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The expression of high affinity IgE receptor β-chain in human mast cells and basophils, and its roles

Research Project

Project/Area Number 20591195
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionNihon University

Principal Investigator

OKAYAMA Yoshimichi  Nihon University, 医学部, 准教授 (80292605)

Co-Investigator(Renkei-kenkyūsha) MATSUDA Akira  順天堂大学, 医学部, 准教授 (00312348)
SAGARA Hironori  独協医科大学, 医学部, 教授 (80275742)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsアレルギー・ぜんそく / シグナル伝達 / マスト細胞 / 好塩基球 / FcεRIβ鎖 / FcεRI β鎖
Research Abstract

The ratio of the FcεRIβ^+ cell number to the mast cell number was significantly increased in cases of atopic conjunctivitis, compared with non-allergic conjunctivitis. The diminution of FcεRIβ significantly down-regulated IgE-dependent mediator release, and the redistribution of Lyn to the cell membrane following IgE sensitization. Specific inhibition of the interaction between FcεRIβ and Lyn may represent a new therapeutic strategy for the treatment of human allergic diseases.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (79 results)

All 2011 2010 2009 2008

All Journal Article (28 results) (of which Peer Reviewed: 24 results) Presentation (39 results) Book (8 results) Patent(Industrial Property Rights) (4 results) (of which Overseas: 2 results)

  • [Journal Article] マスト細胞2011

    • Author(s)
      岡山吉道,柏倉淳一,権寧博,相良博典,大森一光,照井正,橋本修,羅智靖
    • Journal Title

      救急医学 5(5)

      Pages: 533-535

    • Related Report
      2010 Final Research Report
  • [Journal Article] Relationships between cytokine profiles and signaling pathways (IkB kinase and p38 MAPK) in parainfluenza virus-infected lung fibroblasts.2011

    • Author(s)
      Yoshizumi M
    • Journal Title

      Front in Virol

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of human mast cells through the platelet activating factor receptor.2010

    • Author(s)
      Kajiwara N, Sasaki T, Bradding P, Cruse G, Sagara H, Ohmori K, Saito H, Ra C, Okayama Y
    • Journal Title

      J Allergy Clin Immunol 125(5)

      Pages: 1137-1145

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Basophils in the giant allergic keratoconjunctivitis.2010

    • Author(s)
      Matsuda A, Ebihara N, Yokoi N, Okayama Y, Watanabe Y, Kawasaki S, Tanioka H, Kawasaki S, Walls AF, Hamuro J, Kinoshita S, Murakami A
    • Journal Title

      Brit J Ophthalomol 94(4)

      Pages: 513-518

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] アトピー関連遺伝子ST2,IL-33のアレルギー疾患における発現とその機序2010

    • Author(s)
      岡山吉道,松田彰,佐々木朋美,羅智靖
    • Journal Title

      臨床免疫・アレルギー科 54(5)

      Pages: 553-557

    • Related Report
      2010 Final Research Report
  • [Journal Article] マスト細胞と高親和性IgE受容体beta鎖2010

    • Author(s)
      岡山吉道,松田彰,布村聡,佐々木朋美,羅智靖
    • Journal Title

      臨床免疫・アレルギー科 53(5)

      Pages: 481-485

    • Related Report
      2010 Final Research Report
  • [Journal Article] Basophils in the giant allergic keratoconjunctivitis.2010

    • Author(s)
      Matsuda A
    • Journal Title

      Brit J Ophthalomol

      Volume: 94(4) Pages: 513-518

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of human mast cells through the platelet activating factor receptor.2010

    • Author(s)
      Kajiwara N
    • Journal Title

      J Allergy Clin Immunol

      Volume: 125(5) Pages: 1137-1145

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Basophils in the giant allergic keratoconjunctivitis2010

    • Author(s)
      Matsuda A
    • Journal Title

      Brit J Ophthalomol (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of human mast cells through the platelet activating factor receptor2010

    • Author(s)
      Kajiwara N
    • Journal Title

      J Allergy Clin Immunol (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of interleukin-33 in chronic allergic conjunctivitis.2009

