Regulation of heme oxygenase-1 expression and the therapeutic application in rheumatic and inflammatory diseases

• Project/Area Number: 20591174
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Yokohama City University
• Principal Investigator: TAKENO Mitsuhiro Yokohama City University, 医学部, 准教授 (50236494)
• Co-Investigator(Kenkyū-buntansha): UEDA Atsuhisa 横浜市立大学, 附属病院, 准教授 (60295483)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: ヘムオキシゲナーゼ-1 / Bach1 / 成人発症スティル病 / 血球貪食症候群 / ベーチェット病 / 破骨細胞 / アトピー性皮膚炎 / 白血病 / 肺癌 / 睡眠時無呼吸症候群 / 一酸化炭素 / 成人スティル病 / 血球貧食症候群 / IL-10 / 破骨細胞分化 / 癌 / スティル病 / Nrf2 / サイトカイン / Toll-like receptor / 関節リウマチ / アレルギー性疾患

Research Abstract

This project investigated pathogenic roles of heme oxygenase (HO)-1 in rheumatic and inflammatory diseases. We showed implication of defective HO-1expressoin in Behcet's disease, a protective role of HO-1 in atopic dermatitis, and serum HO-1 as a biomarker in hemophagocytic syndrome. Moreover, our studies revealed that HO-1 is involved in sleep apnea syndrome, osteoclastogenesis, tumor growth and acquired resistance to anticancer agents.

Research Products

• [Journal Article] Power Doppler ultrasonography is useful for assessing disease activity and predicting joint destruction in rheumatoid arthritis patients receiving tocilizumab-preliminary data. (2011)
  • Author(s): Hama M, Takeno M, et al
  • Journal Title: Rheumatol Int. Volume: 32(In press)
  • Peer Reviewed
• [Journal Article] Behcet disease : evolution of clinical manifestations. (2011)
  • Author(s): Ideguchi H, Takeno M, et al
  • Journal Title: Medicine (Baltimore). Volume: 90 Pages: 125-132
  • Peer Reviewed
• [Journal Article] Behcet's disease and colon cancer. (2011)
  • Author(s): Inamori M, Takeno M.
  • Journal Title: Internal Med. Volume: 50 Pages: 537-538
  • Peer Reviewed
• [Journal Article] TNF阻害薬(ベーチェット病および血管炎症候群) (2011)
  • Author(s): 岳野光洋、石ヶ坪良明
  • Journal Title: リウマチ科 Volume: 45 Pages: 41-47
• [Journal Article] Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behcet's disease susceptibility loci. (2010)
  • Author(s): Mizuki N, Takeno M, et al.
  • Journal Title: Nat Genet. 42(8) Pages: 703-706
• [Journal Article] Expression of heme oxygenase-1 in human leukemic cells and its regulation by transcriptional repressor Bach1. (2010)
  • Author(s): Miyazaki T, Takeno M, Ueda A., et al.
  • Journal Title: Cancer Sci. 101(6) Pages: 1409-1416
  • NAID: 10026593365
• [Journal Article] Serum HO-1 is useful to make differential diagnosis of secondary hemophago-cytic syndrome from other similar hematological conditions. (2010)
  • Author(s): Miyazaki T, Takeno M, Ueda A., et al.
  • Journal Title: Int J Hematol. 91(2) Pages: 229-237
• [Journal Article] Inhibition of heme oxygenase-1 with an epidermal growth factor receptor inhibitor and cisplatin decreases proliferation of lung cancer A549 cells. (2010)
  • Author(s): Kuroda H, Takeno M, et al.
