Mechanism of regulation of immune response by hypoxia-inducible factors and its therapeutic application to inflammatory diseases
Project/Area Number |
20591181
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
膠原病・アレルギー・感染症内科学
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Research Institution | Asahikawa Medical College |
Principal Investigator |
MAKINO Yuichi Asahikawa Medical College, 医学部, 講師 (90345033)
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Co-Investigator(Kenkyū-buntansha) |
KOMURA Keiji 旭川医科大学, 大学病院, 医員 (10396385)
|
Project Period (FY) |
2008 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 低酸素 / HIF-1 / 炎症細胞 / 関節炎 / IPAS / マクロファージ / ChREBP |
Research Abstract |
This study was performed to elucidate the role of hypoxia-inducible factors in regulation of immune cell functions and to develop a novel therapeutic approach for inflammatory diseases by targeting the hypoxia-inducible factors. We demonstrated that the expression of HIF-1α was regulated not only by local oxygen tension but also by glucose level and cytokines. Expressed HIF-1α critically contributed to the regulation of the cellular functions. Inhibition of HIF-1 signals in vivo resulted in amelioration of autoimmune arthritis model in mice, indicating that the hypoxia-inducible factors are possible therapeutic targets for inflammatory diseases.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Abnormal heart development and lung remodeling in mice lacking a HIF-related bHLH-PAS protein NEPAS2008
Author(s)
Toshiharu Yamashita, Osamu Ohneda, Masumi Nagano, Motoyuki Iemitsu, Yuichi Makino, Hirotoshi Tanaka, Takashi Miyauchi Katsutoshi Goto, Kuniko Ohneda, Yoshiaki Fujii-Kuriyama, Lorenz Poellinger, Masayuki Yamamoto
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Journal Title
Mol.Cell.Biol. 28
Pages: 1285-1297
Related Report
Peer Reviewed
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