    • Author(s)
      Matsuda A, Okayama Y, Terai N, Yokoi N, Ebihara N, Tanioka H, Kawasaki S, Inatomi T, Katoh N, Ueda E, Hamuro J, Murakami A, Kinoshita S
    • Journal Title

      Invest Ophth Vis Sci 50(10)

      Pages: 4646-4652

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic aspects of ocular atopic diseases.2009

    • Author(s)
      Matsuda A, Ebihara N, Yokoi N, Hamuro J, Hopkin JM, Okayama Y
    • Journal Title

      Cornea 28(9)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hyperexpression of the high-affinity IgE receptor-β chain in chronic allergic keratoconjunctivitis.2009

    • Author(s)
      Matsuda A, Okayama Y, Ebihara N, Yokoi N, Hamuro J, Walls AF, Ra C, Hopkin JM, Kinoshita S
    • Journal Title

      Invest Ophth Vis Sci 50(6)

      Pages: 2871-2877

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] FcεRI-mediated thymic stromal lymphopoietin production by IL-4-primed human mast cells.2009

    • Author(s)
      Okayama Y, Okumura S, Sagara H, Yuki K, Sasaki T, Watanabe N, Fueki M, Sugiyama K, Takeda K, Fukuda T, Saito H, Ra C
    • Journal Title

      Eur Respir J 34

      Pages: 425-435

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tissue remodeling by hypersecreted epidermal growth factor and amphiregulin in the airway following an acute asthma attack.2009

    • Author(s)
      Enomoto Y, Orihara K, Takamasu T, Matsuda A, Gon Y, Saito H, Ra C, Okayama Y
    • Journal Title

      J Allergy Clin Immunol 124

      Pages: 913-920

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proteomic approach to FcεRI aggregation-initiated signal transduction cascade in human mast cells.2009

    • Author(s)
      Yamaoka K, Okayama Y, Kaminuma O, Katayama K, Mori A, Tatsumi H, Nemoto S, Hiroi T
    • Journal Title

      Int Arch Allergy Immunol 149(Suppl.1)

      Pages: 73-76

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hyperexpression of the high-affinity IgE receptor-β chain in chronic allergic keratoconjunctivitis2009

    • Author(s)
      Matsuda A
    • Journal Title

      Invest Ophth Vis Sci 50(6)

      Pages: 2871-2877

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FcεRI-mediated thymic stromal lymphopoietin production by IL-4-primed human mast cells2009

    • Author(s)
      Okayama Y
    • Journal Title

      Eur Respir J 34

      Pages: 425-435

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of interleukin-33 in chronic allergic conjunctivitis2009

    • Author(s)
      Matsuda A
    • Journal Title

      Invest Ophth Vis Sci 50(10)

      Pages: 4646-4652

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proteomic approach to FcεRI aggregation-initiated signal transduction cascade in human mast cells2009

    • Author(s)
      Yamaoka K
    • Journal Title

      Int Arch Allergy Immunol 149(Suppl.1)

      Pages: 73-76

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tissue remodeling by hypersecreted epidermal growth factor and amphiregulin in the airway following an acute asthma attack2009

    • Author(s)
      Enomoto Y
    • Journal Title

      J Allergy Clin Immunol 124

      Pages: 913-920

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic aspects of ocular atopic diseases2009

    • Author(s)
      Matsuda A
    • Journal Title

      Cornea 28(9)

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Hyperexpression of NOD2 in intestinal mast cells of Crohn's disease patients ; preferential expression of inflammatory cell-recruiting molecules via N0D2 in mast cells.2009

    • Author(s)
      Okumura S
    • Journal Title

      Clin Immunol 130

      Pages: 175-185

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hyperexpression of the high-affinity IgE receptor-β chain in chronic allergic keratoconjunctivitis.2009

    • Author(s)
      Matsuda A
    • Journal Title

      Invest Ophth Vis Sci (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FcsRI-mediated thymic stromal lymphopoietin production by IL-4-primed human mast cells.2009

