Qualitative analysis of adjuvant activities and its application to immunity-related diseases
| Project/Area Number |
20591192
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Saitama Medical University |
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Principal Investigator |
MATSUSHITA Sho Saitama Medical University, 医学部, 教授 (50167649)
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| Co-Investigator(Kenkyū-buntansha) |
HIGASHI Takehiro 埼玉医科大学, 医学部, 助教 (00468381)
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| Co-Investigator(Renkei-kenkyūsha) |
AWATA Takuya 埼玉医科大学, 医学部, 教授 (40184303)
OKADA Hirokazu 埼玉医科大学, 医学部, 准教授 (60233342)
KOUSAKA Hitoshi 東京医科歯科大学, 医学部, 准教授 (00251554)
SIMOJYO Naoki 千葉大学, 医学(系)研究科(研究院), 准教授 (40221303)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | アレルギー学 / アジュバント / Th17アジュバント / curdlan / Notch ligands / Jaggedl / NODマウス / 腎炎 / アトピー性皮膚炎 / Th2アジュバント / Th17アジュバントcurdlan / Jagged1 |
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| Research Abstract |
We qualitatively analyzed Th2/17 adjuvant activities and clarified : 1) activity of estrogens and their derivatives ; 2) qualivative evaluation of adjuvant activities based intracellular cAMP concentration ; 3) activitiy of dopamine released from dendritic cells ; 4) function of jagged 1 highly expressed on DC17 cells ; and furthermore, 5) Th2 adjuvant activity of coenzyme A contained in mothers' milk. We will keep focusing on CoA in association with atopic dermatitis.
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Report
(4 results)
Research Products
(112 results)
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[Journal Article] Fibroblasts stimulated via HLA-II produce PGE 2 and regulate cytokine production from Th cells.2010
Author(s)
Nahoko Kato-Kogoe, Hideki Ohyama, Fusanori Nishimura, Michio Meguro, Sayuri Yoshizawa, Yuka Okada, Keiji Nakasho, Koji Yamanegi, Naoko Yamada, Masaki Hata, Takehiro Higashi, Nobuyuki Terada, Sho Matsushita
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Journal Title
Lab Invest 90
Pages: 1747-1756
Related Report
Peer Reviewed
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[Journal Article] Dopamine D1-like receptor antagonist, SCH23390, exhibits a preventive effect on diabetes mellitus that occurs naturally in NOD mice2009
Author(s)
Hashimoto, K., Inoue, T., Higashi T., Takei S., Katayama S., Takagi, R., Okada, H., Matsushita S.
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Journal Title
Biochem. Biophys. Res. Commun 383
Pages: 460-463
Related Report
Peer Reviewed
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[Journal Article] Role of human non-invariant NKT lymphocytes in the maintenance of type 2 T helper environment during pregnancy.2008
Author(s)
Uemura, Y., Suzuki, M., Liu, T-Y., Narita, Y., Hirata, S., Ohyama H., Ishihara, O., Matsushita S.
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Journal Title
Int.Immunol. 20
Pages: 405-412
NAID
Related Report
Peer Reviewed
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[Journal Article] Polymorphisms in the 5' flanking region of IL12RB2 are associated with susceptibility to periodontal diseases in the Japanese population.2008
Author(s)
Takeuchi-Hatanaka, K., Ohyama H., Nishimura, F., Kato-Kogoe, N., Soga, Y., Matsushita S., Nakasho, K., Yamanegi, K., Yamada, N., Terada, N. ,Takashiba, S.
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Journal Title
J.Clin.Periodontol 35(4)
Pages: 317-323
Related Report
Peer Reviewed
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[Journal Article] Distinct subsets of human invariant NKT cells differentially regulate T helper responses via dendritic cells.2008
Author(s)
Liu, T-Y., Uemura, Y., Suzuki, M., Narita, Y., Hirata, S., Ohyama H., Ishihara, O., Matsushita S.
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Journal Title
Eur.J.Immunol 38
Pages: 1012-1023
Related Report
Peer Reviewed
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[Journal Article] Differential effects of polymorphisms in the 5? flanking region of IL12RB2 on NK and T cell activity.2008
Author(s)
Ohyama H., Kato-Kogoe, N., Nishimura, F., Takeuchi-Hatanaka, K., Matsushita S., Yamanegi, K., Yamada, N., Hata, M., Nakasho, K., Terada, N.
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Journal Title
J. Interferon Cytokine Res 28(9)
Pages: 563-569
Related Report
Peer Reviewed
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[Journal Article] B-cell chemoattractant CXCL13 is preferentially expressed by human Th17 cell clones.2008
Author(s)
Takagi, R., Higashi T., Hashimoto, K., Nakano K., Mizuno, Y., Okazaki, Y., Matsushita S.
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Journal Title
J.Immunol 181
Pages: 186-189
Related Report
Peer Reviewed
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