Inspection of receptor-Ig protein heterodimer for inhibition of its ligand
| Project/Area Number |
20591185
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Niigata University |
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Principal Investigator |
HANAWA Haruo Niigata University, 医歯学系, 講師 (40282983)
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| Co-Investigator(Kenkyū-buntansha) |
小玉 誠 新潟大学, 医歯学系, 准教授 (10242447)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 臨床免疫学 / 生物学的製剤 / 遺伝子治療 / IL-1 / 徙免疫疾患 / IL-1受容体-Igヘテロダマー / アナキンラ / 鉄代謝 / ヘム / 内因性リガンド / 自己免疫疾患 / IL-1受容体-Igヘテロダイマー |
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| Research Abstract |
Interleukin (IL)-1 inhibitor may be a candidate anti-inflammatory drug. We examined the effect of a heterodimer of IL-1 receptor accessory protein (Acp)-immunoglobulin (Ig) and IL-1R type II (IL1R2)-Ig named AcP-Ig/IL1R2-Ig heterodimer, and compared its effects with other IL-1 inhibitors reported previously. Our results demonstrated that the AcP-Ig/IL1R2-Ig heterodimer (rat, IC50=1.95 pM ; human, IC50=0.14 pM) inhibited IL-1 response to a greater extent than IL1RA (rat, IC50=1,935 pM), Acp-IL1R type I (IL1R1)-Ig homodimer (rat, IC50=73.7 pM ; human, IC50=4.48 pM) and Acp-IL1R2-Ig homodimer (rat IC50=72.8 pM) and strongly inhibited responses of both IL-1α and IL-1β.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Expression of the peptide hormone hepcidin increases in cardiomyocytes under myocarditis and myocardial infarction.2010
Author(s)
Isoda M, Hanawa H, Watanabe R, Yoshida T, Toba K, Yoshida K, Kojima M, Otaki K, Hao K, Ding L, Tanaka K, Takayama T, Kato K, Okura Y, Kodama M, Ota Y, Hayashi J, Aizawa Y
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Journal Title
J Nutr Biochem 21
Pages: 749-756
Related Report
Peer Reviewed
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[Journal Article] Lipocalin-2/neutrophil gelatinase-B associated lipocalin is strongly induced in hearts of rats with autoimmune myocarditis and in human myocarditis.2010
Author(s)
Ding L, Hanawa H, Ota Y, Hasegawa G, Hao K, Asami F, Watanabe R, Yoshida T, Toba K, Yoshida K, Ogura M, Kodama M, Aizawa Y
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Journal Title
NAID
Related Report
Peer Reviewed
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[Journal Article] IL-1 Receptor Accessory Protein-Ig/IL-1 Receptor Type II-Ig Heterodimer Inhibits IL-1 Response More Strongly than Other IL-1 Blocking Biopharmaceutical Agents.
Author(s)
Hanawa H, Ota Y, Ding L, Chang H, Yoshida K, Otaki K, Hao K, Kasahara S, Kodama M, Nakazawa M, Aizawa Y
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Journal Title
J Clin Immunol (in press)
Related Report
Peer Reviewed
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