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Regulation of heme oxygenase-1 expression and the therapeutic application in rheumatic and inflammatory diseases

Research Project

Project/Area Number 20591174
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionYokohama City University

Principal Investigator

TAKENO Mitsuhiro  Yokohama City University, 医学部, 准教授 (50236494)

Co-Investigator(Kenkyū-buntansha) UEDA Atsuhisa  横浜市立大学, 附属病院, 准教授 (60295483)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsヘムオキシゲナーゼ-1 / Bach1 / 成人発症スティル病 / 血球貪食症候群 / ベーチェット病 / 破骨細胞 / アトピー性皮膚炎 / 白血病 / 肺癌 / 睡眠時無呼吸症候群 / 一酸化炭素 / 成人スティル病 / 血球貧食症候群 / IL-10 / 破骨細胞分化 / 癌 / スティル病 / Nrf2 / サイトカイン / Toll-like receptor / 関節リウマチ / アレルギー性疾患
Research Abstract

This project investigated pathogenic roles of heme oxygenase (HO)-1 in rheumatic and inflammatory diseases. We showed implication of defective HO-1expressoin in Behcet's disease, a protective role of HO-1 in atopic dermatitis, and serum HO-1 as a biomarker in hemophagocytic syndrome. Moreover, our studies revealed that HO-1 is involved in sleep apnea syndrome, osteoclastogenesis, tumor growth and acquired resistance to anticancer agents.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (81 results)

All 2011 2010 2009 2008 Other

All Journal Article (50 results) (of which Peer Reviewed: 30 results) Presentation (25 results) Book (4 results) Remarks (2 results)

  • [Journal Article] Power Doppler ultrasonography is useful for assessing disease activity and predicting joint destruction in rheumatoid arthritis patients receiving tocilizumab-preliminary data.2011

    • Author(s)
      Hama M, Takeno M, et al
    • Journal Title

      Rheumatol Int.

      Volume: 32(In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Behcet disease : evolution of clinical manifestations.2011

    • Author(s)
      Ideguchi H, Takeno M, et al
    • Journal Title

      Medicine (Baltimore).

      Volume: 90 Pages: 125-132

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Behcet's disease and colon cancer.2011

    • Author(s)
      Inamori M, Takeno M.
    • Journal Title

      Internal Med.

      Volume: 50 Pages: 537-538

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TNF阻害薬(ベーチェット病および血管炎症候群)2011

    • Author(s)
      岳野光洋、石ヶ坪良明
    • Journal Title

      リウマチ科

      Volume: 45 Pages: 41-47

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behcet's disease susceptibility loci.2010

    • Author(s)
      Mizuki N, Takeno M, et al.
    • Journal Title

      Nat Genet. 42(8)

      Pages: 703-706

    • Related Report
      2010 Final Research Report
  • [Journal Article] Expression of heme oxygenase-1 in human leukemic cells and its regulation by transcriptional repressor Bach1.2010

    • Author(s)
      Miyazaki T, Takeno M, Ueda A., et al.
    • Journal Title

      Cancer Sci. 101(6)

      Pages: 1409-1416

    • NAID

      10026593365

    • Related Report
      2010 Final Research Report
  • [Journal Article] Serum HO-1 is useful to make differential diagnosis of secondary hemophago-cytic syndrome from other similar hematological conditions.2010

    • Author(s)
      Miyazaki T, Takeno M, Ueda A., et al.
    • Journal Title

      Int J Hematol. 91(2)

      Pages: 229-237

    • Related Report
      2010 Final Research Report
  • [Journal Article] Inhibition of heme oxygenase-1 with an epidermal growth factor receptor inhibitor and cisplatin decreases proliferation of lung cancer A549 cells.2010

    • Author(s)
      Kuroda H, Takeno M, et al.
    • Journal Title

      Lung Cancer 67(1)