  • Journal Title: Lung Cancer 67(1) Pages: 31-36
• [Journal Article] Inhibition of heme oxygenase-1 with an epidermal growth factor receptor inhibitor and cisplatin decreases proliferation of lung cancer A549 cells. (2010)
  • Author(s): Kuroda H, Takeno M, et al
  • Journal Title: Lung Cancer Volume: 67 Pages: 31-36
  • Peer Reviewed
• [Journal Article] Serum HO-1 is useful to make differential diagnosis of secondary hemophagocytic syndrome from other similar hematological conditions. (2010)
  • Author(s): Miyazaki T, Takeno M, et al
  • Journal Title: Int J Hematol Volume: 91 Pages: 229-37
  • NAID: 10026111361
  • Peer Reviewed
• [Journal Article] Neurological manifestations of Behcet's disease in Japan : a study of 54 patients. (2010)
  • Author(s): Ideguchi H, Takeno M, et al
  • Journal Title: J Neurol. Volume: 257 Pages: 1012-1020
  • Peer Reviewed
• [Journal Article] Therapeutic angiogenesis in patients with systemic sclerosis by autologous transplantation of bone-marrow-derived cells. (2010)
  • Author(s): Ishigatsubo Y, Takeno M, et al
  • Journal Title: Mod Rheumatol. Volume: 20 Pages: 263-272
  • NAID: 10027169345
  • Peer Reviewed
• [Journal Article] Armadillo Repeat Containing 8alpha Binds to HRS and Promotes HRS Interaction with Ubiquitinated Proteins. (2010)
  • Author(s): Tomaru K, Takeno M, et al
  • Journal Title: Open Biochem J. Volume: 4 Pages: 1-8
  • Peer Reviewed
• [Journal Article] Expression of heme oxygenase-1 in human leukemic cells and its regulation by transcriptional repressor Bach1. (2010)
  • Author(s): Miyazaki T, Takeno M, et al
  • Journal Title: Cancer Sci. Volume: 10 Pages: 1409-1416
  • NAID: 10026593365
  • Peer Reviewed
• [Journal Article] Completion rate and compliance of anti-tuberculosis chemopro phylaxis in patients with rheumatic disease receiving tumor necrosis factor antagonists. (2010)
  • Author(s): Ideguchi H, Takeno M, et al
  • Journal Title: Clin Exp Rheumatol. Volume: 26 Pages: 294-295
  • Peer Reviewed
• [Journal Article] Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behcet's disease susceptibility loci. (2010)
  • Author(s): Mizuki N, Takeno M, et al
  • Journal Title: Nat Genet. Volume: 42 Pages: 703-766
  • Peer Reviewed
• [Journal Article] 関節リウマチ患者の満足度に影響する因子の分析 (2010)
  • Author(s): 青木昭子, 岳野光洋, 他
  • Journal Title: 臨床リウマチ Volume: 22 Pages: 42-50
  • Peer Reviewed
• [Journal Article] ベーチェット病 (2010)
  • Author(s): 岳野光洋、石ヶ坪良明
  • Journal Title: 特集関節リウマチ(宮坂信之編集)日本臨床 Volume: 66 Pages: 602-605
• [Journal Article] Serum HO-1 is useful to make differential diagnosis of secondary hemophagocytic syndrome from other similar hematological conditions (2010)
  • Author(s): 宮崎拓也, 岳野光洋
  • Journal Title: International Journal of Hematology 91(2) Pages: 229-37
  • NAID: 10026111361
  • Peer Reviewed
• [Journal Article] Neurological manifestations of Behcet's disease in Japan : a study of 54 patients (2010)
  • Author(s): Ideguchi H, Takeno M, et al.
  • Journal Title: J Neurol (In press)
  • Peer Reviewed
• [Journal Article] Therapeutic angiogenesis in patients with systemic sclerosis by autologous transplantation of bone-marrow-derived cells (2010)
  • Author(s): 石ヶ坪良明, 岳野光洋
  • Journal Title: Mod Rheumatol (In presee)
  • NAID: 10027169345
  • Peer Reviewed
• [Journal Article] Armadillo Repeat Containing 8alpha Binds to HRS and Promotes HRS Interaction with Ubiquitinated Proteins (2010)
  • Author(s): Tomaru K, Takeno M, et al.
