Identification of mouse IL-25 receptor expressing cells

• Project/Area Number: 20591187
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Kyushu University
• Principal Investigator: ARINOBU Yojiro Kyushu University, 大学病院・遺伝子細胞療法部 (90467928)
• Co-Investigator(Kenkyū-buntansha): AKASHI Koichi 九州大学, 大学院・医学研究院, 教授 (80380385)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: IL-25 / IL-25 receptor / 好酸球前駆細胞 / IL-25レセプター / 生存・増殖因子 / 骨髄球系前駆細胞 / IL-25 レセプター / 好塩基球前駆細胞

Research Abstract

Interleukin-25 (IL-25) is one of the epithelial cell-derived cytokines which play critical roles in allergic inflammations, while it still remained unclear which cell populations express IL-25 receptor (IL-25R) and mediate its biological activities. In this study, we analyzed the expression level of IL-25R on all mouse hematopoietic cells and clarified that IL-25R is preferentially expressed on eosinophil progenitors (EoP). It was also suggested that IL-25 may act as a survival/proliferation factor for EoP.

Research Products

• [Journal Article] Analysis of immune resonstitution after autologous CD34+ stem/progenitor cell transplantation for systemic sclerosis : predominant reconstitution of Th1 CD4+ T cells. (2011)
  • Author(s): Tsukamoto H, Nagafuji K, Horiuchi T, Mitoma H, Niiro H, Arinobu Y, Inoue Y, To K, Miyamoto T, Iwasaki H, Teshima T, Harada M, Akashi K
  • Journal Title: Rheumatology. 50 Pages: 944-952
  • Peer Reviewed
• [Journal Article] TIM-3 is a promising target to selectively kill acute myeloid leukemia stem cells. (2010)
  • Author(s): Kikushige Y, Shima T, Takayanagi S, Urata S, Miyamoto T, Iwasaki H, Takenaka K, Teshima T, Tanaka T, Inagaki Y, Akashi K
  • Journal Title: Cell Stem Cell. 7 Pages: 708-717
  • Peer Reviewed
• [Journal Article] Regulation of hematopoietic cell clusters in the placental niche through SCF/Kit signaling in embryonic mouse. (2010)
  • Author(s): Sasaki T, Mizuochi C, Horio Y, Nakano K, Akashi K, Sugiyama D
  • Journal Title: Development. 137 Pages: 3941-3952
  • Peer Reviewed
• [Journal Article] Single pancreatic beta cells co-express multiple islet hormone genes in mice. (2010)
  • Author(s): Katsuta H, Akashi T, Katsuta R, Nagaya M, Kim D, Arinobu Y, Hara M, Bonner-Weir S, Sharma AJ, Akashi K, Weir GC
  • Journal Title: Diabetologia. 53 Pages: 128-138
  • Peer Reviewed
• [Journal Article] 好塩基球と肥満細胞の発達 (2010)
  • Author(s): 有信洋二郎、赤司浩一
  • Journal Title: 炎症と免疫 18 Pages: 3-8
• [Journal Article] Origin of basophils and mast cells. (2009)
  • Author(s): 有信洋二郎, 岩崎浩己, 赤司浩一
  • Journal Title: Allergol Int. 58 Pages: 21-28
  • NAID: 10025108958
  • Peer Reviewed
• [Journal Article] Cyclin A is redundant in fibroblasts but essential in hematopoietic and embryonic stem cells. (2009)
  • Author(s): Kalaszczynska I, Geng Y, Iino T, Mizuno S, Choi Y, Kondratiuk I, Silver DP, Wolgemuth DJ, Akashi K, Sicinski P
  • Journal Title: Cell. 138 Pages: 352-365
  • Peer Reviewed
• [Journal Article] T cell leukemia/lymphoma 1 and galectin-1 regulate survival/cell death pathways in human naive and IgM+ memory B cells through altering balances in Bcl-2 family proteins. (2009)
  • Author(s): Tabrizi SJ, Niiro H, Masui M, Yoshimoto G, Iino T, Kikushige Y, Wakasaki T, Baba E, Shimoda S, Miyamoto T, Hara T, Akashi K
  • Journal Title: J Immunol 182 Pages: 1490-1499
  • Peer Reviewed
• [Journal Article] 好塩基球の発生・分化 (2009)
  • Author(s): 有信洋二郎、岩崎浩己、赤司浩一
  • Journal Title: アレルギー・免疫 16 Pages: 12-17
• [Journal Article] Origin of basophils and mast cells (2009)
  • Author(s): Arinobu Y, et al.
  • Journal Title: Allergology International 58(1) Pages: 21-28
  • NAID: 10025108958
  • Peer Reviewed
• [Journal Article] CD4 T-cell autoreacrivity to the mitochondrial autoantigen PDC-E2 in AMA-negative primary biliary cirrhosis. (2008)
  • Author(s): Shimoda S, Miyakawa H, Nakamura M, Ishibiashi H, Kikuchi K, Kita H, Niiro H, Arinobu Y, Ono N, Mackay IR, Gershwin ME, Akashi K
  • Journal Title: J Autoimmun 31 Pages: 110-115
  • Peer Reviewed
• [Journal Article] Antagonism of FOG-1 and GATA factors in fate choice for the mast cell lineage (2008)
  • Author(s): Cantor AB, Iwasaki H, Arinobu Y, Moran TB, Shigematsu H, Sullivan MR, Akashi K, Orkin SH
  • Journal Title: J Exp Med. 17 Pages: 611-624
  • Peer Reviewed
• [Presentation] 造血幹細胞からの骨髄球系細胞の分化 (2010)
  • Author(s): 赤司浩一
  • Organizer: 第60回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
• [Presentation] IL-25(IL-17E)レセプターは、骨髄球系前駆細胞に発現する (2010)
  • Author(s): 有信洋二郎
  • Organizer: 第54回日本リウマチ学会総会・学術集会
  • Place of Presentation: 神戸
• [Presentation] IL-25レセプターは、骨髄球系前駆細胞に発現する (2010)
  • Author(s): 有信洋二郎
  • Organizer: 第54回 日本リウマチ学会総会
  • Place of Presentation: 神戸
• [Book] 好塩基球と肥満細胞の発達 (2010)
  • Author(s): 有信洋二郎、赤司浩一
  • Total Pages: 8
  • Publisher: 先端医学社
• [Remarks] ホームページ
  • URL: http://www.idenshi.co.jp/
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  • URL: http://www.idenshi.co.jp/
• [Remarks]
  • URL: http://www.med.kyushu-u.ac.jp/idenshi/research/index.html
• [Remarks]
  • URL: http://www.med.kyushu-u.ac.jp/idenshi/research/index.html