    • Author(s)
      Okayama Y
    • Journal Title

      Eur Respir J (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High-affinity IgE receptor-β chain expression in human mast cells.2008

    • Author(s)
      Okayama Y
    • Journal Title

      J Immunol Methods 336

      Pages: 229-234

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-3 does not affect the differentiation of mast cells derived from human bone marrow progenitors.2008

    • Author(s)
      Shimizu Y
    • Journal Title

      Immunol Invest 37

      Pages: 1-17

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The airway smooth muscle CCR/CCLll axis is inhibited by mast cells.2008

    • Author(s)
      Saunders R
    • Journal Title

      Allergy 63

      Pages: 1148-1155

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 抗II型コラーゲン抗体誘導性関節炎モデルにおけるFcεRIβ鎖の役割2010

    • Author(s)
      吉岡美乃,布村聡,岡山吉道,片岡竜貴,羅智靖
    • Organizer
      第60回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-27
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] アナフィラキシーを繰り返すSystemic Mastocytosisの一例2010

    • Author(s)
      塩谷裕美,菅井和子,小林慈典,鏑木陽一,片岡竜貴,岡山吉道
    • Organizer
      第60回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-26
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 高親和性IgE受容体beta鎖を分子標的としたアレルギー疾患の治療(シンポジウム3 好塩基球・マスト細胞研究の進展とアレルギーの新展開)2010

    • Author(s)
      岡山吉道,松田彰,佐々木朋美,布村聡,小野芳啓,羅智靖
    • Organizer
      第60回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-26
    • Related Report
      2010 Final Research Report
  • [Presentation] 高親和性IgE受容体beta鎖を分子標的としたアレルギー疾患の治療(シンポジウム3好塩基球・マスト細胞研究の進展とアレルギーの新展開)2010

    • Author(s)
      岡山吉道
    • Organizer
      第60回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2010-11-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] IgEによる未成熟ヒトマスト細胞のFcεRIを介する脱顆粒能の獲得とヒト型抗IgE抗体による抑制(イブニングシンポジウム1重症喘息の治療戦略~IgEをターゲットとした治療)2010

    • Author(s)
      岡山吉道
    • Organizer
      第60回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2010-11-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] IgEによる未成熟ヒトマスト細胞のFcεRIを介する脱顆粒能の獲得とヒト型抗IgE抗体による抑制(イブニングシンポジウム1 重症喘息の治療戦略~IgEをターゲットとした 治療)2010

    • Author(s)
      岡山吉道,松田彰,権寧博,照井正,浅野正岳,秋久俊博,佐々木朋美,羅智靖
    • Organizer
      第60回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-25
    • Related Report
      2010 Final Research Report
  • [Presentation] 気道上皮バリア形成におけるErbb2/3シグナルの役割2010

    • Author(s)
      寺門正裕,権寧博,神津悠,関山明子,竹下郁子,松本健,高橋典明,岡山吉道,羅智靖,橋本修
    • Organizer
      第60回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-25
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 呼吸器感染症ウイルスと喘息 教育講演12010

    • Author(s)
      岡山吉道
    • Organizer
      第59回日本感染症学会東日本地方会学術集会 第57回日本化学療法学会東日本支部総会 合同学会
    • Place of Presentation
      東京
    • Year and Date
      2010-10-21
    • Related Report
      2010 Final Research Report
  • [Presentation] 呼吸器感染症ウイルスと喘息 教育講演12010

    • Author(s)
      岡山吉道
    • Organizer
      第59回日本感染症学会東日本地方会学術集会第57回日本化学療法学会東日本支部総会合同学会
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2010-10-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] IgE-dependent human mast cell degranulation is inhibited by intracellular introduction of phosphorylated FcεRI β immunoreceptor tyrosine-based activation motif.(Workshop 20. Mast cells in allergic responses)2010

    • Author(s)
      Okayama Y, Matsuda A, Sasaki T, Nunomura S, Ra C
    • Organizer
      14^<th> International Congress of immunology
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2010-08-23
    • Related Report
      2010 Final Research Report
  • [Presentation] IgE-dependent human mast cell degranulation is inhibited by intracellular introduction of phosphorylated FcεRI β immunoreceptor tyrosine-based a ctivation motif. (Workshop 20. Mast cells in allergic responses)2010