  • Journal Title: Open Biochemical Journal 4 Pages: 1-8
  • Peer Reviewed
• [Journal Article] Expression of heme oxygenase-1 in human leukemic cells andits regulation by transcriptional repressor Bach1 (2010)
  • Author(s): 宮崎拓也, 岳野光洋
  • Journal Title: Cancer Science (In presee)
  • Peer Reviewed
• [Journal Article] Use of musculoskeletal ultrasound in Japan : a survey of practicing rheumatologists (2010)
  • Author(s): Takase K, Takeno M, et al.
  • Journal Title: Mod Rheumatol (In presee)
  • NAID: 10026691486
  • Peer Reviewed
• [Journal Article] ベーチェット病.特集関節リウマチ (2010)
  • Author(s): 岳野光洋, 石ヶ坪良明
  • Journal Title: 日本臨床 68 suppl.5 Pages: 602-605
• [Journal Article] Mycobacterium tuberculosis-specific immunospot assay of pleural exudate mononuclear cells is useful for the exclusion of tuberculous pleuritis in patients with lupus pleuritis.. (2009)
  • Author(s): Takase K, Takeno M, et al.
  • Journal Title: Lupus 18(2) Pages: 175-177
  • Peer Reviewed
• [Journal Article] Screening of tuberculosis by interferon-gamma assay before biologic therapy for rheumatoid arthritis (2009)
  • Author(s): 村上修司, 岳野光洋, et al
  • Journal Title: Tuberculosis 89(2) Pages: 136-141
  • Peer Reviewed
• [Journal Article] Inhibition of heme oxygenase-1 with an epidermal growth factor receptor inhibitor and cisplatin decreases proliferation of lung cancer A549 cells (2009)
  • Author(s): Kuroda H, Takeno M, et al.
  • Journal Title: Lung Cancer. 67(1) Pages: 31-36
  • Peer Reviewed
• [Journal Article] Multiple extra-articular synovial cysts complicated with rheumatoid arthritis (2009)
  • Author(s): Kirino Y, Takeno M, et al.
  • Journal Title: Mod Rheum 19(5) Pages: 533-136
  • NAID: 10025866901
  • Peer Reviewed
• [Journal Article] Successful switching to adalimumab in an infliximab-allergic patient with severe Behcet disease-related uveitis (2009)
  • Author(s): Takase K, Takeno M, et al.
  • Journal Title: Rheumatol Int. (In press)
  • Peer Reviewed
• [Journal Article] ELISPOT法による結核の診断および治療経過の評価法としての可能性感染症誌 (2009)
  • Author(s): 村上修司, 岳野光洋, 他
  • Journal Title: 感染症誌 83 Pages: 229-235
  • Peer Reviewed
• [Journal Article] 特集関節リウマチ合併症の診断と対処法 リンパ増殖性疾患 (2009)
  • Author(s): 岳野光洋, 宮崎拓也
  • Journal Title: リウマチ科 41(4) Pages: 395-400
• [Journal Article] Behcet 病(特殊型、腸管型).特集 Emergency 実戦ガイド (2009)
  • Author(s): 岳野光洋, 石ヶ坪良明
  • Journal Title: 内科 103(6) Pages: 1482-14087
• [Journal Article] (2009)
  • Author(s): 岳野光洋
  • Journal Title: 看護のための最新医学講座第11巻免疫・アレルギー疾患(山本一彦編)(中山書店、東京) Pages: 204-211
• [Journal Article] (2009)
  • Author(s): 岳野光洋, 片山一朗
  • Journal Title: year note 2010(岡庭豊編)(メディックメディア、東京)
• [Journal Article] (2009)
  • Author(s): 岳野光洋
  • Journal Title: 主要病態・主要疾患の論文集(岡庭豊編)(メディックメディア、東京) Pages: 1063-1074
• [Journal Article] (2009)
  • Author(s): 岳野光洋
  • Journal Title: 『レビューブック for medical』(第8版)(メディックメディア、東京)
• [Journal Article] (2009)
  • Author(s): 岳野光洋
  • Journal Title: 『クエスチョン・バンクCBT最新問題vol.3』第3版(メディックメディア、東京) Pages: 76-92
• [Journal Article] (2009)
  • Author(s): 岳野光洋
  • Journal Title: 『病気がみえるvol.6免疫・膠原病・感染症』(第1版)(メディックメディア、東京)
• [Journal Article] Association of reduced heme oxygenase-1 with excessive Toll-like receptor 4 expression in peripheral blood mononuclear cells in Behcet's disease. (2008)
  • Author(s): Kirino Y, Takeno M, Ueda A., et al.