      Pages: 31-36

    • Related Report
      2010 Final Research Report
  • [Journal Article] Inhibition of heme oxygenase-1 with an epidermal growth factor receptor inhibitor and cisplatin decreases proliferation of lung cancer A549 cells.2010

    • Author(s)
      Kuroda H, Takeno M, et al
    • Journal Title

      Lung Cancer

      Volume: 67 Pages: 31-36

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum HO-1 is useful to make differential diagnosis of secondary hemophagocytic syndrome from other similar hematological conditions.2010

    • Author(s)
      Miyazaki T, Takeno M, et al
    • Journal Title

      Int J Hematol

      Volume: 91 Pages: 229-37

    • NAID

      10026111361

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neurological manifestations of Behcet's disease in Japan : a study of 54 patients.2010

    • Author(s)
      Ideguchi H, Takeno M, et al
    • Journal Title

      J Neurol.

      Volume: 257 Pages: 1012-1020

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic angiogenesis in patients with systemic sclerosis by autologous transplantation of bone-marrow-derived cells.2010

    • Author(s)
      Ishigatsubo Y, Takeno M, et al
    • Journal Title

      Mod Rheumatol.

      Volume: 20 Pages: 263-272

    • NAID

      10027169345

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Armadillo Repeat Containing 8alpha Binds to HRS and Promotes HRS Interaction with Ubiquitinated Proteins.2010

    • Author(s)
      Tomaru K, Takeno M, et al
    • Journal Title

      Open Biochem J.

      Volume: 4 Pages: 1-8

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of heme oxygenase-1 in human leukemic cells and its regulation by transcriptional repressor Bach1.2010

    • Author(s)
      Miyazaki T, Takeno M, et al
    • Journal Title

      Cancer Sci.

      Volume: 10 Pages: 1409-1416

    • NAID

      10026593365

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Completion rate and compliance of anti-tuberculosis chemopro phylaxis in patients with rheumatic disease receiving tumor necrosis factor antagonists.2010

    • Author(s)
      Ideguchi H, Takeno M, et al
    • Journal Title

      Clin Exp Rheumatol.

      Volume: 26 Pages: 294-295

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behcet's disease susceptibility loci.2010

    • Author(s)
      Mizuki N, Takeno M, et al
    • Journal Title

      Nat Genet.

      Volume: 42 Pages: 703-766

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 関節リウマチ患者の満足度に影響する因子の分析2010

    • Author(s)
      青木昭子, 岳野光洋, 他
    • Journal Title

      臨床リウマチ

      Volume: 22 Pages: 42-50

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ベーチェット病2010

    • Author(s)
      岳野光洋、石ヶ坪良明
    • Journal Title

      特集関節リウマチ(宮坂信之編集)日本臨床

      Volume: 66 Pages: 602-605

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Serum HO-1 is useful to make differential diagnosis of secondary hemophagocytic syndrome from other similar hematological conditions2010

    • Author(s)
      宮崎拓也, 岳野光洋
    • Journal Title

      International Journal of Hematology 91(2)

      Pages: 229-37

    • NAID

      10026111361

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neurological manifestations of Behcet's disease in Japan : a study of 54 patients2010

    • Author(s)
      Ideguchi H, Takeno M, et al.
    • Journal Title

      J Neurol (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic angiogenesis in patients with systemic sclerosis by autologous transplantation of bone-marrow-derived cells2010

    • Author(s)
      石ヶ坪良明, 岳野光洋
    • Journal Title

      Mod Rheumatol (In presee)

    • NAID

      10027169345

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Armadillo Repeat Containing 8alpha Binds to HRS and Promotes HRS Interaction with Ubiquitinated Proteins2010

    • Author(s)
      Tomaru K, Takeno M, et al.
    • Journal Title

      Open Biochemical Journal 4

      Pages: 1-8

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of heme oxygenase-1 in human leukemic cells andits regulation by transcriptional repressor Bach12010