    • Author(s)
      Okayama Y
    • Organizer
      14^<th> International Congress of immunology
    • Place of Presentation
      Kobe
    • Year and Date
      2010-08-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新規ヒトマスト細胞活性化阻害ペプチド2010

    • Author(s)
      岡山吉道
    • Organizer
      第9回バイオテクノロジー国際会議
    • Place of Presentation
      東京
    • Year and Date
      2010-07-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒトマスト細胞によるPAFを介するアナフィラキシー反応の増幅機構(教育コース15.基礎・その他)2010

    • Author(s)
      岡山吉道
    • Organizer
      第22回日本アレルギー学会春季臨床大会
    • Place of Presentation
      京都
    • Year and Date
      2010-05-09
    • Related Report
      2010 Final Research Report
  • [Presentation] ヒトマスト細胞によるPAFを介するアナフィラキシー反応の増幅機構(教育コース15.基礎・その他)2010

    • Author(s)
      岡山吉道
    • Organizer
      第22回日本アレルギー学会春季臨床大会
    • Place of Presentation
      京都(招待講演)
    • Year and Date
      2010-05-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Intracellular introduction of phosphorylated FcεRI β immunoreceptor tyrosine-based activation motif inhibits IgE-dependent human mast cell activation.2010

    • Author(s)
      Okayama Y, Ra C
    • Organizer
      28^<th> Symposium of the Collegium Internationale Allergologium
    • Place of Presentation
      Ischia, Italy
    • Year and Date
      2010-04-26
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] ヒトアレルギー疾患の治療標的としての高親和性IgE受容体FcεRIβ鎖(シンポジウムS53マスト細胞研究の新たな展開)2010

    • Author(s)
      岡山吉道
    • Organizer
      第130年回日本薬学会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-28
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] The role of human FcεRI β chain expressed in human mast cells in allergic diseases.2009

    • Author(s)
      Okayama Y, Matsuda A, Sasaki T, Nunomura S, Ra C
    • Organizer
      第39回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-12-02
    • Related Report
      2010 Final Research Report
  • [Presentation] The role of human FcεRI β chain expressed in human mast cells in allergic diseases2009

    • Author(s)
      岡山吉道
    • Organizer
      第39回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-12-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] 気管支喘息急性発作時に過剰産生されるEGFとAmphiregulinの気道リモデリングへの関与の検討(ミニシンポジウム)2009

    • Author(s)
      榎本幸典,折原芳波,高増哲也,松田明生,権寧博,斎藤博久,羅智靖,岡山吉道
    • Organizer
      第59回日本アレルギー学会秋季学術大会
    • Place of Presentation
      秋田
    • Year and Date
      2009-10-31
    • Related Report
      2010 Final Research Report
  • [Presentation] Regulation of mast cell activation by FcεRIβ chain(International symposium ; eosinophils, other inflammatory cells and molecules in allergy)2009

    • Author(s)
      Ra C, Nunomura S, Suzuki Y, Okayama Y
    • Organizer
      第59回日本アレルギー学会秋季学術大会
    • Place of Presentation
      秋田
    • Year and Date
      2009-10-31
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 気管支喘息急性発作時に過剰産生されるEGFと Amphiregulin の気道リモデリングへの関与の検討(ミニシンポジウム)2009

    • Author(s)
      榎本幸典
    • Organizer
      第59回日本アレルギー学会秋季学術大会
    • Place of Presentation
      秋田
    • Year and Date
      2009-10-31
    • Related Report
      2009 Annual Research Report
  • [Presentation] アトピー関連遺伝子ST2,IL-33のアレルギー疾患における発現と発現機序(ワークショップ4 アレルギーの感作成立=発症なのか?)2009