  • Journal Title: Arthritis Res Ther. 10(1)
• [Journal Article] Heme oxygenase 1 attenuates the development of atopic dermatitis-like lesions in mice : Implications for human disease. (2008)
  • Author(s): Kirino M, Takeno M, Ueda A., et al.
  • Journal Title: J Allergy Clin Immunol. 122(2)
• [Journal Article] Circulating carbon monoxide level is elevated after sleep in patients with obstructive sleep apnea. (2008)
  • Author(s): Kobayashi M, Takeno M, Ueda A., et al.
  • Journal Title: Chest 134(5) Pages: 904-910
• [Journal Article] Proteasome-dependent degradation of alpha-catenin is regulated by interaction with ARMc8alpha. (2008)
  • Author(s): Suzuki T, Takeno M, et al
  • Journal Title: Biochemical J. 411 Pages: 581-591
  • Peer Reviewed
• [Journal Article] Association of reduced heme oxygenase-1 with excessive Toll-like receptor 4 expression in peripheral blood mononuclear cells in Behcet's disease. (2008)
  • Author(s): Kirino Y, Takeno M, et al
  • Journal Title: Arthritis Res Ther. 10
  • Peer Reviewed
• [Journal Article] Diagnosis of Tuberculous Meningitis due to ESAT-6-specific IFN-gamma production detected by Enzyme-Linked Immunospot Assay in Cerebrospinal Fluid. (2008)
  • Author(s): Murakami S, Takeno M, et al.
  • Journal Title: Clin Vaccine Immunol. 15 Pages: 897-899
  • Peer Reviewed
• [Journal Article] Heme oxygenase 1 attenuates the development of atopic dermatitis-like lesions in mice : Implications for human disease. J Allergy Clin Immunol. (2008)
  • Author(s): Kirino M, Takeno M, et al
  • Journal Title: J Allergy Clin Immunol. . 122
  • Peer Reviewed
• [Journal Article] Circulating carbon monoxide level is elevated after sleep in patients with obstructive sleep apnea. (2008)
  • Author(s): Kobayashi M, Takeno M, et al
  • Journal Title: Chest. 134 Pages: 904-910
  • Peer Reviewed
• [Journal Article] Net positive charge of HIV-1 CRF01_AE V3 sequence regulate sviral sensitivity to humoral immunity. (2008)
  • Author(s): Naganawa S, Takeno M, et al
  • Journal Title: PLoS ONE. 3
  • Peer Reviewed
• [Journal Article] TNF阻害薬使用患者におけるQuantiFERONの有用性(解説) (2008)
  • Author(s): 村上修司, 岳野光洋, ほか
  • Journal Title: リウマチ科 39(1) Pages: 51-56
• [Journal Article] 《膠原病の難治性病態の早期診断・早期治療のこつ》神経Behcet. (2008)
  • Author(s): 岳野光洋, 石ヶ坪良明.
  • Journal Title: 内科 101 Pages: 728-731
• [Presentation] Immunological features of Behcet's disease. A (2010)
  • Author(s): Takeno M, Ishigatsubo Y
  • Organizer: 75th American College of Rheumatology
  • Place of Presentation: USA(招待講演)
  • Year and Date: 2010-11-09
• [Presentation] Infliximab therapy is beneficial for intestinal Behcet's diseasein Japan. (2010)
  • Author(s): Watanabe R, Takeno M, et al.