    • Author(s)
      宮崎拓也, 岳野光洋
    • Journal Title

      Cancer Science (In presee)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Use of musculoskeletal ultrasound in Japan : a survey of practicing rheumatologists2010

    • Author(s)
      Takase K, Takeno M, et al.
    • Journal Title

      Mod Rheumatol (In presee)

    • NAID

      10026691486

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ベーチェット病.特集関節リウマチ2010

    • Author(s)
      岳野光洋, 石ヶ坪良明
    • Journal Title

      日本臨床 68 suppl.5

      Pages: 602-605

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Mycobacterium tuberculosis-specific immunospot assay of pleural exudate mononuclear cells is useful for the exclusion of tuberculous pleuritis in patients with lupus pleuritis..2009

    • Author(s)
      Takase K, Takeno M, et al.
    • Journal Title

      Lupus 18(2)

      Pages: 175-177

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Screening of tuberculosis by interferon-gamma assay before biologic therapy for rheumatoid arthritis2009

    • Author(s)
      村上修司, 岳野光洋, et al
    • Journal Title

      Tuberculosis 89(2)

      Pages: 136-141

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of heme oxygenase-1 with an epidermal growth factor receptor inhibitor and cisplatin decreases proliferation of lung cancer A549 cells2009

    • Author(s)
      Kuroda H, Takeno M, et al.
    • Journal Title

      Lung Cancer. 67(1)

      Pages: 31-36

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multiple extra-articular synovial cysts complicated with rheumatoid arthritis2009

    • Author(s)
      Kirino Y, Takeno M, et al.
    • Journal Title

      Mod Rheum 19(5)

      Pages: 533-136

    • NAID

      10025866901

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Successful switching to adalimumab in an infliximab-allergic patient with severe Behcet disease-related uveitis2009

    • Author(s)
      Takase K, Takeno M, et al.
    • Journal Title

      Rheumatol Int. (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ELISPOT法による結核の診断および治療経過の評価法としての可能性感染症誌2009

    • Author(s)
      村上修司, 岳野光洋, 他
    • Journal Title

      感染症誌 83

      Pages: 229-235

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 特集関節リウマチ合併症の診断と対処法 リンパ増殖性疾患2009

    • Author(s)
      岳野光洋, 宮崎拓也
    • Journal Title

      リウマチ科 41(4)

      Pages: 395-400

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Behcet 病(特殊型、腸管型).特集 Emergency 実戦ガイド2009

    • Author(s)
      岳野光洋, 石ヶ坪良明
    • Journal Title

      内科 103(6)

      Pages: 1482-14087

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2009

    • Author(s)
      岳野光洋
    • Journal Title

      看護のための最新医学講座第11巻免疫・アレルギー疾患(山本一彦編)(中山書店、東京)

      Pages: 204-211

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2009

    • Author(s)
      岳野光洋, 片山一朗
    • Journal Title

      year note 2010(岡庭豊編)(メディックメディア、東京)

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2009

    • Author(s)
      岳野光洋
    • Journal Title

      主要病態・主要疾患の論文集(岡庭豊編)(メディックメディア、東京)

      Pages: 1063-1074

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2009

    • Author(s)
      岳野光洋
    • Journal Title

      『レビューブック for medical』(第8版)(メディックメディア、東京)

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2009

    • Author(s)
      岳野光洋
    • Journal Title

      『クエスチョン・バンクCBT最新問題vol.3』第3版(メディックメディア、東京)

      Pages: 76-92

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2009

    • Author(s)
      岳野光洋
    • Journal Title

      『病気がみえるvol.6免疫・膠原病・感染症』(第1版)(メディックメディア、東京)

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Association of reduced heme oxygenase-1 with excessive Toll-like receptor 4 expression in peripheral blood mononuclear cells in Behcet's disease.2008

    • Author(s)
      Kirino Y, Takeno M, Ueda A., et al.
    • Journal Title

      Arthritis Res Ther. 10(1)

