Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Research Abstract |
We analyzed the repressive mechanism by LECT2 in rheumatoid arthritis. First, we have identified a LECT2 receptor-expressing cell type related in rheumatoid arthritis, and showed the possibility that human synoviocytes expressed the receptor of LECT2. Using those cells, we studied LECT2 effect on the proliferation of the cells, and expression of proinflammatory cytokines and several genes related to rheumatoid arthritis. We identified many genes controlled by main proinflammatory cytokines in a mouse model of rheumatoid arthritis.
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