoyama T, Fujita Y, Imura Y, Yukawa N, Kawabata D, Nojima T, Ohmura K, Usui T, Mimori T.
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Journal Title
Arthritis Rheum
Volume: 62
Pages: 3730-40
NAID
Related Report
Peer Reviewed
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[Journal Article] The RIG-I-like receptor IFIH1/MDA5 is a dermatomyositis-specific autoantigen identified by the anti-CADM-140 antibody.2010
Author(s)
Nakashima R, Imura Y, Kobayashi S, Yukawa N, Yoshifuji H, Nojima T, Kawabata D, Ohmura K, Usui T, Fujii T, Okawa K, Mimori T.
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Journal Title
Rheumatology
Volume: 49
Pages: 433-40
Related Report
Peer Reviewed
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[Journal Article] Gamma/delta T cells are the predominant source of interleukin-17 in affected joints in collagen-induced arthritis, but not in rheumatoid arthritis.2009
Author(s)
Ito Y, Usui T, Kobayashi S, Iguchi-Hashimoto M, Ito H, Yoshitomi H, Nakamura T, Shimizu M, Kawabata D, Yukawa N, Hashimoto M, Sakaguchi N, Sakaguchi S, Yoshifuji H, Nojima T, Ohmura K, Fujii T, Mimori T.
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Journal Title
Arthritis Rheum. 60(8)
Pages: 2294-303
Related Report
Peer Reviewed
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[Presentation] A New ELISA System for Detecting Autoantibodies to aminoacyl-tRNA Synthetases : Usefulness in Myositis and Interstitial Pneumonia.2010
Author(s)
Ran Nakashima, Yoshitaka Imura, Shio Kobayashi, Yuji Hosono, Naoichiro Yukawa, Daisuke Kawabata, Takaki Nojima, Koichiro Ohmura, Takashi Usui, Takao Fujii, Minae Seto, Akihiro Murakami, Tsuneyo Mimori
Organizer
米国リウマチ学会
Place of Presentation
Atlanta.U.S.A.
Year and Date
2010-11-07
Related Report
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[Presentation] リウマチ性疾患の検査血清IL-17F値は関節リウマチの新規バイオマーカーである2009
Author(s)
小林志緒, 臼井崇, 伊藤能永, 橋本美季子, 吉藤元, 清水正和, 湯川尚一郎, 川端大介, 野島崇樹, 大村浩一郎, 藤井隆夫, 三森経世.
Organizer
第53回日本リウマチ学会
Place of Presentation
東京
Year and Date
2009-04-25
Related Report
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