    • Related Report
      2010 Final Research Report
  • [Journal Article] Heme oxygenase 1 attenuates the development of atopic dermatitis-like lesions in mice : Implications for human disease.2008

    • Author(s)
      Kirino M, Takeno M, Ueda A., et al.
    • Journal Title

      J Allergy Clin Immunol. 122(2)

    • Related Report
      2010 Final Research Report
  • [Journal Article] Circulating carbon monoxide level is elevated after sleep in patients with obstructive sleep apnea.2008

    • Author(s)
      Kobayashi M, Takeno M, Ueda A., et al.
    • Journal Title

      Chest 134(5)

      Pages: 904-910

    • Related Report
      2010 Final Research Report
  • [Journal Article] Proteasome-dependent degradation of alpha-catenin is regulated by interaction with ARMc8alpha.2008

    • Author(s)
      Suzuki T, Takeno M, et al
    • Journal Title

      Biochemical J. 411

      Pages: 581-591

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of reduced heme oxygenase-1 with excessive Toll-like receptor 4 expression in peripheral blood mononuclear cells in Behcet's disease.2008

    • Author(s)
      Kirino Y, Takeno M, et al
    • Journal Title

      Arthritis Res Ther. 10

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diagnosis of Tuberculous Meningitis due to ESAT-6-specific IFN-gamma production detected by Enzyme-Linked Immunospot Assay in Cerebrospinal Fluid.2008

    • Author(s)
      Murakami S, Takeno M, et al.
    • Journal Title

      Clin Vaccine Immunol. 15

      Pages: 897-899

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heme oxygenase 1 attenuates the development of atopic dermatitis-like lesions in mice : Implications for human disease. J Allergy Clin Immunol.2008

    • Author(s)
      Kirino M, Takeno M, et al
    • Journal Title

      J Allergy Clin Immunol. . 122

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Circulating carbon monoxide level is elevated after sleep in patients with obstructive sleep apnea.2008

    • Author(s)
      Kobayashi M, Takeno M, et al
    • Journal Title

      Chest. 134

      Pages: 904-910

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Net positive charge of HIV-1 CRF01_AE V3 sequence regulate sviral sensitivity to humoral immunity.2008

    • Author(s)
      Naganawa S, Takeno M, et al
    • Journal Title

      PLoS ONE. 3

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TNF阻害薬使用患者におけるQuantiFERONの有用性(解説)2008

    • Author(s)
      村上修司, 岳野光洋, ほか
    • Journal Title

      リウマチ科 39(1)

      Pages: 51-56

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 《膠原病の難治性病態の早期診断・早期治療のこつ》神経Behcet.2008

    • Author(s)
      岳野光洋, 石ヶ坪良明.
    • Journal Title

      内科 101

      Pages: 728-731

    • Related Report
      2008 Annual Research Report
  • [Presentation] Immunological features of Behcet's disease. A2010

    • Author(s)
      Takeno M, Ishigatsubo Y
    • Organizer
      75th American College of Rheumatology
    • Place of Presentation
      USA(招待講演)
    • Year and Date
      2010-11-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Infliximab therapy is beneficial for intestinal Behcet's diseasein Japan.2010

    • Author(s)
      Watanabe R, Takeno M, et al.
    • Organizer
      75th American College of Rheumatology
    • Place of Presentation
      USA
    • Year and Date
      2010-11-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Suda A, Ideguchi H, Ohno S, Takeno M, Nagaoka S, Ishigatsubo Y : Steroid free remission in Systemic Lupus Erytematosus2010

    • Author(s)
      Suda A, Takeno M, et al
    • Organizer
      75th American College of Rheumatology
    • Place of Presentation
      USA
    • Year and Date
      2010-11-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Bach1 regulates heme oxygenase-1 expression of human monocytes in response to LPS : implication in Behcet's disease.2010