  • Organizer: 75th American College of Rheumatology
  • Place of Presentation: USA
  • Year and Date: 2010-11-09
• [Presentation] Suda A, Ideguchi H, Ohno S, Takeno M, Nagaoka S, Ishigatsubo Y : Steroid free remission in Systemic Lupus Erytematosus (2010)
  • Author(s): Suda A, Takeno M, et al
  • Organizer: 75th American College of Rheumatology
  • Place of Presentation: USA
  • Year and Date: 2010-11-08
• [Presentation] Bach1 regulates heme oxygenase-1 expression of human monocytes in response to LPS : implication in Behcet's disease. (2010)
  • Author(s): Takeno M, et al
  • Organizer: 75th American College of Rheumatology
  • Place of Presentation: USA
  • Year and Date: 2010-11-08
• [Presentation] ベーチェット病 自己免疫か自己炎症か (2010)
  • Author(s): 岳野光洋
  • Organizer: 第3回自己炎症疾患研究会
  • Place of Presentation: 新宿NSビル(東京)(招待講演)
  • Year and Date: 2010-08-06
• [Presentation] Vascular manifestations of Behcet's disease in Japan : a survey of two university hospitals (2010)
  • Author(s): Ideguchi H, Takeno M, et al
  • Organizer: 14th International Conference on Behcet's disease
  • Place of Presentation: UK
  • Year and Date: 2010-07-08
• [Presentation] Chronological manifestations in Japanese patients with Behcet's disease : Retrospective cohort study in two university hospitals. (2010)
  • Author(s): Ideguchi H, Takeno M, et al
  • Organizer: 14th International Conference on Behcet's disease
  • Place of Presentation: UK
  • Year and Date: 2010-07-08
• [Presentation] Vascular manifestations of Behcet's disease in Japan : a survey of 98 patients. (2010)
  • Author(s): Suda A, Takeno M, et al
  • Organizer: 14th International Conference on Behcet's disease
  • Place of Presentation: UK
  • Year and Date: 2010-07-08
• [Presentation] Infliximab therapy for intestinal Behcet's disease in Japan 1 (2010)
  • Author(s): Takeno M, et al
  • Organizer: 14th International Conference on Behcet's disease
  • Place of Presentation: UK
  • Year and Date: 2010-07-08
• [Presentation] Infliximab treatment for uveitis in patients with Behcet's disease. (2010)
  • Author(s): Uehara T, Takeno M, et al
  • Organizer: 14th International Conference on Behcet's disease
  • Place of Presentation: UK
  • Year and Date: 2010-07-08
• [Presentation] Treatment with Infliximab for Uveitis in Patients with Behcet's Disease. (2010)
  • Author(s): Uehara T, Takeno M, et al
  • Organizer: EULRA 2010
  • Place of Presentation: Italy
  • Year and Date: 2010-06-17
• [Presentation] Steroid free remission in Systemic Lupus Erytematosus. (2010)
  • Author(s): Omura K, Takeno M, et al
  • Organizer: The 54^<th> Annual General Assembly and Scientific Meeting of the Japan College of Rheumatology.
  • Place of Presentation: 神戸国際会議場(兵庫)
  • Year and Date: 2010-04-23
• [Presentation] 腸管ベーチェット病に対するインフリキシマブ治療の実態 (2010)
  • Author(s): 岳野光洋, 他
  • Organizer: 第54回日本リウマチ学会総会・学術集会
  • Place of Presentation: 神戸国際会議場(兵庫)
  • Year and Date: 2010-04-23
• [Presentation] Bach1 regulates heme oxygenase-1 expression of human monocytes in response to LPS : implication in Behcet's disease. (2010)
  • Author(s): 岳野光洋, 上田敦久, et al.
  • Organizer: American College of Rheumatology 74th ACR
  • Place of Presentation: Atlanta
• [Presentation] Immunological features of Behcet's disease. (2010)
  • Author(s): Takeno M, Ishigatsubo Y.
  • Organizer: American College of Rheumatology 74th ACR
  • Place of Presentation: Atlanta
• [Presentation] S Management of Intestinal Behcet's disease (2009)
  • Author(s): Takeno M.
  • Organizer: Korean Japan Joint Symposium.