    • Author(s)
      岡山吉道,松田彰,小野芳啓,羅智靖
    • Organizer
      第59回日本アレルギー学会秋季学術大会
    • Place of Presentation
      秋田
    • Year and Date
      2009-10-29
    • Related Report
      2010 Final Research Report
  • [Presentation] ErbB受容体シグナルによる気道上皮透過性バリア機能の制御(ミニシンポジウム)2009

    • Author(s)
      権寧博,寺門正裕,関山明子,神津悠,竹下郁子,松本健,岡山吉道,橋本修,羅智靖
    • Organizer
      第59回日本アレルギー学会秋季学術大会
    • Place of Presentation
      秋田
    • Year and Date
      2009-10-29
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] アトピー関連遺伝子ST2, IL-33のアレルギー疾患における発現と発現機序(ワークショップ4 アレルギーの感作成立=発症なのか?)2009

    • Author(s)
      岡山吉道
    • Organizer
      第59回日本アレルギー学会秋季学術大会
    • Place of Presentation
      秋田
    • Year and Date
      2009-10-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] アレルギーの発症と病態の現在の考え方2009

    • Author(s)
      岡山吉道
    • Organizer
      第27回産業医科大学学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2009-10-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] FcεRI-mediated thymic stromal lymphopoietin production by IL-4-primed human mast cells.2009

    • Author(s)
      Okayama Y, Sagara H, Fueki M, Sasaki T, Sugiyama K, Fukuda T, Saito H, Ra C
    • Organizer
      第19回国際喘息学会日本北アジア部会
    • Place of Presentation
      東京
    • Year and Date
      2009-07-10
    • Related Report
      2010 Final Research Report
  • [Presentation] FcεRI-mediated thymic stromal lymphopoietin production by IL-4-primed human mast cells2009

    • Author(s)
      岡山吉道
    • Organizer
      第19回国際喘息学会日本北アジア部会
    • Place of Presentation
      東京
    • Year and Date
      2009-07-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] Activation of PAF receptor via PLCβ2 activation leads to degranulation in human lung mast cells.2009

    • Author(s)
      Okayama Y, Kajiwara N, Saito H, Ra C
    • Organizer
      第49回日本呼吸器学会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2009-06-14
    • Related Report
      2010 Final Research Report
  • [Presentation] Activation of PAF receptor via PLCβ2 activation leads to degranulation in human lung mast cells2009

    • Author(s)
      岡山吉道
    • Organizer
      第49回日本呼吸器学会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2009-06-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] マスト細胞と高親和性IgE受容体(シンポジウム12アレルギーと炎症細胞)2009

    • Author(s)
      岡山吉道,松田彰,羅智靖
    • Organizer
      第21回日本アレルギー学会春季臨床大会
    • Place of Presentation
      岐阜
    • Year and Date
      2009-06-06
    • Related Report
      2010 Final Research Report
  • [Presentation] マスト細胞と高親和性IgE受容体(シンポジウム12 アレルギーと炎症細胞)2009

    • Author(s)
      岡山吉道
    • Organizer
      第21回日本アレルレギー学会春季臨床大会
    • Place of Presentation
      岐阜
    • Year and Date
      2009-06-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] インターロイキン33と慢性アレルギー性結膜炎2009

    • Author(s)
      松田彰,海老原伸行,横井則彦,川崎諭,谷岡秀敏,岡山吉道,羽室淳爾,木下茂
    • Organizer
      第113回日本眼科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-04-16
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] ヒトマスト細胞のGaiに結合したPAF受容体の活性化はPLCβ2の活性化を介して脱顆粒を惹起する2008

    • Author(s)
      Okayama Y
    • Organizer
      第37回日本免疫学会総会・学術集会
    • Place of Presentation
      京都
    • Year and Date
      2008-12-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] ヒトマスト細胞におけるIgE依存性の亜鉛分泌2008

    • Author(s)
      Nakasima K
    • Organizer
      第37回日本免疫学会総会・学術集会
    • Place of Presentation
      京都
    • Year and Date
      2008-12-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] 各EGF受容体リガンドによるヒト気道平滑筋・上皮細胞の増殖効果の相違2008

