Analysis on signal transduction pathway through CD103 molecule
| Project/Area Number |
20591193
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Saitama Medical University |
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Principal Investigator |
TAKEUCHI Tsutomu Saitama Medical University, 医学部, 教授 (50179610)
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| Co-Investigator(Renkei-kenkyūsha) |
KAMEDA Hideto 慶應義塾大学, 医学部, 講師 (00265795)
YOSHIMOTO Keiko 慶應義塾大学, 医学部, 研究員 (20383292)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 自己免疫 / 上皮障害 / カドヘリン / インテグリン / CD103 / シグナル伝達 / CDIO3 |
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| Research Abstract |
Given the evidence that αEβ7(CD03) expressed on T cells is involved in adhesion with E-cadherin on epithelial cells, the CD103 molecule may play a wide variety role in cellular function. In this study, it has been shown that for induction of CD103, not only the expression of TGF-βreceptor by lectin, but also signal transduction through Smad 2/3 is required. After expression of CD103, T cells become proliferate poor, and exhibit unique cytokine prolife. Since CD103+subset of cells can mediate immune-regulatory and immune- inflammatory function, farther investigation may be regained to dissect thesignal leady to two distinct function.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] IgG4-positive multi-organ lymphoproliferative syndrome manifesting as chronic symmetrical sclerosing dacryo-sialo-adenitis with subsequent secondary portal hypertension and remarkable IgG4-linked IL-4 elevation.2010
Author(s)
Suzuki K, Tamaru J, Okuyama A, Kameda H, Amano K, Nagasawa H, Nishi, E, Yoshimoto K, Setoyama Y, Kaneko K, Osada H, Honda N, Yasaki Y, Itoyama S, Tsuzaka K, Takeuchi T.
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Journal Title
Rheumatology
Volume: 49
Pages: 1789-1791
Related Report
Peer Reviewed
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[Journal Article] IgG4-positive mufti-organ lymphoproliferative syndrome manife sting as chronic symmetrical sclerosing dacryo-sialo-adenitis with subsequent secondary portal hypertension and remarkable IgG4-linked IL-4 elevation.2010
Author(s)
Suzuki K, Tamaru J, Okuyama A, Kameda H, Amano K, Nagasawa H, Nishi, E, Yoshimoto K, Setoyama Y, Kaneko K, Osada H, Honda N, Yasaki Y, Itoyama S, Tsuzaka K, Takeuchi T.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] The comparison of efficacy and safety between continuation and discontinuation of methotrexate(MTX)at the commencement of etanercept in patients with active rheumatoid arthritis despite MTX therapy : 24-week results from the JESMR study.2010
Author(s)
Kameda H, Ueki Y, Saito K, Nagaoka S, Hidaka T, Atsumi T, Tsukano M, Kasama T, Shiozawa S, Tanaka Y, Takeuchi T, Japan Biological Agent Integrated Consortium(J-BASIC).
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Related Report
Peer Reviewed
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[Journal Article] Prediction of efficacy of anti-TNF biologic agent, infliximab, for rheumatoid arthritis patients using a comprehensive transc riptome analysis of white blood cells.2009
Author(s)
Tanino M, Matoba R, Nakamura S, Kameda H, Amano K, Okayama T, Nagasawa H, Suzuki K, Matsubara K, Takeuchi T.
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Journal Title
Biochem Biophys Research Comm 387
Pages: 261-265
Related Report
Peer Reviewed
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