  • Place of Presentation: 韓国、ソウル
  • Year and Date: 2009-11-13
• [Presentation] Clinical aspect of Neuro-Behcet's Disease in Japan (2009)
  • Author(s): Takeno M.
  • Organizer: 第74回米国リウマチ学会
  • Place of Presentation: 米国、フィラデルフィア
  • Year and Date: 2009-10-10
• [Presentation] Infliximab Therapy Significantly Suppresses Ocular Inflammation in Behcet's Disease (2009)
  • Author(s): Uehara T, Takeno M, et al
  • Organizer: 第74回米国リウマチ学会
  • Place of Presentation: 米国、フィラデルフィア
  • Year and Date: 2009-10-10
• [Presentation] Immunosuppressant related neurological involvement in Behcet's disease (2009)
  • Author(s): Suda A, Takeno M, et al
  • Organizer: 第74回米国リウマチ学会
  • Place of Presentation: 米国、フィラデルフィア
  • Year and Date: 2009-10-10
• [Presentation] MRI Findings in Neuro-Behcet Disease (2009)
  • Author(s): Suda A, Takeno M, et al
  • Organizer: 第74回米国リウマチ学会
  • Place of Presentation: 米国、フィラデルフィア
  • Year and Date: 2009-10-10
• [Presentation] Enzyme-linked Immunospot Assay Based Immunological Procedure, but not Tuberculin Skin Test, is Helpful for Diagnosis of Tuberculosis in BCG Vaccinated Population : as a Screening before Anti-TNF Therapy (2008)
  • Author(s): Takeno M, et al
  • Organizer: 72nd American College of Eheumatology
  • Place of Presentation: 米国 サンフランシスコ
  • Year and Date: 2008-10-27
• [Presentation] Excessive TLR4 expression is associated with reduced HO-1 expression in peripheral mononuclear cells in patients with Behcet's disease (2008)
  • Author(s): Takeno M, et al
  • Organizer: 13^<th> Interanational Conference for Behcet's Disease
  • Place of Presentation: オーストリア・クラーゲンフルト
  • Year and Date: 2008-05-25
• [Presentation] Increased Serum Heme Oxygenase 1 and IL-18 Levels are Associated with Skin Manifestations in Adult Still's Disease and Atopic Dermatitis. (2008)
  • Author(s): 桐野洋平, 岳野光洋, 上田敦久, et al
  • Organizer: American College of Rheumatology 72nd Annual Scientific Meetings
  • Place of Presentation: San Francisco
• [Presentation] Excessive TLR4 expression is associated with reduced HO-1 expression in peripheral mononuclear cells in patients with Behcet's disease (2008)
  • Author(s): 岳野光洋, 上田敦久, et al.
  • Organizer: 13^<th> International Conference for Behcet's Disease
  • Place of Presentation: Klagenfurt
• [Presentation] 血清heme oxygenase-1の上昇と成人スティル病の病態 (2008)
  • Author(s): 桐野洋平, 岳野光洋, 上田敦久、他
  • Organizer: 第52回日本リウマチ学会総会
  • Place of Presentation: 札幌
• [Book] 結核のスクリーニングはどうすればようか?.ファーマナビゲーター『リウマチ～生物学的製剤編』(竹内勤編集) (2010)
  • Author(s): 岳野光洋
  • Publisher: メディカルレビュー社
• [Book] 免疫病・アレルギー性疾患・膠原病year note 2011(岡庭豊編) (2010)
  • Author(s): 岳野光洋、片山一朗
  • Publisher: メディックメディア社
• [Book] ファーマナビゲーター『リウマチ～生物学的製剤編』竹内勤編 (2010)
  • Author(s): 岳野光洋
  • Publisher: メディカルレビュー社、東京(印刷中)
• [Book] year note 2009 (2008)
  • Author(s): 岳野光洋, 片山一朗
  • Publisher: メディックメディア、東京
• [Remarks]
  • URL: http://www-user.yokohama-cu.ac.jp/^naika1/graduate_achieve.html
• [Remarks]
  • URL: http://www-user.yokohama-cu.ac.jp/~naikal/graduate_achieve.html