    • Author(s)
      折原芳波
    • Organizer
      第58回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2008-11-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] 気道における肥満細胞とアレルギー(シンポジウム6アレルギー疾患とStructure Cells)2008

    • Author(s)
      岡山吉道
    • Organizer
      第58回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2008-11-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] ヒトマスト細胞の培養法と多様性, 教育講演102008

    • Author(s)
      岡山吉道
    • Organizer
      第58回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2008-11-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] PAF causes degranulation via PLCβ2 in human mast cells.2008

    • Author(s)
      Okayama Y
    • Organizer
      第58回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2008-11-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] The significant increase in number of thymic stromal lymphopoietin (TSLP) -positive mast cells in the airways of asthmatic patients.2008

    • Author(s)
      Okayama Y
    • Organizer
      第48回日本呼吸器学会学術講演会
    • Place of Presentation
      神戸
    • Year and Date
      2008-06-16
    • Related Report
      2008 Annual Research Report
  • [Book] ライノウイルス(田代眞人 編集)臨床ウイルス診断学必携2011

    • Author(s)
      岡山吉道
    • Publisher
      羊土社(掲載確定 印刷中)
    • Related Report
      2010 Annual Research Report
  • [Book] アレルギー疾患イラストレイテッド第2版(永倉俊和,森田寛,足立満 編集)(マスト細胞)2010

    • Author(s)
      岡山吉道
    • Publisher
      メディカルレビュー社,東京
    • Related Report
      2010 Final Research Report
  • [Book] 総合アレルギー学(改訂2版)(福田健 編集)(マスト細胞、好塩基球の細胞生物学)2010

    • Author(s)
      岡山吉道
    • Publisher
      南山堂,東京
    • Related Report
      2010 Final Research Report
  • [Book] マスト細胞、好塩基球の細胞生物学(福田健 編集)総合アレルギー学(改訂2版)2010

    • Author(s)
      岡山吉道
    • Total Pages
      11
    • Publisher
      南山堂
    • Related Report
      2010 Annual Research Report
  • [Book] マスト細胞(桂義元, 山本一彦, 小安重夫, 河本宏 編集)免疫の事典2010

    • Author(s)
      岡山吉道
    • Publisher
      朝倉書店(In press)
    • Related Report
      2009 Annual Research Report
  • [Book] 花粉症(桂義元, 山本一彦, 小安重夫, 河本宏 編集)免疫の事典2010

    • Author(s)
      岡山吉道
    • Publisher
      朝倉書店(In press)
    • Related Report
      2009 Annual Research Report
  • [Book] マスト細胞、好塩基球の細胞生物学(福田健 編集)総合アレルギー学(改訂2版)2010

    • Author(s)
      岡山吉道
    • Publisher
      南山堂(In press)
    • Related Report
      2009 Annual Research Report
  • [Book] 難治性気管支喘息とヒトマスト細胞(大田健、伊藤幸治 監修)The 15^<th> Symposium of Asthma in Tokyo2008

    • Author(s)
      岡山吉道
    • Total Pages
      68
    • Publisher
      ライフサイエンス株式会社
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 新規ヒトマスト細胞活性化阻害ペプチド2010

    • Inventor(s)
      岡山吉道、羅智靖
    • Industrial Property Rights Holder
      日本大学
    • Filing Date
      2010-09-11
    • Related Report
      2010 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 新規ヒトマスト細胞活性化阻害ペプチド2010

    • Inventor(s)
      岡山吉道、羅智靖
    • Industrial Property Rights Holder
      日本大学
    • Filing Date
      2010-09-11
    • Related Report
      2010 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 新規ヒトマスト細胞活性化阻害ペプチド2009

    • Inventor(s)
      岡山吉道、羅智靖
    • Industrial Property Rights Holder
      日本大学
    • Filing Date
      2009-09-11
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 新規ヒトマスト細胞活性化阻害ペプチド2009

    • Inventor(s)
      岡山吉道, 羅智靖
    • Industrial Property Rights Holder
      日本大学
    • Industrial Property Number
      2009-206324
    • Filing Date
      2009-09-11
    • Related Report
      2009 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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