    • Author(s)
      Takeno M, et al
    • Organizer
      75th American College of Rheumatology
    • Place of Presentation
      USA
    • Year and Date
      2010-11-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] ベーチェット病 自己免疫か自己炎症か2010

    • Author(s)
      岳野光洋
    • Organizer
      第3回自己炎症疾患研究会
    • Place of Presentation
      新宿NSビル(東京)(招待講演)
    • Year and Date
      2010-08-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] Vascular manifestations of Behcet's disease in Japan : a survey of two university hospitals2010

    • Author(s)
      Ideguchi H, Takeno M, et al
    • Organizer
      14th International Conference on Behcet's disease
    • Place of Presentation
      UK
    • Year and Date
      2010-07-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Chronological manifestations in Japanese patients with Behcet's disease : Retrospective cohort study in two university hospitals.2010

    • Author(s)
      Ideguchi H, Takeno M, et al
    • Organizer
      14th International Conference on Behcet's disease
    • Place of Presentation
      UK
    • Year and Date
      2010-07-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Vascular manifestations of Behcet's disease in Japan : a survey of 98 patients.2010

    • Author(s)
      Suda A, Takeno M, et al
    • Organizer
      14th International Conference on Behcet's disease
    • Place of Presentation
      UK
    • Year and Date
      2010-07-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Infliximab therapy for intestinal Behcet's disease in Japan 12010

    • Author(s)
      Takeno M, et al
    • Organizer
      14th International Conference on Behcet's disease
    • Place of Presentation
      UK
    • Year and Date
      2010-07-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Infliximab treatment for uveitis in patients with Behcet's disease.2010

    • Author(s)
      Uehara T, Takeno M, et al
    • Organizer
      14th International Conference on Behcet's disease
    • Place of Presentation
      UK
    • Year and Date
      2010-07-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Treatment with Infliximab for Uveitis in Patients with Behcet's Disease.2010

    • Author(s)
      Uehara T, Takeno M, et al
    • Organizer
      EULRA 2010
    • Place of Presentation
      Italy
    • Year and Date
      2010-06-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Steroid free remission in Systemic Lupus Erytematosus.2010

    • Author(s)
      Omura K, Takeno M, et al
    • Organizer
      The 54^<th> Annual General Assembly and Scientific Meeting of the Japan College of Rheumatology.
    • Place of Presentation
      神戸国際会議場(兵庫)
    • Year and Date
      2010-04-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 腸管ベーチェット病に対するインフリキシマブ治療の実態2010

    • Author(s)
      岳野光洋, 他
    • Organizer
      第54回日本リウマチ学会総会・学術集会
    • Place of Presentation
      神戸国際会議場(兵庫)
    • Year and Date
      2010-04-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] Bach1 regulates heme oxygenase-1 expression of human monocytes in response to LPS : implication in Behcet's disease.2010

    • Author(s)
      岳野光洋, 上田敦久, et al.
    • Organizer
      American College of Rheumatology 74th ACR
    • Place of Presentation
      Atlanta
    • Related Report
      2010 Final Research Report
  • [Presentation] Immunological features of Behcet's disease.2010

    • Author(s)
      Takeno M, Ishigatsubo Y.
    • Organizer
      American College of Rheumatology 74th ACR
    • Place of Presentation
      Atlanta
    • Related Report
      2010 Final Research Report
  • [Presentation] S Management of Intestinal Behcet's disease2009

    • Author(s)
      Takeno M.
    • Organizer
      Korean Japan Joint Symposium.
    • Place of Presentation
      韓国、ソウル
    • Year and Date
      2009-11-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] Clinical aspect of Neuro-Behcet's Disease in Japan2009

    • Author(s)
      Takeno M.
    • Organizer
      第74回米国リウマチ学会
    • Place of Presentation
      米国、フィラデルフィア
    • Year and Date
      2009-10-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] Infliximab Therapy Significantly Suppresses Ocular Inflammation in Behcet's Disease2009

