| Project/Area Number |
20591175
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Kitasato University |
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Principal Investigator |
HIROHATA Shunsei Kitasato University, 医学部, 教授 (90189895)
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| Co-Investigator(Kenkyū-buntansha) |
NAGAI Tatsuo 北里大学, 医学部, 講師 (60365947)
WADA Tatsuhiko 北里大学, 医学部, 助教 (60383585)
ENDO Hirahito 北里大学, 医学部, 准教授 (20213598)
MATSUI Toshimichi 北里大学, 医学部, 講師 (20348519)
HASHIMOTO Atsushi 北里大学, 医学部, 助教 (50327376)
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| Co-Investigator(Renkei-kenkyūsha) |
KATO Tomohiro 聖マリアンナ医科大学, 医学部, 教授 (80233807)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 中枢神経ループス / ループス精神病 / 神経芽細胞腫細胞 / 抗神経細胞抗体 / エピトープ / プロテオミクス / ミトコンドリア酵素タンパク質 / 核酸結合タンパク質 / 全身性エリテマトーデス / 中枢神経病変 / 脳脊髄液 / 自己抗体 / グルタミン酸レセプター / 抗リボソームP抗体 / Th1反応 / 神経細胞 |
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| Research Abstract |
In the current studies, we first demonstrated that cerebrospinal fluid anti-NR2 levels were significantly higher in patients with lupuspsychosis than in control groups, suggesting that anti-NR2 antibodies might play a pivotalrole in the pathogenesis of lupus psychosis. Using a proteomics approach, we next pickedup several antigens, including peroxiredoxin-4, ubiquitin carboxyl-terminal hydrolaseisozyme L1, splicing factor arginine/serine-rich 3, and histone H2A type 1, as candidates for the autoantigens of anti-neuronal antibodies. Finally, we disclosed that thatanti-ribosomal P antibodies induced Th1 responses by upregulating the production of IL-12 by activated monocytes.
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