| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
Recent studies have demonstrated that adipocytokines secreted by adipocytes may have a role in the inflammatory process. We investigated their clinical significance in patients with rheumatoid arthritis (RA). We have reported that adiponectin stimulates the production of IL-8 (Biochem Biophys Res Commun. 2009 ; 378 : 218-223), and prostaglandin E2 (Arthritis Rheum. 2010 ; 62 : 1641-1649) by rheumatoid synovial fibroblasts in vitro. We also have reported that the serum levels of adiponectin, resistin, and leptin in RA patients were elevated (Intern Med. 2011 ; 50 : 269-275). These findings suggest that adipocytekines may, at least in part, contribute to synovial inflammation in RA.
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