    • Author(s)
      Uehara T, Takeno M, et al
    • Organizer
      第74回米国リウマチ学会
    • Place of Presentation
      米国、フィラデルフィア
    • Year and Date
      2009-10-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] Immunosuppressant related neurological involvement in Behcet's disease2009

    • Author(s)
      Suda A, Takeno M, et al
    • Organizer
      第74回米国リウマチ学会
    • Place of Presentation
      米国、フィラデルフィア
    • Year and Date
      2009-10-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] MRI Findings in Neuro-Behcet Disease2009

    • Author(s)
      Suda A, Takeno M, et al
    • Organizer
      第74回米国リウマチ学会
    • Place of Presentation
      米国、フィラデルフィア
    • Year and Date
      2009-10-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] Enzyme-linked Immunospot Assay Based Immunological Procedure, but not Tuberculin Skin Test, is Helpful for Diagnosis of Tuberculosis in BCG Vaccinated Population : as a Screening before Anti-TNF Therapy2008

    • Author(s)
      Takeno M, et al
    • Organizer
      72nd American College of Eheumatology
    • Place of Presentation
      米国 サンフランシスコ
    • Year and Date
      2008-10-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] Excessive TLR4 expression is associated with reduced HO-1 expression in peripheral mononuclear cells in patients with Behcet's disease2008

    • Author(s)
      Takeno M, et al
    • Organizer
      13^<th> Interanational Conference for Behcet's Disease
    • Place of Presentation
      オーストリア・クラーゲンフルト
    • Year and Date
      2008-05-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] Increased Serum Heme Oxygenase 1 and IL-18 Levels are Associated with Skin Manifestations in Adult Still's Disease and Atopic Dermatitis.2008

    • Author(s)
      桐野洋平, 岳野光洋, 上田敦久, et al
    • Organizer
      American College of Rheumatology 72nd Annual Scientific Meetings
    • Place of Presentation
      San Francisco
    • Related Report
      2010 Final Research Report
  • [Presentation] Excessive TLR4 expression is associated with reduced HO-1 expression in peripheral mononuclear cells in patients with Behcet's disease2008

    • Author(s)
      岳野光洋, 上田敦久, et al.
    • Organizer
      13^<th> International Conference for Behcet's Disease
    • Place of Presentation
      Klagenfurt
    • Related Report
      2010 Final Research Report
  • [Presentation] 血清heme oxygenase-1の上昇と成人スティル病の病態2008

    • Author(s)
      桐野洋平, 岳野光洋, 上田敦久、他
    • Organizer
      第52回日本リウマチ学会総会
    • Place of Presentation
      札幌
    • Related Report
      2010 Final Research Report
  • [Book] 結核のスクリーニングはどうすればようか?.ファーマナビゲーター『リウマチ~生物学的製剤編』(竹内勤編集)2010

    • Author(s)
      岳野光洋
    • Publisher
      メディカルレビュー社
    • Related Report
      2010 Annual Research Report
  • [Book] 免疫病・アレルギー性疾患・膠原病year note 2011(岡庭豊編)2010

    • Author(s)
      岳野光洋、片山一朗
    • Publisher
      メディックメディア社
    • Related Report
      2010 Annual Research Report
  • [Book] ファーマナビゲーター『リウマチ~生物学的製剤編』竹内勤編2010

    • Author(s)
      岳野光洋
    • Publisher
      メディカルレビュー社、東京(印刷中)
    • Related Report
      2009 Annual Research Report
  • [Book] year note 20092008

    • Author(s)
      岳野光洋, 片山一朗
    • Publisher
      メディックメディア、東京
    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www-user.yokohama-cu.ac.jp/^naika1/graduate_achieve.html

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www-user.yokohama-cu.ac.jp/~naikal/graduate_achieve.html

    • Related Report
      2008 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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