The expression of high affinity IgE receptor β-chain in human mast cells and basophils, and its roles
| Project/Area Number |
20591195
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Nihon University |
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Principal Investigator |
OKAYAMA Yoshimichi Nihon University, 医学部, 准教授 (80292605)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUDA Akira 順天堂大学, 医学部, 准教授 (00312348)
SAGARA Hironori 独協医科大学, 医学部, 教授 (80275742)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | アレルギー・ぜんそく / シグナル伝達 / マスト細胞 / 好塩基球 / FcεRIβ鎖 / FcεRI β鎖 |
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| Research Abstract |
The ratio of the FcεRIβ^+ cell number to the mast cell number was significantly increased in cases of atopic conjunctivitis, compared with non-allergic conjunctivitis. The diminution of FcεRIβ significantly down-regulated IgE-dependent mediator release, and the redistribution of Lyn to the cell membrane following IgE sensitization. Specific inhibition of the interaction between FcεRIβ and Lyn may represent a new therapeutic strategy for the treatment of human allergic diseases.
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Report
(4 results)
Research Products
(79 results)
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[Journal Article] Basophils in the giant allergic keratoconjunctivitis.2010
Author(s)
Matsuda A, Ebihara N, Yokoi N, Okayama Y, Watanabe Y, Kawasaki S, Tanioka H, Kawasaki S, Walls AF, Hamuro J, Kinoshita S, Murakami A
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Journal Title
Brit J Ophthalomol 94(4)
Pages: 513-518
Related Report
Peer Reviewed
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[Journal Article] The role of interleukin-33 in chronic allergic conjunctivitis.2009
Author(s)
Matsuda A, Okayama Y, Terai N, Yokoi N, Ebihara N, Tanioka H, Kawasaki S, Inatomi T, Katoh N, Ueda E, Hamuro J, Murakami A, Kinoshita S
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Journal Title
Invest Ophth Vis Sci 50(10)
Pages: 4646-4652
Related Report
Peer Reviewed
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[Journal Article] FcεRI-mediated thymic stromal lymphopoietin production by IL-4-primed human mast cells.2009
Author(s)
Okayama Y, Okumura S, Sagara H, Yuki K, Sasaki T, Watanabe N, Fueki M, Sugiyama K, Takeda K, Fukuda T, Saito H, Ra C
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Journal Title
Eur Respir J 34
Pages: 425-435
Related Report
Peer Reviewed
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