| Project/Area Number |
20591192
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Saitama Medical University |
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Principal Investigator |
MATSUSHITA Sho Saitama Medical University, 医学部, 教授 (50167649)
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| Co-Investigator(Kenkyū-buntansha) |
HIGASHI Takehiro 埼玉医科大学, 医学部, 助教 (00468381)
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| Co-Investigator(Renkei-kenkyūsha) |
AWATA Takuya 埼玉医科大学, 医学部, 教授 (40184303)
OKADA Hirokazu 埼玉医科大学, 医学部, 准教授 (60233342)
KOUSAKA Hitoshi 東京医科歯科大学, 医学部, 准教授 (00251554)
SIMOJYO Naoki 千葉大学, 医学(系)研究科(研究院), 准教授 (40221303)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | アレルギー学 / アジュバント / Th17アジュバント / curdlan / Notch ligands / Jaggedl / NODマウス / 腎炎 / アトピー性皮膚炎 / Th2アジュバント / Th17アジュバントcurdlan / Jagged1 |
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| Research Abstract |
We qualitatively analyzed Th2/17 adjuvant activities and clarified : 1) activity of estrogens and their derivatives ; 2) qualivative evaluation of adjuvant activities based intracellular cAMP concentration ; 3) activitiy of dopamine released from dendritic cells ; 4) function of jagged 1 highly expressed on DC17 cells ; and furthermore, 5) Th2 adjuvant activity of coenzyme A contained in mothers' milk. We will keep focusing on CoA in association with atopic dermatitis.
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